• Journal of the Korea institute for structural maintenance and inspection
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• v.17 no.1
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• pp.133-142
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• 2013

The shear wall system with coupling beams has been known as an effective means for moderate and high rise buildings up to 40 stories, because this structural system can provide the enhanced lateral stiffness compared to individual shear walls. Typical reinforced concrete coupling beams have difficulties in construction due to complicated reinforcing work on site, and steel coupling beams also have disadvantages in economical point of view because of a large number of stiffeners required for its stability under lateral loading. To overcome these disadvantages in existing coupling beam systems, this study developed the prestressed composite coupling beam with discontinuous webs, which have improved constructability, economic feasibility, and reduced sectional size. The reversed cyclic loading test on two prestressed composite coupling beams with discontinuous webs having different shear reinforcement ratios have been conducted to investigate their structural performances, and test results showed that the proposed composite coupling beams had good seismic performances.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5973-5981
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• 2013

At present, the most common cause of cancer-related death in women is breast cancer. In a large proportion of breast cancers, there is the overexpression of human epidermal growth factor receptor 2 (HER2). This receptor is a 185 KDa growth factor glycoprotein, also known as the first tumor-associated antigen for different types of breast cancers. Moreover, HER2 is an appropriate cell-surface specific antigen for passive immunotherapy, which relies on the repeated application of monoclonal antibodies that are transferred to the patient. However, vaccination is preferable because it would stimulate a patient's own immune system to actively respond to a disease. In the current study, several bioinformatics tools were used for designing synthetic peptide vaccines. PEPOP was used to predict peptides from HER2 ECD subdomain III in the form of discontinuous-continuous B-cell epitopes. Then, T-cell epitope prediction web servers MHCPred, SYFPEITHI, HLA peptide motif search, Propred, and SVMHC were used to identify class-I and II MHC peptides. In this way, PEPOP selected 12 discontinuous peptides from the 3D structure of the HER2 ECD subdomain III. Furthermore, T-cell epitope prediction analyses identified four peptides containing the segments 77 (384-391) and 99 (495-503) for both B and T-cell epitopes. This work is the only study to our knowledge focusing on design of in silico potential novel cancer peptide vaccines of the HER2 ECD subdomain III that contain epitopes for both B and T-cells. These findings based on bioinformatics analyses may be used in vaccine design and cancer therapy; saving time and minimizing the number of tests needed to select the best possible epitopes.

• Journal of Digital Convergence
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• v.16 no.8
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• pp.169-179
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• 2018

Recently, web search query information has been applied in advanced predictive model research. Google dominates the global web search market in the Korean market; however, Naver possesses a dominant market share. Based on this characteristic, this study intends to compare the utility of the Korean web search query information of Google and Naver using predictive models. Therefore, this study develops three time-series predictive models to estimate the youth unemployment rate in Korea using the ARIMA model. Model 1 only used the youth unemployment rate in Korea, whereas Models 2 and 3 added the Korean web search query information of Naver and Google, respectively, to Model 1. Compared to the predictability of the models during the training period, Models 2 and 3 showed better fit compared with Model 1. Models 2 and 3 correlated different query information. During predictive periods 1 (continuous with the training period) and 2 (discontinuous with the training period), Model 3 showed the best performance. During predictive period 2, only Model 3 exhibited a significant prediction result. This comparative study contributes to a general understanding of the usefulness of Korean web query information using the Naver and Google search engines.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.39 no.2 s.120
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• pp.25-30
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• 2007

Recently the use of web offset printing has been increasing, which can provide high print speed, mass production, and high print quality. However, high speed web offset printing has frequently undergone a blistering problem when the printed paper passes through hot air dryers. Blistering occurs in the middle of the base paper or in the coating layer. This paper focused on the blistering occurring in the base paper. In order to elucidate the effect of pigment ratio on blistering, 6 types of coating color were prepared with varying GCC/clay ratios and printability and blistering were investigated focusing on structure changes in the coating layer. When the clay content in the coating layer was increased, surface roughness and surface strength were decreased and paper gloss was increased. In addition, it was found that the coating layer structure with high clay content, which contains lots of discontinuous pores, hindered water vapors to penetrate out and, as a result, blistering occurred.

• Journal of Korean Society of Steel Construction
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• v.25 no.6
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• pp.601-612
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• 2013

In the present study, details of the TSC beam-to-PSRC column connection for low and middle seismic zones were developed. For ease construction, the top and bottom flanges of the steel section of the TSC beam were discontinuous at the joint face on purpose, while the web passes through the joint. Thus, tensile resistance of the top and bottom flanges is not considered in the calculation of nominal strength of the connection. Cyclic loading tests on two interior connections and an exterior connection were performed to verify the seismic performance. The test parameter for two interior connections was the depth of the TSC beams: 600 and 700 mm including the slab depth. The test results showed that the nominal strength of the connections predicted by KBC 2009 correlated well with the test results. The connection specimens exhibited relatively good deformation and energy dissipation capacities, greater than the requirements for the ordinary and intermediate moment frames. Ultimately, the connection specimens were failed at the story drift ratios of 3.0 to 4.0 % due to local buckling and tensile fracture of the web of the TSC beam passing through the joint. By modifying the existing provisions of ASCE, the joint shear strength of the TSC beam-PSRC column connection was evaluated.