• 제목/요약/키워드: Distribution rate constant

검색결과 362건 처리시간 0.021초

충수돌기염 환자에서 겐타마이신의 임상약물동태 (Clinical Pharmacokinetics of Gentamicin in Appendicitis Patients)

  • 최준식;정해광;범진필;이진환;김성환
    • 한국임상약학회지
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    • 제5권2호
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    • pp.1-12
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    • 1995
  • The purpose of this investigation was to determine pharmacokinetic parameters of gentamicin using linear least square regression(LLSR) and Bayesian analysis in Korean normal volunteers and appendicitis patients. Nonparametric expected maximum(NPEM) algorithm for population pharmacokinetic parameters was used. Gentamicin was administered every 8 hours for 3 days by infusion over 30 minutes. The volume of distribution(V) and elimination rate constant(K) of gentamicin were $0.215\pm0.0562,\;0.226\pm0.0325L/kg\;and\;0.339\pm0.0443,\;0.357\pm0.0243hr^{-1}$ for normal volunteers and appendicitis patients using LLSR analysis. Population pharmacokinetic parameters, VS and KS were $0.228\pm0.0614L/kg\;and\;0.00356\pm0.00041(hr{\cdot}mL/min/1.73m^2)^{-1}$ for appendicitis patients using NPEM algorithm. The V and K were $0.232\pm0.0568L/kg\;and\;0.337\pm0.0385hr^{-1}$ for appendicitis patients using Bayesian analysis. There were no differences in gentamicin pharmacokinetics between LLSR and Bayesian analysis.

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변형된 SSD법에 의한 InP결정 성장 (InP crystal growth by modified SSD method)

  • 송복식;정성훈;문동찬;김선태
    • E2M - 전기 전자와 첨단 소재
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    • 제8권3호
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    • pp.291-297
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    • 1995
  • The InP crystals have been grown by modified synthesis solute diffusion (SSD) method and its properties have been investigated. The crystals have been grown by lowering the crucible quartz for growth in the furnace and crystal growth rate is 1.8mm/day. The lattice constant a. of the grown crystals is 5.867.angs.. Etch pits density along growth direction of crystal changes from 3.0*10.sup 3/cm$\^$-2/ of first freeze part to 6.7*10$\^$4/cm$\^$-2/ of last freeze part and the radial direction of wafer shows nearly uniform distribution. The resistivity and the carrier concentration of the grown crystals are 1.43*10$\^$-1/.ohm.-cm, 7.7*10$\^$15/cm$\^$-3/ at room temperature, respectively. In the photolurninescence at 10K, the radiation transitions are observed by the near band edge recombination, a pair recombination due to Si donor - Zn acceptor and its phonon replica in the InP. The activation energy by Zn diffusion in undoped n-InP crystals is 1.22eV.

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RRA 처리가 AA 7039 Al 합금의 기계적 성질과 내응력 부식성에 미치는 영향 (The Effect of the Retrogression and Reaging Treatments on the Mechanical Properties and Susceptibility to Stress Cracking of AA 7039 Al Alloy)

  • 전상조;김준수;김송희
    • 산업기술연구
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    • 제7권
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    • pp.49-58
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    • 1987
  • To investigate the effect of the Retrogression and Reaging (RRA) treatment on the strength and the stress corrosion cracking in AA 7039 the measurement of hardness, tensile properties and the time to failure in a constant rate method were measured. Transmission electron microscope was used to examine the microstructural changes within graln and grain boundary. The results show that the RRA treatment of the T6 condition results in a significant increase in the time to failure without sacrifying the original T6 strength. It is believed that high density and even distribution of precipitates in RRA condition were observed within grain so that the RRA condition could have similar strength to the T6 condition. The presence of fine dispersion of semicohernt ${\eta}^{\prime}$ transition phase is also believed to contribute to that effect. Examination of the grain boundary microstructure shows that the RRA treatments increases significantly the average size of the grain boundary preciptates. It is suggested that the benificial effect of the RRA treatment on the susceptibility to SCC be due to the increase in the size of grain boundary precipitates obtained during the retrogression treatment.

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Monitoring of Corrosion Rates of Carbon Steel in Mortar under a Wet-Dry Cyclic Condition

  • Kim, Je-Kyoung;Kang, Tae-Young;Moon, Kyung-Man
    • 전기화학회지
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    • 제10권3호
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    • pp.179-183
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    • 2007
  • The corrosion behavior of metal covered with mortar under a wet-dry cyclic condition were investigated to apply for the measurement of corrosion rates of reinforcing steel in concrete structure. The carbon steel in mortar having t=3 mm cover thickness was exposed to the alternate condition of 6 h immersion in chloride containing solution and 18 h drying at $25^{\circ}C$ and 50%RH. The electrochemical phenomena of a carbon steel and mortar interface was explained by an equivalent circuit consisting of a solution resistance, a charge transfer resistance and a CPE(Constant Phase Element). The corrosion rates were monitored continuously during exposure using an AC impedance technique. Simultaneously, the current distribution over the working electrode during impedance measurement was analyzed from the phase shift, $\theta$, in an intermediate frequency. The result showed that corrosion rate monitoring using an AC impedance method is suitable under the given exposure conditions even during the drying period when the metal is covered with the wetted mortar.

Choline and basic amine drugs efflux from brain to blood across the blood-brain barrier

  • Lee, Na-Young;Kang, Young-Sook
    • 한국응용약물학회:학술대회논문집
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    • 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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    • pp.107-107
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    • 2003
  • The purpose of this study is to examine that the efflux transport system for choline from brain to blood is present at the blood-brain barrier (BBB) using brain efflux index (BEI) method. [$^3$H]Choline was microinjected into parietal cortex area 2 (Par2) region of rat brain, and was eliminated from the brain with an apparent elimination half life of 45 min. The BBB efflux clearance of [$^3$H]choline was 0.12 $m\ell$/min/g brain, which was calculated from the efflux rate constant (1.5${\times}$10$\^$-2/ min$\^$-1/) and the distribution volume in the brain slice (8.1 $m\ell$/g brain). This process was saturable and significantly inhibited by various organic cationic compounds including hemicholinium-3, tetraethylammonium chloride (TEA) and verapamil, by antioxidant, ${\alpha}$-phenyl-n-tert-butyl nitrone (PBN), and by Alzheimer's disease therapeutics, such as acetyl $\ell$-carnitine and tacrine. In conclusion, this finding is the first direct in vivo evidence that choline is transported from brain to the blood across the BBB via a carrier-mediated efflux transport process.

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피록시캄이 니페디핀의 약력학 및 약동학에 미치는 영향 (Effects of Piroxicam on Pharmacodynamics and Pharmacokinetics of Nifedipine in Spontaneously Hypertensive Rats)

  • 최기환;박인숙;김동섭;정혜주
    • 약학회지
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    • 제44권3호
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    • pp.245-250
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    • 2000
  • Because nonsteroidal anti-inflammatory drugs are reported to cause fluid retention and hypertension by inhibition of prostaglandin synthesis, the effects of piroxicam on pharmacodynamics and pharmacokinetics of nifedipine were studied in male spontaneously hypertensive rats. They received nifedipine (0.5 mg/kg) alone or combined with piroxicam (5 mg/kg) intravenously. Plasma levels norepinephrine, an index of sympathetic stimulation, were measured prior to each treatment and 5 min after drug administration. Changes in blood pressure were examined serially and blood samples for analysis of nifedipine were also taken for 6 hr following drug administration. Plasma nifedipine concentration were assayed by HPLC and pharmacokinetic parameters were calculated. Blood pressure was reduced (p<0.01), but plasma norepinephrine level was increased (p<0.05) by nifedipine administration. Anti-hypertensive effect of nifedipine was potentiated (p<0.05) by piroxicam coadministration, but effect of nifedipine on plasma norepinephrine level was not affected. In case of rats received nifedipine and piroxicam, plasma nifedipine concentrations were higher (p<0.05) than those from rats received nifedipine alone at 2,3,4,5 and 6 hours following drug administration. The area under the plasma concentration vs. time curve was increased (p<0.05), while the elimination rate constant was decreased (p<0.01) by piroxicam coadministration. No significant differences were observed in the plasma clearance, apparent volume of distribution and elimination half-life. Thus, piroxicam not only potentiated antihypertensive effect of nifedipine, but also altered nifedipine pharmacokinetics in the rats. It is concluded that the potentiation of nifedipine antihypertensive effect might correlate with the increment of its plasma concentration by piroxicam coadministration.

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재충전이 있는 연속시간 리스크 모형에서 파산확률 연구 (The Ruin Probability in a Risk Model with Injections)

  • 고한나;최승경;이의용
    • 응용통계연구
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    • 제25권1호
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    • pp.81-87
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    • 2012
  • 재충전이 있는 연속시간 리스크 모형이 고려된다. 프레미엄은 일정한 율로 들어오고, 보험금 청구는 복합 포아송 과정을 따라 이루어진다. 초기 잉여금 u > 0로 시작하여 잉여금은 프레미엄에 의해 증가하고 보험금 청구에 의해 감소한다. 잉여금의 수준이 ${\tau}$(0 < ${\tau}$ < u)아래로 떨어지면 초기 잉여금 수준까지 재충전이 이루어진다고 가정한다. 재충전이 고려된 리스크 모형에서 잉여금이 없어지는 파산확률을 적미분 방정식을 통해 유도하고, 보험 청구액이 독립적으로 지수분포를 따르는 경우는 파산확률의 명확한 공식이 유도됨을 보인다.

Distribution of Silver Particles in Silver-containing Activated Carbon Fibers

  • Ryu, S.K.;Eom, S.Y.;Cho, T.H.;Edie, D.D.
    • Carbon letters
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    • 제4권4호
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    • pp.168-174
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    • 2003
  • Silver nitrate ($AgNO_3$) powder was mixed into a reformed pitch precursor. Then, the silver-containing pitch was melt spun to form round and "C" shape fibers. A wire mesh was inserted prior to the nozzle to improve the spinnability of the silvercontaining precursor pitch. Silver particles in the carbon fibers (CFs) were detected by XRD and TEM. These tests showed that silver particles were uniformly distributed and the total amount of silver remained constant during stabilization and carbonization. Next, the silver-containing CFs were activated by steam diluted in nitrogen gas. Silver particles accelerated the activation rate, but the specific surface areas of the silver-containing ACFs were similar to those of non-silver containing ACFs at the same burn-off levels. The specific surface area of the C-shaped activated carbon fibers was larger than that of the round activated carbon fibers. The likely reason is that the surface area of a C-shaped CF is about two times larger than that of a round CF when equivalent cross-sectional areas are compared. A small amount of silver particles in the periphery of the CFs was removed during the activation, but the remainder of silver was stayed within the ACFs.

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폐플라스틱 필름의 액상 열분해 특성에 관한 연구 (Liquid-phase Thermal Degradation Properties of Waste Plastic Film)

  • 황택성;김영수;강태원;황의환
    • 한국자원리싸이클링학회:학술대회논문집
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    • 한국자원리싸이클링학회 2003년도 추계정기총회 및 국제심포지엄
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    • pp.116-121
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    • 2003
  • In this study, the thermal degradation process has been investigated at various reaction temperature$(350{\sim}400^{\circ}C)$ and times$(30{\sim}120\;min)$ in order to recycle waste plastic films as solid state wax. Waste plastic films were easily melted by adding a small amount of waxes. The effects of wax addition and nitrogen flow rate on their thermal degradation properties were investigated. FT-IR, GPC and viscometer were used to analyze properties of the solid wax including the structure, molicular weight distribution and melt viscosity. The average molecular weight of solid wax was decreased with increasing the reaction time, temperature and amount of wax added, Also, the viscosity of solid wax decreased with increasing the stirring speed at a constant reaction temperature and time, and its viscosity got close to zero above $390^{\circ}C$.

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위장관 수술환자에서 겐타마이신의 임상약물동태 (Clinical Pharmacokinetics of Gentamicin in Gastrointestinal Surgical Patients)

  • 최준식;문홍섭;최인;범진필
    • 약학회지
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    • 제40권1호
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    • pp.1-9
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    • 1996
  • The purpose of this investigation was to determine pharmacokinetic parameters of gentamicin using nonlinear least square regression(NLSR) and Bayesian analysis in Korean normal volunteers and gastrointestinal surgical patients. Nonparametric expected maximum(NPEM) method for population pharmacokinetic parameters was used. Gentamicin was administered every 8 hours for 3 days by infusion over 30 minutes. The volume of distribution(V) and elimination rate constant(K) of gentamicin were $0.226{\pm}0.032,\;0.231{\pm}0.063L/Kg\;and\;0.357{\pm}0.024,\;0.337{\pm}0.041hr^{-1}$ for normal volunteers and gastrointestinal surgical patients using NLSR analysis. Population pharmacokinetic parameters, KS and VS were $0.00344{\pm}0.00049(hr{\cdot}ml/min/1.73m^2)^{-1}\;and\;0.214{\pm}0.0502L/Kg$ for gastrointestinal surgical patients using NPEM method. The V and K were $0.216{\pm}0.048L/Kg\;and\;0.336{\pm}0.043hr^{-1}$ for gastrointestinal surgical patients using Bayesian analysis. There were no differences in gentamicin pharmacokinetics between NLSR and Bayesian analysis in gastrointestinal surgical patient.

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