• Proceedings of the Korean Society of Applied Pharmacology
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• 2001.11a
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• pp.80-80
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• 2001

The roots of Scutellaria baicalensis Georgi have been used in the chinese medicine for the treatment of inflammation, fever and headache. Recent studies had shown that baicalin and baicalein showed a detoxifying effect and could inhibit peripheral capillary permeability, and Wogonin was found to inhibit the proliferation of tumor cells. Wogonin has been synthesized as shown in schem. Compound 2 was prepared from 2,6-dimethoxy-1,4-benzoquinone(1) followed by acylation to give compound 3. The base treatment of 3 gave cyclized product which was carried by deprotection of methyl group chemoselectively. Overall step included relatively simple ten steps.

• YAKHAK HOEJI
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• v.30 no.6
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• pp.329-333
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• 1986

6-[3-(Hydroxymethyl)-2, 3-epoxybutyl]-3, 5-dimethoxyphenol was synthesized by means of the eight steps, such as allylether, Claissen rearrangement, tosylation, oxidation, Wittig reaction, reduction and epoxidation from 3, 5-dimethoxyphenol. The epoxidation of 6-[3- (hydroxymethyl)-2-butenyl]-3,5-dimethoxy phenol using the L-(+)-diethyltartrate(DET), titanium (IV) isopropoxide Ti[(O-iPr)$_4$] and t-butylhydroperoxide(TBHP) is described.

• Journal of the Korean Wood Science and Technology
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• v.29 no.3
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• pp.99-103
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• 2001

Three flavan-3,4-diol derivatives were isolated from the heartwood of Robinia pseudoacacia and characterized by spectroscopic methods including $^1H$ and $^{13}C$ NMR and positive FAB-MS. The structures were identified as 4,4'-dimethoxy-, 4-ethoxy- and 4-ethoxy-4'-methoxy-2,3-trans-3,4-cis-(+)-leucorobinetinidin.

• Archives of Pharmacal Research
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• v.6 no.2
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• pp.133-136
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• 1983

From ether-soluble neutral fraction of the whole plant of Peperomia pellucida (L) HBK (Piperaceae), 4, 7-dimethoxy-5-(2-propenyl)-1, 3-benzodioxole or apiol, in a liquid state, 2, 4, 5-trime-thoxy styrene, mp 138.deg. and three phytosterols, campesterol, stigmasterol and .betha.-sitosterol, were isolated and characterized by spectral data.

• Bulletin of the Korean Chemical Society
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• v.29 no.12
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• pp.2533-2536
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• 2008

• Bulletin of the Korean Chemical Society
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• v.29 no.9
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• pp.1689-1694
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• 2008

• YAKHAK HOEJI
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• v.43 no.1
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• pp.11-15
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• 1999

A brief route for regiospecific synthesis of novel 10-Oxodaunomycinone Derivatives (10a, b) is described. Dimethoxy-l-tetralone 4 was converted to acetyl tetralone (5a, b) which was oxidized with oxygen to obtain cis-diol compound (8a, b). The construction of (10a, b) was completed by the condensation of phthaloyl dichloride 9 with cis-diol (8a, b)

• Bulletin of the Korean Chemical Society
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• v.13 no.5
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• pp.547-550
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• 1992

The oxidation of benzaldehyde, 3,4-dimethoxy benzaldehyde, p-methoxy benzaldehyde, m-$NO_2$-benzaldehyde, and m-chlorobenzaldehyde by pyridinium chlorochromate (Corey's reagent) are reported. Michaelis-Menten behaviour is observed. The rate determining step appears to be the decomposition of a complex of benzaldehyde with PCC either through a loss of $H^+$ or $H^-$ ions.

• Archives of Pharmacal Research
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• v.23 no.1
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• pp.22-25
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• 2000

Formation of glutathione (GSH) conjugates with 2- or 6-(1-hydroxymethyl)- and 2-(1-hydroxyethyl)-DMNQ derivatives (DMNQ, 5,8-dimethoxy-1,4-naphthoquone was carried out in phosphate buffer (pH 7.4), in the presence of glutathione-S-transferase (GST), in rat liver S-9 fraction and by perfusion, and the rates of conjugates formation were compared and correlated to cytotoxicity. The GSH conjugates of 6-(1-hydroxyalkyl)-DMNQ derivatives were formed faster than 2-(1-hydroxyalkyl)-DMNQ derivatives under all of the media, implying that steric hindrance was the cause of lowering the rate of conjugate formation of 2-substituted derivatives. For both isomers, addition of GST did not improve the reaction rate, compared with that in buffer, while the reaction in the S-9 fraction and the perfusate was accelerated to a great extent. The catalytic effect of the S-9 fraction and the perfusate contain an effective system relaxing the steric hindrance of 2-(1-hydroxyalkyl)-DMNQ derivatives. Furthermore, a good correlation between the formation of the GSH conjugates and the cytotoxic activity of both naphthazarin isomers suggests that the steric hindrance is a cause of lowering the cytotoxicity of 2-isomers.

• Journal of the Korean Wood Science and Technology
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• v.34 no.3
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• pp.64-72
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• 2006

Two compounds were isolated from the diethylether and ethyl acetate fraction of hot water extracts by TLC and column chromatography as dyeing components. The isolated compounds were characterized as H-dibenzoquinoline-2,10-diol,5,6,6a,7-tetrahydro-1,9-dimethoxy-6-methyl (compoundI) and lyoniresinol (compoundII) by NMR and Mass spectrophotometry. To investigate if the isolated compounds are involved in the dyeing process, HPLC analysis was used. The retention time of the components from dye used in the study and the dye decolorized from the dyed substrate, silk by ethyl acetate were compared to conform the identity of those compounds. The retention time of the components from the dye and decolorized solution were identical. As a results, those two compounds were considered as dye bound to the silk.