• 제목/요약/키워드: Dithiocarbamate chitosan-Ca(II)-Tetracycline complex

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Dithiocarbamate Chitosan을 Matrix로 이용한 고분자 약물의 개발 : Dithiocarbamate Chitosan-Ca(II)-Tetracycline Complex 의 생성 및 항균성 (Development of Polymeric Drugs Utilizing Dithiocarbamate Chitosan: Formation and Antimicrobial Activities of Dithiocarbamate Chitosan-Ca(II)-Tetracycline Complex)

  • 김윤택;김영미;한석규;정연진;유종호
    • 약학회지
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    • 제39권1호
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    • pp.48-54
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    • 1995

  • Coupling of tetracycline(Tc) to dithiocarbamate chitosan(DTCC) via chelate bond was investigated varying reaction time, concentration, temperature, pH, and Ca(II)/Tc ratio. The amount of Tc bound to matrix increased to give a maximum and decreased as the reaction proceeded. The degree and rate of dissociation of Tc complex were affected by the reaction temperature, and pH. By running the reaction at low temperature and pH, the degree of dissociation was greatly diminished. Properties of drug-release from DTCC-Ca(II)-Tc complex were studied by batch- and flow-method and release of Tc and CA(II) by flow method followed nearly zero-order. DTCC-Ca(II)-Tc showed very prolonged antimicrobial activity compared to that of free Tc.

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