• 한국환경보건학회지
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• 제36권1호
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• pp.44-51
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• 2010

This study aimed to develop analytical method for 8-isoprostanes as biomarkers for oxidative stress with LC/MS/MS technique and to apply the method for human urine samples. Analyzed compounds for urinary oxidative stress markers were 7 stereo-isomers of prostaglandins and the internal standard (iso-$PGF_{2{\alpha}}-d_4$) was used to adjust the recovery rate. The method for determining urinary iso-$PGF_{2{\alpha}}$ consisted of solid phase extraction and LC/MS/MS detection. Separation of isomers of prostaglandins completed by porous graphitic carbon column and buffer solution. Detection limits for urinary markers of oxidative stress, iso-$PGF_{2{\alpha}}$ with LC/MS/MS were 0.01 ng/ml by S/N ratio 3 and 0.028 ng/ml by calculated as to FDA method. The recovery (92.8~101.9%) and precision (8.8~20.7%) of analysis were feasible for detecting iso-$PGF_{2{\alpha}}$ in real human urine samples. We detected 4 isomers of prostaglandins in human urine samples. Mean (standard deviation) of urinary iso-$PGF_{2{\alpha}}$ concentration were 0.231 (0.117) ng/mg creatinine for smoking group and 0.154 (0.082) ng/mg creatinine for non-smoking group.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2007년도 한국컴퓨터종합학술대회논문집 Vol.34 No.1 (C)
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• pp.332-335
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• 2007

이메일은 누구나 쉽게 정보를 교환할 수 있는 편리함 때문에 인터넷에서 가장 중요한 수단으로 사용되고 있다. 그러나 순수한 의사소통의 수단이 아닌 스팸메일의 범람은 성인뿐만 아니라, 어린이 청소년에게도 무차별적으로 전송됨으로써 심각한 부작용을 낳고 있다. 본 논문은 점차 지능화 되는 신 유형의 음란 스팸메일로부터 청소년을 보호하기 위하여 새로운 방법의 음란메일 차단시스템을 제안하고자 한다. 기존의 스팸메일 차단시스템은 사용자가 직접 음란한 메일이라고 판단되는 메일에 대해 일일이 키워드를 설정하거나, 메일 내용 중에 텍스트만을 추출하여 패턴 매칭방법으로 분류하는 것이 대부분이었지만, 본 논문은 기존 방법의 문제점을 해결하기 위하여 이미지 내 Skin-Color분포의 Human Detection 알고리즘과 웹 로봇 에이전트의 하이퍼링크 분석기법을 사용하였다. 성능 측정결과, 형태소 분석과 Human Detection 알고리즘을 병합하여 적용한 경우 성능 측정에서 90% 정도의 F-measure를 보였지만, 추가적으로 웹 로봇 에이전트의 하이퍼링크 분석기법을 병합하여 적용한 경우 97% 이상의 F-measure를 보이며, 신뢰성이 높은 음란스팸메일 차단 시스템을 구현할 수 있다는 것을 증명하였다.

• 정보과학회 논문지
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• 제44권4호
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• pp.417-422
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• 2017

비정상행위 탐지는 데이터로부터 특징을 추출하여 정상 행위 모델을 만들어, 이 정상 모델로부터 얼마나 벗어나 있는 가를 찾아내어 탐지하는 기법이다. 즉, 특정 기기가 생성하는 데이터를 기반으로 기기의 오류를 탐지하거나 사회망 데이터에서의 사용자 행위 변화를 찾아내어 비정상행위를 탐지하는 데 활용할 수 있다. 본 논문에서는 순위 상관 계수를 이용하여 건물 내의 기기의 비정상적인 데이터를 탐지하고자 한다. 에너지 절약 문제에 대한 관심이 높아짐에 따라 에너지를 효율적으로 사용하기 위해 여러방법들이 제안되었다. IT 기술의 발달과 더불어 공조 시스템(HVAC)이 건물에 도입되어 활용되고 있으며, 이 시스템을 통하여 에너지 소비의 문제점을 찾고 에너지를 효율적으로 관리할 수 있다. 따라서 본 논문은 공조 시스템에 속한 각 기기간의 순위 관계 변화를 관찰함으로써 이상 현상 탐지의 효율성을 높이는 방법을 제안하며, 사회망 데이터 내에서의 비정상행위 탐지 가능성도 함께 제안한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9801-9804
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• 2014

Background: Colorectal cancer is currently the third most common cancer in Indonesia, yet colonoscopy - the most accepted mode of screening to date - is not done routinely and national data are still lacking. Objective: To determine the detection rate of colorectal cancers and adenomas in unselected patients undergoing colonoscopy for various large bowel symptoms at the Digestive Disease and GI Oncology Centre, Medistra Hospital in Jakarta, Indonesia. Materials and Methods: Colonoscopy data from January 2009 to December 2012 were reviewed. New patients referred for colonoscopy were included. Data collected were patient demographic and significant colonoscopy findings such as the presence of hemorrhoids, colonic polyps, colonic diverticula, inflammation, and tumor mass. Histopathological data were obtained for specimens taken by biopsy. Associations between categorical variables were analyzed using chi-square test, while mean differences were tested using the t-test. Results: A total of, 1659 cases were included in this study, 889 (53.6%) of them being men. Polyps or masses were found in 495 (29.8%) patients while malignancy was confirmed in 74 (4.5%). Patients with a polyp or mass were significantly older (60.2 vs 50.8 years; p<0.001; t-test) and their presence was significantly associated with male gender (35.0% vs 23.9%; prevalent ratio [PR] 1.71; 95% confidence interval [CI] 1.38-2.12; p<0.001) and age >50 years (39.6% vs 16.6%; PR 3.29; 95% CI 2.59-4.12; p<0.001). Neoplastic lesions was found in 257 (16.1%), comprising 180 (11.3%) adenomas, 10 (0.6%) in situ carcinomas, and 67 (4.2%) carcinomas. Conclusions: Polyps or masses were found in 30% of colonoscopy patients and malignancies in 16.1%. These figures do not represent the nation-wide demographic status of colorectal cancer, but may reflect a potentially increasing major health problem with colorectal cancer in Indonesia.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.595-598
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• 2013

Background: Lung cancer is the leading cause of cancer death worldwide Therefore, identification of genetic as well as environmental factors is very important in developing novel methods of lung cancer prevention. However, this is a multi-layered problem. Therefore a lung cancer risk prediction system is here proposed which is easy, cost effective and time saving. Materials and Methods: Initially 400 cancer and non-cancer patients' data were collected from different diagnostic centres, pre-processed and clustered using a K-means clustering algorithm for identifying relevant and non-relevant data. Next significant frequent patterns are discovered using AprioriTid and a decision tree algorithm. Results: Finally using the significant pattern prediction tools for a lung cancer prediction system were developed. This lung cancer risk prediction system should prove helpful in detection of a person's predisposition for lung cancer. Conclusions: Most of people of Bangladesh do not even know they have lung cancer and the majority of cases are diagnosed at late stages when cure is impossible. Therefore early prediction of lung cancer should play a pivotal role in the diagnosis process and for an effective preventive strategy.

• 한국컴퓨터정보학회논문지
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• 제21권10호
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• pp.11-19
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• 2016

The size of a display is large, The form becoming various of that do not apply to previous methods of gaze tracking and if setup gaze-track-camera above display, can solve the problem of size or height of display. However, This method can not use of infrared illumination information of reflected cornea using previous methods. In this paper, Robust pupil detecting method for eye's occlusion, corner point of inner eye and center of pupil, and using the face pose information proposes a method for calculating the simply position of the gaze. In the proposed method, capture the frame for gaze tracking that according to position of person transform camera mode of wide or narrow angle. If detect the face exist in field of view(FOV) in wide mode of camera, transform narrow mode of camera calculating position of face. The frame captured in narrow mode of camera include gaze direction information of person in long distance. The method for calculating the gaze direction consist of face pose estimation and gaze direction calculating step. Face pose estimation is estimated by mapping between feature point of detected face and 3D model. To calculate gaze direction the first, perform ellipse detect using splitting from iris edge information of pupil and if occlusion of pupil, estimate position of pupil with deformable template. Then using center of pupil and corner point of inner eye, face pose information calculate gaze position at display. In the experiment, proposed gaze tracking algorithm in this paper solve the constraints that form of a display, to calculate effectively gaze direction of person in the long distance using single camera, demonstrate in experiments by distance.

• 산업경영시스템학회지
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• 제39권2호
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• pp.129-137
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• 2016

To identify the cause of the error and maintain the health of system, an administrator usually analyzes event log data since it contains useful information to infer the cause of the error. However, because today's systems are huge and complex, it is almost impossible for administrators to manually analyze event log files to identify the cause of an error. In particular, as OpenStack, which is being widely used as cloud management system, operates with various service modules being linked to multiple servers, it is hard to access each node and analyze event log messages for each service module in the case of an error. For this, in this paper, we propose a novel message-based log analysis method that enables the administrator to find the cause of an error quickly. Specifically, the proposed method 1) consolidates event log data generated from system level and application service level, 2) clusters the consolidated data based on messages, and 3) analyzes interrelations among message groups in order to promptly identify the cause of a system error. This study has great significance in the following three aspects. First, the root cause of the error can be identified by collecting event logs of both system level and application service level and analyzing interrelations among the logs. Second, administrators do not need to classify messages for training since unsupervised learning of event log messages is applied. Third, using Dynamic Time Warping, an algorithm for measuring similarity of dynamic patterns over time increases accuracy of analysis on patterns generated from distributed system in which time synchronization is not exactly consistent.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제6권2호
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• pp.702-721
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• 2012

In the DVB-T2 system with a multiple-input single-output (MISO) transmission mode, Alamouti coded orthogonal frequency division multiplexing (OFDM) signals are transmitted simultaneously from two spatially separated transmitters in a single frequency network (SFN). In such systems, each transmit-receive link may have a distinct carrier frequency offset (CFO) due to the Doppler shift and/or frequency mismatch between the local oscillators. Thus, the received signal experiences dual CFOs. This not only causes dual phase errors in desired data but also introduces inter-carrier interference (ICI), which cannot be removed completely by simply performing a CFO compensation. To overcome this problem, this paper proposes an iterative detection with dual phase errors compensation technique. In addition, we propose a successive-iterative ICI cancellation technique. This technique successively eliminates ICI in the initial iteration by exploiting pre-detected data pairs. Then, in subsequent iterations, it performs a fine interference cancellation using a priori information, iteratively fed back from the channel decoder. In contrast to previous works, the proposed techniques do not require estimates of dual CFOs. Their performances are evaluated via a full DVB-T2 simulator. Simulation results show that the DVB-T2 receiver equipped with the proposed dual phase errors compensation and the successive-iterative ICI cancellation techniques achieves almost the same performance as ideal dual CFOs-free systems, even for large dual CFOs.

• 대한의용생체공학회:의공학회지
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• 제35권3호
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• pp.55-61
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• 2014

In sleep monitoring system, polysomnography (PSG) is the gold-standard but previous studies revealed that attaching numerous amount of sensors disturb sleep during the test which is the fundamental disadvantage of PSG. We suggest an unconstrained rapid-eye-movement (REM) sleep monitoring method measured with polyvinylidene (PVDF) film-based sensor for the normal and the obstructive sleep apnea (OSA) patients. Nine normal subjects and seventeen OSA patients have participated in the study. During REM sleep, rate and variability of respiration are known to be greater than in other sleep stages. Based on this phenomena, respiratory signals of participants were unconstrainedly measured using the PVDF-based sensor with the PSG and REM sleep were extracted from the average rate and variability of respiration. In epoch-by-epoch REM sleep detection, proposed method classified REM sleep with an average sensitivity of 72.3%, specificity of 92.5%, accuracy of 88.9%, and kappa statistic of 0.60 compared to the results of PSG. Student's t-test showed no significant difference between the results of normal and OSA group. This method is potentially applicable to REM sleep detection in homing environment or ambulatory monitoring.

• Natural Product Sciences
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• 제16권1호
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• pp.26-31
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• 2010

High performance liquid chromatographic method with diode-array detection (HPLC-DAD) has been performed for the simultaneous determination of four marker constituents, paeoniflorin, trans-cinnamic acid, schisandrin and glycyrrhizin in traditional herbal medicinal preparation, So-Cheong-Ryong-Tang (SCRT). The presence of paeoniflorin, trans-cinnamic acid, schisandrin and glycyrrhizin in this decoction was ascertained by retention time, spiking with each authentic standard, UV spectrum and ESI mass spectrum. All four compounds showed good linearity ($r^2$ > 0.998) in a relatively wide concentration ranges. The RSD for intra-day and inter-day precision was less than 3% and the limits of detection (LOD) were less than 30 ng. The mean recovery of each compound was 94.1-113.0% with RSD values less than 3.0%. These results suggest that the developed HPLC method is simple, effective and could be readily utilized as a quality control method for commercial SCRT products.