• 대한임상독성학회지
• /
• 제20권1호
• /
• pp.25-30
• /
• 2022

In this study, we report the case of a 59-year-old male patient with organophosphate pesticide poisoning. He visited the local emergency medical center after ingesting 250 ml of organophosphate pesticide. The patient's symptoms improved after the initial intravenous infusion of pralidoxime 5 g and atropine 0.5 mg. However, 18 hours after admission, there was a worsening of the symptoms. A high dose of atropine was administered to improve muscarinic symptoms. A total dose of 5091.4 mg of atropine was used for 30 days, and fever and paralytic ileus appeared as side effects of atropine. Anticholinergic symptoms disappeared only after reducing the atropine dose, and the patient was discharged on the 35th day without any neurologic complications.

• 생물정신의학
• /
• 제8권1호
• /
• pp.153-155
• /
• 2001

There had been few reports of arachnoid cyst accompanying psychiatric disturbance and no report treated with low-dose risperidone administration. We report a patient, developed first-transient psychotic episode considered to be provoked by an arachnoid cyst, responsive to risperidone, which was found in the middle cranial fossa as follows. A 57-year-old man was admitted by suddenly developed headache, auditory hallucination, delusion of persecution and, an arachnoid cyst in the anteromedial aspect of middle cranial fossa was found on MRI after admission. The psychotic episode was first to him and he was also negative to other clinical evaluation including endocrine abnormality, his psychotic symtom was suspected to be induced by arachnoid cyst and was well controlled to low-dose risperidone administration. He left hospital free from psychotic symptoms on 14 hospital days.

• The Korean Journal of Pain
• /
• 제23권1호
• /
• pp.42-45
• /
• 2010

Hiccups are an involuntarily powerful spasm of the diaphragm, followed by a sudden inspiration with a closure of the glottis. Hiccups that are caused by gastric distention, spicy foods and neural dysfunction can resolve themselves without any treatment. Some hiccups are associated with certain diseases or they occur postsurgically, and life-restricting intractable hiccups should be treated. The cause of hiccups should be quickly determined so as to administer the proper treatment. Hiccups often remit spontaneously within a short period of time, but they may also occur without remission for a prolonged period in some cases. We report here on a 36-year-old man who suffered with intractable hiccups for 5 years. We administered a single oral dose of baclofen, and then the hiccups disappeared. We conclude that a single dose of baclofen is a good treatment for intractable hiccups.

• The Korean Journal of Pain
• /
• 제22권1호
• /
• pp.92-95
• /
• 2009

Transverse myelitis is a focal inflammatory disorder of the spinal cord characterized by motor, sensory, and autonomic dysfunction. A 41-year-old man with transverse myelitis and no pre-existing neurologic disease presented with hypesthesia, numbness, weakness in the both lower extremities, back pain, decreased libido, constipation, and dysuria. A MRI test showed intramedullary high signal intensity between T4 and T8 on a T2-weighted image. After high-dose intravenous methylprednisolone and oral prednisolone therapy, he showed facial swelling and acneiform eruption. Therefore, we injected 40 mg methylprednisolone via an epidural route. A 7-dose serial treatment improved most symptoms. A follow up MRI showed radiological improvement. We report a case of transverse myelitis treated by epidural steroids.

• Journal of Chest Surgery
• /
• 제35권3호
• /
• pp.227-230
• /
• 2002

혈관확장성 쇼크(Vasodilatory shock)는 혈관마비 증후군(vasoplegic syndrome), 심폐바이패스후 혈관마비(post-cardiopulmonary bypass vasoplegia)라고도 불리며, 개심술 직후 나타나는 저혈압, 빈맥, 정상 또는 약간 증가한 심박출량 및 체혈관저항 감소 등을 특징으로 하며, 일반적인 수액공급이나 카테콜아민 혈관수축제(cathecolamine vasopressor)에 대한 반응이 적거나 거의 없기 때문에 개심술후 높은 이환율 및 사망율을 나타내는 상태를 말한다. 저자들은 개심술후 혈관확장성 쇼크(vasodilatory shock)로 진단되는 3명의 환자들에서 저용량의 아르기닌 바소프레신(AVP)를 사용하여 성공적으로 치료하였기에 관련된 문헌 고찰과 함께 보고하는 바이다.

• Journal of Pharmaceutical Investigation
• /
• 제5권2호
• /
• pp.51-56
• /
• 1975

In the course of the investigations on drug metabolism and drug disposition in man, it has been noted that there are often rather striking individual differences in the response to drugs and in the ability to metabolize and dispose of drugs. Some of the person-to-person differences are due to environmental factors, but some have clearly demonstrated to be genetically determined. This report determined the rate of acetylation and some constants of sulfa-methizole to korean. The results are as follows: The overall removal rate of drug from the body is 0.572(k, $hr^{-1}$) the rate constant for acetylation, 0.222($k_2$, $hr^{-1}$) the rate constant for excretion of unchanged drug, 0.350($k_3$, $hr^{-1}$) and the faction of a dose ultimately excreted in the urine as unchanged drug is 0.677. And this report determined the optimal time to make a single blood level determination after an oral dose of the drug and obtain a reasonable index of the rate of sulfamethizole metabolism. The resulting data(sulfamethizole levels at 5 hours after drug administration) clearly established bimodality even though only about 106 subjects were tested.

• Journal of Dental Anesthesia and Pain Medicine
• /
• 제22권3호
• /
• pp.233-237
• /
• 2022

Postpolio syndrome (PPS) is widely known to manifest as muscle weakness in patients affected by poliomyelitis in early childhood. This is caused by the long-term overwork of motor nerves regenerated from surviving nerve cells. We report a characteristic delay in recovery from muscle relaxation after administering rocuronium to a patient with PPS under general anesthesia with desflurane. A 59-year-old woman was scheduled to undergo surgical debridement for jaw osteonecrosis. She had a history of poliomyelitis at the age of 2 years, and was diagnosed with PPS at the age of 51 years. General anesthesia was induced with 80 mg propofol, 50 ㎍ fentanyl, and 30 mg (0.69 mg/kg) rocuronium, and maintained with desflurane and remifentanil. The durations of train-of-four (TOF) count 0 and 1 were 96 and 37 min, respectively. Five minutes after discontinuing desflurane, the TOF count was 4. Three minutes after administering 200 mg sugammadex, the TOF ratio was 0.83, and the tracheal tube was subsequently removed. In summary, the effect of a single dose of rocuronium on twitch in TOF monitoring was significantly prolonged in a patient with PPS, which may have been exacerbated by desflurane.

• Journal of Medicine and Life Science
• /
• 제19권3호
• /
• pp.125-129
• /
• 2022

Patients with nephrotic syndrome (NS) are generally known to be at greater risk for thrombosis, with arterial thrombosis-related complications being relatively rare compared to venous thrombosis-related complications. This report describes a 46-year-old male with historically proven minimal change disease (MCD) complicated by acute aortoiliac thrombosis. He had been diagnosed with MCD 8 months previously and was treated successfully with steroids. He was prescribed a second course of high-dose steroids (prednisolone 1 mg/kg/day) due to a relapse of MCD at the outpatient clinic 8 days before the emergency department visit. The patient presented with severe pain in both lower limbs and was diagnosed with aortoiliac thrombosis that developed during high-dose steroid treatment. He subsequently underwent surgical thromboembolectomy. Hypoalbuminemia has the strongest association with the risk of thromboembolism. According to international clinical practice guidelines, anticoagulant therapy is recommended when serum albumin is ≤2-2.5 g/dL. However, as serum albumin levels may be relatively high in the early phase of NS, as in this case report, an individualized anticoagulation strategy for each patient should be considered, regardless of serum albumin levels.

• Journal of Radiation Protection and Research
• /
• 제40권4호
• /
• pp.244-251
• /
• 2015

본 연구에서는 격납건물의 건전성을 유지시켜 원전 주변의 오염범위를 축소할 수 있는 격납건물 여과배기계통(containment filtered venting system, CFVS)에 초점을 맞추고, 동 설비의 설치 전 후의 피해규모를 분석하여 여과장치의 효용성을 분석하였다. 본 연구에 사용된 코드는 확률론적 영향평가 코드인 MACCS2 이며, 평가에 이용한 사고선원항은 신고리 원자력발전소 1&2 호기의 확률론적 안전성 평가 보고서의 결과를 활용하였다. 주어진 총 19 개의 사고선원항 중 선정된 3 개의 방출군에 대하여 CFVS 적용 전후의 주민이 받는 유효선량과 갑상선선량을 산출하였다. 선량평가 결과는 거리에 따른 선량으로 산출되었으며, IAEA 주민보호조치 권고 기준인 갑상선방호약품 복용 및 방호조치가 필요한 갑상선선량과 유효선량을 초과하는 거리를 기준으로 비교하였다. STC-3, STC-4, STC-6 의 거리에 따른 유효선량은 전 범위(0~35 km)에서 95~99 % 내외의 감소율을 확인할 수 있었으며, 갑상선 선량의 경우 약 96~98 % 내외의 수준으로 유효선량과는 선량감소에서의 비슷한 경향이 있음을 확인 하였다. CFVS 를 적용한 후 대피 및 소개가 취해지는 유효선량 기준값을 초과하는 거리는 모든 방출군에 대하여 평균 1 km 내외로 평가되었다. 특히 STC-4 의 경우 26 km 에서 1.2 km 로 유효 선량을 초과하는 범위가 타 방출군에 비하여 대폭 줄어든 것을 확인할 수 있었다. 갑상선선량 기준값 초과거리의 경우 CFVS 를 적용한 후의 피해범위는 2~3 km 수준으로 산출되었다. 또한 갑상선선량 평가결과는 유효선량의 경우와 같이 STC-4 에서의 피해범위가 대략 50 km 줄어들어 CFVS 적용으로 가장 큰 효과를 보았다.

• 한국의학물리학회:학술대회논문집
• /
• 한국의학물리학회 2002년도 Proceedings
• /
• pp.141-143
• /
• 2002

In 1995, the American Association of Physicists in Medicine (AAPM) Task Group 43 published a report dealing with the dosimetry of interstitial brachytherapy sources, generally known as the TG-43 report. Compared to previously adopted formalisms, a formalism proposed in this report provides a more accurate and systematic brachytherapy dose calculation method, especially for Ir-192 and other low energy gamma sources such as 1-125 and Pd-l03. In this lecture, an overview of the TG-43 formalism will be presented, along with the lecturer's experience in determining the TG-43 parameters by the Monte Carlo method and experimental methods such as TLD and radiochromic film.