• 한국초등과학교육학회지:초등과학교육
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• 제36권2호
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• pp.113-128
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• 2017

This study aims to investigate the research trend of elementary environmental education. Thus, author keywords were extracted from a total of 197 academic these related to elementary environmental education during two different periods when detailed goals were applied to the 2007 and 2009 revised curriculums respectively, and then this study analyzed the network of author keywords. The results of this study can be summarized as below. Firstly, as a result of analyzing the frequency of author keywords from academic theses related to elementary environmental education, this study discovered 369 author keywords from the period when detailed goals were applied to 2009 revised curriculum. Out of them, it was found that the keyword, 'climate change education', showed the highest frequency, followed by 'environmental literacy' and 'environmental perception', except such central keywords as 'environmental education' and 'elementary school student'. From the period when detailed goals were applied to the 2007 revised curriculum, a total of 394 author keywords were discovered, and the keyword, 'environmental literacy', showed the highest frequency, followed by 'environmental perception' and 'ESD (education for sustainable development)'. Secondly, as a result of analyzing the network of author keywords, this study found out that in the total number of network connections, average connection degree, density and clique, the period when detailed goals were applied to the 2007 revised curriculum was somewhat higher than the period when detailed goals were applied to the 2009 revised curriculum. As a result of analyzing the centrality of author keywords, this study found out that during both the periods, 'environmental perception' and 'environmental literacy' were high in degree centrality and betweenness centrality, except such central keywords as 'environmental education' and 'elementary school student'. As a result of analyzing the components of author keywords as sub-networks, this study discovered 9 components from the period when detailed goals were applied to the 2009 revised curriculum and 6 components from the period when detailed goals were applied to the 2007 revised curriculum. During both the periods, the largest component was composed of keywords high in degree centrality and betweenness centrality.

• 한국도서관정보학회지
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• 제34권3호
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• pp.259-275
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• 2003

본고는 無垢淨光大陀羅尼經의 현존본 사이에서 형성된 문자이동의 유형을 고찰하여, 한국의 경주 석가탑에서 발견된 無垢淨光大陀羅尼經의 문자이동 상태를 고찰한 것이다. 그 결과 無垢淨光大陀羅尼經의 원문은 돈황사경이 현존본 가운데 가장 이른 시기의 원문 상태이며, 이것은 방산석경ㆍ조성장ㆍ고려장에 와서 한번 변화되었고, 다시 석가탑에서 발견된 無垢淨光大陀羅尼經ㆍ자복장ㆍ적사장ㆍ영락남장ㆍ경산장ㆍ청장에서 크게 변화된 것으로 밝혀졌다. 그리고 석가탑에서 발견된 無垢淨光大陀羅尼經의 문자이동 상태는 자복장과 동일하게 나타나고 있는 바 석가탑에서 발견된 無垢淨光大陀羅尼經의 저본과 계통은 자복장의 저본과 밀접한 관계에 있는 것으로 추정되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권21호
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• pp.9427-9432
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• 2014

Background: Delayed presentation of symptomatic breast cancer is a public health issue in Iran, making a major contribution to low survival. Despite the importance of this problem, current knowledge is insufficient to inform interventions to shorten patient delay. The aim of this study was to explore factors influencing patient delay in Iranian women with self-discovered breast cancer symptom. Materials and Methods: This qualitative study was conducted during 2012-2013. Purposeful sampling was used to recruit 20 Iranian women with self-discovered symptoms of breast cancer who attended the Cancer Institute of Tehran University of Medical Sciences, Tehran, Iran. Data were collected through semi-structured in-depth audiotaped interviews, which were transcribed and analyzed using conventional content analysis with MAXqda software version 10. Findings: Content analysis of the data revealed four main themes related to the delay in seeking medical help including: 1) attributing symptoms to the benign conditions; 2) conditional health behavior; 3) inhibiting emotional expression; and 4) barriers to access to health care systems. Conclusions: These results suggest that patient delay is influenced by complex and multiple factors. Effective intervention to reduce patient delay for breast cancer should be developed by focusing on improvement of women's medical knowledge, managing patients' emotional expression and reform of the referral system.

• 한국지구과학회지
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• 제37권1호
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• pp.1-10
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• 2016

신생대 어류 화석 4개체가 포항의 마이오세 두호층에서 발견되었다. 본 화석은 뒷지느러미의 앞쪽 담기골(pterygiophore)이 연장되어 있고, 후의쇄골(postcleithrum)이 존재하며, 두 개의 인접한 혈관극 사이에 뒷지느러미 담기골 두개가 거의 일정하게 존재한다. 그리고 첫 번째와 두 번째 하미축골(hypurals)이 융합되었고, 세 번째와 네 번째 하미축골과 첫 번째 전미추체(preural centrum)가 융합되어 있다. 그리고 두부인근의 잘 발달된 판상 신경극과 낚시바늘모양의 미설골(urohyal)이 존재하고, 그 좌골부(sciatic part)가 꺾여있다. 그리고 준하미골(parahypural)이 첫 번째 전미추체로부터 분리되어 있다. 이를 근거로 볼 때, 이 화석은 국내 최초의 가지미목으로 동정되었다. 그간의 두호층 지질학적 연구는 천해환경의 생물들이 육상의 큰 홍수와 같은 사건으로 떠내려가 저탁류에 의해 심해환경에서 퇴적되었다고 주장해 왔다. 하지만 여태껏 천해환경 생물들만 발견되어 왔다. 본 연구에서는 두호층에서 최초로 심해생물인 가자미류가 보고되었다.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2000년도 International Symposium on Bioinformatics
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• pp.74-82
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• 2000

Prostate cancer initially responds and regresses in response to androgen depletion therapy, but most human prostate cancers will eventually recur, and re-grow as an androgen independent tumor. Once these tumors become hormone refractory, they usually are incurable leading to death for the patient. Little is known about the molecular details of how prostate cancer cells regress following androgen ablation and which genes are involved in the androgen independent growth following the development of resistance to therapy. Such knowledge would reveal putative drug targets useful in the rational therapeutic design to prevent therapy resistance and control androgen independent growth. The application of genome scale technologies have permitted new insights into the molecular mechanisms associated with these processes. Specifically, we have applied functional genomics using high density cDNA microarray analysis for parallel gene expression analysis of prostate cancer in an experimental xenograft system during androgen withdrawal therapy, and following therapy resistance, The large amount of expression data generated posed a formidable bioinformatics challenge. A novel template based gene clustering algorithm was developed and applied to the data to discover the genes that respond to androgen ablation. The data show restoration of expression of androgen dependent genes in the recurrent tumors and other signaling genes. Together, the discovered genes appear to be involved in prostate cancer cell growth and therapy resistance in this system. We have also developed and applied tissue microarray (TMA) technology for high throughput molecular analysis of hundreds to thousands of clinical specimens simultaneously. TMA analysis was used for rapid clinical translation of candidate genes discovered by cDNA microarray analysis to determine their clinical utility as diagnostic, prognostic, and therapeutic targets. Finally, we have developed a bioinformatic approach to combine pharmacogenomic data on the efficacy and specificity of various drugs to target the discovered prostate cancer growth associated candidate genes in an attempt to improve current therapeutics.

• 대한두경부종양학회지
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• 제2권1호
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• pp.23-31
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• 1986

During the past 14years 267 patients presented with a lump in the neck proven to be metastatic cancer histologically. In most cases the primary site was discovered by thorough physical examination, E.U.A.(examination under anesthesia) and radiodiagnostic studies. However in 31 cases complete diagnostic evaluation failed to reveal the primary site. This paper discusses the characteristics of this group of patients in terms of the frequency of the ultimately discovered primary sites, policies for diagnosis, methods of management, and the ultimate prognosis for such cases in Korea. The male: female ratio was 6.8:1 and 84 % of all cases occurred in the $51{\sim)70$ age group. The majority of these cancers were epidermoid carcinomas(67.7%) and 22 of the 31(71 %) were Stage IV lesinos(17 N3A lesions and 5 N3B lesions). Surgical management was employed in 7 cases only, and in 5 cases this was combined with rediotherapy, chemotherapy, or both. Nevertheless, the only patients who survived disease-free for two years or more (one for over 5 years) were two patients in this management group. None of the patients treated by radiotherapy or chemotherapy of a combination of these two modalities survived. Occult primary sites were eventually discovered in 5 of the 31 cases, two in the nasopharynx, and one each in the base of tongue, pyrifrom sinus, middle ear. Of the 21 cases with epidermoid carcinoma which presented in the neck, 2 are free of disease for 3years or more. Of those who underwent radical surgery two of five survived. This study thus confirms the principle enunciated by MacComb in 1972 that surgical treatment in the form of radical neck dissection is the cornerstone of management whenever feasible.

• 한국균학회소식:학술대회논문집
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• 한국균학회 2018년도 춘계학술대회 및 임시총회
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• pp.37-37
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• 2018

Mating type of Lentinula edodes is determined by two unlinked genetic loci, A and B. To better understand mating behavior of L. edodes, we investigated variations in mating type genes in129 dikaryotic strains collected from East Asia. Through sequence analysis of A locus, we discovered that hypervariable region spanning N-term of HD2-intergenic region-N-term of HD1 could represent A mating type. Mating and hypervariable region analyses revealed 70 unique A mating types: 27 from 98 cultivated strains, 53 from 31 wild strains, and 10 commonly found. It was also revealed that only a few A mating type alleles such as A1, A4, A5, and A7 were prevalent in cultivated strains. Contrarily, A mating type in wild strains was highly diverse: 23 unique A alleles were discovered in small mountainous area in Korean peninsula, suggesting rapid evolution of A mating type in nature. The B locus was assessed by allelic variations in pheromone (PHB) and pheromone receptor (RCB) pairs which constituted subloci Ba and Bb. Sequence analyses and mating assay revealed 5 alleles of RCB1 with 9 associated PHBs in Ba sublocus and 3 alleles of RCB2 with 5 associated PHBs in Bb sublocus. Each RCB was primarily associated with two PHBs. Each PHB-RCB pair was always discovered as a distinct unit. This allowed us to propose 15 B mating types via combinations of five Ba and three Bb subloci. Further investigation on 129 strains confirmed that the B locus, unlike the A locus, was indeed restricted to 15 mating types. Thus, the total number of mating types became 1,050 in L. edodes through a combination of 70 A and 15 B. This number will further increase because of rapid diversification of A mating type. Our findings provide a comprehensive and practical knowledge on mating behaviors of L. edodes.

• Journal of Ginseng Research
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• 제44권5호
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• pp.680-689
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• 2020

Background: Peptides have diverse and important physiological roles in plants and are ideal markers for species identification. It is unclear whether there are specific peptides in Panax quinquefolius L. (PQ). The aims of this study were to identify Quinetides, a series of diverse posttranslational modified native peptides of the ribonuclease-like storage protein (ginseng major protein), from PQ to explore novel peptide markers and develop a new method to distinguish PQ from Panax ginseng. Methods: We used different fragmentation modes in the LTQ Orbitrap analysis to identify the enriched Quinetide targets of PQ, and we discovered Quinetide markers of PQ and P. ginseng using ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry analysis. These "peptide markers" were validated by simultaneously monitoring Rf and F11 as standard ginsenosides. Results: We discovered 100 Quinetides of PQ with various post-translational modifications (PTMs), including a series of glycopeptides, all of which originated from the protein ginseng major protein. We effectively distinguished PQ from P. ginseng using new "peptide markers." Four unique peptides (Quinetides TP6 and TP7 as markers of PQ and Quinetides TP8 and TP9 as markers of P. ginseng) and their associated glycosylation products were discovered in PQ and P. ginseng. Conclusion: We provide specific information on PQ peptides and propose the clinical application of peptide markers to distinguish PQ from P. ginseng.

• 산업경영시스템학회지
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• 제21권45호
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• pp.121-133
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• 1998

This study suggests an efficient algorithm for updating discovered association rules in large database, because a database may allow frequent or occasional updates, and such updates may not only invalidate some existing strong association rules, but also turn some weak rules into strong ones. FUP and DMI update efficiently strong association rules in the whole updated database reusing the information of the old large item-sets. Moreover, these algorithms use a pruning technique for reducing the database size in the update process. This study updates strong association rules efficiently in the whole updated database reusing the information of the old large item-sets. An updating algorithm that is suggested in this study generates the whole candidate item-sets at once in an incremental database in view of the fact that it is difficult to find the new set of large item-sets in the whole updated database after an incremental database is added to the original database. This method of generating candidate item-sets is different from that of FUP and DMI. After generating the whole candidate item-sets, if each item-set in the whole candidate item-sets is large at an incremental database, the original database is scanned and the support of each item-set in the whole candidate item-sets is updated. So, the whole large item-sets in the whole updated database is found out. An updating algorithm that is suggested in this study does not use a pruning technique for reducing the database size in the update process. As a result, an updating algoritm that is suggested updates fast and efficiently discovered large item-sets.

• 한국초등과학교육학회지:초등과학교육
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• 제38권4호
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• pp.484-495
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• 2019

This study divided pre-service elementary school teachers' knowledge conversion into four types, socialization, externalization, combination and internalization, based on their inquiry activities on the life cycle of cabbage butterfly. As research subjects, this study collected results from 24 pre-service elementary school teachers who carried out inquires on the life cycle of cabbage butterfly for about 2 months. The type of socialization indicates the conversion of tacit knowledge into tacit knowledge, and this study found out that pre-service elementary school teachers acquired and accumulated tacit knowledge from their fellow pre-service teachers, professors and even acquaintances inside and outside the lab. However, there appeared no process that they shared their tacit knowledge with other pre-service teachers or delivered it to them. The type of externalization indicates the conversion of tacit knowledge into explicit knowledge, and this study discovered some cases that pre-service elementary school teachers expressed their inner tacit knowledge into explicit knowledge. However, there was no case found that they converted the verbally-unexpressed tacit knowledge of their fellow teachers or experts into well-defined explicit knowledge. The type of combination indicates the conversion of explicit knowledge into explicit knowledge, and this study discovered some cases that they collected explicit knowledge and converted it into new explicit knowledge for the acquisition, integration and delivery or distribution of explicit knowledge. However, there were few cases that they creatively devised new explicit knowledge by acquiring new knowledge through direct observation and supplementing the existing explicit knowledge. The type of internalization indicates the conversion of explicit knowledge into tacit knowledge, and this study discovered both explicit knowledge embodied through personal experiences and explicit knowledge embodied through simulations and experiments that formed tacit knowledge in process of examining the existing explicit knowledge.