• 대한핵의학회지
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• 제22권1호
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• pp.39-45
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• 1988

To evaluate diagnostic accuracy of liver scintigraphy we analysed liver scans of 143 normal and 258 patients with various liver diseases. Three ROC curves for SOL, liver cirrhosis and diffuse liver disease were fitted using rating methods and areas under the ROC curves and their standard errors were calculated by the trapezoidal rule and the variance of the Wilcoxon statistic suggested by McNeil. We compared these results with that of National Institute of Radiological Science in Japan. 1) The sensitivity of liver scintigraphy was 74.2% in SOL, 71.8% in liver cirrhosis and 34.0% in diffuse liver disease. The specificity was 96.0% in SOL, 94.2% in liver cirrhosis and 87.6% in diffuse liver diasease. 2) ROC curves of SOL and liver cirrhosis approached the upper left-hand corner closer than that of diffuse liver disease. Area (${\pm}$ standard error). under the ROC curve was $0.868{\pm}0.024$ in SOL and $0.867{\pm}0.028$ in liver cirrhosis. These were significantly higher than $0.658{\pm}0.043$ in diffuse liver disease. 3) There was no interobserver difference in terms of ROC curves. But low sensitivty and high specificity of authors' SOL diagnosis suggested we used more strict decision threshold.

• 한국방사선학회논문지
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• 제9권4호
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• pp.227-234
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• 2015

본 연구는 간 초음파영상에서 통계적 속성 기반의 밝기 히스토그램에 기초한 픽셀 질감분석 파라미터(평균밝기, 왜곡도, 균일도, 엔트로피)와 간과 콩팥실질의 밝기 차를 이용한 영상분석을 통해 미만성 간질환의 컴퓨터보조진단 적용 가능성을 알아보고자 하였다. 실험은 간 초음파영상(정상, 지방간, 간경화)에서 관심영역($50{\times}50$픽셀)을 설정하고 4가지의 픽셀 질감분석 파라미터와 간과 콩팥의 실질 밝기의 차를 이용하여 질환인식률을 평가하였다. 그 결과 평균밝기, 균일도, 엔트로피의 질환인식률은 100%, 왜곡도 96%로 높게 나타났으며, 간과 콩팥의 실질 밝기 차는 정상 $-1.129{\pm}12.410$, 지방간 $33.182{\pm}11.826$으로 뚜렷한 차이를 나타내었으나, 간경화의 경우 $-1.668{\pm}10.081$로 정상과는 다소 작은 차이를 나타내었다. 이러한 결과를 바탕으로 높은 질환인식률을 보인 픽셀 질감분석 파라미터와 실질 밝기 차를 이용한 컴퓨터보조진단은 미만성 간질환의 감별에 유용한 도구로써 임상적인 활용 가능성이 있으며, 판독 오류를 최소화하고 정확한 진단과 치료방향 제시에 도움이 될 것으로 기대된다.

• 대한방사선기술학회지:방사선기술과학
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• 제42권5호
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• pp.345-350
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• 2019

Liver biopsy is the gold standard for diagnosing liver fibrosis, but it is invasive and has a risk for complications. For this reason, recently, study has been actively conducted on non-invasive liver fibrosis evaluation method. But, there is no established standard for the type of diffuse liver disease. Therefore, this study was suggest the usefulness and cut-off values of Fibroscan, FIB-4, APRI and AAR of patients with hepatitis C in Korea. According to the diagnosis, 240 people in hepatitis C are classified into fatty liver, chronic hepatitis, and liver cirrhosis. The statistical analysis was performed by ANOVA to verify difference between groups. The ROC curve was analyzed to determine the usefulness and practical cut-off value. As a result, for all diseases, the AUC value for Fibroscan was 0.8 over and the APRI was 0.7 over. Cut-off value of serum based liver fibrosis markers was increased in order of fatty liver, chronic hepatitis and liver cirrhosis. If Fibroscan and serological liver fibrosis markers are applied to predict liver fibrosis, it is expected that excessive liver biopsy can be reduced.

• 한국방사선학회논문지
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• 제11권4호
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• pp.205-212
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• 2017

만성간질환(Chronic diffuse hepatopathy)의 진단은 간경화, 간부전, 간암으로 인한 사망률과 유병율을 감소시키는 중요한 임상과제 중 하나이다. 이에 본 연구에서는 초음파진단 영상을 바탕으로 간탄력도검사(Fibroscan)를 통해 지방간, 만성간질환을 예측할 수 있는 기준을 알아보고자 하였다. 280명의 환자를 대상으로 혈청학적 검사, 간탄력도 검사 측정값(kPa)을 분석하였으며 ROC 곡선분석을 이용하여 지방간 및 만성간질환을 예측을 위한 간탄력도 측정값의 cut-off value를 결정하였다. 혈청학적 검사에서 Bililubin, PT(prothrombin time)은 질병예측에 관련성이 없었으며(p=0.243, p=0.115), 혈당과 중성지방수치는 지방간에서 의미 있는 차이를 보이며 높게 나타났다(p<0.05). 간탄력도 측정값은 정상 대조군, 지방간, 만성간질환 순으로 높게 측정되었으며 만성간질환 예측을 위한 cut-off value는 10.3 kPa(AUC 0.98, Sensitivity 94.94%, Specificity 94.93%)로 결정하였다. 따라서 정량적인 평가로 만성간질환 환자의 진단에 일차적인 도구로 활용될 것으로 사료된다.

• 대한의용생체공학회:의공학회지
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• 제11권1호
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• pp.121-130
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• 1990

In this study, the coefficients of ultrasound attenuation for human liver were determined in 6 normal humans and in 38 patients with diffuse liver disease. The coefficients with linear frequency dependency as well as nonlinear frequency dependency were evaluated. Gaussian pulse propagating in a lossy medium suffers downshifting of a center frequency and decreasing in the bandwidth. Such changes in frequency domain spectrum were quantified in terms of changes in the attenuation coefficients with nonlinear dependency, which in turn improve clinical Implications of the coefficients. Statistical analysis shows that the attenuation coefficients evaluated with nonlinear dependency reflect an improved accuracy for the diffuse liver disease than those with linear dependency. The discriminant analysis also indicate the improved classification with nonlinear dependency(75%) than with linear dependency(61%).

• 대한한방내과학회지
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• 제11권2호
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• pp.128-136
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• 1990

I Studied some important medical literatures inorder to examine the cause & syndrome of diffuse fluid-retention syndrome and found out some facts as follows ; 1. cause of diffuse fluid-retention syndrome is Hwang Je Nae Kyong(黃帝內經) and so forth six kinds of medicine books are reffered sudden thirst of intestin and stomark cause of disease Golden chamber(金?要略) and so forth fifteen kinds of medicine books are reffered fluid water promote obscesses atributide at four extrenities and unable hidrosis cause of disease Elementary cause for medicine(醫學入門) and so forth kinds of book medicine books are reffered water in four extrenities cause of disease. The classified Medical Records of Famous physicians(名醫類安) reffered rest at wetness earthly cause of disease. 2. syndrome of diffuse fluid-retention syndrome is Golden chamber and so forth nineteen kinds of medicine books are reffered compression and pain of body syndrome of disease. Hwang Je Nae Kyong(黃帝內經) and so forth seven kinds of medicine books are reffered pulse ; the liver-pulse is soft and powder syndrome of disease. The classified Medical Records of Famous physicians(名醫類安) and so forth two kinds at medicine book are reffered general syndrome of disease. Today is reffered edema of four extremites syndrome of disease. The cause & syndrome of diffuse fluid-retention syndrome obtained was as follows ; cause of diffuse fluid-retention syndrome is fluid water promote abscess attributide at four extremities and unable hidrosis and compression and pain body is main syndrome and hyperhidrosis, vertigo, edema of four extremities alternating episodes of chills and fever can guan pulse is sunken and slippery and both chi wiry are represented syndrome of diffuse fluid-retention syndrome.

• 한국콘텐츠학회논문지
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• 제8권10호
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• pp.217-223
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• 2008

성인형 다낭성 간질환(adult polycystic liver disease, PLD)은 양성 질환으로 매우 드물고 상염색체우성 다낭성 신장질환(autosomal dominant polycystic kideny disease, ADPKD)을 동반한다. 다낭성 간질환(PLD)은 간실질에 여러 개의 미만성 낭성질환을 특징으로 하는 상염색체우성 유전성 질환이다. 간과 관련된 중요한 증상 또는 합병증이 발생할 수 있으며 이로 인하여 복강경 또는 간을 절제하거나 또는 절제 없이 천공설치술을 포함하는 치료가 이루어지며 간이식도 할 수 있다. 본 고찰에서는 복부 불쾌감이 있는 성인형 다낭성 간질환을 경험하였기에 초음파 검사와 복부 CT 소견에 대해 참고 문헌과 함께 보고하고자 한다.

• 대한수의학회지
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• 제38권4호
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• pp.918-928
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• 1998

The present study was done with two aims. First, to evaluate the radiographic measurements of liver volumes in normal and hepatomegaly dogs induced by carbon tetrachloride. Second, to investigate quantitative tissue echo pattern by ultrasonography. Gray level histogram of the normal liver and the kidney were estimated with carbon tetra-chloride intoxication. In normal, r-square for liver volume to body weight was 0.93372, and this showed direct linear regression. Gray level histograms of the normal liver and the kidney were $19.150{\pm}2.490$(mean${\pm}$SD) and $13.175{\pm}2.686$(mean${\pm}$SD) respectively(p < 0.01). Liver parenchymal echogenicity was more hyperechogenic than kidney cortex echogenicity. Liver/Kidney ratio was $1.504{\pm}0.313$ and it can be used relative comparison of liver and kidney parenchymal echogenicity. In carbon-tetrachloride($CCl_4$) intoxication, changes of liver volume appeared to increase up to 24 hours after administration (p < 0.05), and decreased gradually to normal level after 2~5 days. Gray level histogram of liver parenchyma decreased up to 24hours (p < 0.01) after intoxication and then gradually increased to normal level. But that of kidney cortex had no significant change. Liver/Kidney ratio also decreased by 2 days(p < 0.01) and then gradually increased to normal level. On histopathologic features of hepatic tissues in carbon tetrachloride intoxication, both coagulative necrosis of hepatic cell and hemorrhage of centrilobular & midzonal area were identified. Conclusively, plain radiography is a useful diagnostic method for evaluating liver volume in mild hepatomegaly. Especially, it is considered that an adequate numerical processing of the liver length, depth and thoracic width and depth measurement would be helpful. Using gray level histogram, ultrasonographic evaluation was useful objective methods in early diagnosis of diffuse hepatic disease.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5677-5679
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• 2012

Background and Aim: Gastric cancer is the second most common cancer worldwide. In this study the clinical and histological features of gastric cancer in the cardia and distal stomach were evaluated. Method: Proximal and distal gastric cancer diagnosed and treated in eight provinces of Iran from 2010-2011 were reviewed in all collected cases. The age standardized incident rates were calculated and tumor location and histological type were recorded. Results: The age-standardized incidence rate for the eight centers was 40.6 per 100,000 populations per year with an upper and lower range of 22.1 and 102.4 per 100,000 population per year. Thirty four percent of the tumors were located in the cardia, 3% in fundus, and 63% in the distal stomach. In 7 provinces the prevalence of distal tumors was significantly greater than proximal tumors (p=0.006). A significant relationship was observed between diffuse form of gastric cancer and distal gastric tumors (p=0.007) and between poor tumor differentiation and distal gastric tumors (p<0.001). Conclusions: the result of this study shows that distal gastric cancer is more common than proximal gastric cancer in Iran.

• 한국콘텐츠학회논문지
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• 제9권3호
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• pp.278-287
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• 2009

전국 6개 도시의 종합검진센터에서 검진 서비스를 받은 건강한 성인 총 수진자 29,531명(서울 11,976명, 인천 3,749명, 대전 3,759명, 광주 3,155명, 대구 3,470명 부산 3,422명)을 대상으로 간질환 유병률을 분석한 결과는 다음과 같다. 간질환 유병률은 43.1％로 나타났고, 성별로는 남성에서 23.3％, 여성에서 19.8％로 남성에게서 유의하게 높게 나타났으며(p<0.001), 지역별 간질환 유병률은 대전이 49.6％로 가장 높았고, 서울 48.2％, 부산 42.9％, 인천, 대구 각각 36.2％, 광주 32.1％ 순으로 유의한 차이가 있는 것으로 나타났다(P<0.001). 간질환 유병률 순위는 지방간 69.7％으로 가장 높게 나타났으며, 간내낭종 13.2％, 간내석회화 9.6％, 간내혈관종 4.5％, 간내종양 1.4％, 미만성간질환 1.0％, 간경화 0.5％ 순으로 나타났다. 연령별 유병률은 전 간질환이 40대에서 가장 높게 나타났으며 30대에서 50대에 높은 유병률로 유의성이 있는 것으로 나타났다(p<0.001). 간질환의 지역별 유병률은 부산은 지방간, 대전은 간내낭종, 간내혈관종, 간내석회화, 간내종양, 서울은 미만성간질환이 타 지역에 비하여 높았으며 이는 통계적으로 유의성이 있는 것으로 나타났다(p<0.001). 간질환 유병률에 영향을 미치는 관련요인의 다중회귀분석 결과는 연령이 증가할수록 발병 가능성이 높게 나타났고, 연령 및 성별의 유병률에서 유의성이 있는 것으로 나타났다(p<0.05).