• Title/Summary/Keyword: Dosing

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A Contrast Nephropathy in a Preterm Infant Following Preoperative Embolization of Giant Sacrococcygeal Teratoma

  • Lee, Byong Sop
    • Childhood Kidney Diseases
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    • 제21권1호
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    • pp.26-30
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    • 2017
  • Newborn infants with huge and highly vascular sacrococcygeal teratoma (SCT) are frequently subjected to renal hypoperfusion secondary to high-output cardiac failure. Any underlying renal dysfunction is a significant risk factor for the development of contrast-induced nephropathy (CIN). However, reports on CIN in infants are rare. I report here a case of a premature infant born at 28 weeks and 3 days of gestation with a huge SCT who survived preoperative embolization and surgical resection but presented with persistent non-oliguric renal failure that was suggestive of CIN. During radiological intervention, a contrast medium had been administered at about 10 times the manufacturer-recommended dose for pediatric patients. Despite hemodynamic stabilization and normalization of urine output immediately following surgery, the patient's serum creatinine and cystatin-C levels did not return to baseline until 4 months after birth. No signs of reflux nephropathy were observed in follow-up imaging studies. Dosing guidelines for the use of a contrast medium in radiological interventions should be provided for infants or young patients.

굳지 않은 콘크리트의 슬럼프손실 저감을 위한 혼화재의 활용 (Utillization of Mineral Admixtures for the Reduction of Slump Loss in Fresh Concrete)

  • 문한영;문대중
    • 콘크리트학회지
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    • 제10권2호
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    • pp.155-165
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    • 1998
  • 굳지 않은 콘크리트의 슬럼프손실을 저감시키기 위한 목적으로 고로슬래그 미분말 및 플라이애쉬의 혼합비율과 혼화제의 첨가방법을 변화시킨 콘크리트의 믹싱후 경과시간에 따른 슬럼프 변화에 대하여 고찰하였다. 연구결과 보통포틀랜드시멘트에 고로슬래그 비분말 또는 플라이애쉬를 혼합한 콘크리트가 혼화재를 혼합하지 않은 콘크리트보다 슬럼프손실을 줄일 수 있었으며, 고로슬래그 미분말과 플라이애쉬를 각각 50 및 5%를 혼합한 3성분계 콘크리트의 경우 슬럼프손실을 저감시키는데 유효하였다. 또한 혼화제의 일부를 15분후 분할하여 후첨가하는 혼합방법이 굳지않은 콘크리트의 슬럼프손실을 저감시키는데 가장 큰 효과가 있다. 한편 혼화재를 혼합한 3성분계 보통강도용 및 고강도용 콘크리트의 재령 28일까지의 압축강도는 혼화재를 혼합하지 않은 콘크리트보다 작았으나 재령 91일 압축강도는 31% 및 15%정도 크게 증가하였다.

가토에서 정맥투여시 생체리듬이 아세부토롤의 약물동태에 미친영향 (The Effect of Circadian Rhythm on the Pharmacokinetics of Acebutolol after Intravenous Administration to Rabbits)

  • 최준식
    • 한국임상약학회지
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    • 제11권2호
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    • pp.57-61
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    • 2001
  • The effect of circadian rhythm on the pharmacokinetics of acebutolol was studied in rabbits administered intravenous 5 mg/kg dose of acebutolol at 09:00 in the morning (a.m) and 22:00 in the evening (p.m). A significant effect of circadian rhythm of pbarmacokinetic parameters as a function of time of day was noted in rabbits, showing lower total body clearance (CLt), higher plasma concentration and the area under the plasma concentration time curve (AUC) when acebutolol was given in the evening. The plasma concentration of acebutolol was increased significantly (p<0.05) at 12-24 hr after dosing in the evening. The AUC was greater in the evening $(111\%)$ than that in the morning and $CL_t$, was higher when acebutolol was given in the morning ($1.12\pm0.24$ ml/hr) versus in the evening ($1.01\pm0.22$ ml/hr), but those were not significant. Therefore, It is reasonable to consider individual circadian rhythm for effective dosage regimen of acebutolol in clinical chronotherapeutics.

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건물의 가압방연시스템 설계를 위한 유동해석에 관한 연구 (Flow Analysis of Building Pressurization System for Smoke Control)

  • 김명배;한용식
    • 한국화재소방학회논문지
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    • 제14권2호
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    • pp.14-20
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    • 2000
  • 건물화재시에 연기에 의한 피난자의 위험을 감소시키고 소방대의 구조활동을 원활히 하기 위하여 건물 외부의 공기를 이용, 건물내부의 일부를 가압하는 가압방연시스템이 이용되고 있다. 본 연구에서는 건물의 가압방연시스템을 설계하기 위하여 건물의 각 요소, 방, 로비, 계단실, 급기샤프트 등을 연결하는 유로를 구성하여 각 요소에서의 압력손실과 유량을 계산할 수 있는 컴퓨터 프로그램을 개발하였다. 본 프로그램을 이용하여 가압용 송풍기의 적절한 용량선정과 송풍기의 용량 최적화를 위한 방안을 강구하였다.

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고성능AE감수재를 사용한 시멘트복합체의 유동성 유지성능 (Fluidity Retention of Cement-Based Composites Using High range water reducing AE agent)

  • 김기형;김인수
    • 한국콘크리트학회:학술대회논문집
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    • 한국콘크리트학회 1998년도 가을 학술발표회 논문집(I)
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    • pp.93-98
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    • 1998
  • Fluidity retention of concrete used high range water reducing AE agent(HWAE) is varied according to type, dosage amount and dosing method of HWAE. The type and substitution ratio of mineral admixture also have influence on the fluidity retention of concrete using HWAE. For the purpose of improving the fluidity retention in concrete used HWAE, 3 types of HWAE and ground granulated blast furnace slag(SG) are applied in cement-based composites such as cement paste, mortar and concrete respectively. According to using the HWAE of naphthalene sulfonates and SG, the fluidity retention of mortar and concerete is improving the fluidity retention and strength of concrete regardless of type of HWAE.

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WAP 게이트웨이의 유/무선 프로토콜 변환 기능에 대한 설계 및 구현 (Dosing and Implementation of wire/wireless protocol Converting Function for WAP Gateway)

  • 이정은;이종렬;노강래;신동일;신동규
    • 한국정보처리학회:학술대회논문집
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    • 한국정보처리학회 2001년도 추계학술발표논문집 (하)
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    • pp.1549-1552
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    • 2001
  • 무선통신 단말기의 발전과 함께 이를 활용할 수 있는 방법론에 대한 논의도 활발해지고 있으며, 이중 가장 주목받고 있는 것이 이동 통신 단말기를 이용한 무선인터넷 서비스이다. 이러한 서비스의 기반이 되는 것이 무선 인터넷 프로토콜인 WAP(Wireless Application Protocol)이다. 현재의 셀룰러망을 이용한 통신은 비교적 낮은 전송률을 가지고 있어, 대용량의 데이터들을 포함하는 WWW 문서 및 대량의 무선 마크업 언어(WML: Wireless Markup Language) 문서를 전송하기에는 너무 느린 단점을 가지고 있다. 이에 대한 대안으로 본 논문에서는 WAP 포럼 내에서 제정한 프로토콜에 변환기능을 추가한 Gateway를 설계 및 구현하였다.

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전자선조사에 의한 선형저밀도폴리에틸렌의 개질 (Modification of Linear Low Density Polyethylene by Irradiation of Electron Beam)

  • 오장훈;천성득;황규면
    • 유변학
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    • 제10권4호
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    • pp.256-258
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    • 1998
  • 선형저밀도폴리에틸렌(LLDPE)의 필름 제조시 가공성 및 필름의 투명성을 개선하기 위한 실험을 하였다. LLDPE에 전자선을 조사하여 분자구조를 변형시켜줌으로써 가공 특성 및 광학적 특성이 향상된 필름을 얻을 수 있었다. 전자선 조사량의 세기를 조절하여 일정량만 조사하고 자외선 안정제를 소량 처방하면 필름 가공시 젤이 생기지 않았고 투명성 및 가공성이 개선되었다.

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Atomic Layer Deposition of $Sb_2S_3$ Thin Films on Mesoporous $TiO_2$

  • 한규석;정진원;성명모
    • 한국진공학회:학술대회논문집
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    • 한국진공학회 2013년도 제44회 동계 정기학술대회 초록집
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    • pp.282-282
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    • 2013
  • The antimony sulfide ($Sb_2S_3$) thin films were deposited using the gas phase method which known as atomic layer deposition (ALD) on mesoporous micro-films. Tris (dimethylamido) antimony (III[$(Me_2N)_3Sb$] and hydrogensulfide ($H_2S$) were used as precursors to deposit $Sb_2S_3$. Self-terminating nature of $(Me_2N)_3Sb$ and $H_2S$ reaction were demonstrated by growth rate saturation versus precursors dosing time. Absorption spectra and extinction coefficient were investigated by UV-VIS spectroscopy. Scanning electron microscopic analysis and X-ray photoelectron spectroscopy (XPS) depth profile were employed to determine the conformal deposition.

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Effects of Sustained-Release Formulation of Recombinant Human Growth Hormone on Body weight. Bone growth and Organs in Hypophysectomized Rats

  • Jo, Yeong-Woo;Park, Yong-Man;Lee, Ghun-Il;Park, Yong-Man;Yang, Hi-Chang;Kim, Mi-Ryang;Lee, Sung-Hee;Kwon, Jong-Won;Kim, Won-Bae
    • 대한약학회:학술대회논문집
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    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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    • pp.417.2-418
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    • 2002
  • The rhGH-loaded PLGA microsphere formulation was prepared using a double emulsion process from hydrophilic 0:50 poly(D.L-lactide-co-glycolide) (PLGA) polymers. To investigate the sustained efficacy of this formulation, ts pharmacodynamic characteristics were analyzed. It showed particle size of ca 53.1 $\mu\textrm{m}$ with high drug ncorporation efficiency and it was sucutaneously administrated to hypophysectomized rats and whole body rowth responses of this formulation were compared to those of the different dosing patterns of rhGH. (omitted)

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INVESTIGATIONS ON VARIABLE WELD PENETRATIONS IN GTA WELDING OF AUSTENITIC AND MARTENSITIC STAINLESS STEELS

  • Puybouffat, Sylvain;Chabenat, Alain;Boudot, Cecile;Marya, Surendar
    • 대한용접접합학회:학술대회논문집
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    • 대한용접접합학회 2002년도 Proceedings of the International Welding/Joining Conference-Korea
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    • pp.752-756
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    • 2002
  • Variable weld bead penetrations related to the base metal chemistry of stainless steels in GTA welding have been under constant investigations due to their industrial implications. It has been proposed that among other elements, the sulfur content of steels determines the weld pool geometry, particularly its penetration. It is suggested that the surface tension temperature gradient of steels becomes positive with appropriate dosing in sulfur and results in inward melt flow, propitious for deeper welds. However, the chemistry of industrial steels is complex due to the presence of multiple minor elements either deliberately added or remnant impurity traces. With this in view, investigations on 41 austenitic and nine martensitic stainless steels were carried to see if there existed any possible relation between the weld profile and some of the designated elements. The results suggest no direct correlation between sulfur or any other major or trace element and weld penetration. At first glance the results are contradictory to what is often asserted.

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