• Journal of the Korea Society of Computer and Information
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• 제28권1호
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• pp.71-78
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• 2023

In this paper, we analyze the structure of TV video software, one of the warship combat management system software, and propose a standard architecture that minimizes software modification due to the discontinuation replacement of warship hardware. The class structure was newly designed to minimize the class modified when replacing the warship hardware by separating the variable elements and common elements of TV video software through FORM(Feature-Oriented Reuse Method), the common part that communicates with the warship combat management system and displays the TV screen and the variable part that communicates between the operator and the TV camera. In addition, the Strategy design pattern is applied to efficiently add and modify classes that directly use hardware-dependent APIs when replacing hardware discontinuation, and to make both discontinued and replacements available software. Finally, the reliability testing time and functional testing time of the existing TV video software and the proposed software were measured and compared, and finally, it was confirmed that the hardware discontinuation replacement cost was reduced.

• Journal of Korean Neurosurgical Society
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• 제57권5호
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• pp.371-375
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• 2015

Spontaneous spinal subdural hematoma is reported at a rare level of incidence, and is frequently associated with underlying coagulopathy or those receiving anticoagulant or antiplatelet agents; some cases accompany concomitant intracranial hemorrhage. The spontaneous development of spinal subdural hemorrhage (SDH) is a neurological emergency; therefore, early diagnosis, the discontinuation of anticoagulant, and urgent surgical decompression are required to enable neurological recovery. In this report, we present a simultaneous spinal subdural hematoma and cranial subarachnoid hemorrhage, which mimicked an aneurysmal origin in a female patient who had been taking warfarin due to aortic valve replacement surgery.

• Journal of Genetic Medicine
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• 제13권2호
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• pp.72-77
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• 2016

Purpose: Gaucher disease (GD) is the most common lysosomal storage disease caused by beta-glucocerebrosidase (GBA) deficiency. Oral substrate reduction therapy with miglustat ($Zavesca^{(R)}$) was approved for the treatment of adults with GD type 1, for whom enzyme replacement therapy (ERT) is unsuitable or not a therapeutic option. In this study, we report the effect of miglustat ($Zavesca^{(R)}$) in three Korean GD patients. Materials and Methods: Clinical findings comprising age at diagnosis, presenting signs, laboratory findings at diagnosis, GBA activity and mutations, and clinical courses of the three patients were reviewed. Results: Miglustat was administered to three patients who reported allergic reactions during intravenous imiglucerase infusions. One patient withdrew after 15 months of miglustat administration owing to continuous elevation of disease biomarker levels (chitotriosidase, acid phosphatase, and angiotensin-converting enzyme). Poor adherence to medication was suspected but was denied by the patient. In the other two patients, platelet count and levels of hemoglobin and other biomarkers remained stable during miglustat administration. However, they suffered from severe diarrhea and weight loss, which led to miglustat discontinuation after 1 and 12 months of administration. Conclusion: Our study shows that although miglustat is suggested to GD patients as an alternative treatment to ERT, significant adverse reactions may lead to discontinuation of miglustat. In addition, it is difficult to monitor the drug adherence.

• Korean Journal of Biological Psychiatry
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• 제4권1호
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• pp.136-145
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• 1997

We are report on three cases of typical clinical characterstics and treatment response in neuroleptic maligant syndrome(NMS), and reviewed the literatures of NMS. NMS was first recognized as a life-threatening complication of dopamine receptor antagonists, and defined as a catatonic-like states associated with fever, obtundation, muscle rigidity, and unstable vital sign in patients taking neuroleptic agents. Concepts of NMS have changed because medications other than classic neuroleptic drugs have been implicated as triggering agents and syndromes identical to NMS have been observed in other conditions. The important neurochemical features are probably functional dopamine deficiency and ensuing hyperactivity of excitatory amino acid neurotransmission in the basal ganglia and hypothalamus. Recognition of NMS and early discontinuation of neuroleptics are the most important step in its management. Supportive care includes management of hyperthermia and fluid replacement. Controversial therapeutic measures include the application of dopamine receptor agonists, excitatory amino acid antagonists, or dantrolene. Psychiatric patients with a history on NMS and psychotic relapse necessitating antipsycotics do not commonly redevelop NMS.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• 제8권7호
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• pp.475-484
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• 2018

The propulsion control device of an electric railway vehicle is a key main component corresponding to an engine of an automobile, and a device for controlling this is a device called a GDU (Gate Drive Unit). Also, when the frequency of failure of the propulsion control system was analyzed, the nonconformity ratio of GDU was the highest. GDU was not able to access core technologies due to the introduction of foreign products, and there were general problems with overall maintenance activities due to discontinuation of GDU of the manufacturer. The GDU has reached the end of its life with 23 to 14 years of long-term use.In order to solve these problems, this study was designed to identify the proper life span by analyzing compatible GDU's acquisition and failure, and to improve the existing system of maintenance focusing on health inspection. Maintenance of the components with a short life span compared to the entire service life is essential. Most foreign parts introduced at the beginning of the construction are not replaced due to technical problems or long-term operation. However, due to the characteristics of railway vehicles with a long life span of more than 25 years, it is necessary to maintain them for a long period of time. The study should be more concrete and empirical. The replacement type GDU of capacitors was able to easily measure the life of the capacitance by removing the capacitor modules, measure the life span of each unit test, and accurately perform preventive maintenance of the capacitor.

• The Korean Journal of Nuclear Medicine
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• 제31권3호
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• pp.346-355
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• 1997

To evaluate the utility of I-131, T1-201 scintigraphy, and serum thyroglobulin(Tg) in the follow-up of differentiated thyroid cancer, we compared retrospectively the data from 33 patients who underwent total or subtotal thyroidectomy. I-131 scintigraphy was performed after optimal endogenous TSH stimulation ($TSH>50{\mu}U/ml$). Total 41 cases of I-131 and T1-201 scintigraphy pairs were examined. Concomitant serum thyroglobulin levels were measured for 41 pairs of scan. Tg-off levels(that measured after discontinuation of the thyroid hormone) higher than 40ng/m1 were considered positive, and Tg-on levels(that measured during the thyroid hormone replacement) higher than 5ng/ml were considered positive. The concordance rates between I-131 therapeutic scintigraphy and T1-201 scintigraphy was 48% in the 38 case of total scan pairs(59% in the 17 cases of postoperative preablation group, and 38% in the 21 cases of postoperative postablation group). Of 17 studies before the I-131 ablation therapy(preablation group), 7 showed positive I-131 therapeutic scintigraphy despite of negative T1-201 scintigraphy. Among patients with negative I-131 therapeutic scintigraphy, no patients had abnormal T1-201 uptake. However, of 21 studies which were done after radioiodine therapy(postablation group) 6 had abnormal uptake on T1-201 scintigraphy which were not seen on I-131 therapeutic scintigraphy, and Tg-off levels also elevated in this 4 of 6 cases. As a result, I-131 therapeutic scintigraphy showed highest positive rate at postoperative preablation follow-up study in differentiated thyroid cancer patients. T1-201 scintigraphy may be useful in postablation studies, and the use of the combined modalities(T1-201 and Tg levels) provides a higher diagnostic yield.