• Journal of Korea Multimedia Society
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• v.18 no.2
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• pp.199-206
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• 2015

Since security vulnerabilities newly discovered in a popular Web browser immediately put a number of users at risk, urgent attention from developers is required to address those vulnerabilities. Analysis of characteristics in the Web browser vulnerabilities can be used to assess security risks and to determine the resources needed to develop patches quickly to handle vulnerabilities discovered. So far, being a new research area, the quantitative aspects of the Web browser vulnerabilities and risk assessments have not been fully investigated. However, due to the importance of Web browser software systems, further detailed studies are required related to the Web browser risk assessment, using rigorous analysis of actual data which can assist decision makers to maximize the returns on their security related efforts. In this paper, quantitative software vulnerability analysis has been presented for major Web browsers with respect to the Common Vulnerability Scoring System. Further, vulnerability discovery trends in the Web browsers are also investigated. The results show that, almost all the time, vulnerabilities are compromised from remote networks with no authentication required systems. It is also found that a vulnerability discovery model which was originally introduced for operating systems is also applicable to the Web browsers.

• Journal of Digital Contents Society
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• v.8 no.3
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• pp.269-277
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• 2007

Web service is an important technology to develop business to business e-commerce application. From a business perspective of time to market, dynamic evolution offers flexibility that software can adapt to unforeseen and fluctuating business requirements. OWL-S, based on OWL, is a service ontology language. The semantics provided by OWL support automation of service discovery, invocation, and service composition. In this paper we propose a framework to support dynamic evolution of service-oriented applications. We extend use-case analysis method to derive service description by defining requirements concept and mapping from requirement concept to activity diagram. A prototype is provided to show the validity of this framework.

• The Bulletin of The Korean Astronomical Society
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• v.38 no.1
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• pp.29.2-29.2
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• 2013

The presence of dark energy, suggested from Type Ia supernovae (SNe) cosmology, is the most pronounced astronomical discovery made during the past decade. The basic assumption of this discovery is that the look-back time evolution of SNe luminosity would be negligible after light-curve correction. Several recent works, however, show that there are some differences in Hubble residual among host galaxies having different morphology and mass, indicating that SNe luminosity might be affected by population age. In order to investigate this more directly, we are continuing the YONSEI (YOnsei Nearby Supernovae Evolution Investigation) project, where we are obtaining low-resolution spectra of some 60 nearby early-type host galaxies. The early-type galaxies are preferred because the mean population ages and metallicities can be estimated from the absorption lines, and they are less affected by dust extinction. In this talk, we will report our progress in determining the ages and metallicities of host galaxies to investigate their correlation with the Hubble residual.

• YAKHAK HOEJI
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• v.57 no.6
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• pp.412-419
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• 2013

Drug discovery and development processes are time consuming and costly endeavors. It has been reported that on average it takes 10 to 15 years and costs more than $ 1billion to bring a molecule from discovery to market. Compounds fail for various reasons but one of the significant reasons that accounts for failures in clinical trials is poor prediction/understanding of pharmacokinetics and drug metabolism in human. In an effort to improve the number of compounds that exhibit optimal absorption, distribution, metabolism, elimination (ADME), and pharmacokinetic properties in human, drug metabolism, pharmacokinetic scientists have been continually developing new technologies and compound screening strategies. Over the last few years, accelerator mass spectrometry (AMS) and its applications to preclinical/clinical pharmacokinetics and ADME studies have significantly increased, particularly for new chemical/biological entities that are difficult to support with conventional radiolabel studies. In this review, the application of AMS for micro-dosing, micro-tracer absolute bioavailability, mass balance and metabolite profiling studies will be discussed.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.7
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• pp.3369-3385
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• 2019

There are various research challenges in vehicular ad hoc networks (VANETs) that need to be focused until an extensive deployment of it becomes conceivable. Design and development of a scalable routing algorithm for VANETs is one of the critical issue due to frequent path disruptions caused by the vehicle's mobility. This study aims to provide a novel road-aware routing protocol for vehicular networks named as Two-level hierarchical Hybrid Road-Aware (THERA) routing for vehicular ad hoc networks. The proposed protocol is designed explicitly for inter-vehicle communication. In THERA, roads are distributed into non-overlapping road segments to reduce the routing overhead. Unlike other protocols, discovery process does not flood the network with packet broadcasts. Instead, THERA uses the concept of Gateway Vehicles (GV) for the discovery process. In addition, a route between source and destination is flexible to changing topology, as THERA only requires road segment ID and destination ID for the communication. Furthermore, Road-Aware routing reduces the traffic congestion, bypasses the single point of failure, and facilitates the network management. Finally yet importantly, this paper also proposes a probabilistical model to estimate a path duration for each road segment using the highway mobility model. The flexibility of the proposed protocol is evaluated by performing extensive simulations in NS3. We have used SUMO simulator to generate real time vehicular traffic on the roads of Gangnam, South Korea. Comparative analysis of the results confirm that routing overhead for maintaining the network topology is smaller than few previously proposed routing algorithms.

• Biomolecules & Therapeutics
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• v.27 no.1
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• pp.78-84
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• 2019

Cell therapeutic agents for treating degenerative brain diseases using neural stem cells are actively being developed. However, few systems have been developed to monitor in real time whether the transplanted neural stem cells are actually differentiated into neurons. Therefore, it is necessary to develop a technology capable of specifically monitoring neuronal differentiation in vivo. In this study, we established a system that expresses cell membrane-targeting red fluorescent protein under control of the Synapsin promoter in order to specifically monitor differentiation from neural stem cells into neurons. In order to overcome the weak expression level of the tissue-specific promoter system, the partial 5' UTR sequence of Creb was added for efficient expression of the cell surface-specific antigen. This system was able to track functional neuronal differentiation of neural stem cells transplanted in vivo, which will help improve stem cell therapies.

• Journal of Species Research
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• v.11 no.4
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• pp.335-342
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• 2022

Through the 'Discovery of Korean Indigenous Species' project hosted by the National Institute of Biological Resources (NIBR), new or unrecorded species of various protozoans inhabiting the Korean Peninsula have been discovered. Samples were collected from marine, freshwater, and soil habitats in South Korea and all species were identified and reviewed by experts working on the respective taxonomic group. This study includes 17 unrecorded Korean protozoan species discovered through this project, which belong to four phyla: Amoebozoa Lühe, 1913, Cercozoa Cavalier-Smith, 1998, Euglenozoa Cavalier-Smith, 1981, and Ciliophora Doflein, 1901. Among them, three families (Rhogostomidae Dumack et al., 2017, Parauronematidae Small and Lynn, 1985, and Cyclidiidae Ehrenberg, 1838) and three genera (Rhogostoma Belar, 1921, Parauronema Thompson, 1967, and Cyclidium Müller, 1773) were reported for the first time in Korea. Unlike the previous paper of 2017, this study provides a comprehensive taxonomic account of each species (e.g., species name, collection site, synonyms, specimen vouchers, diagnoses, and figures). Additionally, all the species were assigned Korean names.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2020.12a
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• pp.14-14
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• 2020

In December 2019, the COVID-19 epidemic was discovered in Wuhan, China, and since has disseminated around the world impacting human health for millions. Herein, in-silico drug discovery approaches were utilized to identify potential candidates as Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) main protease (M^pro) inhibitors. We investigated several databases including natural and natural-like products (>100,000 molecules), DrugBank database (10,036 drugs), major metabolites isolated from daily used spices (32 molecules), and current clinical drug candidates for the treatment of COVID-19 (18 drugs). All tested compounds were prepared and screened using molecular docking techniques. Based on the calculated docking scores, the top ones from each project under investigation were selected and subjected to molecular dynamics (MD) simulations followed by molecular mechanics-generalized Born surface area (MM-GBSA) binding energy calculations. Combined long MD simulations and MM-GBSA calculations revealed the potent compounds with prospective binding affinities against M^pro. Structural and energetic analyses over the simulated time demonstrated the high stabilities of the selected compounds. Our results showed that 4-bis([1,3]dioxolo)pyran-5-carboxamide derivatives (natural and natural-like products database), DB02388 and Cobicistat (DB09065) (DrugBank database), salvianolic acid A (spices secondary metabolites) and TMC-310911 (clinical-trial drugs database) exhibited high binding affinities with SARS-CoV-2 M^pro. In conclusion, these compounds are up-and-coming anti-COVID-19 drug candidates that warrant further detailed in vitro and in vivo experimental estimations.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.4 no.2
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• pp.224-227
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• 2001

Esophageal duplication cysts are quite uncommon benign lesions of the esophagus that have previously been described as occurring only in the thoracic cavity. We experienced a rare case of completely intra-abdominal esophageal duplication cyst in a 10-year-old boy who has suffered from epigastric abdominal pain. Surgical excision is recommended at the time of cyst discovery whether symptoms present or not.

• Journal of The Korean Astronomical Society
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• v.38 no.2
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• pp.289-290
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• 2005

The 6th East Asian Meeting of Astronomy was held just at the time of 400 years after the discovery of SN (supernova) 1604 and its pre-maximum observation by the astronomers both from the East and the West in the 17th century. It has a special meaning and is interesting to look back on the historical observation of SN 1604. In this paper, we only limit to concern the Chinese observation on SN 1604.