• Fisheries and Aquatic Sciences
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• 제27권9호
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• pp.614-621
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• 2024

Channel catfish (Ictalurus punctatus), an introduced species in Vietnam, is widely cultured in the Northern provinces. The off-white grub disease in Channel catfish, caused by metacercariae of Dollfustrema bagarii (Digenea: Bucephalidae) lodged in internal organs, often results in heavy economic losses. Up to the present, there have been no specific guidelines for preventing and treating this disease. Here, we explore the potential treatment of infected channel catfish through the injection of Ivermectin. We evaluated the tolerance of channel catfish to the drug and determined the optimal dosage for treating off-white grubs disease. Healthy fish weighing 180-200 g received dosages of up to 3.250 mg/kg of body weight. The median lethal dose (LD₅₀) throughout a 24-hour period was 0.808 mg/kg body weight, with a confidence interval ranging from 0.583 to 1.118 mg/kg body weight. The infected fish used for treatment testing ranged in weight from 400 to 500 g. The value for the 24-hour median effective dose (ED₅₀) was 0.253 mg, and the appropriate therapeutic injection ranged from 0.300 to 0.700 mg per kg of body weight. Flowing the histopathological alterations, after the metacercariae were shriveled and died, the immune cells cleaned and eliminated them from fish.