• Research in Plant Disease
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• v.11 no.2
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• pp.162-166
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• 2005

Disease progress of gray blight of tea (Camellia sinensis O. Kuntze) cv. Yabukita was investigated during the growing season of 2004 at Boseong Tea Experiment Station, Jeonnam Agriculture Research and Extension Service, Boseong, Jeonnam. The disease began to occur from late June and peaked in late July. Antagonistic bacteria against Pestalotiopsis longiseta, the causal pathogen of causing gray blight of tea plants were isolated from phylloplanes of tea plants. An isolate BD0310 which showed the strongest antifungal activity against the pathogen but nonpathogenic to tea plants was selected as a biocontrol agent for the gray blight. The isolate was identified as Bacillus subtilis based on its cultural, morphological, and biochemical characterization and 16S rDNA sequence analysis.

• Journal of Veterinary Clinics
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• v.37 no.1
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• pp.9-14
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• 2020

Left atrial enlargement (LAE) is an important diagnostic factor in dogs with myxomatous mitral valve disease (MMVD). It is associated with the onset of congestive heart failure (CHF). Recently, a new radiographic left atrial measurement called vertebral left atrial size (VLAS) was introduced. This can be considered as a left atrial enlargement above 2.3. It appears to be related to the severity of MMVD. However, serial changes in VLAS in relation to disease progression and improvement in patients have yet to be studied. This study aims to assess the value of VLAS as a left atrial size monitoring indicator by examining correlations with VHS, LA/Ao ratio and LVIDDN, and comparing serial changes in dogs. A total of 126 dogs were studied with their owners' consent. The dogs were classified into four MMVD groups (Control, B1, B2, C-D) following the ACVIM Guideline by performing a physical examination, radiography and echocardiography. Besides, 24 and 17 dogs were reevaluated to compare values in relation to the progression and improvement of MMVD. VLAS showed significant increase according to the progress of the MMVD stage. This was the same in the Maltese breed group. A strong positive correlation was found between LVIDDN, VHS, LA/Ao ratio, and VLAS. The results of this study found VLAS to be significantly different according to left atrium size, and there was a correlation between disease progression and VLAS levels in each dog. Therefore, VLAS may be used to detect changes in left atrium size as an additional monitoring index of MMVD.

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.34-63
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• 2003

Idiopathic Parkinson's disease (IPD) represents a common neurodegenerative disorder. While epidemiological studies have suggested a number of risk factors including age, gender, race, and inherited disorder, the cumulative evidence supports the view that environmental or occupational exposure to certain chemicals may contribute to the initiation and progress of Parkinsonism.(omitted)

• Journal of Oriental Neuropsychiatry
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• v.18 no.3
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• pp.261-275
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• 2007

Parkinson's Disease is a well known degenerative disease which result's in the depletion of dopamin-producing neurons in the pars compacta of the substantia nigra. This is a chronic, progressive disorder characterized by progressive muscular rigidity, pill-rolling tremor, flexed posture, shuffling gate and akinesia. This study was designed to evaluate the effects of an oxygen therapy with various scales on symptoms of Parkinson's disease. We treated his disease with Oxygen treatment , including herbal medicine acupuncture, and trigger point therapy, and we evaluated the clinical progress of the patient using UPDRS and H- Y stage. After treatment for about 1-month, the chief complaints and tremor symptoms were improved. This study suggests that oxygen therapy is significantly effective in the treatment of Parkinson's disease.

• Progress in Superconductivity
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• v.10 no.1
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• pp.6-11
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• 2008

Multi-channel magnetocardiography (MCG) has been proposed to detect ischemic heart disease because its sensitivity is quite high comparing with other conventional diagnostic tools. Especially, current map and magnetic field map of MCG provide crucial information on whether myocardiac muscles maintain the normal conduction pathway. In addition, MCG parameters derived from repolarization are useful to detect coronary artery disease. Recently, there was a study reporting that R- and T- wave amplitude are highly correlated with ischemic heart disease. In this study, we studied R- and T-wave amplitude and their ratio as well as MCG parameters. MCG data from 20 young, 20 age-matched controls, and 20 myocardial infarction (MI) patients were analyzed. As a result, MCG parameters showed significant change in MI patients comparing to those of controls. R- and T-wave amplitude of MI patients showed a feature of severe ischemic heart disease even though it was difficult to find consistent values. Further study is needed to reveal the relations between small T-wave amplitude and coronary artery disease.

• Journal of Chest Surgery
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• v.32 no.9
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• pp.831-834
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• 1999

The Kawasaki disease has been reported worldwide since the first description in 1967 in Japan. Approximately 20% of the children with untreated Kawasaki disease are believed to develop coronary artery aneurysm of which 2-3% progress to coronary artery stenosis. The Kawasaki disease rarely affects adults and accordingly, there have been only a few cases reported in literatures. The present case describes a successful surgical treatment of a 43-year-old female patient with coronary artery aneurysm and stenosis, which resulted from an episode of the Kawasaki disease that occurred 20 years earlier. The patient was well at 5 months followup.

• BMB Reports
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• v.52 no.4
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• pp.250-258
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• 2019

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by selective and progressive loss of dopaminergic neurons. Genetic and environmental risk factors are associated with this disease. The genetic factors are composed of approximately 20 genes, such as SNCA, parkin, PTEN-induced kinase1 (pink1), leucine-rich repeat kinase 2 (LRRK2), ATP13A2, MAPT, VPS35, and DJ-1, whereas the environmental factors consist of oxidative stress-induced toxins such as 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), rotenone, and paraquat. The analyses of their functions and mechanisms have provided important insights into the disease process, which has demonstrated that these factors cause oxidative damage and mitochondrial dysfunction. The most invaluable studies have been performed using disease model organisms, such as mice, fruit flies, and worms. Among them, Drosophila melanogaster has emerged as an excellent model organism to study both environmental and genetic factors and provide insights to the pathways relevant for PD pathogenesis, facilitating development of therapeutic strategies. In this review, we have focused on the fly model organism to summarize recent progress, including pathogenesis, neuroprotective compounds, and newer approaches.

• The Plant Pathology Journal
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• v.24 no.3
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• pp.245-268
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• 2008

The outcome of plant-pathogen interactions is influenced significantly by endogenous small molecules that coordinate plant defence responses. There is currently tremendous scientific and commercial interest in identifying chemicals whose exogenous application activates plant defences and affords protection from pathogen infection. In this review, we provide a survey of compounds known to induce disease resistance in plants, with particular emphasis on how each compound was originally identified, its putative or demonstrated mechanism of defence induction, and the known biological target(s) of each chemical. Larger polymeric structures and peptides/proteins are also discussed in this context. The quest for novel defence-inducing molecules would be aided by the capability for high-throughput analysis of candidate compounds, and we describe some issues associated with the development of these types of screens. Subsequent characterization of hits can be a formidable challenge, especially in terms of identifying chemical targets in plant cells. A variety of powerful molecular tools are available for this characterization, not only to provide insight into methods of plant defence activation, but also to probe fundamental biological processes. Furthermore, these investigations can reveal molecules with significant commercial potential as crop protectants, although a number of factors must be considered for this potential to be realized. By highlighting recent progress in the application of chemical biology techniques for the modulation of plant-pathogen interactions, we provide some perspective on the exciting opportunities for future progress in this field of research.

• Journal of Acupuncture Research
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• v.20 no.3
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• pp.217-228
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• 2003

Objective : Spinal meningeal cysts can be the cause of the low back pain and sciatica. We tried to manage the low back pain and sciatica caused by other disease besides intervertebral disc herniation. Methods : We treated the patient who diagnosed as spinal meningeal cyst and hospitalized. And we investigate the progress of physical condition, VAS, modified VAS, PRS by treatment and MRI before and after treatment. Results : There was remarkable improvement in condition of the patient who has spinal meningeal cyst after bee venom therapy. We found the size of cyst decreased in MRI and also progress in VAS modified VAS PRS physical view improved. Conclusions : We think that the result of this case can be a pilot study that proves the effect of bee venom therapy the low back pain and sciatica caused by variable disease.

• Korean Circulation Journal
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• v.52 no.5
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• pp.341-353
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• 2022

Cardiovascular disease (CVD) is the leading causes of morbidity and death globally. In particular, a heart failure remains a major problem that contributes to global mortality. Considerable advancements have been made in conventional pharmacological therapies and coronary intervention surgery for cardiac disorder treatment. However, more than 15% of patients continuously progress to end-stage heart failure and eventually require heart transplantation. Over the past year, numerous numbers of protocols to generate cardiomyocytes (CMCs) from human pluripotent stem cells (hPSCs) have been developed and applied in clinical settings. Number of studies have described the therapeutic effects of hPSCs in animal models and revealed the underlying repair mechanisms of cardiac regeneration. In addition, biomedical engineering technologies have improved the therapeutic potential of hPSC-derived CMCs in vivo. Recently substantial progress has been made in driving the direct differentiation of somatic cells into mature CMCs, wherein an intermediate cellular reprogramming stage can be bypassed. This review provides information on the role of hPSCs in cardiac regeneration and discusses the practical applications of hPSC-derived CMCs; furthermore, it outlines the relevance of directly reprogrammed CMCs in regenerative medicine.