• 동의생리병리학회지
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• 제35권5호
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• pp.193-198
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• 2021

The purpose of this study is to observe the effect of Cordyceps Militaris(CM) complex extract treatment on patients diagnosed with rheumatoid arthritis(RA). We reviewed medical records of 9 rheumatoid arthritis patients who visited the pain & rehabilitation center, Daejeon Korean Medicine Hospital of Daejeon University and were treated with CM complex extract from October 14, 2019 to October 14, 2020. We analyzed the records of DAS 28(Disease Activity Score 28), CDAI(Clinical Disease Activity Index), SDAI(Simplified Disease Activity Index), VAS(Visual analogue Scale), and KHAQ-D(Korean Health Assesment Questionnaire-Disability Index) before and after treatment to evaluate the effects of CM complex extract on RA. As a result, the scores of DAS 28(p<0.05), CDAI(p<0.01), SDAI(p<0.01) and VAS(p<0.01) were statistically significantly decreased, after 8 weeks of taking CM complex extract in RA patients. In conclusion, CM complex extract treatment may have potential effects of reducing disease activity and pain and improving quality of life in patients diagnosed with RA.

• Korean Journal of Radiology
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• 제22권10호
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• pp.1671-1679
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• 2021

Objective: We quantitatively measured the fat fraction (FF) in the vertebrae of patients with ankylosing spondylitis (AS) using magnetic resonance imaging (MRI) and investigated the role of FF as an indicator of both active inflammation and chronicity. Materials and Methods: A total of 52 patients with AS who underwent spinal MRI were retrospectively evaluated. The FF values of the anterosuperior and anteroinferior corners of the bone marrow in the L1-S1 spine were assessed using the modified Dixon technique. AS activity was measured using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), AS Disease Activity Score (ASDAS), and serum inflammatory marker levels. AS disease chronicity was assessed by AS disease duration and the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS). Univariable and multivariable regression analyses were conducted to investigate the correlation between FF and other clinical characteristics. Results: The mean FF ± standard deviation of the total lumbar spine was 43.0% ± 11.3%. At univariable analysis, spinal FF showed significant negative correlation with BASDAI (β = -0.474, p = 0.002) and ASDAS with C-reactive protein (ASDAS-CRP; β = -0.478, p = 0.002) and a significant positive correlation with AS disease duration (β = 0.440, p = 0.001). After adjusting for patient age, sex, and total mSASSS score, spinal FF remained significantly negatively correlated with BASDAI (β = -0.543, p < 0.001), ASDAS-CRP (β = -0.568, p < 0.001), and ASDAS with erythrocyte sedimentation rate (β = -0.533, p = 0.001). Spinal FF was significantly lower in patients with very high disease activity (ASDAS-CRP > 3.5) than in those with only high disease activity (2.1 ≤ ASDAS-CRP ≤ 3.5) (p = 0.010). Conclusion: Spinal FF may help assess both AS disease activity and chronicity.

• Clinical Endoscopy
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• 제55권4호
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• pp.480-488
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• 2022

Endoscopy is vital for diagnosis, assessing treatment response, monitoring and surveillance in patients with inflammatory bowel disease (IBD). With the growing importance of mucosal healing as a treatment target, the assessment of disease activity by endoscopy has been accepted as the standard of care for IBD. There are many endoscopic activity indices for facilitating standardized reporting of the gastrointestinal mucosal appearance in IBD, and each index has its strengths and weaknesses. Although most endoscopic indices do not have a clear-cut validated definition, endoscopic remission or mucosal healing is associated with favorable outcomes, such as a decreased risk of relapse. Therefore, experts suggest utilizing endoscopic indices for monitoring disease activity and optimizing treatment to achieve remission. However, the regular monitoring of endoscopic activity is limited in practice owing to several factors, such as the complexity of the procedure, time consumption, inter-observer variability, and lack of a clear-cut, validated definition of endoscopic response or remission. Although experts have recently suggested consensus-based definitions, further studies are needed to define the values that can predict long-term outcomes.

• 가정∙방문간호학회지
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• 제17권2호
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• pp.120-126
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• 2010

Purpose: The study sought to identify the differences in chronic diseases and physical activity in elderly women by BMI. Method: The subjects of this study were 644 elderly women 60-80-years-of-age living at home. The research instruments were physical activity levels and chronic diseases. Subjects were given a self-report questionnaire. Data were analyzed using the SPSS win program. Result: Hypertension, prevalence of diabetes mellitus and hyperlipemia were significantly different in the subjects according to body mass index, being higher in obese subjects than in non-obese subjects. Physical activity in each of the body mass index groups did not differ significantly. Conclusion: Obesity increases the risk of chronic diseases. This knowledge could help elderly women control their weight, reduce chronic diseases, and ultimately, gain better health.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제12권2호
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• pp.171-176
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• 2009

목 적: 최근 우리나라 소아에서 염증장병이 꾸준히 증가추세에 있으나 이들의 혈액학적 특징에 대해서는 알려진 바가 없다. 국내 염증장병 환아들의 장기간 관리에 도움이 되고자 혈액학적 소견을 분석하여 보았다. 방 법: 가천의대 길병원 소아청소년과에서 2002년 9월부터 2008년 9월 사이에 대장경과 생검으로 확진된 염증장병 환자 중 18세 이하인 25명의 염증장병 환아를 대상으로 하였다. 진단 당시의 혈색소, 적혈구용적률, 백혈구 수, 혈소판 수, 평균적혈구용적, 평균적혈구 혈색소량을 조사했다. 환아의 빈혈 빈도, 혈색소와 질병 이환기간과의 관계, 혈색소와 활동도지수와의 관계에 대하여 알아보았다. 결 과: 빈혈은 전체적으로 76% (19/25)에서 있었으며, 크론병 환아에서는 88% (14/16), 궤양결장염 환아에서는 56% (5/9)였다. 백혈구증가와 혈소판증가는 크론병 환아에서만 있었으며 빈도는 각각 56% (9/16), 25% (4/16)였다. 증상의 이환기간과 혈색소치는 크론병과 궤양결장염 모두에서 통계적인 유의성이 없었다. 활동도지수와 혈색소치도 크론병과 궤양결장염 모두에서 통계적인 유의성이 없었다. 결 론: 본 연구에서 염증장병 환아의 혈액학적 소견은 외국 문헌의 보고 내용과 큰 차이는 없었으나 빈혈의 빈도가 높았으며 질병의 이환기간 또는 활동도지수와 빈혈은 상관관계가 없었다. 이러한 사실은 염증장병환아를 장기간 관리하는 동안 빈혈에 대한 관리 역시 포함해야 하는 것을 시사하였다. 백혈구증가와 혈소판증가는 크론병에서만 관찰되어 궤양성장염과 감별진단하는데 도움이 될 수 있음을 제시하였다.

• Journal of Nutrition and Health
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• 제39권3호
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• pp.286-298
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• 2006

The study aimed to identify major factors related to global self-rated health of the community-dwelling elderly people in rural areas. Interviews were conducted with 433 persons over 65 years of age. The socio-economic characteristics, chronic disease status, measures of functional and mental health, life satisfaction, health-related behaviors including smoking, drinking, exercise, social activity, dietary habit, and food intakes were analyzed to determine their influence on self-rated health index. Data on food intake were obtained through the 24-hour recall method. The self-rated health of rural elderly was poor or very poor as reported by 42.6% and 52.4% of the men and women, respectively. Poor self-rated health was found to be related to elderly aged $65{\sim}74$, female, absence of work, more chronic diseases, dependence on Instrumental Activity Daily Living (IADL), higher mental unhealthy days, lower current life satisfaction, less social activity, lower dietary habit scores, lower intake of total food, fruit, eggs, fishes & shell fishes, vitamin C (%RDA), and Nutrient Adequacy Ratio (NAR). The results of the multiple regression analysis showed that poor self-rated health index is significantly associated with more chronic diseases, mental unhealthy days, gastrointestinal disease, musculoskeletal disease, less social activity, and lower intake of fruits. The results also suggested that improving the nutritional status and functional ability, and reducing the burden of chronic diseases are beneficial to the self-rated health index of the elderly.

• Korean Journal of Radiology
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• 제19권6호
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• pp.1077-1088
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• 2018

Objective: To correlate CT parameters on detector-based dual-energy CT enterography (DECTE) with Crohn's disease activity index (CDAI) and externally validate quantitative CT parameters. Materials and Methods: Thirty-nine patients with CD were retrospectively enrolled. Two radiologists reviewed DECTE images by consensus for qualitative and quantitative CT features. CT attenuation and iodine concentration for the diseased bowel were also measured. Univariate statistical tests were used to evaluate whether there was a significant difference in CTE features between remission and active groups, on the basis of the CDAI score. Pearson's correlation test and multiple linear regression analyses were used to assess the correlation between quantitative CT parameters and CDAI. For external validation, an additional 33 consecutive patients were recruited. The correlation and concordance rate were calculated between real and estimated CDAI. Results: There were significant differences between remission and active groups in the bowel enhancement pattern, subjective degree of enhancement, mesenteric fat infiltration, comb sign, and obstruction (p < 0.05). Significant correlations were found between CDAI and quantitative CT parameters, including number of lesions (correlation coefficient, r = 0.573), bowel wall thickness (r = 0.477), iodine concentration (r = 0.744), and relative degree of enhancement (r = 0.541; p < 0.05). Iodine concentration remained the sole independent variable associated with CDAI in multivariate analysis (p = 0.001). The linear regression equation for CDAI (y) and iodine concentration (x) was y = 53.549x + 55.111. For validation patients, a significant correlation (r = 0.925; p < 0.001) and high concordance rate (87.9%, 29/33) were observed between real and estimated CDAIs. Conclusion: Iodine concentration, measured on detector-based DECTE, represents a convenient and reproducible biomarker to monitor disease activity in CD.

• 지역사회간호학회지
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• 제25권4호
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• pp.248-258
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• 2014

Purpose: This study was to investigate factors influencing the Framingham risk score-Coronary heart disease (FRS-CHD) according to gender and body mass index (BMI) of adults who participated in the 5th Korea National Health and Nutrition Examination Survey (KNHANES V-3). Methods: This study used a cross-sectional design with secondary analysis with KNHANES V-3. The FRS-CHD scores were measured with ages, sex, blood pressure, cholesterol, high density lipoprotein, smoking, and diabetes mellitus. With demographic characteristics, family history of ischemic heart disease, types (intensity) and days of physical activities, perceived stress, drinking, menopause (in female), and BMI scores were measured. The data were analyzed with descriptive statistics, Pearson's correlation coefficients, and multiple regressions. Results: FRS-CHD was significantly associated with types (intensity) and days of physical activities, educational level, occupation, and marital status, explaining 19.1~76.8% of the variance in men. FRS-CHD was significantly associated with types (intensity) and days of physical activities, menopause, and education level, explaining 55.0~59.5% of the variance in women. Conclusion: Factors influencing FRS-CHD were significantly different according to gender and BMI. To reduce the risk of coronary artery disease, it is necessary to develop gender-specific physical activity programs according to BMI.

• 재활치료과학
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• 제4권2호
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• pp.7-15
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• 2015

목적 : 본 연구의 목적은 운동 프로그램이 치매환자의 일상생활활동에 미치는 효과를 살펴본 연구에 대해서 분석하는 것이다. 연구방법 : 2007년부터 2014년까지 국외학술지에 게재된 논문을 Pubmed를 통해 검색하였다. 주요 검색용어로는 'dementia',' alzheimer disease', 'exercise program', 'physical activity', 'activity of daily living', 'ADL'을 사용하였다. 최초 검색된 논문은 215편 이었으나 프로토콜을 거쳐 5편의 연구가 선정 되었다. 결과 : 선정된 논문의 Pedro score는 평균 7점으로 높은 편이었으며, 일상생활측정도구로 Katz index of ADLs, Bathel ADL index, IADL이 사용되었다. 연구들의 결과로는 실험군에서의 독립적인 일상생활수행능력의 유의미한 향상이 나타났고 시간이 지남에 따라 독립적인 일상생활활동수행능력이 저하되는 것을 늦추었다. 결론 : 본 연구는 치매환자를 대상으로 한 운동프로그램의 임상적 적용에 대한 근거를 제시하였으며, 연구결과 독립적인 일상생활활동을 수행하는데 효과적인 것으로 나타났다. 이와 같은 결과는 향후 임상가들이 치매환자의 독립적인 일상생활수행능력을 향상키기 위한 운동프로그램의 기초자료를 제시하고, 효과적인 치료접근법을 개발하는데 도움이 될 것으로 사료된다.

• 척추신경추나의학회지
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• 제5권1호
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• pp.57-66
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• 2010

항통을 주소로 내원한 환자의 크론병에 대한 침구(鍼灸)치료로 복통 및 설사의 관해 상태가 되는 양호한 효과를 얻었기에 보고하는 바이다. 다만, 치료 기간이 짧아 증상의 변화의 추적이 필요한 상태이며, 다양한 임상적 연구를 위한 임상사례 데이터가 축적되어야 할 것으로 사료된다.