통합 검색 | Korea Science

Isolation of phosphate starvation induced genes by SSH

Kim, Eun-Jeong;Jeong, Soon-Jae;Yi, Young-Byung;Nam, Jae-Sung;Lee, Jae-Heon;Kim, Kyung-Tae;Eun, Moo-Young;Kim, Doh-Hoon
- 한국식물생명공학회:학술대회논문집
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- 한국식물생명공학회 2003년도 추계학술대회 발표논문 초록집
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- pp.118-118
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- 2003
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In Vitro Genotoxicity Assessment of a Novel Resveratrol Analogue, HS-1793

Jeong, Min Ho;Yang, Kwangmo;Lee, Chang Geun;Jeong, Dong Hyeok;Park, You Soo;Choi, Yoo Jin;Kim, Joong Sun;Oh, Su Jung;Jeong, Soo Kyung;Jo, Wol Soon
- Toxicological Research
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- 제30권3호
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- pp.211-220
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- 2014
Resveratrol has received considerable attention as a polyphenol with various biological effects such as anti-inflammatory, anti-oxidant, anti-mutagenic, anti-carcinogenic, and cardioprotective properties. As part of the overall safety assessment of HS-1793, a novel resveratrol analogue free from the restriction of metabolic instability and the high dose requirement of resveratrol, we assessed genotoxicity in three in vitro assays: a bacterial mutation assay, a comet assay, and a chromosomal aberration assay. In the bacterial reverse mutation assay, HS-1793 did not increase revertant colony numbers in S. typhimurium strains (TA98, TA100, TA1535 and TA1537) or an E. coli strain (WP2 uvrA) regardless of metabolic activation. HS-1793 showed no evidence of genotoxic activity such as DNA damage on L5178Y $Tk^{+/-}$ mouse lymphoma cells with or without the S9 mix in the in vitro comet assay. No statistically significant differences in the incidence of chromosomal aberrations following HS-1793 treatment was observed on Chinese hamster lung cells exposed with or without the S9 mix. These results provide additional evidence that HS-1793 is non-genotoxic at the dose tested in three standard tests and further supports the generally recognized as safe determination of HS-1793 during early drug development.
https://doi.org/10.5487/TR.2014.30.3.211 인용 PDF KSCI