• Archives of Pharmacal Research
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• v.29 no.11
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• pp.1055-1060
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• 2006

The objective of this study was to formulate itraconazole semisolid dosage forms and characterize their physicochemical properties. Itraconazole and excipients such as polysorbate 80, fatty acids, fatty alcohols, oils and organic acids were melted at $160^{\circ}C$. The fused solution was then cooled immediately at $-10^{\circ}C$ to make wax-like semisolid preparations. Their physicochemical attributes were first characterized using differential scanning calorimetry, Fourier transform infrared spectroscopy and nuclear magnetic resonance spectrometry. The solubility of itraconazole in semisolid preparations and their dispersability in the simulated gastric fluid were also determined. Our semisolid preparations did not show any distinct endothermic peak of a crystalline form of itraconazole around $160-163^{\circ}C$. This suggested that it was changed into amorphous one, when it was formulated into semisolid preparations. In addition, the distinctive functional peaks and chemical shifts of itraconazole were well retained after processing into semisolid preparations. It could be inferred from the data that itraconazole was stable during incorporation into semisolid preparations by the hot melt technique. In particular, itraconazole semisolid preparations composed of polysorbate 80, fatty acids and organic acids showed good solubility and dissolution when dispersed in an aqueous medium. It was anticipated that the semisolid dosage forms would be industrially applicable to improving the bioavailability of poorly water-soluble drugs.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.292-292
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• 2017

하천에서 주로 부유사의 형태로 이송되는 유사는 크게 점착성 유사와 비점착성 유사로 구분된다. 입자의 크기가 약 $63{\mu}m$이하인 유사는 입자 표면의 전자기적 점착력의 영향이 우세하여 유사입자들은 지속적인 응집현상을 겪는다. 응집 현상을 통해 유사의 가장 단위인 일차입자(Primary Particle)들은 하나의 커다란 덩어리인 플럭(Floc)을 형성한다. 응집현상이 중요한 이유는 형성된 플럭의 크기 및 밀도가 끊임없이 변화하는 데 있다. 크기와 밀도의 지속적인 변화로 인하여 유사의 부유에 직접적으로 관계하는 침강속도가 변화한다. 우리나라의 금강 및 낙동강의 하구는 점착성 유사가 지배적인 환경으로, 하구에서의 유사 이동을 살펴보기 위해서는 흐름 방향 및 연직방향으로의 흐름 특성(Hydrodynamics)변화와 응집 모형을 통한 응집 현상의 고려가 필수적이다. 이에따라, 본 연구에서는 흐름 방향 및 연직방향으로의 2차원 점착성 유사 이동모형에 관한 개념적 틀(Framework)을 제시한다. 2차원 점착성 유사 이동 모형의 개념적 틀은 기존의 1차원 연직 점착성 유사 이동 모형을 근간으로 한다. 모형에서 흐름을 구성하는 지배 방정식은 오일러-오일러 이상방정식(Eulerian-Eulerian Two-Phase Equation)을 통해 얻는다. 유사상(Sediment Phase, Dispersed Phase)와 유체상(Fluid Phase, Continuous Phase)는 혼합물 이론(Mxiture Theory)를 통해 하나의 혼합물 상(Mixture Phase)의 지배방정식으로 대표된다. 난류의 계산은 와점성 모형 중 -${\varepsilon}$모형을 통해 수행되며, 부유사의 농도는 유사의 이송-확산 방정식을 통해 모의된다. 입력된 흐름 조건을 따라 초기 흐름이 모의되면, 유체 내에서 시간에 따른 플럭의 크기가 계산된다. 플럭의 크기가 계산되는 과정에서 밀도와 침강 속도가 계산되며, 그 이후에 유체 내 유사의 농도가 계산된다. 난류 모의가 수행되고 난 이후에, 유속이 재계산 된다. 이러한 과정을 통해 흐름 방향 및 연직 방향으로의 유사 이동 모의가 가능한 2차원 점착성 유사 이동 모형이 개발될 수 있을 것이라고 생각된다.

• Proceedings of the SAREK Conference
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• 2006.06a
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• pp.52-57
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• 2006

This study investigates the distribution stability of binary nanofluids where binary mixtures such as $NH_3/H_2O$ and $H_2O/LiBr$ solution are used as a base fluid. When a little amount of certain nanosized particles is added into a basefluid, the thermal conductivity of that mixture increases greatly. Such mixtures are named 'nanofluids' where nano-particles should be distributed stably and uniformly so the distribution stability of nanoparticles in nanofluids is one of the most important factors for nanofluid application. Therefore, binary nanofluids in which binary mixtures are applied as the basefluids are considered as working fluids. The kind and the concentration of nanoparticles, and the concentration of ammonia are considered as the key parameters. The objectives of this paper are to visualize the dispersed status of particles in binary nanofluids and to find the effect of key parameters on the distribution stability in the ammonia absorption system.

• Journal of the Korean Society of Safety
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• v.38 no.3
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• pp.43-50
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• 2023

Silicone tetrachloride (SiCl₄) leak accidents cause enormous human and environmental damage because it is highly toxic. Some handling facilities use water curtains to reduce the impact range of SiCl₄. Although the water curtain is known as one of the most efficient technologies for post-release mitigation, its effect on reducing SiCl₄ concentration needs to be investigated scientifically and quantitatively. In this study, three-dimensional computational fluid dynamics (CFD) was used to investigate the physical and chemical effects of water curtains as a release-mitigation system for SiCl₄. SiCl₄ is released and dispersed five seconds prior to the operation of the water curtain. Once the water curtain works, the SiCl₄ reacts chemically with the water and its concentration decreases rapidly; it reaches an emergency response planning guidelines level 2 (ERPG-2) of 5 parts per million (ppm) at about 570 m. We observed, however, that the physical effect of water curtains on reducing SiCl₄ concentration is insignificant when the chemical effect is eliminated. These results are crucial since they can be a scientific and quantitative basis for the 'technical guidelines for estimating the accident affected range'. In order to protect the public from chemical accidents, more toxic gas mitigation technologies need to be developed.

• Journal of Bio-Environment Control
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• v.8 no.1
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• pp.9-18
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• 1999

Natural ventilation in a four and one-half span, double polyethylene commercial greenhouse was investigated with actual data collected at Quailcrest Farm near Wooster, Ohio. Moreover, a computational fluid dynamics (CFD) numerical technique, FLUENT V4.3, was used to predict natural ventilation rates, thermal conditions, and airflow distributions in the greenhouse. The collected climate data showed that the multi-span greenhouse was well ventilated by the natural ventilation system during the typical summer weather conditions. The maximum recorded air temperature difference between inside and outside the greenhouse was 3.5$^{\circ}C$ during the hottest (34.7$^{\circ}C$) recorded sunny day; the air temperatures in the greenhouse were very uniform with the maximum temperature difference between six widely dispersed locations being only 1.7$^{\circ}C$. The CFD models predicted that air exchange rates were as high as 0.9 volume per minute (A.C. .min$^{-1}$ ) with 2.5m.s$^{-1}$ winds from the west as designed.

• Korea-Australia Rheology Journal
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• v.21 no.4
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• pp.269-280
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• 2009

The drop formation dynamics of a shear thinning, elastic, yield stress ($\tau_o$) fluid (Carbopol 980 (poly(acrylic acid)) dispersions) in silicone oil has been investigated in a flow-focusing microfluidic channel. The rheological character of each solution investigated varied from Netwonian-like through to highly non-Newtonian and was varied by changing the degree of neutralization along the poly (acrylic acid) backbone. We have observed that the drop size of these non-Newtonian fluids (regardless of the degree of neutralisation) showed bimodal behaviour. At first we observed increases in drop size with increasing viscosity ratio (viscosity ratio=viscosity of dispersed phase (DP)/viscosity of continuous phase (CP)) at low flowrates of the continuous phases, and thereafter, decreasing drop sizes as the flow rate of the CP increases past a critical value. Only at the onset of pinching and during the high extensional deformation during pinch-off of a drop are any differences in the non-Newtonian characteristics of these fluids, that is extents of shear thinning, elasticity and yield stress ($\tau_o$), apparent. Changes in these break-off dynamics resulted in the observed differences in the number and size distribution of secondary drops during pinch-off for both fluid classes, Newtonian-like and non-Newtonian fluids. In the case of the Newtonian-like drops, a secondary drop was generated by the onset of necking and breakup at both ends of the filament, akin to end-pinching behavior. This pinch-off behavior was observed to be unaffected by changes in viscosity ratio, over the range explored. Meanwhile, in the case of the non-Newtonian solutions, discrete differences in behaviour were observed, believed to be attributable to each of the non-Newtonian properties of shear thinning, elasticity and yield stress. The presence of a yield stress ($\tau_o$), when coupled with slow flow rates or low viscosities of the CP, reduced the drop size compared to the Newtonian-like Carbopol dispersions of much lower viscosity. The presence of shear thinning resulted in a rapid necking event post onset, a decrease in primary droplet size and, in some cases, an increase in the rate of drop production. The presence of elasticity during the extensional flow imposed by the necking event allowed for the extended maintenance of the filament, as observed previously for dilute solutions of linear polymers during drop break-up.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.36 no.9
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• pp.895-900
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• 2012

This paper aims to examine the effect of nanodroplets on pool-type absorption heat transfer enhancement and to find the relationship between the dispersion stability and the absorption performance. The concentrations of oil and surfactant are considered as the key parameters. $C_{12}E_4$ and Tween20 are used as the surfactants and N-decane oil is added to the $NH_3/H_2O$ solution to make the binary nanoemulsion fluids. Binary nanoemulsion fluids are dispersed by the ultrasonic vibrator and the stirrer under specific conditions. The dispersion stability of binary nanoemulsion fluids for each oil concentrations is evaluated from the droplet size and Tyndall effect analysis. The absorption performance of binary nanoemulsion fluids is compared with the result of dispersion stability. In addition, it is found that the binary nanoemulsion fluid is a strong candidate as a new working fluid for absorption applications.

• Korean Journal of Environment and Ecology
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• v.34 no.5
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• pp.466-482
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• 2020

This study used 3D computational fluid dynamics (CFD) in the ENVI-met program to investigate how particulate matters (PM) generated on roads disperse through adjacent urban neighborhoods according to the urban development pattern. An urban area centered on a six-lane road in the vicinity of Miryang City Hall in Gyeongnam Province was selected to simulate the effect of the green space and building height on the PM concentration. The ENVI-met model considered the presence of green space and different building heights (high/low) on both sides of the road to examine the dispersion of PM. The result showed that the area of high-rise buildings and green space had the lowest PM concentration dispersed to the adjacent area, followed by the area of high-rise buildings and no green space. In contrast, the PM concentration remained relatively high for low-rise buildings, regardless of the green space. The reason for the low PM concentration in the area with high-rise buildings was a strong building wind, which caused PM to disperse to the outside, lowering the PM concentration quickly. These results indicate that the PM can disperse faster, and the PM concentration remains low in the urban neighborhood. On the other hand, green space had no significant effect on reducing PM in the urban neighborhood. In particular, when there are low-rise buildings on both sides of the road, the green space has no effect on the PM concentration in the urban neighborhood. Since this study considered only the case of PM emitted from the road, future studies should investigate other factors to figure out the dispersion model of PM and conduct on-site experiments.

• Journal of Korean Society of Environmental Engineers
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• v.30 no.8
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• pp.817-822
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• 2008

In this study, the photocatalytic degradation of methylene blue in TiO$_2$ particles-dispersed water solution was carried out by irradiating microwave and UV light simultaneously. A microwave-discharged electrodeless UV lamp was developed to use microwave and UV simultaneously for photocatalytic reactions. The results of photocatalytic degradation of methylene blue showed that the decomposition rate increased with the microwave intensity, the circulating fluid velocity, and the amount of TiO$_2$ particles and auxiliary oxidizing agents added. Especially, the rate constant of H$_2$O$_2$-added photocatalytic reaction increased about three times from 0.0075 min$^{-1}$ to 0.0250 min$^{-1}$ when microwave was additionally irradiated. This study demonstrates that the microwave irradiation can play a very important role in photocatalytic degradation using peroxides although it is not easy to quantitatively assess the effect of microwave on photocatalytic reactions from the experimental data of this study.

• Clinical and Experimental Reproductive Medicine
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• v.30 no.4
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• pp.333-340
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• 2003

Objective: This study was performed to examine the maturation and the development to the blastocyst stage of immature oocytes collected from patients with high risk of ovarian hyperstimulation syndrome (OHSS). Materials and Methods: Cumulus-oocyte complexes (COCs) were collected following only HCGpriming for non stimulated IVF-ET cycles of the patients. At the time of oocyte collection, COCs were classified into three groups in accordance with their appearance (Group I: oocytes with dispersed cumulus cells; Group II: oocytes with compacted cumulus cells; Group III: oocytes with sparse cumulus cells). The in vitro maturation and blastocyst development rates of the COCs were compared among these groups. From August 2001 to June 2002, 48 IVM/IVF-ET cycles from 42 patients (mean age: $32.4{\pm}3.8$ years) were performed. To prevent the occurrence of OHSS, the patients were primed with 10, 000 IU HCG alone 36 h before oocyte collection without gonadotropin stimulation. Oocytes were aspirated on cycle days from 7 to 13. The normal COCs were classified into three groups according to their appearance. The aspirated immature oocytes were cultured in YS maturation medium containing 30% (v/v) human follicular fluid (HFF), 1 IU/ml FSH, 10 IU/ml HCG and 10 ng/ml rhEGF. Fertilization was induced by intracytoplasmic sperm injection (ICSI). All zygotes were co-cultured with cumulus cells in $10{\mu}l$ YS medium containing 10% HFF until day 7 after oocyte collection. Blastocyst transfer was performed on day 5 after ICSI. Results: Th e mean number of oocytes cultured in the IVM/IVF cycles was $24.7{\pm}10.6$. Of 1185 COCs, those assigned to Group I, II and III were 470 (39.7%), 414 (35.0%) and 301 (25.4%), respectively. The maturation rate (94.5%, 444/470, p<0.05) in Group I was significantly higher than those of Group II (62.8%, 260/414) and Group III (73.1%, 220/301). Especially, 30.9% of COCs in Group I (145/470) was matured on the day of oocyte aspiration. There were no differences in the rates of fertilization and cleavage among the three groups. The development rate to the blastocyst stage in Group I (54.6%, 206/377, p<0.05) was also significantly higher than those in Group II (33.0%, 68/206) and Group III (30.1%, 52/173). Twenty-four clinical pregnancies (50.0%) was obtained and 22 pregnancies (45.8%) are ongoing. Implantation rate in the present study was 24.6%. Conclusion: These results suggest that there is a positive correlation between the appearance of COCs and the developmental competence of the immature oocytes in non stimulated IVM/IVF cycles.