• Korean Journal of Clinical Pharmacy
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• v.18 no.2
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• pp.75-83
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• 2008

Purpose: Currently lung cancer ranks second in cancer for incidence rate and is a disease that ranks first for a death rate by cancerous growth because it is already advanced at the time of diagnosis. The purpose of this paper was to analyze the factors that affect the effectiveness of and rash occurrence by Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR TKI) in patients with non-small cell lung cancer. Methods: A retrospective chart review of 100 patients, who took EGFR TKI (erlotinib, gefitinib) among patients who were diagnosed with non-small cell lung cancer in a Hospital in Korea between May 2005 and February 2008, was conducted. The drug effectiveness was evaluated by Response Evaluation Criteria In Solid Tumor. Results: EGFR mutation was the only factor associated with drug response (complete response and partial response). When stable disease was added to drug response as the evaluation parameter, ECOG and rash as well as EGFR mutation were found to be important factors. Survival, however, was not affected by EGFR mutation. The factors influenced on survival were older age (${\geq}65$), low ECOG ($1{\sim}2$), adenocarcinoma and rash. In the case of rash, group with EGFR mutation or low ECOG showed significantly higher chance of occurrence. There was no significant difference in rash occurrence between gefitinib and erlotinib groups. Conclusions: Based on the results, EGFR mutation positive and low ECOG ($1{\sim}2$) were significantly important factors for both effectiveness of EGFR TKI and rash occurrence. Also, rash itself was found to be an independently significant factor for the disease control and survival. Therefore, while administering EGFR TKI, patients who have the factors associated with rash occurrence should be closely monitored for effective and safe drug therapy.

• Korean Journal of Agricultural Science
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• v.11 no.1
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• pp.61-67
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• 1984

In an attempt to obtain a basic information to develop methods of an effective chemical control and disease forecasting of panicle blast of rice, effects of conidial number of the causal fungus, Pyricularia oryzae, collected in different periods and the rate of leaf blast occurrence on the occurrence of panicle blast were investigated. Conidial number the fungus collected in 5 days before and after heading date were closely related with panicle blast occurrence. But no relationship was obtained between the occurrence rate of leaf blast and that of panicle blast. Considering the incubation period of the disease, we presume that the most effective application periods of chemicals are 5-10 days and 10-15 days before heading, when immediate effective chemicals and slow effective chemicals are applied, respectively.

• Journal of Korean Society of Forest Science
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• v.110 no.2
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• pp.280-288
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• 2021

Understanding the occurrence characteristics of pine wilt disease (PWD) is essential for determining a suitable strategy to minimize the damage caused by PWD. Thus, in this study, we characterized various environmental conditions, including meteorological factors, geographical factors, and artificial factors influencing the occurrence of PWD. The occurrence data of PWD from May 2016 to April 2018 and spatial data of various environmental factors, including natural and anthropogenic factors, were collected. We evaluated the relative contribution of the environmental variables on the number of dead pine trees by PWD. In this study, among the 17 natural and anthropogenic factors, the factors affecting the occurrence of dead trees by PWD were verified. The results showed that altitude and temperature from May to August, among natural factors, and distance to building and forest road among anthropogenic factors were the most influential factors on the occurrence of PWD.

• Research in Plant Disease
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• v.20 no.3
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• pp.189-195
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• 2014

Genetic engineering is being used to enhance disease resistance and nutritional value of crops including rice plant. Considering the fast-growing agricultural biotechnology and rapidly increasing global area of transgenic crops, the risk evaluation on environment is necessary. In this study, we surveyed the difference of disease occurrence between transgenic rice variety, Iksan526 transformed with peanut stilbene synthase gene and non-transgenic rice varieties, Dongjin and Nampyeong in the field. Moreover, the possibility of gene transfer from transgenic rice to bacterial and fungal pathogens was investigated. The results of this study indicated that there was no significant difference in the occurrence and severity of the diseases between Iksan526 and Dongjin or Nampyeong. In addition, the results suggested that rice pathogen, such as Xanthomonas oryzae pv. oryzae, Rhizoctonia solani and Magnaporthe grisea did not take up stilbene synthase and bar genes under natural conditions. Moreover the transformed DNA was not transferred to the pathogens even in repetitive contacts.

• The Plant Pathology Journal
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• v.39 no.6
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• pp.548-565
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• 2023

Armillaria root disease affects forests around the world. It occurs in many habitats and causes losses in the infested stands. Weather conditions are important factors for growth and development of Armillaria species. Yet, the relation between occurrence of damage caused by Armillaria disease and weather variables are still poorly understood. Thus, we used generalized linear mixed models to determine the relationship between weather conditions of current and previous year (temperature, precipitation and their deviation from long-term averages, air humidity and soil temperature) and the incidence of Armillaria-induced damage in young (up to 20 years old) and older (over 20 years old) coniferous stands in selected forest districts across Poland. We used unique data, gathered over the course of 23 years (1987-2009) on tree damage incidence from Armillaria root disease and meteorological parameters from the 24-year period (1986-2009) to reflect the dynamics of damage occurrence and weather conditions. Weather parameters were better predictors of damage caused by Armillaria disease in younger stands than in older ones. The strongest predictor was soil temperature, especially that of the previous year growing season and the current year spring. We found that temperature and precipitation of different seasons in previous year had more pronounced effect on the young stand area affected by Armillaria. Each stand's age class was characterized by a different set of meteorological parameters that explained the area of disease occurrence. Moreover, forest district was included in all models and thus, was an important variable in explaining the stand area affected by Armillaria.

• Proceedings of the Korean Society of Plant Pathology Conference
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• 2003.10a
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• pp.9-12
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• 2003

Clubroot disease of curcifer crops caused by Plasmodiophora brassicae had been first reported in 1920 in Korea, and maintained mild occurrence until 1980s. Since 1990s the disease has become severe in alpine areas of Kyonggi and Kangwon, gradually spread to plain fields throughout the country, and remains as the greatest limiting factor for its production. Researches on the disease has begun in late 1990s in our laboratory after experiencing severe epidemics. Survey of occurrence and etiological and ecological studies have been carried out, particularly, on the pathogen physiology, race identification, quantification of soil pathogen population, host spectrum of the pathogen, and control measures.(중략)

• Journal of the korean veterinary medical association
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• v.19 no.2
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• pp.8-20
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• 1983

Clinical and pathological survey on the first occurrence of Johne's disease in south Korea were practised from November 1979 to September 1982 in Kangweondo. The results obtained in the survey were as follows. 1. The clinical cases of the disease were fir

• Korean Journal of Veterinary Research
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• v.43 no.2
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• pp.311-314
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• 2003

Pacheco's disease (PD) is a highly contagious, acute disease of psittacines caused by a herpesvirus. Five 56-day-old dead parakeets (Neophema bourkii) were submitted to the National. Veterinary Research & Quarantine Service for diagnosis. At necropsy, principle lesions were seen in the pancreas, which were hard, whitish, nodular and atrophic resulting in distortion of the duodenal loop. Histologically, lymphocytic pancreatitis with eosinophilic intranuclear inclusions syncytium-formed acinar epithelium was prominent. In the brain, marked focal gliosis and perivascular lymphocytic cuffing were observed. On the electron microscopy examination, various forms of viral particles were found in both the nucleus and cytoplasm of acinar epithelium of pancreas, identified as a herpesvirus. These results were suggested that the cases were diagnosed as PD in the parrakeet.

• Journal of fish pathology
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• v.25 no.3
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• pp.249-256
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• 2012

Disease occurrence and dead cell ratio of Porphyra cultivated at Seocheon area were studied. Seaweed samples were collected monthly at 12 cultivating sites of Porphyra from Nov. 2008 to Mar. 2009. Although disease occurrence was low at the beginning of cultivation at the most of collecting sites, the occurrence increased with time. The most common symptom of Porphyra disease in this area was diatom attachment, followed by white rot disease. Licmophora sp. was the most common species of diatom and its attachment was the highest on November, the beginning of cultivation. Although the occurrence ratios of green spot disease and white rot disease were high on November, chytrid disease was increased at the end of cultivation period. Dead cell ratio of Porphyra thalli was different at each study site and cultivating time, but normally the ratio was high at the end of cultivating season. The changes of dead cell ratio could be related to the nutrition supplement and currents, and the more precise reason of dead cell ratio would be revealed by further research related to cultivating environment conditions.

• Korean Journal of Adult Nursing
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• v.14 no.3
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• pp.411-417
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• 2002

Purpose: This study was to investigate symptom occurrence related to the disease characteristics of patients with cancer. Method: A total of 301 patients with cancer participated in this study. The participants were recruited from University Hospitals located in Seoul, Wonju, Kwangju, Daegu, and Pusan. Data collection was performed by using a questionnaire on symptom occurrence. The obtained data was analyzed using SPSS computer program that included descriptive statistics, Pearson correlation, one-way ANOVA, and t-test. Result: The mean score of fatigue was the highest (3.24), followed by loss of appetite, lack of concentration, change in appearance, pain, insomnia, change in bowel pattern, nausea/vomiting, coughing, and dyspnea. Most symptoms were significantly correlated with each other. The level of symptom occurrence in patients with lung cancer or cervix cancer was significantly higher than the level in patients with stomach cancer. Patients receiving radiation therapy or a combined therapy of radiation therapy and chemotherapy experienced significantly higher level of symptom occurrence than those receiving chemotherapy only. Also, female patients experienced higher level of symptom occurrence than male patients did. Conclusion: The sites of cancer, types of treatment, and gender influence the level of symptom occurrence of patients with cancer. Thus, these variables should be considered when assessing and planing for symptom occurrence of patients with cancer.