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Orthogonal Stimulus-Response as a Tool to Formulate Traditional Chinese Medicinal Herbal Combination - New Scientific-Based TCM Herbal Formulating Method -

  • Loh, Yean Chun;Tan, Chu Shan;Yam, Mun Fei;Oo, Chuan Wei;Omar, Wan Maznah Wan
    • Journal of Pharmacopuncture
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    • v.21 no.3
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    • pp.203-206
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    • 2018
  • Objectives: There is an increasing number of complex diseases that are progressively more difficult to be controlled using the conventional "single compound, single target" approach as demonstrated in our current modern drug development. TCM might be the new cornerstone of treatment alternative when the current treatment option is no longer as effective or that we have exhausted it as an option. Orthogonal stimulus-response compatibility group study is one of the most frequently employed formulas to produce optimal herbal combination for treatment of multi-syndromic diseases. This approach could solve the relatively low efficacy single drug therapy usage and chronic adverse effects caused by long terms administration of drugs that has been reported in the field of pharmacology and medicine Methods: The present review was based on the Science Direct database search for those related to the TCM and the development of antihypertensive TCM herbal combination using orthogonal stimulus-response compatibility group studies approach. Results: Recent studies have demonstrated that the orthogonal stimulus-response compatibility group study approach was most frequently used to formulate TCM herbal combination based on the TCM principles upon the selection of herbs, and the resulting formulated TCM formula exhibited desired outcomes in treating one of global concerned complex multi-syndromic diseases, the hypertension. These promising therapeutic effects were claimed to have been attributed by the holistic signaling mechanism pathways employed by the crude combination of herbs. Conclusion: The present review could serve as a guide and prove the feasibility of TCM principles to be used for future pharmacological drug research development.

Systematic review on the DongUiBoGam in the Korean Medicine Journal (국내 한의학 학술지에 발표된 동의보감 연구 현황 조사)

  • Han, Chang-hyun;Park, Sang-young;Kwon, Oh-min;Ahn, Sang-young;Ahn, Sang-woo
    • The Journal of Korean Medical History
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    • v.22 no.2
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    • pp.7-13
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    • 2009
  • Background : To understand Korean medicine it is crucial to first understand medical aspect of 'DongUiBoGam'. It is also meaningful that it became one of the influential book even to posterity. Also based on the apprehension, we can take a view of development of Korean medicine led by 'DongUiBoGam'. Objectives : This study aims to review the status, study field, specialist of DongUiBoGam. In the process, this review will grasp trends in this field of studies and will direct further researches into the right direction. Method : The computerized Korean databases were searched from their respective inceptions up to December 2008. The search terms used were 'DongUiBoGam' and random or Korean language terms related to DongUiBoGam. Several specialized journals were also manually searched for relevant articles. Result : Since the 2000s, DongUiBoGam papers in the Korean Literature is increased. Published 58 papers on The Korean Journal of Oriental Medical Prescription were more than the other journals. 58 papers published in The Korean Journal of Oriental Medical Prescription are the best in many areas related to Korean medicine. Most people have submitted papers related to DongUiBoGam was Woo-yeal Jeong. Conclusions : 'DongUiBoGam' research is conducted and current tendency and outlook for 'DongUiBoGam' is carried out focusing on several associations.

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Development of Monte Carlo Simulation Code for the Dose Calculation of the Stereotactic Radiosurgery (뇌 정위 방사선수술의 선량 계산을 위한 몬테카를로 시뮬레이션 코드 개발)

  • Kang, Jeongku;Lee, Dong Joon
    • Progress in Medical Physics
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    • v.23 no.4
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    • pp.303-308
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    • 2012
  • The Geant4 based Monte Carlo code for the application of stereotactic radiosurgery was developed. The probability density function and cumulative density function to determine the incident photon energy were calculated from pre-calculated energy spectrum for the linac by multiplying the weighting factors corresponding to the energy bins. The messenger class to transfer the various MLC fields generated by the planning system was used. The rotation matrix of rotateX and rotateY were used for simulating gantry and table rotation respectively. We construct accelerator world and phantom world in the main world coordinate to rotate accelerator and phantom world independently. We used dicomHandler class object to convert from the dicom binary file to the text file which contains the matrix number, pixel size, pixel's HU, bit size, padding value and high bits order. We reconstruct this class object to work fine. We also reconstruct the PrimaryGeneratorAction class to speed up the calculation time. because of the huge calculation time we discard search process of the ThitsMap and used direct access method from the first to the last element to produce the result files.

Design of DRM System in P2P Network Environment (P2P네트워크 환경을 위한 DRM 시스템 설계)

  • Lee Jeong-Gi;Kim Kuk-Se;Lee Gwang;Ahn Seong-Soo;Lee Joon
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2006.05a
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    • pp.829-832
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    • 2006
  • The word P2P implies significant changes in current business dynamics. The P2P service enables individuals to be connected to the Internet for the direct provision of information and even downloads from one another without the conventional method of passing through search engines. This can be utilized to extend the path of retrieving information from limited web sites to personal and enterprise databases. That is, it is now possible for individuals to manage their own information on a national or global scope, share various information with other members, form communities of users interested in sharing homogeneous information, and utilize remote conference and remote education using groupware.

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Effectiveness of Arch Support Taping is Subjects With Excessive Foot Pronation: A Meta-analysis

  • Park, So-yeon
    • Physical Therapy Korea
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    • v.26 no.4
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    • pp.70-76
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    • 2019
  • Background: An excessive pronated foot is defined as a flattening or complete loss of the medial longitudinal arch. Excessive foot pronation is considered to have high risk factors of overuse injuries in the lower limb. Various treatments have been investigated in attempts to control excessive pronation. Objects: This meta-analysis identifies the effects of an anti-pronation taping technique using different materials. Methods: The electronic databases used include MEDLINE, the Physiotherapy Evidence Database (PEDro), Science Direct, the Korean Studies Information Service System (KISS), the Research Information Sharing Service (RISS), the Korea National Library, and the Korean Medical Database (studies published up to July 31, 2019). The database search used the following keywords: "foot drop" OR "foot arch" OR "foot pronation" OR "flat foot (pes planus)" AND "taping" OR "support." Eight eligible studies were analyzed to determine the effectiveness of anti-pronation taping in study and control groups. Results: The overall random effect size (Hedges'g) of the anti-pronation taping technique was 0.147 (95% confidence interval [CI]: -.214 to .509). When the effect (Hedges' g) was compared by the type of tape material, rigid tape (RT; Lowdye taping) was .213 (95% CI: -.278 to .704) and kinesiotape (KT; arch support taping) was -.014 (95% CI: -.270 to .242). Based on this meta-analysis, it was not possible to identify the extent to which anti-pronation taping was effective in preventing navicular drop, improving balance, or changing foot pressure. Only three of the eight eligible studies applied KT on excessive pronated feet, and the outcome measure areas were different to those of the RT studies. The KT studies used EMG data, overall foot posture index (FPI) scores, and rear foot FPI scores. In contrast, the RT studies measured navicular heights, various foot angles, and foot pressure. Conclusion: This review could not find any conclusive evidence about the effectiveness of any taping method for patients with pronated feet. Future studies are needed to develop the anti-pronation taping technique based on the clinical scientific evidence.

The Effects of Motor-cognitive Dual Task on Cognitive Function of Elderly with Cognitive Disorders: Systematic Review of Randomized Controlled Trials (운동-인지 이중과제가 인지장애를 가진 노인의 인지기능에 미치는 영향: 무작위 실험연구에 대한 체계적 고찰)

  • Shin, Su-Jung;Park, Kyoung-Young
    • Journal of Convergence for Information Technology
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    • v.10 no.12
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    • pp.216-225
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    • 2020
  • This study was conducted to qualitatively analyze the selected research through a systematic review to find out application method, outcome measures, and intervention effects of dual task. We searched for published studies from January 2010 to December 2019. Electrical database were PubMed and ProQuest. Search terms were 'dual task' OR 'multi modal' AND 'mild cognitive impairment' OR 'dementia' OR 'Alzheimer's disease'AND 'intervention' OR 'rehabilitation. There were 8 studies selected finally. The dual task was applied not as a single intervention but as a combined intervention with other exercises. The contents of dual task were consisted of motor and cognitive tasks to be independent each other. The outcome measures included general cognitive function such as MMSE and CERAD, executive function, and memory. Additionally the dual task cost was also used to identify the direct improvement of the dual task. This study could provide informations of dual task application on elderly with cognitive impairment.

Effect of Complementary Medicine on Pain Relief and Wound Healing after Cesarean Section: A Systematic Review

  • Niazi, Azin;Moradi, Maryam;Askari, Vahid Reza;Sharifi, Neda
    • Journal of Pharmacopuncture
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    • v.24 no.2
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    • pp.41-53
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    • 2021
  • Objectives: Cesarean sections are one of the common surgical procedures around the world. Management of cesarean section side effects, including pain, hematoma, delayed wound healing, is of particular importance in maintaining maternal health and ability to care for the baby. The tendency to use complementary medicine strategies is on the rise because of the easy treatment with low side effects. The purpose of this study was to systematically review the efficacy and safety of clinical trials performed in Iran and worldwide on the effect of complementary medicine on pain relief and wound healing after cesarean section. Methods: PRISMA checklist was followed to prepare the report of this systematic review. The search process was carried out on databases on databases of Magiran, SID, Iran Medex, Scopus, Pub Med, Science direct, Medline and Cochrane library using keywords of cesarean, pain, wound healing, Herbal medicine, acupressure, massage, complementary medicine and their Persian equivalent and all possible combinations, from inception until February 2020. We used the Jadad scale to assess the quality of the searched articles. According to the Jadad scale, the articles with a score of at least 3 were included in the study. Results: Finally, 28 clinical trials (with a sample size of 3,245) scored at least 3 on the Jadad scale were included into the analysis. This article reviewed 13 articles on medicinal herbs, 4 articles on massage, 1 article on reflexology, 2 articles on acupressure. Conclusion: According to the present review, the use of medicinal herbs was the most common method of complementary medicine in pain relief and wound healing after cesarean section.

Systematic Literature Review on Coronavirus Infectious Disease-19 and Dental Masks

  • Kim, Ji-Hyun;Kim, Min-Young
    • Journal of dental hygiene science
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    • v.21 no.1
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    • pp.1-7
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    • 2021
  • Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted primarily through droplets, and dental practitioners are at risk of occupational exposure to SARS-CoV-2 infection owing to direct contact with the patient's mouth, aerosols from dental procedures, and saliva. Wearing a mask is believed to be the best method of protection against infection, and a systematic literature review was conducted on whether the dental masks used in dentistry are effective in preventing Coronavirus Infectious Disease-19 (COVID-19). Methods: We used PubMed, Google Scholar, DBpia, NDSL, and KISS databases for this study. Of the 917 documents narrowed down by the search terms "Coronavirus, COVID-19, and dental," 83 documents were collected and studied. Ultimately, 42 of these papers were selected for analysis after considering duplication from the flow chart of the literature selection process. Results: While dental masks are often used when treating patients with unknown COVID-19 status, the Ministry of Food and Drug Safety stated that the use of dental masks is insufficient in preventing cross-transmission of COVID-19; instead, it was recommended that N95 masks, which correspond to KF94 masks, should be worn daily. On the other hand, wearing a dental mask and following precautions such as hand hygiene may not pose a significantly higher risk of infection than wearing an N95 mask when treating COVID-19 patients. Conclusion: There is an ongoing discussion regarding the use of dental masks when treating dental patients, and many argue that different types of masks should be selected according to the degree of infection and the individual's respiratory condition. By considering the safety and efficacy of dental masks in preventing infection, improvements can be made in the management of COVID-19 and dental-related infections.

Reviews Analysis of Korean Clinics Using LDA Topic Modeling (토픽 모델링을 활용한 한의원 리뷰 분석과 마케팅 제언)

  • Kim, Cho-Myong;Jo, A-Ram;Kim, Yang-Kyun
    • The Journal of Korean Medicine
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    • v.43 no.1
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    • pp.73-86
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    • 2022
  • Objectives: In the health care industry, the influence of online reviews is growing. As medical services are provided mainly by providers, those services have been managed by hospitals and clinics. However, direct promotions of medical services by providers are legally forbidden. Due to this reason, consumers, like patients and clients, search a lot of reviews on the Internet to get any information about hospitals, treatments, prices, etc. It can be determined that online reviews indicate the quality of hospitals, and that analysis should be done for sustainable hospital marketing. Method: Using a Python-based crawler, we collected reviews, written by real patients, who had experienced Korean medicine, about more than 14,000 reviews. To extract the most representative words, reviews were divided by positive and negative; after that reviews were pre-processed to get only nouns and adjectives to get TF(Term Frequency), DF(Document Frequency), and TF-IDF(Term Frequency - Inverse Document Frequency). Finally, to get some topics about reviews, aggregations of extracted words were analyzed by using LDA(Latent Dirichlet Allocation) methods. To avoid overlap, the number of topics is set by Davis visualization. Results and Conclusions: 6 and 3 topics extracted in each positive/negative review, analyzed by LDA Topic Model. The main factors, consisting of topics were 1) Response to patients and customers. 2) Customized treatment (consultation) and management. 3) Hospital/Clinic's environments.

Prevalence of Workplace Microaggressions and Racial Discrimination: A Systematic Review and Meta-analysis

  • Nader Salari;Ahoura Fattah;Amin Hosseinian-Far;Mojdeh Larti;Sina Sharifi;Masoud Mohammadi
    • Safety and Health at Work
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    • v.15 no.3
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    • pp.245-254
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    • 2024
  • Background: In recent years, the rise of workplace racial discrimination and microaggressions has decreased the efficiency and productivity of organizations and institutions, and realization of organizational goals globally. Accordingly, it was decided to conduct a systematic review and meta-analysis in the present study with the aim of investigating the prevalence of microaggression and racial discrimination in the workplace. Methods: The PubMed, Scopus, Web of Science, ScienceDirect and Google Scholar databases were systematically searched for studies that had reported the effects of work stress among managers. The search did include a lower time limit and was conducted in June 2023. The heterogeneity of the studies was investigated using the I2 index, and accordingly random effects method was adopted for meta-analysis. Data analysis was conducted with the Comprehensive Meta-Analysis (v.2) software. Results: In the review of seven studies with a sample size of 2998 people, the overall prevalence of microaggression and racial discrimination in the workplace was found to be 73.6% and 18.8%, respectively. Publication bias within the selected studies was examined with the Egger's test, which indicated the absence of publication bias for the pooled prevalence of workplace microaggression (p: 0.264) and for the pooled prevalence of workplace racial discrimination (p: 0.061). Conclusion: The results obtained from this report indicate the high impact of micro-aggression and racial discrimination in the workplace. Considering the negative effects of such behaviours, the findings from this study will be helpful to managers and health policymakers.

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