• Title/Summary/Keyword: Door

Search Result 1,927, Processing Time 0.031 seconds

The Role of the Insulin-like Growth Factor System during the Periimplantation Period (착상기 Insulin-like Growth Factor System의 역할)

  • 이철영
    • Journal of Embryo Transfer
    • /
    • v.12 no.3
    • /
    • pp.229-246
    • /
    • 1997
  • Implantation is a most important biological process during pregnancy whereby conceptus establishes its survival as well as maintenance of pregnancy. During the periimplantation period, both uterine endometriurn and conceptus synthesize and secrete a host of growth factors and cytokines which mediate the actions of estrogen and /or progesterone and also exert their steroid-independent actions. Growth factors expressed by the materno-conceptal unit en masse have important roles in cell migration, stimulation or inhibition of cell proliferation, cellular differentiation, maintenance of pregnancy and materno-conceptal communications in an autorcrine /paracrine manner. The present review focuses on the role of the intrauterine IGF system during periimplantation conceptus development. The IGF system comprises of IGF- I and IGF- II ligands, types I and II IGF receptors and six or more IGF-binding proteins(IGFBPs). IGFs and IGFBPs are expressed and secreted by uterine endometrium with tissue, pregnancy stage and species specificities under the influence of estrogen, progesterone and other growth factor(s). Conceptus also synthesizes components of the IGF system beginning from a period between 2-cell and blastocyst stages. Maternal IGFs are utilized by both maternal and conceptal tissues; conceptus-derived growth factors are believed to be taken up primarily by conceptus. IGFs enhance the development of both maternal and conceptal compartments in a wide range of biological processes. They stimulate proliferation and differentiation of endometrial cells and placental precursor cells including decidual transformation from stromal cells, placental formation and the synthesis of some steroid and protein hormones by differentiated endometrial cells or placenta. It is also well-documented in a number of experimental settings that both IGFs stimulate preimplantation embryo development. In slight contrast to these, prenatal mice carrying a null mutation of IGF and /or IGF receptor gene do not exhibit any apparent growth retardation until after implantation. Reason (s) for this discrepancy between the knock-out result and the in vitro ones, however, is not known. IGFBPs, in general, are believed to inhibit IGF action within the materno-conceptal unit, thereby allowing endometrial stromal cell differentiation as well as dampening ex cessive placental invasion into maternal tissue. There is evidence, however, indicating that IGFBP can enhance IGF action depending on environrnental conditions perhaps by directioning IGF ligand to the target cell. There is also a third possibility that certain IGFBPs and their proteolytic fragments may have their own biological activities independent of the IGF. In addition to IGFBPs, IGFBP proteases including those found within the uterine tissue or lumen are thought to enhance IGF bioavailability by degrading their substrates without affecting their bound ligand. In this regard, preliminary results in early pregnant pigs suggest that a partially characterized IGFBP protease activity in uterine luminal fluid enhances intrauterine IGF bioavailability during conceptus morphological development. In summary, a number of in vitro results indicate that IGFs stimulates the development of the rnaterno-conceptal unit during the periimplantation period. IGFBPs appear to inhibit IGF action by sequestering their ligands, whereas IGFBP proteases are thought to enhance intrauterine bioavailability of IGFs. Much is remaining to be clarified, however, regarding the roles of the individual IGF system components. These include in vivo evidence for the role of IGFs in early conceptus development, identification of IGF-regulated genes and their functions, specific roles for individual IGFBPs, identification and characterization of IGFBP proteases. The intrauterine IGF club house thus will be paying a lot of attention to forthcoming results in above and other areas, with its door wide-open!

  • PDF

Genetic Analysis of Low Temperature Germinability of Rice (벼의 저온발아성에 관한 유전분석)

  • Kang, Jong-Re;Ko, Mi-Suk;Kim, Ho-Young;Lim, Sang-Jong;Kim, Soon-Chul
    • KOREAN JOURNAL OF CROP SCIENCE
    • /
    • v.42 no.6
    • /
    • pp.766-777
    • /
    • 1997
  • The purpose of this study was to investigate inheritance modes of low temperature germinability(LTG) on rice. Two experiments were carried out: In experiment I, the seeds of 10 rice varieties yielded at the different cultivation conditions which were transplanted in a paddy field from May 20 to July 5 with 15-day interval, were tested at fixed temperature (13$^{\circ}C$) in-door and at field with natural conditions to find out the change of LTG according to different cultivating condition among the each variety, In experiment II, F$_1$ seeds of full diallal cross from six parents, were analyzed for combining ability and reciprocal differences of low temperature germinability. The results are summarized as follows. The seeds of 10 varieties showed significant differences of LTG at the different cultivation conditions, varieties and their interaction. And the relationship between LTG coefficient at 13$^{\circ}C$ and low temperature emergence(LTE) coefficient at field was highly significantly positive(r=0.511). From the analysis of the diallel cross, high significance was found at reciprocal difference and alpha inheritance. The mean squares of general combining ability(GCA) and specific combining ability of LTG were highly significant with higher mean squares of GCA. Seventeen out of 30 cross combinations showed transgressive segregation.

  • PDF

애니메이션 <하울의 움직이는 성>에 나타난 여성상의 고찰

  • Lim, Chan
    • Archives of design research
    • /
    • v.19 no.2 s.64
    • /
    • pp.293-300
    • /
    • 2006
  • Mr. Miyazaki's heroines tend to be plucky young women who combine guileless decency with tough-mindedness. However, in his the latest film the female character often change herself into wise older women who sometimes serve as foils, sometimes as mother figures. His heroine, Sophie, starts out as a shy girl, but then a curse transforms her into 90-year-old. Her partner is Howl who supports and is supported by Sophie their mutual drawbacks. At first horrified by the change, she comes to embrace it as a liberation from anxiety, fear and self-consciousness, and discovers in herself a new zest for adventure. The castle is surely one of the most extraordinary contraptions to appear on screen recently, more ingenious in its way than the intergalactic armada. It ranges freely from place to place and is also, somehow, in several places at once, its magical front door opening onto different landscapes with the flip of a knob. It is not exactly haunted, but it is nonetheless infused with whimsical and sometimes somber spirits. Sophie, in both her incarnations, joins an impressive sisterhood of Miyazaki heroines, whose version of girl power presents a potent alternative to the mini-machismo that dominates American juvenile entertainment.

  • PDF

The Evaluation of UWB Wireless Communication Position Determination Function in an Enclosed Space for Fire Fighting (소방활동을 위한 밀폐공간 무선통신 측위성능 평가)

  • Kim, Dong-Hyun;Kim, Chung-Il
    • Fire Science and Engineering
    • /
    • v.31 no.5
    • /
    • pp.117-122
    • /
    • 2017
  • The absence of fire fighters' connection to communication can bring about increased loss of life due to errors and delays in rescue and actions and danger to their own safety. Therefore, when communication infrastructure has been destroyed in an enclosed space, it is necessary to set up an emergency wire or wireless telecommunication environment to fire fighting and to secure safer environment to deal with the disaster by checking the location of fire fighters. In this research, for the establishment communication environment in an enclosed inside using Ultra-Wide Band (UWB) wireless communication network, the performance of communication position determination of a single UWB communication module was evaluated regarding 6 kinds of indoor surroundings. When the communication distance in an indoor environment of each 6 channels bandwidth of UWB communication frequency was measured, the results were as follows: the open space (Ave. 15.5 m, Max. 20 m), the corridor (Ave. 17.33 m, Max 20 m), inside retaining home furnishings (Ave. 15.3 m, Max. 20 m), vertical stairs (Ave. 4.33 m, Max. 6 m), horizontal space with a closed fire door (Ave. 6.5 m, Max. 17 m). It was also found out that the communication function and the distance function were best in the frequency range from 6489.6 to 1081.6 MHz by 7 Ch. Accordingly, the establishment of communication environment in an enclosed space is judged to be possible when UWB communication module is set up at 20 m apart and multiple channels are used.

Fire Alarm Sound Transmission in Apartment Units (공동주택에서의 화재경보음 전달)

  • Jeong, Jeong-Ho
    • Fire Science and Engineering
    • /
    • v.32 no.3
    • /
    • pp.67-75
    • /
    • 2018
  • To reduce the number of casualties in the case of fire, an alarm sound needs to be delivered to the people who remain in the apartment unit. On the other hand, it was reported that the fire alarm sound generated in the elevator hall was not delivered sufficiently to the people staying in the apartment units. In this study, the background noise level and noise level generated in an apartment unit were measured during the day and night time. In addition, the transmission of the fire alarm sound into the each room of apartment units was simulated and compared with the background noise level. The fire alarm sound generated in the elevator halls was reduced by the fire door and doors, and was not transmitted sufficiently into the internal spaces of the apartment units. Starting evacuation action was difficult after hearing the fire alarm sound generated outside the apartment units. To improve the transmission of an alarm sound to the inner spaces of apartment units, an acoustic simulation was carried out for cases where the alarm sound generator was installed on a wall-pad in the living room and the alarm sound generator was installed on the ceiling of each rooms in apartment units. Background noise of + 15 dB and 75 dB (A) were satisfied when alarm sound generator was installed on the ceiling of each room.

A study on the heat recovery Characteristics of double tube type heat recovery ventilation system by double pipe material (이중관 재질에 따른 이중관형 열회수 환기장치의 열회수 특성 연구)

  • Kim, Eun-Young;Cho, Jin-Pyo
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.18 no.4
    • /
    • pp.21-26
    • /
    • 2017
  • In this study, performance tests were conducted to investigate the applicability of a double-tube heat recovery ventilation system. Paper, aluminum, polymer, were investigated as materials for the inner tube using the same exhaust-air volume. In all cases, the temperature exchange efficiency of the aluminum tube was the highest, while the paper tube showed similar results to those of the polymer tube. This probably resulted from the differences in thermal conductivity and thicknesses of the materials. The humidity exchange efficiency was the highest for the paper tubes in all cases, while the aluminum tubes and polymer tubes showed similar results. The total heat exchange efficiency, which includes the values of humidity exchange and temperature exchange, was highest in the case of the paper tube, and the aluminum tube and the polymer tube showed similar results. In the case of the paper tube, sensible heat and latent heat exchange occur at the same time, and the coefficient of energy of the aluminum tube and polymer tube are large values, when to be compared with only applicably sensible heat exchange coefficient of the aluminum tube and the polymer tube of total heat exchange efficiency value. The results of this study could be applied to the design of a ventilation system.

The Predictable Factors of the Postoperative Kyphotic Change of Sagittal Alignment of the Cervical Spine after the Laminoplasty

  • Lee, Jun Seok;Son, Dong Wuk;Lee, Su Hun;Kim, Dong Ha;Lee, Sang Weon;Song, Geun Sung
    • Journal of Korean Neurosurgical Society
    • /
    • v.60 no.5
    • /
    • pp.577-583
    • /
    • 2017
  • Objective : Laminoplasty is an effective surgical method for treating cervical degenerative disease. However, postoperative complications such as kyphosis, restriction of neck motion, and instability are often reported. Despite sufficient preoperative lordosis, this procedure often aggravates the lordotic curve of the cervical spine and straightens cervical alignment. Hence, it is important to examine preoperative risk factors associated with postoperative kyphotic alignment changes. Our study aimed to investigate preoperative radiologic parameters associated with kyphotic deformity post laminoplasty. Methods : We retrospectively reviewed the medical records of 49 patients who underwent open door laminoplasty for cervical spondylotic myelopathy (CSM) or ossification of the posterior longitudinal ligament (OPLL) at Pusan National University Yangsan Hospital between January 2011 and December 2015. Inclusion criteria were as follows : 1) preoperative diagnosis of OPLL or CSM, 2) no previous history of cervical spinal surgery, cervical trauma, tumor, or infection, 3) minimum of one-year follow-up post laminoplasty with proper radiologic examinations performed in outpatient clinics, and 4) cases showing C7 and T1 vertebral body in the preoperative cervical sagittal plane. The radiologic parameters examined included C2-C7 Cobb angles, T1 slope, C2-C7 sagittal vertical axis (SVA), range of motion (ROM) from C2-C7, segmental instability, and T2 signal change observed on magnetic resonance imaging (MRI). Clinical factors examined included preoperative modified Japanese Orthopedic Association scores, disease classification, duration of symptoms, and the range of operation levels. Results : Mean preoperative sagittal alignment was $13.01^{\circ}$ lordotic; $6.94^{\circ}$ lordotic postoperatively. Percentage of postoperative kyphosis was 80%. Patients were subdivided into two groups according to postoperative Cobb angle change; a control group (n=22) and kyphotic group (n=27). The kyphotic group consisted of patients with more than $5^{\circ}$ kyphotic angle change postoperatively. There were no differences in age, sex, C2-C7 Cobb angle, T1 slope, C2-C7 SVA, ROM from C2-C7, segmental instability, or T2 signal change. Multiple regression analysis revealed T1 slope had a strong relationship with postoperative cervical kyphosis. Likewise, correlation analysis revealed there was a statistical significance between T1 slope and postoperative Cobb angle change (p=0.035), and that there was a statistically significant relationship between T1 slope and C2-C7 SVA (p=0.001). Patients with higher preoperative T1 slope demonstrated loss of lordotic curvature postoperatively. Conclusion : Laminoplasty has a high probability of aggravating sagittal balance of the cervical spine. T1 slope is a good predictor of postoperative kyphotic changes of the cervical spine. Similarly, T1 slope is strongly correlated with C2-C7 SVA.

Belle Epoque and Dadaism in the Modern Culture (벨 에포크와 다다이즘 - 근대문화의 총체와 해체)

  • Lee, Byung Soo
    • Cross-Cultural Studies
    • /
    • v.33
    • /
    • pp.171-192
    • /
    • 2013
  • The article is a research about the Belle Epoque era and Dadaism in the modern culture as a whole and separate. The years from 1890s to 1914, is known as the Belle Epoque era, in which the European continent including France had developed the climax of the modern culture after the Renaissance. At the same time, it was the period where the postmodern developments were being spread, leading to the present days. Moreover, the main ideologies in art that led to the cultural advancement of the time were impressionism, cubism, art nouveau, evolutionized painting category, symbolism and futurism. It was a literature category that was maintained to present Dadaism and surrealism. Dadaism began since the magazine, Bulletin Dada was published, originating in 1916 by Tristan Tzara of Zurich, Switzerland during the WWI. The extreme motto that the Dadaists supported was a contradiction, as they had to dissolve from their own art movements and expression techniques. However, until Andre Breton introduced 'Manifeste du Surrealisme' in 1924, the "Dada group" had a tremendous influence in France as an epicenter and rejected the modern cause and art that continued during the time, thus attempting its dissolution. First, they rejected the ideology, ethics and customs of rationalism from the previous system and demonstrate an anarchical and anti-bourgeoisie characteristic. They also reject the French lucid thoughts and the artistic techniques. They strongly emphasized on their motto "The idea is created from the mouth", while reframing from the philosophical ideology and at the same time, attempting to express the psychical unconsciousness. Second, the most important catchphrase that the Dadaists supported was the theory of negation. The question "Why do you write?" connotes the negative consciousness about the artistic value and the stereotyped method of the preexisting writing and drawing. Third, the Dadaists bring forward a radical query about all of the former esthetic and morals, and reveal an admirable resistance spirit. They emphasized on the slogan "Dada, means nothing" and insist on 'the anti-literal Dada, anti-artistic Dada, anti-musical Dada'. The Dadaist movement manifested their resistant spirit and the new artistic spirit through the publication of , , and most importantly through the magazine . Fourth, the Dadaists embodied the volume, density, and quality into an image through the auto-technical, cubistic writings and drawings. They ignored the fixed form of arrangements, verses, and rhymes of a poetic diction. The Dadaists utilized an unfamiliar and inversed expression method of applying the combination of the size of print, or capital letters and lowercase letters, even combining printed and handwritten writings. As presented, the auto-technical and cubistic characteristic of expressing the auto-psychical ideology into writing is called as the radical aesthetic and moral and can be considered as the most essential cause of the Dadaists' avant-garde features. As a conclusion, Dadaism demonstrated dual characteristics of consuming the nutritive elements of the modern culture through the most powerful resistance and liberation of the artistic movement of the Belle Epoque era, where at the same time, it deconstructed the modern art. By revolting against the former grounds and expression techniques, and dominating the era with the new artistic spirit, their resistant actions were artistic movements that symbolized the dissolution of the modern times. Moreover, the Dada's expressionism and resistance of saying "There's nothing" can be evaluated as postmodernity's initiative of outweighing the modern history and opening the door for new period of nowadays.

A Study on the Issue of "Existence" for Merleau-Ponty (메를로-퐁티에 있어서 '실존'의 문제)

  • Sim, Gui-yeon
    • Journal of Korean Philosophical Society
    • /
    • v.139
    • /
    • pp.81-104
    • /
    • 2016
  • Given that the goal of study lies in the pursuit of truth and that philosophy asks questions about the origin of being, dealing with existence rather than essence is distant from the original meanings of philosophy. In spite of this, people talk about existence because it is closely related to the academic goals of phenomenology. It is true that phenomenology is Wesenswissenschaft ("the science of essences") in that it tries to restore the original nature of philosophy and establish philosophy as a strict science, but it cannot be ignored in phenomenological research that essence starts from existence. The purpose of this study is to examine the issues that traditional philosophy has sought after and missed by focusing on the issue of "existence." Existence is man's participation in the world, thus being expressed as being-to-the-world. All that has been perceived is understood in total unity and accordingly cannot be restored to ideological essence. In the end, the issue of existence should make a new start at the root of perception. Man is a thinking being and, at the same time, acting being. Here, an attempt to determine the priority between thinking and acting will be meaningless, indeed, and make an issue where there is none. Human beings will not thus stay at Descartes cogito argument' and try to go out into the world through the door opened by cogito. With these reasons in mind, this study examines the issue of existence with a focus on a phenomenal field and body.

Epidemiological Analysis of a Food Poisoning Outbreak Caused by Multiple Pathogens in a High School in Chungnam Korea, 2019 (2019년 충남지역 고등학교에서 발생한 다병원체에 의한 집단식중독의 역학적 분석)

  • Lee, Hyunah;Choi, Jihye;Park, Seongmin;Nam, Hae-Sung;Choi, Jinha;Park, Junhyuk
    • Journal of Environmental Health Sciences
    • /
    • v.45 no.5
    • /
    • pp.434-442
    • /
    • 2019
  • Objectives: This study was performed in order to report the epidemiological features of a food poisoning outbreak caused by multiple pathogens in a high school in Chungcheongnam-do Province, Korea in April 2019 and to suggest measures to prevent a similar incidence. Methods: A total of 39 patients with diarrhea were examined. Environmental samples were obtained from 6 food handlers, 4 food utensils, 72 preserved foods served during the food poisoning outbreak, 9 door handles, 10 drinking water samples from water dispensers, and 6 ground water samples from water taps. These analyzed to detect viruses and bacteria. Results: Among the 39 patients, 21 cases (53.8%) of enteroaggregative E. coli (EAEC), 7 cases of Staphylococcus aureus (17.9%), and 17 cases of norovirus (43.6%) were positive, and in 16 of the cases a co-infection with at least one other pathogen were observed. EAEC was assumed to be transmitted from contaminated drinking water because it was also detected in the water sample from a water dispenser in the dormitory. Staphylococcus aureus was isolated only in the fecal samples of patients, meaning it was not possible to trace its origin. The genotype of norovirus detected in the drinking water and ground water was consistent with that isolated from patients, and it was determined that the norovirus infection originated from the school's water environment. Conclusions: These findings indicate that a lack of environmental hygiene management related to school meals caused the food poisoning incident. In particular, a lack of management of drinking water, water supply, and personal hygiene should be pointed out. This should be urgently addressed and continuous monitoring should be carried out in the future. In addition, students and staff should be educated and trained to improve their personal hygiene.