• Journal of Korean Neurosurgical Society
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• v.54 no.6
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• pp.467-476
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• 2013

Objective : This study aimed to evaluate the hypotheses that administration routes [intra-arterial (IA) vs. intravenous (IV)] affect the early stage migration of transplanted human bone marrow-derived mesenchymal stem cells (hBM-MSCs) in acute brain infarction. Methods : Male Sprague-Dawley rats (n=40) were subjected to photothrombotic infarction. Three days after photothrombotic infarction, rats were randomly allocated to one of four experimental groups [IA group : n=12, IV group : n=12, superparamagnetic iron oxide (SPIO) group : n=8, control group : n=8]. All groups were subdivided into 1, 6, 24, and 48 hours groups according to time point of sacrifice. Magnetic resonance imaging (MRI) consisting of T2 weighted image (T2WI), $T2^*$ weighted image ($T2^*WI$), susceptibility weighted image (SWI), and diffusion weighted image of rat brain were obtained prior to and at 1, 6, 24, and 48 hours post-implantation. After final MRI, rats were sacrificed and grafted cells were analyzed in brain and lung specimen using Prussian blue and immunohistochemical staining. Results : Grafted cells appeared as dark signal intensity regions at the peri-lesional zone. In IA group, dark signals in peri-lesional zone were more prominent compared with IV group. SWI showed largest dark signal followed by $T2^*WI$ and T2WI in both IA and IV groups. On Prussian blue staining, IA administration showed substantially increased migration and a large number of transplanted hBM-MSCs in the target brain than IV administration. The Prussian blue-positive cells were not detected in SPIO and control groups. Conclusion : In a rat photothrombotic model of ischemic stroke, selective IA administration of human mesenchymal stem cells is more effective than IV administration. MRI and histological analyses revealed the time course of cell migration, and the numbers and distribution of hBM-MSCs delivered into the brain.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.11
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• pp.181-188
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• 2019

The migration path of a multiple-generation technology that occurs during a technological substitution by a new technology is important to understanding the phenomenon of technological substitution, and can contribute to understanding the process of technological innovation. This research defines the concept of migration path and develops a model of the types of migration paths by multiple dimensions (actor, generation, and time) in a multiple-generation technology. Based on a literature review and tracking of migration paths according to multiple dimensions, the definitions and types of migration paths were provided, and the accuracy of the model was verified based on a case study of the semiconductor industry. The migration paths of suppliers are modeled with three types (switching, leapfrogging, and new entrance paths), and the migration paths of customers are modeled with four types (switching, leapfrogging, new entrance, and diffusion paths) in a multiple-generation technology. This research will be useful for understanding the migration paths in the phenomenon of technological substitution, and can be applied to other industries in addition to the semiconductor industry, including various actors. In addition, suppliers and customers can understand technological substitution and can establish a technology strategy against their competitors.

• Journal of Korea Technology Innovation Society
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• v.10 no.3
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• pp.383-405
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• 2007

In this paper we estimate knowledge production function for 15 South Korean industry sectors using panel data. To accommodate the influence of inter-sectoral interactions on the creation of knowledge, we estimate parameters for related knowledge production functions using the Dynamic Seemingly Unrelated Regression(DSUR) model proposed by Mark et al. (2005). We find the elasticity of knowledge production with respect to the size of research staff to be 0.25 and that with respect to the existing stock of knowledge to be 0.35. The fact that the elasticity of new knowledge creation with regard to the existing knowledge stock is below 1 in South Korea corroborates the view that the rate of long-term growth of her economy is chiefly determined by the elasticity related to production functions of goods and services and the rate of population growth, and that her government policy, to ensure a continued growth for the Korean economy, must shift the focus of R&D policies from the current direct intervention-centered model to one consisting of indirect measures, namely supporting knowledge management and diffusion and the creation of a knowledge sharing system. In terms of R&D policy implications it could be consider that the national knowledge production system should strengthen the cumulative process of knowledge accumulation and population for research and development. Our country R&D policy, also, need to adopt a global approach to increase knowledge stock at the highest levels of a country.

• Journal of the Korean Society for Marine Environment & Energy
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• v.4 no.4
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• pp.3-11
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• 2001

To know the seawater infiltration into tidal flat sediment in coastal area is very important, because it is significantly correlated with the infiltration and transportation of pollutants in soil, the supply of dissolved oxygen, nutrients and organic matter to benthic organisms for survival of benthic organisms and the seawater purification. So, we set up purpose to clarify the infiltration behavior of seawater by wave action in tidal flat, to clear the effects of slope of tidal flat and breaking wave height on seawater infiltration and to quantify the infiltration volume of seawater. For purpose, the seawater infiltration was studied with visualization method by using coloring tracer and transparent glass beads replaced as natural sediment in model tidal flat. Specific conclusions derived from this study are as follows. The semi-circular type infiltration of seawater by wave action into saturated sediment was a new infiltration behavior that was not considered in previous studies. The infiltration rate of seawater was increased with increasing of breaking wave height and slope of tidal flat. However, the effects of the slope was bigger than that of breaking wave height on seawater infiltration into tidal flat sediments. It was possible to calculate the infiltration volume of seawater by wave action in natural tidal flat sediment and in fields. Therefore, we can point out that wave action play an important role in the supply of dissolved oxygen, nutrients and organic matter to benthic organisms, transportation or diffusion of pollutants and seawater purification. So, we hope to be studied the supply of food to benthic organism, pollutant transport and seawater purification on the base of these results.

• Journal of Korea Water Resources Association
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• v.47 no.8
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• pp.703-715
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• 2014

This study aims to investigating the effect of Schmidt number (${\sigma}_c$) on sediment suspension and hydrodynamics calculation. The range of ${\sigma}_c$ is also studied based on the flux Richardson number ($Ri_f$) and gradient Richardson number ($Ri_g$). Numerical experiments are carried out by 1 dimensional vertical model. Both cohesive and non-cohesive sediments are tested under the conditions of pure current and oscillatory flow. The turbulence damping effect due to sediment suspension is examined considering ${\sigma}_c$ as a constant for the damping effect. The results of this study show the consistent effect of ${\sigma}_c$ on sediment suspension regardless of hydrodynamic condition. It is also found that the model overestimates the flow velocity and turbulent kinetic energy when the damping effect is not considered. Under the conditions of $Ri_f$ and $Ri_g$ causing density stratification, it is known that the vertical mixing of sediment is reasonably calculated in the range of ${\sigma}_c$ from 0.3 to 0.5.

• Journal of Information Technology Applications and Management
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• v.20 no.1
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• pp.43-51
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• 2013

Human being does work to live out and they have their private life because human has sociality. Both work and life are important to live out but they are on the trade-off relationship. Because keeping the balance between work and life is too hard, it has been interested by academic and practical areas. Definition of Work-life balance here is that balance or imbalance arising between work and life has no negative impact on their daily life. Above all, Work-life balance is important because it is strongly related to identity. Recently, the introduction of the mobile office system has emerged as a way to solve the problem of work-life balance. It is based on the teleworking which was formerly generated. Teleworking is to perform the work in the employee's home or office space set aside without going into the workplace. Concept of the mobile office system here is not only using portable devices during work for convenience but also the system which is designed for the performance. Thanks to the diffusion of smart devices(smart phone, tablet pc), mobile office system has been spread. Although the importance of mobile office systems is emerging, there are few researches about it. Even they mostly focus on the standpoint of performance of mobile office system. However, Quality of life is as important as the performance. As a part of Quality of Life field, Work-life balance is the closest to employee's quality of life. So this study aims to examine the effect of the use of mobile office systems on work-life balance. To do so, we try to find factors effecting Work-life balance from existing studies and then set a research model. We set the use of mobile office systems as independent variables which are divided by use of function, use by location and use by situation. There are four dependent variables - sense of self command, sense of balance, solving work problem, solving life problem. We collected data from employees who are using mobile office systems on their job. 215 people were participated in the survey and we used multiple regression analysis to verify our research model. Results show that every independent variable has no impact on solving work problem while they have slight impact on the other dependent variables. Especially use on the business trip has significant effect on dependent variables. It means that there is a possibility use of mobile office system could control the employee's quality of life and system should be evolved until it covers even critical tasks. Also, support for mobile office system -education, encouragement-should be provided. By mobile office system is maturing, future research would be done.

• Journal of Animal Environmental Science
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• v.14 no.1
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• pp.61-68
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• 2008

The roof structural model of liquid manure storage tank was designed to improve a structural safety and an ability of resistance to corrosion by the bad environmental condition with high humidity and high gas concentration. Due to corrosion of a general steel, the 5 years used materials were reduced to one-third of a new material in the result of a bending strength test. Some structural materials were tested to evaluate a strength and an anti-corrosion, and stainless steel pipe (STS439), steel angle with zinc hot dipping, rectangular steel pipe covered with FRP (Fiberglass Reinforced Plastics) resin were selected finally. A stainless steel is more expansive about $3{\sim}5$ times than general structural steel. But its durability under heavy corrosive environment is expected twice as long as general steel. The roof models were designed as closed cone type for each of the three structural materials. In the result of a FEM (Finite Element Method) structural analysis for the developed models, the safe snow depth was higher 2.3 times than a general roof structure, when elements of equal section modulus were used.

• Journal of Biosystems Engineering
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• v.42 no.4
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• pp.314-322
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• 2017

Purpose: This study was conducted to investigate the hot air drying characteristics of squash slices depending on the drying conditions (input air velocity, input air temperature, and sample thickness). Methods: The developed drying system was equipped with a controllable air blower and electric finned heater, drying chamber, and ventilation fan. Squash (summer squash called Korean zucchini) samples were cut into slices of two different thicknesses (5 and 10 mm). These were then dried at two different input air temperatures (60 and $70^{\circ}C$) and air velocities (5 and 7 m/s). Six well-known drying models were tested to describe the experimental drying data. A non-linear regression analysis was applied to determine model constants and statistical indices such as the coefficient of determination ($R^2$), reduced chi-square (${\chi}^2$), and root mean square error (RMSE). In addition, the effective moisture diffusivity ($D_{eff}$) was estimated based on the curve of ln(MR) versus drying time. Results: The results clearly showed that drying time decreased with an increase in input air temperature. Slice thickness also affected the drying time. Air velocity had a greater influence on drying time at $70^{\circ}C$ than at $60^{\circ}C$ for both thicknesses. All drying models accurately described the drying curve of squash slices regardless of slice thickness and drying conditions; the Modified Henderson and Pabis model had the best performance with the highest R2 and the lowest RMSE values. The effective moisture diffusivity ($D_{eff}$) changes, obtained from Fick's diffusion method, were between $1.67{\times}10^{-10}$ and $7.01{\times}10^{-10}m^2/s$. The moisture diffusivity was increased with an increase in input air temperature, velocity, and thickness. Conclusions: The drying time of squash slices varied depending on input temperature, velocity, and thickness of slices. The further study is necessary to figure out optimal drying condition for squash slices with retaining its original quality.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.4
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• pp.2876-2882
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• 2015

The object of this study is to identify changes in air pollution in the maximum ground level concentration and the surrounding area when air pollution control facilities are improved in the thermal power plants. The effects of improved facilities are analyzed by comparing air quality after applying improved air pollution control facilities. For prediction of air quality, the change of wind field can be represented with movement of Puff and CALPUFF Model, air pollution diffusion models which can implement abnormal conditions. Major air pollutants of thermal power plants such as $SO_2$, $NO_2$, and $PM_{10}$ are selected as prediction items. That results show that improvement of air pollution control facilities is significantly effective in reduction of air pollution of $SO_2$ and $NO_2$ in the maximum ground level concentration and areas around of thermal power plants. In the case of $PM_{10}$, it is found that the effect of reduction in pollution is high in the maximum ground level concentration, but the effect of reduction in air pollution is somewhat low in the area around of the thermal power plant.

• Journal of the Korea institute for structural maintenance and inspection
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• v.16 no.5
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• pp.112-120
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• 2012

A numerical model considering the internal vaporization and the creep effect, in the form of a analytical program, for tracing the behavior of high strength concrete(HSC) members exposed to fire is presented. The two stages, i.e., spalling procedure and fire resistance time, associated with the thermal, moisture flow, creep and structural analysis, for the prediction of fire resistance behavior are explained. The use of the analytical program for tracing the response of HSC member from the initial pre-loading stage to collapse, due to fire, is demonstrated. Moisture evaporates, when concrete is exposed to fire, not only at concrete surface but also at inside the concrete to adjust the equilibrium and transfer properties of moisture. Finite element method is employed to facilitate the moisture diffusion analysis for any position of member, so that the prediction method of the moisture distribution inside the concrete members at fire is developed. The validity of the numerical model used in this program is established by comparing the predictions from this program with results from others fire resistance tests. The analytical program can be used to predict the fire resistance of HSC members for any value of the significant parameters, such as load, sectional dimensions, member length, and concrete strength.