• 감성과학
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• 제13권2호
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• pp.301-308
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• 2010

본 연구는 톤 인 톤 배색과 톤 온 톤 배색을 활용한 배색의 감성 효과에 관한 것이다. 톤 인 톤 배색 과 톤 온 톤 배색에 근거하여 제작한 24개 배색에 대하여 Osgood의 SD법(Semantic Differential Method)을 이용하여 10명 대학생에게 배색에 대한 인상 평가를 받았으며 자료 분석은 엑셀 통계 프로그램 2004를 사용하여 요인분석을 하였다. 연구결과, 톤 인 톤 배색에 근거한 배색과 톤 온 톤 배색에 근거한 배색의 인상이 매우 다르게 평가되는 것을 확인했다. 따라서 색채조화의 형식으로 제안되는 배색 기법이 배색의 감성 효과에 영향을 미칠 가능성을 확인하였다. 그리고 '좋다-싫다', '어린이답다-어른답다', '강하다-약하다', '따뜻하다-차갑다' 4개 이미지 차원이 도출되었으며 이러한 이미지에는 색상과 색조가 영향을 주는 요소로 작용한다는 것을 확인하였다. 제품의 사진배색과 거의 동일한 색종이 배색의 인상을 비교한 것으로 색표를 이용한 배색과 그 배색에 근거한 제품의 배색 인상에는 거의 차이가 없다는 것을 확인하였다. 그러나 제품이 가진 고유 특성이나 형태, 재질 등에 의해 인상이 크게 달라지는 것도 확인하였다. 이러한 연구 결과는 배색 이미지나 색채 디자인의 기초 자료로 활용 될 것이다.

• Journal of Microbiology and Biotechnology
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• 제25권12호
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• pp.2153-2159
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• 2015

Mycoplasma hyopneumoniae is known to cause porcine enzootic pneumonia (EP), an important disease in swine production. The objective of this study was to examine the effects of sonicated protein fractions of M. hyopneumoniae on inflammatory response and gene expression in the murine alveolar macrophage MH-S cell line. The effects of sonicated protein fractions and intact M. hyopneumoniae on the gene expression of cytokines and iNOS were assessed using RT-PCR. The Annealing Control Primer (ACP)-based PCR method was used to screen differentially expressed genes. Increased transcription of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, COX-2, and iNOS mRNA was observed after exposure to the supernatant (SPT), precipitant (PPT), and intact M. hyopneumoniae protein. A time-dependent analysis of the mRNA expression revealed an upregulation after 4 h for IL-6 and iNOS and after 12 h for IL-1β and TNF-α, for both SPT and PPT; the fold change in COX-2 expression was less. A dose- and time-dependent correlation was observed in nitrite (NO) production for both protein fractions; however, there was no significant difference between the effects of the two protein fractions. In a differential gene analysis, PCR revealed differential expression for nine gene bands after 3 h of stimulation — only one gene was downregulated, while the remaining eight were upregulated. The results of this study provide insights that help improve our understanding of the mechanisms underlying the pathogenesis of and macrophage defenses against M. hyopneumoniae assault, and suggest targets for future studies on therapeutic interventions for M. hyopneumoniae infections.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 1995년도 제5회 학술강연회논문집
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• pp.3-8
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• 1995

An experimental investigation was conducted in order to figure out the multiple fire effects on the combustion efficiency and fuel properties of the solid fuel ramjet. Pure HTPB and metallized $B_4$C/HTPB fuel were studied. Fuel property effects were analyzed by using differential scanning calorimetry, The thermal or mechanical properties of the fuel grain were not affected and the combustion efficiency was a little increased.

• Structural Engineering and Mechanics
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• 제8권2호
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• pp.193-205
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• 1999

A formulation for the dynamic stability analysis of cylindrical shells resting on elastic foundations is presented. In this previously not studied problem, a normal-mode expansion of the partial differential equations of motion, which includes the effects of the foundation as well as a harmonic axial loading, yields a system of Mathieu-Hill equations the stability of which is analyzed using Bolotin's method. The present study examines the effects of the elastic foundation on the instability regions of the cylindrical shell for the transverse, longitudinal and circumferential modes.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.213.1-213.1
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• 2003

Alpha-viniferin was isolated from Carex humilis (Cyperaceae), and showed anti-inflammatory effects on carrageenin or histamine-induced paw edema in mice. To understand mode of the anti-inflammatory action. effects of alpha-viniferin on cyclooxygenase (COX)-2, iNOS, oxygen radicals and proinflammatory cytokines have been analyzed. Alpha-viniferin showed selective inhibitory effect with an IC50 value of 5 $\mu\textrm{m}$ on COX-2 activity but showed weak inhibitory effect on the synthesis of COX-2 transcript which was identified by RT-PCR. (omitted)

• 복식문화연구
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• 제16권5호
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• pp.841-851
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• 2008

The purpose of the study was to examine the effect of motif categories and motif colors on evaluating sensory image of fashion materials with the gestalt theory as the background. The research was conducted on a quasi experimental basis, with subjects numbering 187 male and 207 female college students. Data were collected in the period from march 19th to march 31st, 2007. A set of fabric stimuli and semantic differential scales were developed. The stimuli were thirteen fabric species(each measuring 12 by 13cm). Variables included; (a) motif colour(white, grey, pink and blue) (b) motif categories(plain, paisley, flower, stripes and zebra effect). The semantic differential scale to measure sensory image of fabric stimuli included 23 sets of bi-polar adjectives. The data were analysed by factor analysis and ANOVA and the major finding were as follows. 1) Four sensory dimensions emerged of importance: salience, attractiveness, comfort and softness. 2) The motif category effected on the four sensory image dimensions while the motif colour effected on salience, comfort and softness sensory dimensions. 3) An interaction effect was founded between motif category and motif colour. 4) Motif category showed significant effects on the preference and liking of the fashion, however the motif colour did not show any significant effects on the preference and liking. As a whole the results supported the gestalt theory and the results can be used for the marketing strategy for developing fashion fabrics.

• Steel and Composite Structures
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• 제28권6호
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• pp.749-758
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• 2018

Free axial vibration of axially functionally graded (AFG) nanorods is studied by focusing on the inertia of lateral motions and shear stiffness effects. To this end, Bishop's theory considering the inertia of the lateral motions and shear stiffness effects and the nonlocal theory considering the small scale effect are used. The material properties are assumed to change continuously through the length of the AFG nanorod according to a power-law distribution. Then, nonlocal governing equation of motion and boundary conditions are derived by implementing the Hamilton's principle. The governing equation is solved using the harmonic differential quadrature method (HDQM), After that, the first five axial natural frequencies of the AFG nanorod with clamped-clamped end condition are obtained. In the next step, effects of various parameters like the length of the AFG nanorod, the diameter of the AFG nanorod, material properties, and the nonlocal parameter value on natural frequencies are investigated. Results of the present study can be useful in more accurate design of nano-electro-mechanical systems in which nanotubes are used.

• Biomolecules & Therapeutics
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• 제7권2호
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• pp.112-120
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• 1999

The protective actions of ambroxol, rutin, glutathione and harmaline on oxidative damages of various tissue components were compared. The mechanisms by which they prevent oxidative tissue damages were explored. Lipid peroxidation of liver microsomes induced by combinations of $Fe^{2+}$ and ascorbate or $Fe^{+3}$, ADP and NADPH was inhibited by $50\; \muM$ of rutin, ambroxol, harmaline and glutathione. Ambroxol ($100\; \muM$) inhibited the degradation of hyaluronic acid by $Fe^{2+}$, $H_2O$_2$ and ascorbate, and it was greater than that of harmaline, whereas hyaluronic acid degradation was not prevented by rutin and glutathione. The compounds used ($100\; \muM$) did not protect the degradation of cartilage collagen by xanthine and xanthine oxidase. Rutin, glutathione and harmaline decreased the degradation of IgG by xanthine and xanthine oxidate, while ambroxol did not attenuate degradation of IgG. Glutathione showed a scavenging action on $H_2O_2$. The compounds all showed scavenging actions on hydroxyl radical. Ambroxol and harmaline exhibited quenching effects en singlet oxygen. In conclusion, ambroxol, rutin, glutathione and harmaline may exert protective effects differently on tissue components against oxidative attack depend on kind of tissue component and free radical.

• Structural Engineering and Mechanics
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• 제63권2호
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• pp.161-169
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• 2017

In this paper, using consistent couple stress theory and Hamilton's principle, the free vibration analysis of Euler-Bernoulli nano-beams made of bi-directional functionally graded materials (BDFGMs) with small scale effects are investigated. To the best of the researchers' knowledge, in the literature, there is no study carried out into consistent couple-stress theory for free vibration analysis of BDFGM nanostructures with arbitrary functions. In addition, in order to obtain small scale effects, the consistent couple-stress theory is also applied. These models can degenerate into the classical models if the material length scale parameter is taken to be zero. In this theory, the couple-tensor is skew-symmetric by adopting the skew-symmetric part of the rotation gradients as the curvature tensor. The material properties except Poisson's ratio are assumed to be graded in both axial and thickness directions, which it can vary according to an arbitrary function. The governing equations are obtained using the concept of Hamilton principle. Generalized differential quadrature method (GDQM) is used to solve the governing equations for various boundary conditions to obtain the natural frequencies of BDFG nano-beam. At the end, some numerical results are presented to study the effects of material length scale parameter, and inhomogeneity constant on natural frequency.

• 대한수의학회지
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• 제63권1호
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• pp.2.1-2.7
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• 2023

Fenbendazole (FBZ) is a benzimidazole anthelmintic widely used to treat parasitic infections. The anticancer effect of FBZ has been recently highlighted leading to its consideration as a potential anticancer agent. Although previous studies have demonstrated the effect of FBZ on cancer cells, there is a paucity of studies on the effect of FBZ on lymphoma cells and normal immune cells. Herein, we investigated the effects of FBZ on a mouse lymphoma cell line, EL-4 cells, and spleen cells, using vincristine as a positive control. The cellular metabolic activity of EL-4 cells was decreased by FBZ, but that of the spleen cells was not decreased. Moreover, FBZ reduced the mitochondrial membrane potential and induced reactive oxygen species production in EL-4 cells, but not in spleen cells. FBZ induced G2/M phase arrest and increased the sub G0/G1 phase ratio, indicating apoptosis. Furthermore, compared to the control cells, the reactivity of spleen cells pretreated with FBZ to lipopolysaccharide was maintained. In summary, FBZ is cytotoxic to EL-4 cells, but not to spleen cells. This study provides experimental evidence that FBZ exerts an anticancer effect, and less cytotoxic effects and functional damage to normal spleen cells.