• Industrial Engineering and Management Systems
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• 제12권2호
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• pp.74-84
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• 2013

Modern companies have been facing devastating impacts from unexpected events such as demand uncertainties, natural disasters, and terrorist attacks due to the increasing global supply chain complexity. This paper proposes a multi stage logistic network model under disruption risk. To formulate the problem practically, we consider the effect of continuity rate, which is defined as a percentage of ability of the facility to provide backup allocation to customers in the abnormal situation and affect the investments and operational costs. Then we vary the fixed charge for opening facilities and the operational cost according to the continuity rate. The operational level of the company decreases below the normal condition when disruption occurs. The backup source after the disrup-tion is recovered not only as soon as possible, but also as much as possible. This is a concept of the business continuity plan to reduce the recovery time objective such a continuity rate will affect the investments and op-erational costs. Through numerical experiments, we have shown the proposed idea is capable of designing a resilient logistic network available for business continuity management/plan.

• Biotechnology and Bioprocess Engineering:BBE
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• 제10권3호
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• pp.284-288
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• 2005

Baker's yeast was disrupted in a 1.4-L stainless steel horizontal bead mill under a continuous recycle mode using 0.3 mm diameter zirconia beads as abrasive. A single pass in continuous mode bead mill operation liberates half of the maximally released protein. The maximum total protein release can only be achieved after passaging the cells 5 times through the disruption chamber. The degree of cell disruption was increased with the increase in feeding rate, but the total protein release was highest at the middle range of feeding rate (45 L/h). The total protein release was increased with an increase in biomass concentration from 10 to $50\%$(w/v). However, higher heat dissipation as a result of high viscosity of concentrated biomass led to the denaturation of labile protein such as glucose 6-phosphate dehydrogenase (G6PDH). As a result the highest specific activity of G6PDH was achieved at biomass concentration of $20\%$(ww/v). Generally, the degree of cell disruption and total protein released were increased with an increase in impeller tip speed, but the specific activity of G6PDH was decreased substantially at higher impeller tip speed (14 m/s). Both the degree of cell disruption and total protein release increased, as the bead loading increased from 75 to $85\% (v/v)$. Hence, in order to obtain a higher yield of labile protein such as G6PDH, the yeast cell should not be disrupted at biomass concentration and impeller tip speed higher than $20\%(w/v)$ and 10 m/s, respectively.

• 천문학회보
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• 제38권2호
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• pp.60.1-60.1
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• 2013

We study tidal disruption and subsequent mass fallback process for stars approaching supermassive black holes on bound orbits, by performing three dimensional Smoothed Particle Hydrodynamics simulations with a pseudo-Newtonian potential. We find that the mass fallback rate decays with the expected -5/3 power of time for parabolic orbits, albeit with a slight deviation due to the self-gravity of the stellar debris. For eccentric orbits, however, there is a critical value of the orbital eccentricity, significantly below which all of the stellar debris is bound to the supermassive black hole. All the mass therefore falls back to the supermassive black hole in a much shorter time than in the standard, parabolic case. The resultant mass fallback rate considerably exceeds the Eddington accretion rate and substantially differs from the -5/3 power of time. We also show that general relativistic precession is crucial for accretion disk formation via circularization of stellar debris from stars on moderately eccentric orbits.

• Environmental Engineering Research
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• 제11권3호
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• pp.143-148
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• 2006

The ultrasonics is a new technology in waste activated sludge(WAS) treatment. Ultrasonic treatment is well known method for the break up of microbial cells to extract out a variety of intercellular materials inside microorganism cell. This study was done to investigate the effects of the ultrasonic frequency and power on disruption of biosolids in WAS and to examine the effect on methane production of WAS treated by ultrasonics. Biosolids disruption with ultrasound is more effective at ultrasonic frequency of 40 kHz and power of 0.3 watt/mL. In the digestion with WAS pretreated by sonication time for 10 minute at 40 kHz and 0.3 watt/mL, the total quantity of generated methane increased by 75%, as compared with experimental control(non-treatment).

• 천문학회보
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• 제44권1호
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• pp.48.2-48.2
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• 2019

Tidal disruption events (TDEs) provide evidence for quiescent supermassive black holes (SMBHs) in the centers of inactive galaxies. TDEs occur when a star on a parabolic orbit approaches close enough to a SMBH to be disrupted by the tidal force of the SMBH. The subsequent super-Eddington accretion of stellar debris falling back to the SMBH produces a characteristic flare lasting several months. It is theoretically expected that the bolometric light curve decays with time as proportional to $t^{-5/3}$. However, some of the observed X-ray light curves deviate from the $t^{-5/3}$ decay rate, while some of them are overall in good agreement with the $t^{-5/3}$ law. Therefore, it is required to construct the theoretical model for explaining these light curve variations consistently. In this paper, we revisit the mass fallback rates semi-analytically by taking account of the stellar internal structure, orbital eccentricity and penetration factor. We find that the mass fallback rate is shallower than the standard $t^{-5/3}$ decay rate independently of the polytropic index, and the orbital eccentricity only changes the magnitude of the mass fallback rate. Furthermore, the penetration factor significantly can modify the magnitude and variation of mass fallback rate. We confirm these results by performing the computational hydrodynamic simulations. We also discuss the relevance of our model by comparing these results with the observed light curves.

• Journal of Microbiology and Biotechnology
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• 제14권6호
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• pp.1170-1175
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• 2004

The involvement of the relA and rsh genes in the morphological and physiological differentiation of Streptomyces clavuligerus was evaluated with the relA and rsh genes mutants. The morphological differentiation of S. clavuligerus was greatly affected by the disruption of the relA gene, but not very much by the disruption of the rsh gene. The altered morphological characteristics were completely restored by the complementation of the corresponding disrupted genes. Thus, it was apparent that the mycelial morphology and clavulanic acid production were severely affected by the disruption of the relA gene. Production of clavulanic acid in the submerged batch culture and glycerol-limited chemostat showed that production was inversely related to the specific growth rate in the wild-type strain. However, the production of clavulanic acid in the ${\Delta}relA$ and ${\Delta}rsh$ null mutants was completely abolished. Therefore, it seems plausible that the stringent response of S. clavuligerus to starvation for amino acids is governed mainly by ReIA, rather than Rsh, and that the (p)ppGpp synthesized immediately after the depletion of amino acids triggers the initiation of pathways for both morphological and physiological differentiation in this species.

• Journal of Korean Neurosurgical Society
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• 제50권4호
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• pp.311-316
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• 2011

Objective : Stroke is the third leading cause of death in the Republic of Korea. Time is the most important factor in hyperacute stroke. Yet, there had been no protocol for mechanical thrombolysis. We have treated patients with hyperacute stroke by mechanical thrombolysis for 3 years. In current study, we analyzed the outcome of mechanical thrombolysis. Methods : From March 2008 to February 2011, 36 patients were treated with mechanical thrombolysis. Initially we treated the patients by aggressive mechanical clot disruption (AMCD) who were admitted within 6 hours after the symptom onset. If revascularization was not achieved, balloon angioplasty was performed, followed by stenting or temporary endovascular bypass was performed. The result in 15 cases was not so successful. Since then, we started using the thromboaspiration method as the first line treatment of the mechanical thrombolysis. Results : After using the thromboaspiration, we had better results in recanalization rate, modified Rankin Score (mRS) and reperfusion injury compared to AMCD. The recanalization rate was 80.85%, mRS is 2.85, and there was only 0.09% hemorrhagic formation. Conclusion : Even though thromboaspiration is not statistically significant due to the limited numbers of patients enrolled in this study, we think it is a good way in mechanical thronbolysis for hyperacute stroke.

• 천문학회보
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• 제43권1호
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• pp.56.1-56.1
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• 2018

Tidal disruption events (TDEs) provide evidence for quiescent supermassive black holes (SMBHs) in the centers of inactive galaxies. TDEs occur when a star on a parabolic orbit approaches close enough to a SMBH to be disrupted by the tidal force of the SMBH. The subsequent super-Eddington accretion of stellar debris falling back to the SMBH produces a characteristic flare lasting several months. The theoretically expected bolometric light curve decays with time as proportional to $t^{-5/3}$. However, the light curves observed in most of the optical-UV TDEs deviate from the $t^{-5/3}$ decay rate especially at early time, while the light curves of some soft-X-ray TDEs are overall in good agreement with the $t^{-5/3}$ law. Therefore, it is required to construct the theoretical model for explaining these light curve variations consistently. In this paper, we revisit the mass fallback rates analytically and semi-analytically by taking account of the structure of the star, which is simply modeled by the polytrope. We find the relation between a polytropic index and the power law index of the mass fallback rate. We also discuss whether and how the decay curves, which we derived, fit the observed ones.

• Mycobiology
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• 제38권2호
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• pp.102-107
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• 2010

We identified a gene for $\beta$-1,3-glucan synthesis (GBG1), a nonessential gene whose disruption alters cell wall synthesis enzyme activities and cell wall composition. This gene was cloned by functional complementation of defects in $\beta$-1,3-glucan synthase activity of the the previously isolated Saccharomyces cerevisiae mutant LP0353, which displays a number of cell wall defects at restrictive temperature. Disruption of the GBG1 gene did not affect cell viability or growth rate, but did cause alterations in cell wall synthesis enzyme activities: reduction of $\beta$-1,3-glucan synthase and chitin synthase III activities as well as increased chitin synthase I and II activities. GBG1 disruption also showed altered cell wall composition as well as susceptibility toward cell wall inhibitors such as Zymolyase, Calcofluor white, and Nikkomycin Z. These results indicate that GBG1 plays a role in cell wall biogenesis in S. cerevisiae.

• Journal of Chest Surgery
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• 제20권4호
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• pp.851-854
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• 1987

Congenital diaphragmatic hernia remains a disease with high neonatal mortality rate despite recent advance in neonatal intensive care. We experienced one case of the congenital diaphragmatic hernia with acute respiratory distress and left pulmonary hypoplasia in the neonate. The simple closure was performed through left paramedian approach after diagnosis. The postoperative course was uneventful except wound disruption. The patient was follow-up with good general condition.