• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.1318-1321
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• 2005

As recently raw water quality has been polluted as well as its quality has been remarkably varied according to season and region, the precise control of coagulant dosage is being keenly required in water treatment plants. The amount of coagulant is closely related to raw water quality such as turbidity, alkalinity, water temperature, pH, electrical conductivity, etc. Since the optimum quantity of chemicals is not yet finalized, so dosage rate must be decided by using jar test that takes one or two hours. Hereupon, the output signal of stream current and multi-regression on historical data were proposed to be applied to the coagulant dosing control. In consequence of applying the scheme to automatic determination of the dosage rate, it was testified that the determination of dosage rate was very effective in case it is performed as to real-time sensing of water quality and the output signal of stream current.

• The Korean Journal of Physiology and Pharmacology
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• 제20권3호
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• pp.245-251
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• 2016

The objective of this study was to externally validate a new dosing scheme for busulfan. Thirty-seven adult patients who received busulfan as conditioning therapy for hematopoietic stem cell transplantation (HCT) participated in this prospective study. Patients were randomized to receive intravenous busulfan, either as the conventional dosage (3.2 mg/kg daily) or according to the new dosing scheme based on their actual body weight (ABW) ($23{\times}ABW^{0.5}mg\;daily$) targeting an area under the concentration-time curve (AUC) of $5924{\mu}M{\cdot}min$. Pharmacokinetic profiles were collected using a limited sampling strategy by randomly selecting 2 time points at 3.5, 5, 6, 7 or 22 hours after starting busulfan administration. Using an established population pharmacokinetic model with NONMEM software, busulfan concentrations at the available blood sampling times were predicted from dosage history and demographic data. The predicted and measured concentrations were compared by a visual predictive check (VPC). Maximum a posteriori Bayesian estimators were estimated to calculate the predicted AUC ($AUC_{PRED}$). The accuracy and precision of the $AUC_{PRED}$ values were assessed by calculating the mean prediction error (MPE) and root mean squared prediction error (RMSE), and compared with the target AUC of $5924{\mu}M{\cdot}min$. VPC showed that most data fell within the 95% prediction interval. MPE and RMSE of $AUC_{PRED}$ were -5.8% and 20.6%, respectively, in the conventional dosing group and -2.1% and 14.0%, respectively, in the new dosing scheme group. These findings demonstrated the validity of a new dosing scheme for daily intravenous busulfan used as conditioning therapy for HCT.

• The Korean Journal of Physiology and Pharmacology
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• 제16권4호
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• pp.273-279
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• 2012

Busulfan is an antineoplastic agent with a narrow therapeutic window. A post-hoc population pharmacokinetic analysis of a prospective randomized trial for comparison of four-times daily versus once-daily intravenous busulfan was carried out to search for predictive factors of intravenous busulfan (iBu) pharmacokinetics (PK). In this study the population PK of iBu was characterized to provide suitable dosing recommendations. Patients were randomized to receive iBu, either as 0.8 mg/kg every 6 h or 3.2 mg/kg daily over 4 days prior to hematopoietic stem cell transplantation. In total, 295 busulfan concentrations were analyzed with NONMEM. Actual body weight and sex were significant covariates affecting the PK of iBu. Sixty patients were included in the study (all Korean; 23 women, 37 men; mean [SD] age, 36.5 [10.9] years; weight, 66.5 [11.3] kg). Population estimates for a typical patient weighing 65 kg were: clearance (CL) 7.6 l/h and volume of distribution (Vd) 32.2 l for men and 29.1 L for women. Inter-individual random variabilities of CL and $V_d$ were 16% and 9%. Based on a CL estimate from the final PK model, a simple dosage scheme to achieve the target $AUC_{0-inf}$ (defined as median AUC0-inf with a once-daily dosage) of 26.18 $mg/l{\cdot}hr$, was proposed: $24.79{\cdot}ABW^{0.5}mg$ q24h, where ABW represents the actual body weight in kilograms. The dosing scheme reduced the unexplained interindividual variabilities of CL and Vd of iBu with ABW being a significant covariate affecting clearance of iBU. We propose a new simple dosing scheme for iBu based only on ABW.

• 제어로봇시스템학회논문지
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• 제3권6호
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• pp.644-651
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• 1997

In the water purification plant, chemicals are injected for quick purification of raw water. It is clear that the amount of chemicals intrinsically depends on water quality such as turbidity, temperature, pH and alkalinity. However, the process of chemical reaction to improve water quality (e.g., turbidity) by chemicals is not yet fully clarified nor quantified. The feedback signal in the process of coagulant dosage, which should be measured (through the sensor of the plant) to compute the appropriate amount of chemicals, is also not available. Most traditional methods focus on judging the conditions of purifying reaction and determine the amounts of chemicals through manual operation of field experts using Jar-test data. In this paper, a systematic control strategy is proposed to derive the optimum dosage of coagulant, PAC(Polymerized Aluminium Chloride), using Jar-test results. A neural network model is developed for coagulant dosing and purifying process by means of six input variables (turbidity, temperature, pH, alkalinity of raw water, PAC feed rate, turbidity in flocculation) and one output variable, while considering the relationships to the reaction of coagulation and flocculation. The model is utilized to derive the optimum coagulant dosage (in the sense of minimizing turbidity of water in flocculator). The ability of the proposed control scheme validated through the field test has proved to be of considerable practical value.

• 혜화의학회지
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• 제8권1호
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• pp.711-726
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• 1999

Aging in the life form occurs due to a gradual progression of the body growth and degeneration. Morphological and functional changes in the body decreases the adaptation and prevention capacity leading into the decline of a life force. Various studies have been released to examine the anti-aging effects of herbal prescriptions. This experiment has chosen Boganhwan which is used for the deficiency of the liver function and studied the anti-aging factors by examining the biotransformation enzymes. The following results were obtained in this study: 1. Hepatic lipid peroxide activity was significantly suppressed in the experimental group treated with Boganhwan for 2 weeks at the dosage of 350mg/kg, while other dosage groups did not present much changes. 2. Insignificant changes were shown for the cytochrome P-450 level, aminopyrine demethylase, and aniline hydroxylase (AH) activities. Cytochrome P-450 do not appears to be a part of the detoxification scheme. 3. Boganhwan decoction treated group showed most significant increase of superoxide dismutase (SOD), catalase, superoxide, and glutathione activities at the concentration of 350mg/kg and 500mg/kg. 4. Glutathione S-transferase and glutathione made most significant increase at the decoction concentration of 350mg/kg and 500mg/kg compared to the control group. 5. Hepatic glutathione concentration, protein bound-SH, and nonprotein bound-SH made most significant increase at the decoction concentration of 350mg/kg and 500mg/kg compared to the control group. From the above results, Boganhwan decoction played an important role in eliminating foreign substances in the body excluding cytochrome P-450 enzyme system. Thus, Boganhwan decoction can provide substantial aid in preventing and treating senile related illnesses.

• Asian-Australasian Journal of Animal Sciences
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• 제31권9호
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• pp.1387-1392
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• 2018

Objective: In a nucleus breeding scheme, the sire of dam's pathway plays an important role in producing genetic improvement. Selection proportion is the key parameter for predicting selection intensity, through truncating the normal distribution. Semen sexing using flow cytometry reduces the number of vials of sperm that can be obtained from a proved bull. In addition, a lower fertility of this kind of sperm is expected because of the lower sperm dosage in sex sorted semen. Both of these factors could affect the selection proportion in the sire of dam's pathway ($p_{SD}$). Methods: In the current study, through a deterministic simulation, effect of utilizing sex sorted semen on selection ($p_{SD}$) was investigated in three different strategies including 1: continuous use of sex sorted semen in heifers (CS), 2: the use of sex sorted semen for the first two (S2) and 3: the first (S1) inseminations followed by conventional semen. Results: Results indicated that the use of sex sorted semen has a negative impact on the sire of dams (SD) pathway due to increase in selection proportion. Consequently selection intensity was decreased by 10.24 to 20.57, 6.38 to 8.87 and 3.76 to 6.25 percent in the CS, S2, and S1 strategies, respectively. Conclusion: Considering the low effect of sexed semen on genetic improvement in dam pathways, it is necessary to consider the joint effect of using sex sorted semen on the sire and dams pathway to estimate about the real effect of sexed semen on genetic improvement in a nucleus breeding scheme.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1997년도 한국자동제어학술회의논문집; 한국전력공사 서울연수원; 17-18 Oct. 1997
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• pp.317-320
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• 1997

In the water purification plant, chemicals are injected for quick purification of raw water. It is clear that the amount of chemicals intrinsically depends on the water quality such as turbidity, temperature, pH and alkalinity etc. However, the process of chemical reaction to improve water quality by the chemicals is not yet fully clarified nor quantified. The feedback signal in the process of coagulant dosage, which should be measured (through the sensor of the plant) to compute the appropriate amount of chemicals, is also not available. Most traditional methods focus on judging the conditions of purifying reaction and determine the amounts of chemicals through manual operation of field experts or jar-test results. This paper presents the method of deriving the optimum dosing rate of coagulant, PAC(Polymerized Aluminium Chloride) for coagulant dosing process in water purification system. A neural network model is developed for coagulant dosing and purifying process. The optimum coagulant dosing rate can be derived the neural network model. Conventionally, four input variables (turbidity, temperature, pH, alkalinity of raw water) are known to be related to the process, while considering the relationships to the reaction of coagulation and flocculation. Also, the turbidity in flocculator is regarded as a new input variable. And the genetic algorithm is utilized to identify the neural network structure. The ability of the proposed scheme validated through the field test is proved to be of considerable practical value.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제16권2호
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• pp.424-444
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• 2022

In hospitals and pharmacies, the distribution of medicines is an important part. Any mistakes, misses, fake medicines and expired medicines can cause medical accidents. With the widespread application of the Internet of Things technology (IoT), traditional drug distribution methods need to be upgraded. This article proposes a drug distribution management scheme based on the Internet of Things technology. In the production of drugs, a flexible RFID tag was printed on the packaging box, which stored a series of information such as drug name, dosage, raw materials, efficacy, production date, expiration date, and manufacturer. The use of a drug distribution management system combined with RFID readers can identify drug information and effectively prevent the occurrence of erroneous, missed, counterfeit, and expired drugs. It can also improve management efficiency, reduce management costs, and control management risks. Through the circuit design and software system development, the test results show that this solution is effective and feasible, the proposed method can achieve the expected results.

• 콘크리트학회논문집
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• 제26권3호
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• pp.277-285
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• 2014

이 연구는 현장에서 사용하는 재료의 품질 및 계량오차, 현장조건 등에 따라 병용계 자기충전 콘크리트의 유동특성에 영향을 미치는 변동요인의 범위를 실험적으로 규명하기 위한 것이다. 병용계 자기충전 콘크리트의 재료는 벨라이트 시멘트와 석회석 미분말을 사용한 벨라이트계 및 슬래그 시멘트와 석회석 미분말을 사용한 슬래그계가 선정되었으며, 선행연구에서 제시된 최적배합 조건을 대상으로 하였다. 변동요인으로 (1) 콘크리트의 온도 3종류, (2) 잔골재의 표면수율 5종류, (3) 잔골재의 조립률 5종류, (4) 고성능AE감수제의 사용량 5종류, (5) 석회석 미분말의 분말도 3종류 등을 대상으로 민감도 시험을 실시하였다. 민감도 시험의 항목은 슬럼프 플로우, 500 mm 플로우 도달시간, V-깔대기 유하시간, U-box 충전성 높이를 대상으로 하였다. 실험 결과, (1) 콘크리트 온도는 $10{\sim}20^{\circ}C$ 범위, (2) 잔골재의 표면수율은 ${\pm}0.6%$ 범위, (3) 잔골재의 조립률 $2.6{\pm}0.2$ 범위, (4) 고성능AE감수제의 사용량은 ${\pm}0.2%$ 범위, (5) 석회석 미분말의 분말도는 $6000cm^2/g$ 범위에서 현장품질을 관리해야 한다. 벨라이트계 및 슬래그계에 따른 차이는 크지 않았지만, 석회석 미분말 및 $C_2S$ 함량이 높은 벨라이트계가 안정적인 경향을 나타내었다. 따라서 이러한 결과를 현장 시공현장에서 병용계 자기충전 콘크리트의 관리방안으로 제안하고자 한다.

• Parasites, Hosts and Diseases
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• 제24권2호
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• pp.201-204
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• 1986

A study on the effect of diethylcarbamazine (DEC) (Supatonin) against Brugia malayi infection was conducted on Cheju Island in September 1965. A total of 182 persons living in a village of Aiwol Myun, Bukcheju-Gun was examined for microfilaraemia. Microscopic examination of smears of $20{\mu}l$ of blood revealed a microfilaria positivity rate of 28.5%. At the end of September 1965, 34 confirmed microfilaria positive cases were treated with DEC at a daily dosage of 5mg/kg body weight. A full course of 12 days of drug administration divided of two rounds for 6 days each was used. The first round of treatment was given under a strict supervision of the author in order to observe carefully side-effects of the drug. The second round of treatment was given in January 1966. The microfilaria density in $20{\mu}l$ of blood of those who received the drug was checked four times; before the treatment, during the first round of the treatment, 2 weeks and 4 months after the completion of the first round. The pre-treatment mean microfilaria density of 104.6 diminished to nearly zero (only two cases with one microfilaria respectively) 2 weeks after the first round and again slightly rose up to 0.5 four months after the first round. These results indicate that DEC (Supatonin) is highly effective to eliminate the microfilaria of B. malayi. However, severe side-effects, e.g. fever (average $38.6^{\circ}C$, maximum $39.7^{\circ}C$), headache, backache and seldom abdominal discomfort etc. were observed. There were two cases of withdrawal from the scheme due to refusal.