• 한국가금학회:학술대회논문집
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• 한국가금학회 2001년도 제18차 정기총회 및 학술발표 PROCEEDINGS
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• pp.66-68
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• 2001

An experiment was conducted investigate the of supplemental Cu and Zn methionine chelates on the performance, nutrient digestibility, serum IgG level, gizzard erosion, and Cu and Zn contents in the liver and excretion of broiler chickens. One thousand hatched broiler chickens (Ross) of one day old were assigned to 4 treatments:control(T1), 100ppm of copper in the from of Cu-methionine chelate(Cu-Met, T2), 100ppm of zinc in the from of Zn-methionine chelate(Zn-Met, T3) and 100ppm of copper plus 100ppm of zinc in the from of methionine chelate(Cu-Zn-Met, T4). Each treatment had four replications of 50 bird each. Weight gain of chicks fed chelated products were significantly higher than that of chicks fed control(P＜0.05).Combination of Cu and Zn chelates(Cu-Zn-Met) tended to show the best growth rate and feed conversion ratio. Nutrient digestibilities were not affected by dietary treatments. Serum IgG level of chicks fed Cu-Zn-Met was significantly higher than that of chicks fed control(P＜0.05). Gizzard erosion index was not significantly different among treatments. Contents of Cu and Zn in liver were not significantly affected by dietary treatments, whereas excretions of these minerals were significantly affected by dietary treatments.

• 한국가금학회:학술대회논문집
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• 한국가금학회 2006년도 제23차 정기총회 및 학술발표회
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• pp.64-65
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• 2006

The effects of garlic extracts, lactic acid bacteria, copper and selenium as cholesterol lowering material on productivity and content of egg cholesterol in layer were investigated. The layers were divided into seven treatment groups and fed commercial diet or experimental diets containing probiotics, garlic powder, selenium and copper for 6 weeks. There was no significant difference in egg production between groups. The content of egg yolk cholesterol by combination feeding of probiotics, garlic powder, selenium and copper were significantly reduced by 13.5-29.8% as compared to that of control. The levels of mRNA expression of HMG-CoA reductase were significantly decreased by dietary treatments.

• 한국영양학회:학술대회논문집
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• 한국영양학회 1999년도 춘계학술대회 초록
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• pp.102-102
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• 1999

• Journal of Preventive Medicine and Public Health
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• 제22권4호
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• pp.518-527
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• 1989

The relationship between copper content in scalp hair and mental retardation was investigated. Samples of scalp hair were collected from 297 mentally retarded children who were students in one of two schools providing special educational services, one, consisted of children living in an orphan home, the other, children living with parents. For comparison, 117 scalp hair samples were collected from the children who had got average or above average academic achivement in a regular elementary school. Hair samples were taken from the nape of the neck and the copper content was determined by an atomic absorption spectrophotometer (IL 551). There was no statistically significant difference in scalp copper levels across different age groups except female orphan group, but no trend or correlation between copper conents and age was found. The hair copper contents of the mentally retarded children groups were significantly lower than that of control groups. But there was no dose-response relationship between degree of mental retardation and hair copper level. The hair copper contents of the group accompanied by Down's syndrome and unknown group were significantly lower than that of control group in both sex, and in the case of accompanied by epilepsy or autism, lower than control group in male. Although the results of this study show no evidence that mental retardation has owed to copper deficiency, the possibility of copper deficiciency in their fetal or infant age could not be ruled out. Thus further study is needed to determine whether mental retardation could be attributed to copper deficiency, through the examinations about their living environments, dietary pattern, eating habit and the impact of copper deficiency on brain development.

• Journal of Nutrition and Health
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• 제33권8호
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• pp.857-863
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• 2000

The purpose of this study is to investigate zinc and copper intakes of exclusively breast-fed infants. We measured consumed volume and the minerals concentrations of human milk from thirty three lactating women and their infants during the first 5 months of lactation , Zinc concentrations of human milk showed 0.394, 0.290, 0.191, 0.147 and 0.139mg/100g at 0.5, 1, 2, 3, 4 and 5 months of lactation respectively. Copper concentrations in the milk showed 61.04, 45.97, 37.15, 3.94, 26.22 and 26.21$\mu\textrm{g}$/100g respectively. Consumed volume of the milk of infants were 515, 650, 718, 731, 746 and 769g/day. There is significant difference between boys and girls in consumed volume of the milk at 2, 3 and 4 months of lactation. Zinc intakes of breast-fed infants declined(p<0.05) from 2.13mg/day at 0.5 months to 1.21mg/day at 3 months with no change thereafter significantly. Copper intakes of the infants declined(p<0.05) from 323.2$\mu\textrm{g}$/day at 0.5 months to 238.9$\mu\textrm{g}$/day at 3 months with no change thereafter. Form this survey, the reevaluation of zinc and copper intakes and recommended dietary allowance of those minerals during infancy are merited. (Korean J Nutrition 33(8) : 857-863, 2000)

• Asian-Australasian Journal of Animal Sciences
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• 제14권11호
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• pp.1616-1620
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• 2001

Two feeding trials were conducted to study the effects of different chelated copper and zinc compounds on the performance and fecal excretions of weanling pigs. In Exp. 1, 150 weanling pigs ($L{\times}Y{\times}D$, $12.30{\pm}2.07kg$) were randomly assigned to five dietary treatments: 170 ppm Cu from $CuSO_4$, 85 ppm Cu from Cu amino-chelate (CAC), 170 ppm Cu from CAC, 85 ppm Cu from Cu-Lysine (CL), and 170 ppm Cu from CL. In Exp. 2, 150 weanling pigs ($L{\times}Y{\times}D$, $12.52{\pm}1.80kg$) were randomly assigned to five dietary treatments: 120 ppm Zn from $ZnSO_4$, 60 ppm Zn from Zn-amino-chelate (ZAC), 120 ppm Zn from ZAC, 60 ppm Zn from Zn-Methionine (ZM), and 120 ppm Zn from ZM. In both experiments, pigs were randomly distributed to the treatments following a randomized complete block design on the basis of body weight as the blocking variable. Each experiment was conducted for 28 days. Blood and fecal samples were collected to determine mineral contents as affected by the dietary treatments. There was no difference (p>0.05) in ADG and ADFI among treatments, but F/G was improved (p<0.05) in pigs fed diet with 170 ppm CAC than 85 ppm CL but not different (p>0.05) to the control (170 ppm $CuSO_4$). Regardless of copper source, concentration of Cu in serum and feces were higher in pigs fed diet with 170 ppm Cu than pigs fed diet with 85 ppm Cu (Exp 1). In Exp 2 the ADG was higher (p<0.05) in pigs fed diet with 120 ppm ZM than in pigs fed diets with 120 ppm $ZnSO_4$ and 60 ppm ZAC and ZM. The serum zinc concentration was generally higher (p<0.05) in pigs fed diet with organic source than the control group ($ZnSO_4$). Also, there was a trend towards a decrease in fecal excretions of zinc when dietary zinc level was low. The efficacy of the two chelated copper and zinc sources is similar in terms of growth performance. The fecal excretions for Cu and Zn could be reduced in pigs fed low level of these minerals using organic sources.

• Journal of Animal Science and Technology
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• 제47권4호
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• pp.583-592
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• 2005

한우 거세우에 대한 Cu의 급여효과를 규명하기 위하여 농후사료중의 Cu 수준을 사료 kg당 7 mg, 12 mg 또는 17 mg의 3개 처리구에 각 5두씩 계 15두를 공시하여 435일간 비육시험을 실시한 결과는 다음과 같다. 일당증체량은 비육전기, 비육중기 및 비육후기 전기간에 걸처 Cu 7mg, 12mg 또는 17 mg 급여구간에 차이가 없었고 비육 전기간 평균에서도 각각 0.75, 0.76, 0.75kg으로서 처리구간에 유의적인 차이는 없었다. 사료섭취량은 처리구간에 비육전기에는 9.21-9.64 kg, 비육중기에는 9.53-9.75kg, 비육후기에는 10.09-10.93 kg으로 비육시기별로 큰 차이가 없었고 비육전기간에는 9.86-10.21 kg으로 처리구간에 큰 차이가 없었다. 사료효율은 비육전기에는 11.08-11.72, 비육중기에는 13.60-14.34, 비육후기에는 14.01- 15.20으로 처리구간에 큰 차이는 없었고 비육전기간에서도 13.31-13.99로 처리간에 차이가 없었다. 한우 거세우에게 Cu를 급여하였을 때 도체율은 58.4-59.2%로 처리구간에 차이는 없었다. 육량등급중에서 등지방두께는 8.2-10.4 mm로 처리구간에 큰 차이는 없었다. 배최장근단면적은 대조구와 12 mg 및 17 mg 급여구가 각각 78.4, 82.2 및 79.8 $cm^2$로 처리구간에 차이는 없었다. 육량지수는 68.10-68.91로서 처리구간에 차이는 없었다. 육량등급은 모두 B 등급으로서 처리구간에 차이가 없었다. 육질등급에서 가장 중요한 요인인 근내지방도는 Cu 7mg, 12mg 또는 17mg 급여구가 각각 3.6, 4.8 및 4.2로서 12 mg 첨가구가 약간 높게 나타났으나 처리구간에 유의적인 차이는 없었다. 육색, 지방색, 조직감 그리고 성숙도 등에서도 Cu 첨가구간에 큰 차이가 없었다. 육질등급은 처리구간에 모두 1등급을 받았고 Cu 수준간에 차이가 없었다. 경제성분석 결과 조수익은 대조구에서는 두당 2,577,483원, Cu 12mg 급여구는 2,920,432원, Cu 17mg 급여구는 2,653,227원으로써 Cu 12 mg 급여구가 7mg 급여구에 비해 13.3%, 17 mg 급여구에 비해 10.1%가 높게 나타났다. 이상과 같은 결과들을 종합해 볼 때 한우 거세우에게 농후사료 중에 Cu를 사료 kg당 7, 12 또는 17 mg을 넣어 주었을 때 성장, 육량 및 육질등급에서는 처리간에 차이가 없었으나 경제성에서는 12 mg 급여구가 조수익이 높았다.

• Journal of Nutrition and Health
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• 제39권1호
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• pp.28-34
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• 2006

This study was performed to compare nutrients intake and levels of three elements (iron, copper and zinc) in the plasma of breast cancer patients to those in healthy controls. Patients (n = 97) and their age-matched healthy control groups (n = 97) participated in the study. A semi-quantitative food frequency questionnaire specifically formulated to evaluate the consumption of nutrients was used to estimate dietary intake. Only plasma was taken from the 20 patients and their age-matched healthy control group. Plasma concentrations of iron, copper, zinc, ratio of Cu/Zn were measured in both groups. Results showed that patients consumed significantly lower protein, fat, iron. Plasma level of copper and ratio of Cu/Zn were significantly higher in patients compared to those of controls. In conclusion, change of trace elements in plasma might be useful and significant as biomakers involving the initial process. And these results imply that trace elements status is a factor related to breast cancer risk and suggest that proper intake of those nutrients is required for cancer prevention.

• 농업과학연구
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• 제48권3호
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• pp.447-454
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• 2021

This study was conducted to evaluate the effects of different copper sources (inorganic and organic) on the growth performance, fecal copper excretion, intestinal morphology, and health in growing pigs. A total of 40 growing pigs (30.22 ± 1.92 kg) were randomly assigned to 5 dietary treatments: a basal control diet (CON), 4 experimental diets supplemented with either copper sulfate (CuSO₄), Cu-glycine complex (CuGly), Cu-amino acid complex (CuAA), or Cu-hydroxy-4-methylthio butanoate chelate complex (CuHMB) at 100 ppm, respectively. At the end of the study (28 days), fecal and blood samples were collected, and the pigs were slaughtered to determine the intestinal morphology. During the 28 days of the experimental period, pigs fed the inorganic and organic copper showed a higher average daily gain (p < 0.01) and gain feed ratio (p < 0.01). There were no differences in mineral concentrations of the serum; however, the copper concentration of the feces was lower (p < 0.01) in the CuAA and CuHMB groups. The intestinal morphology and blood profiles did not significantly differ between the groups. In conclusion, the organic copper sources (CuAA and CuHMB) can be used as a growth promoter to replace the CuSO₄ without any negative effects on health in growing pigs and to reduce fecal copper excretion.