• Title/Summary/Keyword: Disease condition

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Current understanding of angiosarcoma: disease biology and evolving treatment

  • Woo Ju Kim;Han Koo Kim
    • Archives of Craniofacial Surgery
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    • v.24 no.5
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    • pp.203-210
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    • 2023
  • Angiosarcoma is a very rare soft tissue sarcoma that originates from endothelial cells and typically has a poor prognosis. It is most commonly found in elderly white men and can occur anywhere in the body, particularly in the head, neck, and scalp. Patients who have undergone previous radiation treatment or who have chronic lymphedema also face an elevated risk of this condition. Various genetic changes are suspected to contribute to the development of angiosarcoma, and these changes have been identified as potential targets for treatment. For localized disease, wide surgical resection is often the prudent course of action. A multidisciplinary approach, which may include surgery, radiotherapy, systemic chemotherapy, or immunotherapy, is typically the most effective way to achieve favorable outcomes. In this review, we discuss the general understanding of angiosarcoma and its management, with a particular focus on the current evolving treatments for the disease.

Structure Relationships for Diseased and Health-related Quality of Life in the Elderly (노인들의 질환별 유병여부와 건강관련 삶의 질 구조모형 분석)

  • Lee, Dong-Ho;Bin, Sung-Oh
    • The Journal of the Korea Contents Association
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    • v.11 no.1
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    • pp.216-224
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    • 2011
  • This study conducted a secondary analysis by using original data of performed by Korea Institute for Health and Social Affairs to determine factors affecting health-related quality of life in the elderly. The results were as follows. For medical health condition, it became longer in endocrine diseases and cardiovascular diseases. In the case of functional health condition, subjects with musculoskeletal diseases showed higher functional health condition. Subjective health condition, while it became worse in digestive diseases and musculoskeletal diseases in the order, it recorded the best score when subjects did not have any musculoskeletal disease. Quality of life, while it became lower in endocrine diseases in the order, it was the highest when subjects did not have any musculoskeletal disease. Thus, increase of subjective health status for the elderly is important in the future.

Varietal Evalution of Resistance and Developing Conditions on Sesame Disease (참깨 주요 병해의 저항성 품종 선발과 발병환경구명)

  • 김흥배;김용욱
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.29 no.1
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    • pp.67-71
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    • 1984
  • These experiments were conducted at field and green house in order to screen the resistant sesame varieties to Phytopthora nicotianae var. parasitica. and to ascertain the infection conditions of Corynespora cassiicola at different temperatures, soil moistures and leaf stages. Most of varieties studied in this experiment were very susceptible to the Phytopthora blight. Orotall, Suweon 7, Suweon 27 and Jochiweon were resistant to the disease. PI280795 and IS103 showed a tendency to be morderately resistant. The infected areas by Corynespora leaf blight were 15% in Kwangeui and 25% in Kimpo variety at high temperature condition of 3$0^{\circ}C$, respectively. The infection areas were 50% in Kwangeui and 70% in Kimpo variety at low temperature condition of 17$^{\circ}C$. These results indicate that the development of the leaf blight was highly increased at low temperature. The infection areas by the Corynespora were 55% in Kwangeui and 80% in Kimpo at wet soil moisture condition, and 10% in Kwageui and 15% in Kimpo at dry condition, respectively. The infection of the leaf blight was highly increased at 6 leaf stage and flowering date compared to at 10 and 20 leaf stages. The infection ratios were 20% at 6 leaf stage and 52.5% at flowering date, respectively.

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A study on the Healing Mechanism of Herbal Medicine, Oryoungsan (오령산의 작용기전(作用機轉)에 대한 고찰(考察))

  • Nam, Hyoung-sin;Cho, Chung-sik;Kim, Chul-jung
    • Journal of Haehwa Medicine
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    • v.10 no.1
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    • pp.157-166
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    • 2001
  • Oryoungsan which first recorded in Sanghanron, the clinical medical book consists of treating acute febrile disease according to its change, is one of the frequently used oriental medicines. these days, it has been prescribed in symptoms accompanied by edema mostly. therefore it is easy to consider it as a type of diuretics. In Sanghanron it was originally used in the symptoms of perspiration, decreased urine volume, thirsty, flatulence. these symptoms indicate loss of body fluid and the prescription which orders "taking warm water sufficiently" supports this. On this background, it is supposed that Oryoungsan treats dehydration after providing water and electrolytes. To consider that herbal medicines consisted of Oryoungsan make electrolytes go out of the body, The healing mechanism of dehydration doesn't meet this. Because Oryoungsan was used in condition of fever or in similar condition, it is more resonable to understand that restoration of increasing blood flow to the subcutaneous venous plexus regulating body temperature in febrile condition into body circulation, resulting into maintaining main blood volume and into treating decreased urine volume and thirsty is Oryoungsan's function in the dehydration or febrile condition. That is, symptoms are decreased or disappeared through restoring unbalance of internal body fluid. The other target is pain controls, especially chronic headache, facial pain and trigeminal neuralgia. it is suggested that the function of pain control of Oryoungsan is related to 5-HT(5-hydroxytrypamine), nerve transmitter in the endogenous analgesic system. Moreover it is also suggested that Oryoungsan is relate to 5-HT, considering the fact that gastroparesis, a symptom of cyclic vomiting syndrome treated with 5-HT1D receptor agonist is similar to the 'bi', symptoms appeared in the Oryoungsan-related disease.

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Correlation Between Sasang Constitution and Korean Adult Scalp and Hair Condition (사상체질과 두피상태의 상관관계에 대한 연구보고)

  • Roh, Seok-Seon;Lee, Tae-Hyun;Hwang, Seong-Lok;Yoo, In-Kee;Lee, In-Ho;Kang, Sang-Jin;Ryu, Hyun-Shin
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.20 no.1 s.32
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    • pp.228-238
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    • 2007
  • Objectives ; Sasang Constitional Medicine is a part of Korean traditional Medicine, and classify human constitution into four types. Scalp and hair is a part of skin. Skin is one of constitutional charasteristic element. So we researched a correlation between Sasang constitutions and Korean adult scalp and hair condition. This is a basic study to find constitution can be a important factor to care scalp and hair. Methods ; We examined Sasang constitutions and scalp and hair condition of 80 human who aged from 20-50. Scalp disease, dandruff was observed by video micro scope and sebum tape diagnosis. Thickness of hair was measured by Laser Scan Micrometer(LSM-3100). Itching sense and life habit was also investigated. Constitution diagnosis and scalp, hair diagnosis was investigated seperately as a blind test and the data was statistically analyzed with chi-square test, correlation analysis, one-way analysis of varience. Results ; 1. In Sasang Constitution, Taeumin group had significant tendency of oilily scalp. 70% of Taeumin group had oilily scalp. 2. The group of dry or oilily scalp had more itching sense and more sensativity of scalp compaired to neuter scalp group. 3. There was no correlation between height, weight, thickness of hair, itching sense, scalp disease and Sasang constitution. 4. There was correlation between loss of hair and drinking alcohol, obesity, curly hair, soft scalp. Conclusions ; Korean adult scalp and hair condition had correlation with Sasang constitution.

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A Study of the Medical Records on Metrostaxis(崩漏) of that Made a Profound Study by Yi-Da-Gan(易大艮) and Cold Syndrome with Pesudo-Heat(眞寒假熱) of that Made a Profound Study by Yu-Chang(喩昌) (이대간(易大艮)의 붕루(崩漏) 의안(醫案)과 유창의 진한가열(眞寒假熱) 의안(醫案)에 관한 문헌적(文獻的) 연구(硏究))

  • Kim, Tae-Hee;Han, Kyung-Sook;Park, Young-Bae
    • The Journal of the Society of Korean Medicine Diagnostics
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    • v.9 no.2
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    • pp.1-9
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    • 2005
  • Background: Liu-Yuan-Lei(陸淵雷) said that a medical record is both the marks of treatments and arts made by a excellent practitioner and the essence of TCM(Traditional Chinese Medicine). Jiang-Guan(江瓘) also said that reading medical records is one of the best way to develop one’s abilities If curing a disease without perfect clinical practice. Objectives: study on the special treatment about metrostaxis(崩漏) based on the Yi-Da-Gan(易大艮)’s medical records. and study on the differentiation of abnormal symptoms and signs about cold syndrome with pesudo-heat(眞寒假熱) based on the Yu-Chang(喩昌)'s medical records. Methods: First, read and study the medical records on metrostaxis(崩漏) of that made a profound study by Yi-Da-Gan(易大艮) and cold syndrome with pesudo-heat(眞寒假熱) of that made a profound study by Yu-Chang(喩昌). The next, write a paper on results and conclusions. Results and Conclusions: First, Yi-Da-Gan(易大艮) insist that must control the Qi under the blood disease conditions, taking the case of metrostaxis(崩漏). Secondly, we must study more on estimating the changing condition of Qi and the blood as time goes by, also study on the pulse and pulse condition in the four seasons(四時脈). Thirdly, Yu-Chang(喩昌) insist that be more careful in differentiation of symptoms and signs, taking the case of cold syndrome with pesudo-heat(眞寒假熱). Fourthly, Yu-Chang(喩昌) give an example that in condition of cold syndrome with pesudo-heat(眞寒假熱), sometimes, the pulse and pulse condition can be strong.

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The Change of Taurine Transport in Variable Stress States through the Inner Blood-Retinal Barrier using In Vitro Model

  • Kang, Young-Sook;Lee, Na-Young;Chung, Yeon-Yee
    • Biomolecules & Therapeutics
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    • v.17 no.2
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    • pp.175-180
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    • 2009
  • Taurine is the most abundant free amino acid in the retina and transported into retina via taurine transporter (TauT) at the inner blood-retinal barrier (iBRB). In the present study, we investigated whether the taurine transport at the iBRB is regulated by oxidative stress or disease-like state in a conditionally immortalized rat retinal capillary endothelial cell line (TR-iBRB) used as an in vitro model of iBRB. First, [$^3H$]taurine uptake and efflux by TR-iBRB were regulated in the presence of extracellular $Ca^{2+}$. [$^3H$]Taurine uptake was inhibited and efflux was enhanced under $Ca^{2+}$ free condition in the cells. In addition, oxidative stress inducing agents such as tumor necrosis factor-$\alpha$ (TNF-$\alpha$), lipopolysaccharide (LPS), diethyl maleate (DEM) and glutamate increased [$^3H$]taurine uptake and decreased [$^3H$]taurine efflux in TR-iBRB cells. Whereas, 3-morpholinosydnonimine (SIN-1), which is known to NO donor decreased [$^3H$]taurine uptake. Lastly, TR-iBRB cells exposed to high glucose (25 mM) medium and the [$^3H$]taurine uptake was reduced about 20% at the condition. Also, [$^3H$]taurine uptake was decreased by cytochalasin B, which is known to glucose transport inhibitor. In conclusion, taurine transport in TR-iBRB cells is regulated diversely at extracellular $Ca^{2+}$, oxidative stress and hyperglycemic condition. It suggested that taurine would play a role as a retinal protector in diverse disease states.

Pain management in 『Treatise on Cold Damage and Miscellaneous Disease』 according to sufficiency-deficiency of fluid and humor (mainly with greater yang disease part) (진액(津液)의 유무(有無)에 따른 『상한잡병론(傷寒雜病論)』의 통증(痛症) 치법(治法)에 관하여(태양병편을 중심으로))

  • Lee, Myeong-Cheol;Kang, Yeon-Seok
    • The Journal of Korean Medical History
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    • v.27 no.2
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    • pp.135-143
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    • 2014
  • Human body fluid and humor include not only sweat, joint fluid but also every fluids, for example, blood, essence, kidney essence and marrow. Historically, in the oriental medicine, there are a lot of efforts in order to preserve fluid and humor. In "Treatise on Cold Damage and Miscellaneous Disease (傷寒雜病論)", when treating cold damage, preservation of fluid and humor is put first. I tried to find out the relation about fluid and humor and pain treatment in "Treatise on Cold Damage and Miscellaneous Disease". So, I investigated sentences related to pains in "Treatise on Cold Damage and Miscellaneous Disease" "greater yang disease part" and commentaries of several chinese medical doctors. And I divide pain treatments into four categories. (fluid and humor sufficiency-exterior pattern, fluid and humor sufficiency-interior pattern, fluid and humor deficiency-exterior pattern, fluid and humor deficiency-interior pattern) At first, when treating pains of cold damage, there are many considerations about deficiency and sufficiency of fluid and humor through pulse condition and symptoms. Second, in pain-cases of fluid and humor sufficiency, purge methods is chosen. And in pain-cases of fluid and humor deficiency, tonifying methods is chosen. Finally, one of the main objects of "Treatise on Cold Damage and Miscellaneous Disease" is preservation and supply of fluid and humor.

Evaluation of the recent live vaccination effects against Newcastle disease under field conditions (최근 야외농장에서 실시하고 있는 뉴캣슬병 생독백신 접종효능에 대한 평가)

  • Song, Chang-seon;Lee, Youn-jeong;Han, Myung-guk;Seong, Hwan-woo;Kang, Kyung-soo;Lee, Joong-bok;Kim, Jae-hak
    • Korean Journal of Veterinary Research
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    • v.40 no.3
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    • pp.563-573
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    • 2000
  • Periodic outbreaks of Newcastle disease (ND) caused by velogenic viscerotropic ND virus (vvNDV) has become a major concern in Korea nowadays. Throughout last epidemic, the winter season in 2000, most chicken flocks infected early, under 2-4 weeks of age, showed high mortality up to 50-100%. Serum samples collected from 201 breeder, 284 layer and 112 broiler chicken flocks were examined to evaluate the efficacy of various vaccination methods and programs routinely used for mass vaccination in the field poultry farms. Despite repeated live vaccination, most poultry flocks vaccinated by drinking water route using nipple water supply system failed to produce solid active immune response to NDV during the growing time. In the present study, we applied the spray vaccination technique using Ulvavac or Desvac sprayer to the experimental poultry flocks and examined the efficacy of live vaccination effects induced by it under field condition. Measurable antibody to NDV as well as early protection against vvNDV challenge were found in poultry flocks vaccinated by spray route. Further, we did not found significant post vaccination reactions caused by spray vaccination if properly administered. These data indicate that the spray vaccination will be safe and reliable mass vaccination method for the prevention of ND.

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Change Rate Extraction of Vocal Fold Vibration for Heart Conditional and Pronunciation of Correlative Analysis (심장 상태와 발음간의 연관성 분석을 위한 성대 진동의 변화율 추출)

  • Kim, Bong-Hyun;Cho, Dong-Uk
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.35 no.2B
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    • pp.191-196
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    • 2010
  • To increase heart disease by smoking, diabetes, obesity, stress, etc. is caused by death rate so heart disease has proposed early diagnosis necessity in modem society. Especially, incidence is on the increase rapidly because of ignorance and indifference of people about heart disease. Therefore to solve a social phenomenon about heart disease, this paper would like to design objective output parameter necessary early diagnosis of heart disease based on diagnosis theory about heart condition in the proposed Donguibogam. Specially to prove inaccurate pronunciation by heart disease would like to perform comparison, analysis of experimental group to extract vibration change rate of the vocal cords. This paper is comprised of heart disease patient and healthy people group in adult man speak to standard language then I'd like to propose early diagnosis about heart disease through comparison, analysis of vibration change rate of the vocal cords by acquisition of these voice.