• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2006년도 International Symposium on GPS/GNSS Vol.2
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• pp.203-208
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• 2006

The main research conducted previously on GPS ionosphere in China is first introduced. Besides, the current investigations include as follows: (1) GPS-based spatial environmental, especially the ionosphere, monitoring, modeling and analysis, including ground/space-based GPS ionosphere electron density (IED) through occultation/tomography technologies with GPS data from global/regional network, development of a GNSS-based platform for imaging ionosphere and atmosphere (GPFIIA), and preliminary test results through performing the first 3D imaging for the IED over China, (2) The atmospheric and ionospheric modeling for GPS-based surveying, navigation and orbit determination, involving high precisely ionospheric TEC modeling for phase-based long/median range network RTK system for achieving CM-level real time positioning, next generation GNSS broadcast ionospheric time-delay algorithm required for higher correction accuracy, and orbit determination for Low-Earth-orbiter satellites using single frequency GPS receivers, and (3) Research products in applications for national significant projects: GPS-based ionospheric effects modeling for precise positioning and orbit determination applied to China's manned space-engineering, including spatial robot navigation and control and international space station intersection and docking required for related national significant projects.

• Journal of Advanced Marine Engineering and Technology
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• 제33권8호
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• pp.1203-1211
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• 2009

무인잠수정의 동역학은 추진체의 동력학에 의해 큰 영향을 받는다. 무인잠수정의 호버링 또는 저속 상태의 움직임을 제어하는 것은 자동 도킹 혹은 잠수정의 매니퓰레이터의 제어에 있어서 매우 중요하다. 모터기반의 추진체 동역학은 비선형적이며 불확실한 매개변수를 가지고 있다. 결국, 추진기와 동적 커플링을 이루는 무인잠수정의 운동역학도 매우 비선형적이며 불확실한 매개변수를 가지고 있기 때문에 강인제어기가 무인잠수정의 모션제어에 있어서 효과적이라고 할 수 있다. 따라서 본 논문에서는 전기 추진체에 의해 추진되는 무인잠수정의 저속 또는 호버링 상태를 제어하기 위한 강인제어 기법을 보인다. 또한, 비선형성과 불확실한 매개변수가 결합된 무인잠수정의 상태도 강인제어를 이용하여 동시에 제어한다. 강인제어 방법 중에서 슬라이딩 모드 제어기를 설계하여 추진체와 무인잠수정의 불확실한 변수와 비선형성들을 보상하며 원하는 위치를 유지하는 제어방법을 제안하였다. 모의실험을 통하여 제안한 슬라이딩 모드 제어기는 선형제어기인 PD제어기 보다 성능이 우수함을 확인할 수 있었다.

• Biomolecules & Therapeutics
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• 제25권5호
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• pp.535-544
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• 2017

Carnosol is a phenolic antioxidant present in rosemary (Rosmarinus officinalis). It is known for anti-inflammatory effects, analgesic activity and anti-cancer effects. However, no study has been dedicated yet to its effect on atopic dermatitis (AD). Here, we show that carnosol effectively inhibited LPS-induced nitric oxide (NO) generation and expression of inflammatory marker proteins (iNOS and COX-2) in RAW 264.7 cells. In addition, carnosol effectively inhibits the phosphorylation of STAT3 and DNA binding activity in RAW 264.7 cells. Pull down assay and docking model analysis showed that carnosol directly binds to the DNA binding domain (DBD) of STAT3. We next examined the anti-atopic activity of carnosol ($0.05{\mu}g/cm^2$) using 5% Phthalic anhydride (PA)-induced AD model in HR1 mice. Carnosol treatment significantly reduced 5% PA-induced AD like skin inflammation in skin tissues compared with control mice. Moreover, carnosol treatment inhibits the expression of iNOS and COX-2 in skin tissue. In addition, the levels of $TNF-{\alpha}$, $IL-1{\beta}$, and Immunoglobulin-E in blood serum was significantly decreased in carnosol treated mice compared with those of 5% PA treated group. Furthermore, the activation of STAT3 in skin tissue was decreased in carnosol treated mice compared with control mice. In conclusion, these findings suggest that carnosol exhibited a potential anti-AD activity by inhibiting pro-inflammatory mediators through suppression of STAT3 activation via direct binding to DBD of STAT3.

• 한국항공우주학회지
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• 제43권10호
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• pp.868-874
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• 2015

가변추력은 대기가 없는 행성에 착륙하거나, 우주공간에서의 도킹에 필수적인 것으로 알려져 있다. 추력을 조절하기 위해 질유량 조절이 가능한 분사기를 사용하는 방법이 대표적으로 알려져 있다. 이에 따라 본 연구에서는 추력조절을 위하여 이중매니폴드 분사기를 사용하여 질유량을 조절하였다. 이중매니폴드 분사기의 주요 변수 중 하나로 판단되는 접선방향 유입구의 개수의 변화에 따른 분사특성을 확인하기 위하여 분무각, 분무패턴을 포함하는 외부유동을 측정하였으며 내부유동 특성 파악을 위한 film thickness를 확인하였다.

• Journal of Microbiology and Biotechnology
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• 제32권4호
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• pp.504-513
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• 2022

Chitin deacetylase (CDA) inhibitors were developed as novel antifungal agents because CDA participates in critical fungal physiological and metabolic processes and increases virulence in soil-borne fungal pathogens. However, few CDA inhibitors have been reported. In this study, 150 candidate CDA inhibitors were selected from the commercial Chemdiv compound library through structure-based virtual screening. The top-ranked 25 compounds were further evaluated for biological activity. The compound J075-4187 had an IC50 of 4.24 ± 0.16 µM for AnCDA. Molecular docking calculations predicted that compound J075-4187 binds to the amino acid residues, including active sites (H101, D48). Furthermore, compound J075-4187 inhibited food spoilage fungi and plant pathogenic fungi, with minimum inhibitory concentration (MIC) at 260 ㎍/ml and minimum fungicidal concentration (MFC) at 520 ㎍/ml. Therefore, compound J075-4187 is a good candidate for use in developing antifungal agents for fungi control.

• Tuberculosis and Respiratory Diseases
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• 제67권1호
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• pp.8-13
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• 2009

Background: The insulin receptor substrate-1 (IRS-1) is the primary docking molecule for the insulin-like growth factor I receptor (IGF-IR), and is required for activation of the phosphatidylinositol 3'-kinase (PI3K) pathway. IRS-1 activation of the (PI3K) pathway regulates IGF-mediated survival, enhancement of cellular motility and apoptosis. Therefore, we attempted to ascertain whether IRS-1 genetic variations affect an individual's risk for non-small cell lung cancer (NSCLC). Methods: Two-hundred and eighteen subjects, either diagnosed with NSCLC or control subjects, were matched by age, gender and smoking status. Genomic DNA from each subject was amplified by PCR and analyzed according to the restriction fragment length polymorphism (RFLP) profile to detect the IRS-1 G972R polymorphism. Results: The frequencies of each polymorphic variation, in the control population, were as follows: GG=103 (94.5%) and GR=6 (5.5%); for the NSCLC subjects, the genotypic frequencies were as follows: GG=106 (97.2%) and GR=3 (2.8%). We could not demonstrate statistically significant differences in the genotypic distribution between the NSCLC and the control subjects (p=0.499, Fisher's Exact test). The relative risk of NSCLC, associated with the IRS-1 G972R polymorphic variation, was 1.028 (95% CI; 0.63~9.90). In addition, we found no differences between polymorphic variants with regard to the histological subtype of NSCLC. Conclusion: We did not observe any noteworthy differences in the frequency of the IRS-1 G972R polymorphism in NSCLC patients, compared to control subjects. These results suggest suggesting that, in our study population, the IRS-1 G972R polymorphism does may not appear to be associated with an increased risk of NSCLC.

• International Journal of Aeronautical and Space Sciences
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• 제15권4호
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• pp.444-453
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• 2014

A throttleable rocket engine enables operational possibilities such as the docking of spacecraft, maneuvering in a certain orbit and landing on a planet's surface, altitude control, and entrance to atmosphere-less planets. Thus, throttling methods have long been researched. However, dual-manifold injectors, which represent one throttling method, have been investigated less than others. In this study, dual-manifold and single-manifold injectors were compared to determine the characteristics of dual-manifold injectors. Also, the effects of gas injection were investigated with various F/O ratios. To investigate the characteristics, mass flow rate, spray pattern, spray angle, and droplet size were measured. The spray angle and droplet size were captured by indirect photography. About 30 images were taken to assess the spray patterns and spray angle. Also, 700 images were analyzed to understand the droplet distribution and targeting area, moving to the right from the centerline with 1.11-cm intervals. The droplet size was obtained from an image processing procedure. From the results, the spray angle showed two transition regions, due to swirl momentum in the swirl chamber regardless of the F/O ratio. The droplet size showed similar trends in both dual-manifold and single-manifold injectors except in the low mass flow rate region. In the case of the dual- manifold injector, the spray cone was not fully developed in the low mass flow rate region due to low angular momentum in the swirl chamber.

• 대한의생명과학회지
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• 제23권1호
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• pp.8-16
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• 2017

p-Coumaric acid is an organic compound that is a hydroxyl derivative of cinnamic acid. Due to its multiple biological activities p-coumaric acid has been widely studied in biochemical and cellular systems and is also considered as a useful therapeutic candidate for various neuronal diseases. However, the efficacy of p-coumaric acid on zebrafish developmental regulation has not been fully explored. In this study, therefore, we first investigated the action mechanism of the p-coumaric acid on the zebrafish development in a whole-organism model. p-Coumaric acid treated group significantly inhibited the pigmentation of the developing zebrafish embryos compared with control embryos without any severe side effects. In addition, p-coumaric acid down-regulated more effectively in a lower concentration than the well-known zebrafish's melanogenic inhibitor, phenylthiourea. We also compared the molecular docking property of p-coumaric acid with phenylthiourea on the tyrosinase's kojic acid binding site, which is the key enzyme of zebrafish embryo pigmentation. Interestingly, p-coumaric acid interacted with higher numbers of the amino acid residues and exhibited a tight binding affinity to the enzyme than phenylthiourea. Taken all together, these results strongly suggest that p-coumaric acid inhibits the activity of tyrosinase, consequently down-regulating zebrafish embryo pigmentation, and might play an important role in the reduction of dermal pigmentation. Thus, p-coumaric acid can be an effective and non-toxic ingredient for anti-melanogenesis functional materials.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2009년도 춘계 종합학술대회 논문집
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• pp.626-632
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• 2009

본 연구는 민간경비원의 직무스트레스가 직무만족 및 이직의사에 미치는 영향을 규명하기 위하여 2005년 6월 1일부터 6월 30일까지 30일간에 걸쳐 서울 및 수도권 소재 민간경비 업체 중, 50명 이상 근무하고 있는 경찰청에 등록된 경비업체를 모집단으로 하여 1단계로 서울, 경기도 지역에 위치한 경비업체를 고려하여 4개 구역으로 구분한 다음, 관할경찰청에 등록된 민간경비업체 8곳을 무선으로 선정하고 2단계로, 선정된 민간경비업체를 직접 방문하여 대상자의 성별, 연령층을 고려하여 각 업체당 70부씩, 총 560명을 집락하였다. 실제분석에서는 표집된 560명중 불성실하게 응답했다고 판단되거나 조사내용의 일부가 누락된 75부의 자료는 제외하고 최종분석에 사용된 사례수는 485명 이었다.각 수집된 자료는 SPSSWIN 12.0을 이용하여 요인분석, t 검증 및 F 검증, 일원변량분석, 다중회귀분석, 회귀분석 등의 방법을 활용하였다. 결론은 다음과 같다. 첫째, 직무스트레스는 직무만족 및 이직의사의 영향을 미친다. 둘째, 직무스트레스는 직무만족에 영향을 미친다. 셋째, 직무스트레스는 이직의사에 영향을 미친다. 넷째, 직무만족은 이직의사에 영향을 미친다. 직무스트레스는 직무만족 및 이직의사에 직 간접적 영향을 미친다.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2009년도 춘계 종합학술대회 논문집
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• pp.59-65
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• 2009

에듀테인먼트는 교육적인 효과와 함께 게임 기술 및 게임 이론들을 적용하여 즐거움 외에 교육을 통한 특정 분야의 문제 해결을 목적으로 가지는 콘텐츠를 말한다. 이러한 에듀테인먼트는 재미뿐만 아니라 교육적인 효과 때문에 과학기술 분야 및 산업기술 분야의 교육 및 훈련에 유용하다. 본 연구에서는 사용자가 직관적인 멀티 모달 인터페이스를 사용하여 생명공학에 적용한 바이오 에듀테인먼트 시스템을 제안한다. 이를 위하여 3차원 분자 구조를 특수 모니터를 사용하여 입체 시각화 하였으며 입체 영상화된 분자 구조를 효율적으로 제어하기 위하여 멀티 모달 인터페이스인 WiiRemote를 사용하였다. 본 논문에서 제안된 시스템은 분자 도킹 시뮬레이션이 가지던 문제점인 3차원 분자 모델들의 결합 및 조작이 사용자의 직관과 경험에 많이 의존하기 때문에 초보자들의 접근이 어려운 점을 게임적 요소를 적용하여 재미를 느끼게 하면서 해결하도록 하였다. 이를 위해 사용자가 조작을 하는 객체와 사용자의 수에 따른 게임적 요소인 레벨 업 개념을 적용하여 반복학습이 이루어지도록 하였다.