• Animal cells and systems
• /
• v.13 no.2
• /
• pp.141-145
• /
• 2009

Two new species of the family Spongiidae, Spongia (Heterofibria) cora/lina n. sp. and Spongia (Heterofibria) purpurea n. sp. are described. They were collected from Gageodo Island, Jeollanam-do, Korea. Spongia (H.) coral/ina n. sp. is closest to S. (H.) cristata Cook & Bergquist (2001) from New Zealand in skeletal features, but the new species differs from S. (H.) cristata by the arrangement of fibres and growth form. Spongia (H.) purpurea n. sp. closley resembles S. (H.) cristata, but the new species differs from New Zealand specimens by the arragement and thickness of pseudo-tertiary fibres.

• Animal Systematics, Evolution and Diversity
• /
• v.14 no.4
• /
• pp.335-340
• /
• 1998

Two new species of the family Irciniidae, Psammocinia wandoensis n.sp. and P.samyangensis n. sp., are described. They were collected from the South Sea, Korea. P. wandoensis n. sp. closely resembles P. rugosa(Lendenfed, 1889)from Australia in morphology, but new species differs from P. rugosa by the filaments. Though P. samyangensis n. sp. is very similar to P. jejuensis, but our species differs from P. Jejuensis by the fibre shape.

• Journal of Life Science
• /
• v.14 no.3
• /
• pp.445-452
• /
• 2004

We investigated the cytotoxic effects of seven furanoterpenoids 〔sarcotin A, epi-sarcotin A, ircinin-1, epi-sarcotrine B, sarcotin I, (8E, l3Z, 20Z)-strobilinin/(7E,l3Z, 20Z)-felixinin and (7E,12E,18R,20Z)-variabilin〕 isolated from the sponge Sarcotragus sp. (the order Dictyoceratida) on the growth of A549 human lung carcinoma cells. MTT data revealed that sarcotin A and (7E,12E,18R,20Z)-variabilin exhibited higher potencies on the anti-proliferative activities than the other compounds in A549 cells. The growth inhibition by treatment with compounds (especially epi-sarcotin A, ircinin-1 and epi-sarcotrine B) were associated with the induction of apoptotic cell death through the concentration-dependent increase of Bax/Bcl-2 ratio in a p53-dependent or independent pathway Additionally, epi-sarcotin A and ircinin-1 strongly inhibited the levels of cyclooxygenase (COX)-2 expression without alteration of COX-1. Taken together, the results suggest that the furanoterpenoids from the marine sponge have strong potentials as candidates for anti-cancer drugs.