• 생약학회지
• /
• 제51권4호
• /
• pp.238-243
• /
• 2020

Perilla frutescens Britton var. acuta Kudo, an annual plant primarily cultivated in China, Japan, and Korea, has been used as a traditional medicine to treat inflammatory diseases, depression, and many anxiety-related disorders. Previously, we reported the inhibitory effects of n-hexane layer of P. frutescens var. acuta extract against beta-amyloid (Aβ) aggregation, and the isolation of asarone derivatives as active constituents from n-hexane layer. In this study, dichloromethane layer of P. frutescens var. acuta was applied to bioassay-guided isolation methods accompanied with Thioflavin T (Th T) fluorescence assay to investigate the inhibitory effect on Aβ aggregation and disaggregation. As the results, three triterpenoids including ursolic acid (1), tormentic acid (2) and corosolic acid (3) were isolated. All compounds reduced Aβ aggregation and increased disaggregation of preformed Aβ aggregates in a dose-dependent manner. However, the inhibitory effect of three compounds on Aβ aggregation was not correlated with antioxidant activity, which was measured by DPPH assay. Taken together, these results suggest that the triterpenoid derivatives from P. frutescens have the potential to be developed as good therapeutics or preventatives for AD.

• 자원ㆍ환경경제연구
• /
• 제31권4호
• /
• pp.849-864
• /
• 2022

본 연구는 에너지 및 환경경제학에서 기초 데이터로 많이 활용되는 산업연관표에서 특정 부문이 하부 부문들로 분리되는 경우 새로운 산업연관표를 추계하는 과정을 제시하였다. 보편적으로 산업연관표 추계에 이용되는 RAS 방법은 새로운 산업연관표의 부문별 생산액, 중간투입계, 중간수요계의 정보를 반드시 필요로 하지만, 많은 경우에 부문별 중간수요계 정보를 확보하기 어렵다는 문제가 있다. 본 연구는 특정 부문이 하부 부문들로 분리되는 상황에서 부문별 중간수요계 정보를 사용하지 않고도 새로운 산업연관표를 추계할 수 있는 과정을 제시하였다. 핵심 아이디어는 분리 후 산업연관표의 많은 원소들의 값이 분리 전 산업연관표의 원소들 값과 같다는 점과 분리 후 부문들의 원소 합이 분리 전 부문의 원소 값과 같다는 점이다. 중간수요계 정보 대신에 이들 정보를 이용해서 부문 분리 후의 산업연관표에 대한 중간거래행렬이나 투입계수행렬을 추계하는 과정을 제시하였다. 소규모 시뮬레이션 결과, 본 연구가 제시한 과정은 투입계수행렬의 경우 평균 약 11.23%의 추정 오차를 가지며 이것은 중간수요계 정보를 활용하는 RAS의 11.30%의 평균 추정 오차보다 작은 것으로 나타났다. 그러나 여러 선행연구들에서 추가 정보를 활용하는 것이 활용하지 않는 것보다 추정 성과를 항상 향상시키지 않는 것으로 나타났기 때문에, 본 연구의 방법을 현실에 적용하기 위해서는 다양한 시뮬레이션 연구가 필요하다고 판단된다.

• 한국수자원학회:학술대회논문집
• /
• 한국수자원학회 1991년도 수공학논총 제33권
• /
• pp.114-118
• /
• 1991

• 물과 미래
• /
• 제20권2호
• /
• pp.107-116
• /
• 1987

수자원 시스템의 합리적인 분석, 개발계획과 운영 및 설계를 위하여 필요한 자료를 얻기 위한 추계학적 모형이 계속 개발되어지고 있다. 본연구에서는 한강수계의 과거자료를 이요하여 다지점 AR(1) 모형으로서 연유량을 모의발생시킨후, 장기간, 단기간, 통계적 특성치를 잘 보존하는 분해 모형을 통해 월유량을 발생시켰다. 모의 발생된 자료를 이용하여 모형의 적합도 검정, 통계학적 분석을 실시한 결과 사용된 모형이 국내유역에서의 적용가능성이 검증되었다.

• Korea-Australia Rheology Journal
• /
• 제16권3호
• /
• pp.129-134
• /
• 2004

The aggregation characteristics of red blood cells (RBCs) were measured using a newly developed light-transmission slit rheometer. Conventional methods of RBC disaggregation such as the rotational Couette system were replaced with a pressure-driven slit flow system with a vibrational mechanism. Using a vibration generator, one can disaggregate the RBC aggregates stored in the slit. While shear stress decreases exponentially, instantaneous pressure and the transmitted light intensity were measured over time. Applying an abrupt shearing flow after disaggregation caused a rapid elongation of the RBCs followed by loss of elongation with the decreasing shear stress. While the shear stress is further decreasing, the RBCs start to re-aggregate and the corresponding transmitted intensity increases with time, from which the aggregation indices can be obtained using a curve-fitting program.

• Journal of Electrical Engineering and Technology
• /
• 제8권3호
• /
• pp.572-580
• /
• 2013

Power metering and monitoring system is a basic element of Smart Grid technology. This paper proposes a new Non-Intrusive Load Monitoring (NILM) method for a residential buildings sector using the measured total active power consumption. Home electrical appliances are classified by ON/OFF state models, Multi-state models, and Composite models according to their operational characteristics observed by experiments. In order to disaggregate the operation and the power consumption of each model, an algorithm which includes a switching function, a truth table matrix, and a matching process is presented. Typical profiles of each appliances and disaggregation results are shown and classified. To improve the accuracy, a Time Lagging (TL) algorithm and a Permanent-On model (PO) algorithm are additionally proposed. The method is validated as comparing the simulation results to the experimental ones with high accuracy.

• EDISON SW 활용 경진대회 논문집
• /
• 제5회(2016년)
• /
• pp.55-61
• /
• 2016

$A{\beta}_{40}$ peptides form oligomers that later aggregate into a plaque, which is deemed to be a leading cause of Alzheimer's Disease. Its non-crystalline morphology has limited an understanding of comprehensive structural study. In this research, computational biomolecular simulations were performed in the following order: solvent and ion addition in a box, energy minimization of protein, equilibration, and periodic boundary condition disaggregation of a monomer from fibril. The result founded the two-fold model is 25% more stable in the simulation environment, and the steric zippers held on most tightly until 220 ps of simulation. The study supports the previous findings that two-fold aggregate $A{\beta}_{40}$ is more stable at 310 K and discusses further how much contribution steric-zipper and hydrogen bonding are making.

• 대한토목학회논문집
• /
• 제33권4호
• /
• pp.1651-1664
• /
• 2013

도로포장의 파손과정에는 다양하고 복합적인 원인에서 비롯되는 불확실성이 포함되어 있어 정확한 해석이 쉽지 않다. 이로 인해 최근에는 결정론적 모형보다는 확률이론이 보다 많이 활용되고 있으나, 파손의 전체적 특성만을 설명하는 일반적인 분석방안으로는 포장파손특성의 변화과정에 대해 구체적인 정보를 제공하기 어렵다. 이에 본 연구에서는 포장파손과정을 상태와 시간기준으로 분해함으로써 지역적으로 이질성을 띄는 포장파손속도와 그 분산에 대해 구체적으로 파악하고자 하였다. 또한, 분해된 확률과정을 다시 조합하는 과정을 통해 포장의 기대수명과 불확실성을 예측해 보았다. 실증분석을 위해 일반국도포장관리시스템에서 2003년부터 2010년까지 수집된 균열률 자료를 활용하였다. 이러한 시도들은 자산관리의 주요기법 중 하나인 생애주기비용분석의 신뢰성을 높일 수 있으며, 파손속도의 변화과정에 대한 이해가 필수적인 예방적 유지보수전략에 관한 기반연구로써도 중요한 의의가 있다.

• Structural Engineering and Mechanics
• /
• 제61권4호
• /
• pp.527-538
• /
• 2017

The evaluation of the loss-of-support conditions of frictional beam-to-column connections using simplified numerical models describing the transverse response of a portal-like structure is presented in this paper considering the effects of the seismic-hazard disaggregation. Real earthquake time histories selected from European Strong-motion Database (ESD) are used to show the effects of the seismic-hazard disaggregation on the beam loss-of-support conditions. Seismic events are classified according to different values of magnitudes, epicentral distances and soil conditions (stiff or soft soil) highlighting the importance of considering the characteristics of the seismic input in the assessment of the loss-of-support conditions of frictional beam-to-column connections. A rigid and an elastic model of a frame of a precast industrial building (2-DoF portal-like model) are presented and adopted to find the minimum required friction coefficient to avoid sliding. Then, the mean value of the minimum required friction coefficient with an epicentral distance bin of 10 km is calculated and fitted with a linear function depending on the logarithm of the epicentral distance. A complete parametric analysis varying the horizontal and vertical period of vibration of the structure is performed. Results show that the loss-of-support condition is strongly influenced by magnitude, epicentral distance and soil conditions determining the frequency content of the earthquake time histories and the correlation between the maxima of the horizontal and vertical components. Moreover, as expected, dynamic characteristics of the structure have also a strong influence. Finally, the effect of the column nonlinear behavior (i.e. formation of plastic hinges at the base) is analyzed showing that the connection and the column are a series system where the maximum force is limited by the element having the minimum strength. Two different longitudinal reinforcement ratios are analyzed demonstrating that the column strength variation changes the system response.

• Korea-Australia Rheology Journal
• /
• 제17권1호
• /
• pp.9-13
• /
• 2005

The aggregation of red blood cells (RBCs) is a major determinant of blood flow resistance passing through various veins. Available techniques for measuring RBC aggregation often require pretreating and washing after each measurement, which is not optimal for day-to-day clinical use. A laser reflection technique has been combined with a vibration-aided disaggregation mechanism, which shows significant advances in aggregometer design, operation and data analysis. The essential features of this design are in its simplicity and a disposable element that is in contact with the blood sample. Using extremely small quantities of blood, the RBCs subjected to vibrations can be quickly and completely disaggregated. This is followed by measuring the backscattered light intensity. The measurements with the present sensor were compared with those of a commercial aggregometer and a strong correlation was found between them. The newly-developed optical aggregometer can measure the RBC aggregability difference between young and old cell suspension with ease and accuracy.