• BMB Reports
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• 제38권3호
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• pp.328-333
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• 2005

A human homologue of Sar1, named Sara2, was shown to be preferentially expressed during erythropoiesis in a culture stimulated by EPO. Previous studies, in yeast, have shown that secretion-associated and Ras-related protein (Sar1p) plays an essential role in protein transport from the endoplasmic reticulum to the Golgi apparatus. Here, we report the molecular analysis of Sara2 in erythroid cell culture. A 1250 bp long cDNA, encoding a 198 amino-acid protein very similar to Sar1 proteins from other organisms, was obtained. Furthermore, we also report a functional study of Sara2 with Real-time quantitative PCR analysis, demonstrating that expression of Sara2 mRNA increases during the initial stages of erythroid differentiation with EPO and that a two-fold increase in expression occurs following the addition of hydroxyurea (HU). In K562 cells, Sara2 mRNA was observed to have a constant expression and the addition of HU also up-regulated the expression in these cells. Our results suggest that Sara2 is an important gene in processes involving proliferation and differentiation and could be valuable for understanding the vesicular transport system during erythropoiesis.

• Wind and Structures
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• 제10권3호
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• pp.287-300
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• 2007

Wind action is a factor of fundamental importance in the structural design of light or slender constructions. Codes for structural design usually assume that the incident mean wind velocity is parallel to the ground, which constitutes a valid simplification for frequent winds caused by meteorological phenomena such as Extratropical Storms (EPS) or Tropical Storms. Wind effects due to other phenomena, such as thunderstorms, and its combination with EPS winds in so-called squall lines, are simply neglected. In this paper a model that describes the three-dimensional wind velocity field originated from a downburst in a thunderstorm (TS) is proposed. The model is based on a semi empirical representation of an axially-symmetrical flow line pattern that describes a stationary field, modulated by a function that accounts for the evolution of the wind velocity with time. The model allows the generation of a spatially and temporally variable velocity field, which also includes a fluctuating component of the velocity. All parameters employed in the model are related to meteorological variables, which are susceptible of statistical assessment. A background wind is also considered, in order to account for the translational velocity of the thunderstorm, normally due to local wind conditions. When the translation of the TS is caused by an EPS, a squall line is produced, causing the highest wind velocities associated with TS events. The resulting vertical velocity profiles were also studied and compared with existing models, such as the profiles proposed by Vicroy, et al. (1992) and Wood and Kwok (1998). The present model predicts horizontal velocity profiles that depend on the distance to the storm center, effect not considered by previous models, although the various proposals are globally compatible. The model can be applied in any region of interest, once the relevant meteorological variables are known, to simulate the excitation due to TS winds in the design of transmission lines, long-span crossings, cable-stayed bridges, towers or similar structures.

• Journal of Magnetics
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• 제12권3호
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• pp.97-102
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• 2007

We have investigated the electronic structures and magnetism of a full Heusler alloy $Co_2CrGa(001)$ surface by using the all-electron full-potential linearized augmented plane wave (FLAPW) method within the generalized gradient approximation (GGA). We considered two types of different terminations: the Co-terminated (Co-Term) and the CrGa-terminated (CrGa-Term) surfaces. From the calculated layer-projected density of states (LDOS), we found that the surface of the CrGa-Term shows nearly half-metallic character while that of the Co-Term is far from the half-metallic. For the Co-Term, the surface Co atom moves down to the bulk region by $0.05{\AA}A$, while the subsurface Cr and Ga atoms move up to the surface layer by 0.05 and $0.01{\AA}$, respectively. For the CrGa-Term, there is a large inward relaxation of the surface Ga atom $(0.07{\AA})$, but the relaxation of the surface Cr atom is very small $(0.01{\AA})$. The relaxations affect not much to the overall shapes of DOS for both terminations, but make the surface states of the surface Cr and Ga atoms for the CrGa-Term shift to higher energy that enhances the nearly half-metallic character of the CrGa-Term. The magnetic moments of the surface $Cr(2.98{\mu}_B)$ in the CrGa-Term and the surface $Co(1.17{\mu}_B)$ in the Co-Term were much increased compared to those of the inner-layers $(1.79\;and\;0.77{\mu}_B)$, respectively, while that of the subsurface Cr atom in the Co-Term was decreased to $1.19{\mu}_B$.

• International Journal of Aerospace System Engineering
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• 제2권1호
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• pp.1-5
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• 2015

The Unmanned Air Vehicle (UAV) systems are indispensable tools of air surveillance and reconnaissance nowadays. Via this systems, hazardous end risky intelligence gathering activities are handled easily. Although they are named as "Unmanned" the UAV systems are commanded by pilots/operators. So, because of weather conditions, enemy attacks etc. as well as pilot error it is possible to face with sudden Round per Minute (RPM) drops and subsequently engine cut/stop during a mission flight at high altitudes. In this case, there are some very urgent decisions to make and rapid "emergency procedure" steps to take in a very short time before Line of Sight (LOS) is lost. The time before crash and the distance to landing air base need to be calculated, the Return Home route need to be checked and the landing/crash side need to be determined. Therefore it is a vital necessity that UAV pilots have some extra qualifications like being determined, well instructed and trained, experienced apart from operating ability. Within this scope, for an education process of a UAV pilot experience sharing and lessons learned are as important as simulators even more. By means of lessons learned it is possible to find out the reasons, mistakes and prevent the likely UAV accidents. In this study it is told about a real UAV crash, experienced of the pilot, the dos and don'ts and the difficulties. Thus it is aimed to help the people who can experience the same or similar situations in future.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제17권3호
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• pp.231-238
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• 1995

The scapular flap, described by dos Santos in 1986, has been used successfully for the reconstruction of a variety of defects of oro-mandible. Some have defined the gross and vascular anatomy of the lateral border of the scapula, yet useful anatomical information and a complete description of area and contour of each cut surface of lateral border of scapula, which is very important for esthetic and functional reconstruction using dental implants, are missing. These prompted us to clarify the cross-sectional area of lateral border of scapula. Twenty three scapulas of 15 fixed adult Caucasian cadavers were sectioned in every 1cm interval along the lateral border of scapular, and the metric relations and the shape of cut surface were assessed. The lateral border of the scapula, consisting of cortico-cancellous bone measuring $7.86{\pm}0.97mm$ in width, $19.6{\pm}2.86mm$ in height and $12{\pm}1.78cm$ in length, could be harvested as an osteocutaneous scapular flap or as a single vascularized bone flap. The mean thickness of cortical bone of lateral, medial, dorsal and costal surface was $0.46{\pm}1.48mm$, $1.78{\pm}1.34mm$, $1.54{\pm}1.11mm\;and\;1.35{\pm}0.87mm$, respectively. So we have thought that all scapular transplants could be supported osseointegrated implants for fixation of dental prosthesis.

• 한국자기학회지
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• 제16권2호
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• pp.111-114
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• 2006

Zinc-blonde 구조를 가지는 CrAs와 MnAs에서 (110)면 원자층으로 이루어진 초격자의 자성을 제일원리 방법을 이용하여 연구하였다. 이를 위해 CrAs와 MnAs의 (110)층이 각기 세 층씩 교대로 반복되는 $(CrAs)_3(MnAs)_3(110)$ 초격자계의 전자구조를 총 퍼텐셜 선형보강평면파동(FLAPW) 에너지띠 방법을 이용하여 계산하였다. Cr-As로 이루어진 층과 Mn-As로 이루어진 층이 접합되는 계면에 있는 Cr과 Mn원자의 자기모멘트를 계산한 결과 각기 $3.07\;\mu_B$와 $3.74\;\mu_B$로 가운데 층의 Cr과 Mn의 자기모멘트 값인 $3.06\;\mu_B$와 $3.76\;\mu_B$보다 약간 크거나 작았다. 계산된 상태밀도로부터 이 계의 전자구조와 반쪽금속성을 고찰하였다.

• 대한화학회지
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• 제53권3호
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• pp.266-271
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• 2009

고체 화합물 La7Os4C9 속에 있는 [Os4C9]21‑ 사슬의 전자구조와 화학결합을 extended Hückel 계산 결과에 의해서 논의하였다. 탄소 원자는 물론 (C2)2‑ 분자의 결합 특성은 비교적 큰 Os-C 상호작용을 나 타내었고 특히 (C2)2‑ 분자의 결합길이 증가는 Fermi level 바로 아래에 Os-C2(1 πg) 결합 밴드의 존재로 인 해서 반결합 1πg 오비탈에 부분적인 전자점유가 일어나기 때문인 것으로 해석된다.

• 지구물리
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• 제4권3호
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• pp.145-162
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• 2001

인터넷이 급속도로 발전하고 일반 텍스트 환경의 인터넷 서비스들의 WWW(World Wide Web)환경으로 바뀌어 가면서 쉬운 사용 환경으로 인한 인터넷 응용 서비스의 사용자들도 급속히 증가하고 있다. 따라서, 사용자들이 인터넷을 이용하면서 상대방에게 메시지를 보낼 수 있는 전자 메일 서비스를 이용하는 경우도 크게 증가하고 있다. 웹 기반 전자우편 시스템은 계정과 서비스를 제공하는 서버와 사용자와의 인퍼페이스 역할을 하는 클라이턴트로 구성되며 웹 브라우저가 클아이언트의 역할을 담당한다. 즉. 일반, 메일서버에 계정을 만들수 없는 일반 사용자들이 웹 환경을 통하여 메일서비스를 제공받을 수 있도록 하는 것이다. 본 논문에서는 웹을 기반으로 하는 전자 우편 시스템을 설계하였으며, 인터넷 익스플로러(Internet Explorer)를 기반으로 하는 사용자 환경과 리눅스 시스템을 기반으로 기존 전자 우편시스템의 문제점을 해결하고 저렴한 가격으로 큰 기대효과를 만족시켰다. 스팸으로 등록된 메일 처리, 다중 메일 처리들을 통한 효율적인 사용자 편의성을 제공하고, 메일의 폭주와 사용자의 급증으로 인한 시스템 저하 현상을 극복하는 효율적인 메일 서비스 엔진을 구현해서 시스템의 안정성을 제공하는 전자 우편 시스템을 개발한다.

• Journal of Gastric Cancer
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• 제16권1호
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• pp.14-20
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• 2016

Purpose: Early diagnosis of gastric cancer is still the exception in Western countries. In the East, as in Japan and Korea, this disease is an endemic disorder. More conservative surgical procedures are frequently performed in early gastric cancer cases in these countries where sentinel lymph node navigation surgery is becoming a safe option for some patients. This study aims to evaluate preliminary outcomes of patients with early gastric cancer who underwent sentinel node navigation surgeries in Brazil, a country with non-endemic gastric cancer levels. Materials and Methods: From September 2008 to March 2014, 14 out of 205 gastric cancer patients underwent sentinel lymph node navigation surgeries, which were performed using intraoperative, endoscopic, and peritumoral injection of patent blue dye. Results: Antrectomies with Billroth I gastroduodenostomies were performed in seven patients with distal tumors. The other seven patients underwent wedge resections. Sentinel basin resections were performed in four patients, and lymphadenectomies were extended to stations 7, 8, and 9 in the other 10. Two patients received false-negative results from sentinel node biopsies, and one of those patients had micrometastasis. There was one postoperative death from liver failure in a cirrhotic patient. Another cirrhotic patient died after two years without recurrence of gastric cancer, also from liver failure. All other patients were followed-up for 13 to 79 months with no evidence of recurrence. Conclusions: Sentinel lymph node navigation surgery appears to be a safe procedure in a country with non-endemic levels of gastric cancer.

• 한국정보통신학회논문지
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• 제13권3호
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• pp.482-488
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• 2009

모바일 Ad-hoc 네트워크는 재해지역이나 빠른 구성을 필요로 할 때 중앙 집중 구조 형태가 없는 통신을 제공하여 준다. 반면에 악의적인 공격과 사전 보안 측정 부족으로 인한 개방형 Ad-hoc 네트워크 구조에 때문에 다른 계층에서 문제에 직면할 수 있다. DOS공격은 전파 전송 채널에서 방해를 하는 공격중 하나이며 전파방해 공격으로 알려져 있다. 이러한 종류의 공격은 공격자가 패킷을 방해하는 신호를 보내고 패킷 이 전송되는 동안 많은 에러와 심각한 문제를 발생시킨다. 그 결과 이러한 종류의 공격을 방지하기 위한 방법이 요구된다. 따라서 본 논문에서는 네트워크 시뮬레이터인 OPNET을 활용하여 DoS 공격과 각 노드 상에서 전파방해 공격 시뮬레이션을 수행하였고, 모바일 Ad-hoc 네트워크에서 전파방해에 의 한 채널 접근을 방해하는 공격에 대해서 분석하였다. 우리는 효과적인 이상적 분석 탐지 시스템 사용하여 방해전파 노드의 악의적인 행동을 탐지하고 모바일 Ad-hoc네트워크에서 전파방해 중에 부정적인 채널의 접속한 결과를 분석하였다.