• Proceedings of the Korean Society of Applied Pharmacology
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• 2006.11a
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• pp.51-66
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• 2006

The field of cytochrome P450 pharmacogenomics has progressed rapidly during the past 25 years. Recently, conjugating enzymes including sulfotransferase, acetyltransferase, glucuronosyltransferase and glutathione transferase have been also extensively studied. All the major human drug-metabolizing P450 enzymes and some conjugating enzymes have been identified and cloned, and the major gene variants that cause inter-individual variability in drug response and are related to adverse drug reactions have been identified. This information now provides the basis for the use of predictive pharmacogenomics to yield drug therapies that are more efficient and safer. Today, we understand which drugs warrant dosing based on pharmacogenomics to improve drug treatment. It is anticipated that genotyping could be used to personalize drug treatment for vast numbers of subjects, decreasing the cost of drug treatment and increasing the efficacy of drugs and health in general. It is assumed that such personalized P450 gene-based treatment which is so-called tailor(order)-made drug therapy would be relevant for 10-20% of all drug therapy in the future.

• Proceedings of the Korean Vacuum Society Conference
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• 2012.08a
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• pp.395-395
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• 2012

We fabricate organic-inorganic hybrid thin film for the purpose of encapsulation by molecular layer deposition (MLD) using Trimethylaluminium (TMA) and Adipoyl Chloride (AC). Ellipsometry was employed to verify self limiting reaction of ALD. Linear relationship between number of cycle and thickness was obtained. We found that desirable organic thin film fabrication is possible by MLD surface reaction in nanoscale. Purging was carried out after dosing of each precursor to form monolayer in each sequence. We also confirmed roughness of the organic thin film by atomic force microscopy. We deposit TMA and AC at $70^{\circ}C$ and that 1.78A root mean square was obtained which indicates that uniform organic thin film was formed. We confirmed precursor's functional group by IR spectrum. We calculated WVTR of organic-inorganic hybrid super-lattice epitaxial layer using Ca test. WVTR indicates superlattice film can be possibly use as encapsulation in flexible devices.

• Childhood Kidney Diseases
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• v.21 no.1
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• pp.26-30
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• 2017

Newborn infants with huge and highly vascular sacrococcygeal teratoma (SCT) are frequently subjected to renal hypoperfusion secondary to high-output cardiac failure. Any underlying renal dysfunction is a significant risk factor for the development of contrast-induced nephropathy (CIN). However, reports on CIN in infants are rare. I report here a case of a premature infant born at 28 weeks and 3 days of gestation with a huge SCT who survived preoperative embolization and surgical resection but presented with persistent non-oliguric renal failure that was suggestive of CIN. During radiological intervention, a contrast medium had been administered at about 10 times the manufacturer-recommended dose for pediatric patients. Despite hemodynamic stabilization and normalization of urine output immediately following surgery, the patient's serum creatinine and cystatin-C levels did not return to baseline until 4 months after birth. No signs of reflux nephropathy were observed in follow-up imaging studies. Dosing guidelines for the use of a contrast medium in radiological interventions should be provided for infants or young patients.

• Magazine of the Korea Concrete Institute
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• v.10 no.2
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• pp.155-165
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• 1998

굳지 않은 콘크리트의 슬럼프손실을 저감시키기 위한 목적으로 고로슬래그 미분말 및 플라이애쉬의 혼합비율과 혼화제의 첨가방법을 변화시킨 콘크리트의 믹싱후 경과시간에 따른 슬럼프 변화에 대하여 고찰하였다. 연구결과 보통포틀랜드시멘트에 고로슬래그 비분말 또는 플라이애쉬를 혼합한 콘크리트가 혼화재를 혼합하지 않은 콘크리트보다 슬럼프손실을 줄일 수 있었으며, 고로슬래그 미분말과 플라이애쉬를 각각 50 및 5%를 혼합한 3성분계 콘크리트의 경우 슬럼프손실을 저감시키는데 유효하였다. 또한 혼화제의 일부를 15분후 분할하여 후첨가하는 혼합방법이 굳지않은 콘크리트의 슬럼프손실을 저감시키는데 가장 큰 효과가 있다. 한편 혼화재를 혼합한 3성분계 보통강도용 및 고강도용 콘크리트의 재령 28일까지의 압축강도는 혼화재를 혼합하지 않은 콘크리트보다 작았으나 재령 91일 압축강도는 31% 및 15%정도 크게 증가하였다.

• Korean Journal of Clinical Pharmacy
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• v.11 no.2
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• pp.57-61
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• 2001

The effect of circadian rhythm on the pharmacokinetics of acebutolol was studied in rabbits administered intravenous 5 mg/kg dose of acebutolol at 09:00 in the morning (a.m) and 22:00 in the evening (p.m). A significant effect of circadian rhythm of pbarmacokinetic parameters as a function of time of day was noted in rabbits, showing lower total body clearance (CLt), higher plasma concentration and the area under the plasma concentration time curve (AUC) when acebutolol was given in the evening. The plasma concentration of acebutolol was increased significantly (p<0.05) at 12-24 hr after dosing in the evening. The AUC was greater in the evening $(111\%)$ than that in the morning and $CL_t$, was higher when acebutolol was given in the morning ($1.12\pm0.24$ ml/hr) versus in the evening ($1.01\pm0.22$ ml/hr), but those were not significant. Therefore, It is reasonable to consider individual circadian rhythm for effective dosage regimen of acebutolol in clinical chronotherapeutics.

• Fire Science and Engineering
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• v.14 no.2
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• pp.14-20
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• 2000

Many pressurization systems are designed and built with the goal of providing a smoke-free escape route in the event of a building fire. A secondary objective is to provide a smoke-free staging area for fire fighters. In the present study, a computer program is developed to calculate pressure loss and flow rate at several building elements such as a room, a ]tabby a staircase and an air supply shaft. By the program as the dosing tool for the pressurization system, the capacity of the injection fan is calculated, and the design method is proposed for the optimization of the fan capacity.

• Proceedings of the Korea Concrete Institute Conference
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• 1998.10c
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• pp.93-98
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• 1998

Fluidity retention of concrete used high range water reducing AE agent(HWAE) is varied according to type, dosage amount and dosing method of HWAE. The type and substitution ratio of mineral admixture also have influence on the fluidity retention of concrete using HWAE. For the purpose of improving the fluidity retention in concrete used HWAE, 3 types of HWAE and ground granulated blast furnace slag(SG) are applied in cement-based composites such as cement paste, mortar and concrete respectively. According to using the HWAE of naphthalene sulfonates and SG, the fluidity retention of mortar and concerete is improving the fluidity retention and strength of concrete regardless of type of HWAE.

• Proceedings of the Korea Information Processing Society Conference
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• 2001.10b
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• pp.1549-1552
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• 2001

무선통신 단말기의 발전과 함께 이를 활용할 수 있는 방법론에 대한 논의도 활발해지고 있으며, 이중 가장 주목받고 있는 것이 이동 통신 단말기를 이용한 무선인터넷 서비스이다. 이러한 서비스의 기반이 되는 것이 무선 인터넷 프로토콜인 WAP(Wireless Application Protocol)이다. 현재의 셀룰러망을 이용한 통신은 비교적 낮은 전송률을 가지고 있어, 대용량의 데이터들을 포함하는 WWW 문서 및 대량의 무선 마크업 언어(WML: Wireless Markup Language) 문서를 전송하기에는 너무 느린 단점을 가지고 있다. 이에 대한 대안으로 본 논문에서는 WAP 포럼 내에서 제정한 프로토콜에 변환기능을 추가한 Gateway를 설계 및 구현하였다.

• The Korean Journal of Rheology
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• v.10 no.4
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• pp.256-258
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• 1998

An experimental study was done to improve the processability and optical property of linear low density polyethylene(LLDPE) film. By modifying the molecular structure of LLDPE with electron beam we could get the improved processability and optical property of film. By appropriate dosing of electron beam and a small addition of UV-stabilizer it was possible to produce gel-free film with low haze. The proceassability was also improved.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.02a
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• pp.282-282
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• 2013

The antimony sulfide ($Sb_2S_3$) thin films were deposited using the gas phase method which known as atomic layer deposition (ALD) on mesoporous micro-films. Tris (dimethylamido) antimony (III[$(Me_2N)_3Sb$] and hydrogensulfide ($H_2S$) were used as precursors to deposit $Sb_2S_3$. Self-terminating nature of $(Me_2N)_3Sb$ and $H_2S$ reaction were demonstrated by growth rate saturation versus precursors dosing time. Absorption spectra and extinction coefficient were investigated by UV-VIS spectroscopy. Scanning electron microscopic analysis and X-ray photoelectron spectroscopy (XPS) depth profile were employed to determine the conformal deposition.