• BMB Reports
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• 제40권5호
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• pp.765-772
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• 2007

Eosinophils act as effectors in the inflammatory reactions of allergic diseases including atopic dermatitis. Atopic dermatitis patients and others with allergic disorders suffer from eosinophilia, an accumulation of eosinophils due to increased survival or decreased apoptosis of eosinophils. In this study, a differential phosphoproteome analysis of AML14.3D10 eosinophil cell line after treatment with IL-5 or dexamethasone was conducted in an effort to identify the phosphoproteins involved in the proliferation or apoptosis of eosinophils. Proteins were separated by 2-DE and alterations in phosphoproteins were then detected by Pro-Q Diamond staining. The significant quantitative changes were shown in nineteen phosphoproteins including retinoblastoma binding protein 7, MTHSP75, and lymphocyte cytosolic protein 1. In addition, seven phosphoproteins including galactokinase I, and proapolipoprotein, were appeared after treatment with IL-5 or dexamethasone. Especially, the phospho-APOE protein was down-regulated in IL-5 treated AML14.3D10, while the more heavily phosphorylated APOE form was induced after dexamethasone treatment. These phosphoproteome data for the AML14.3D10 cell line may provide clues to understand the mechanism of eosinophilia as well as allergic disorders including atopic dermatitis.

• 대한치과보철학회지
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• 제26권1호
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• pp.153-169
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• 1988

There is a little scientific documentation reporting the stress, distribution to the edentulous mandible by different concepts of occlusal scheme. So, this study was to investigate the hypothesis that the magnitude and distribution of the occlusal stresses, transmitted through a mandibular complete denture base to the edentulous mandible, would be influenced by the lingualized occlusion. This investigation was performed to analyze the stresses induced in a three-dimensional photoelastic edentulous mandible, when a load is applied to the denture arranged into lingualized occlusion in centric relation, lateral and protrusive functional position. The mounted denture on a Dentatus Type ARO articulator was loaded in a pure vertical direction with 15kgs on the center of articulator in each case and the stresses were frozen into epoxy edentulous model at $127^{\circ}C$ in the stress freezing furnace. The stress-frozen epoxy models were sliced with diamond disc saw into 4mm thick. The slices were examined with a circular polariscope. The results were as follows: 1. In centric relation, the stresses were low at anteriors, and gradually increase to the premolar, molar area and highest at the first molar and gradually decrease from the second molar and lowest at the retromolar pad region. The lingual side showed higher stresses than labiobuccal side. 2. In lateral functional position, the working side showed higher stresses than the balancing side. In working side, the lingual side showed higher stresses than the buccal side and in balancing side, the buccal side showed higher stresses than the lingual side. 3. In protrusive position, stress distribution was symmetrical on the posteriors and the stresses were concentrated at the labial side of the anteriors.

• 한국정보시스템학회지:정보시스템연구
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• 제26권4호
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• pp.379-400
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• 2017

Purpose The purpose of this study is to investigate the effects of ICT on multilevel marketing organizations (MLMs) whose members are both salespeople and consumers. This study explores the effects of the latest ICT convergence on the direct selling, which is the oldest sales method, and suggests the direction for the development of network marketing. Therefore, we will propose the changes in direct sales brought by ICT and predict the future direction of network marketing in preparation for the 4th Industrial Revolution era. Design/methodology/approach Exploratory case study was the methodology selected for this paper. The case study enables the use of multiple methods for data collection and analysis. This study applies qualitative case-study methodology on Amway Korea, which is the top seller of MLM organizations, to better understand the impact of ICT. This study conducted an in-depth interview with four different levels of MLM members (e.g. membership, ruby, emerald, diamond) which are based on the qualification system of MLM organizations and observed their behaviors. Findings This study revealed that the ICT impact on network marketing organizations(MLMs) could be summarized as follows : new membership growth, easier communication with customers, increase in work efficiency, increase in organizational trust, change in educational environment, and increase in the use of social media. Based on the interview, we propose the changes of network marketing organizations in the fourth industrial revolution era and the future strategy of Amway Korea as follows: (1) retention of royal ABOs, (2) harmony with SMEs, (3) utilization of Big Data, (4) creation of IoT business model, and (5) construction of successful O2O business platform.

• 한국정보통신학회논문지
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• 제21권4호
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• pp.663-671
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• 2017

본 연구에서는 Porter의 다이아몬드 모형에 입각하여 관련 분야 전문가들의 의견 수렴을 통해 우리나라 인공지능 산업의 국가 경쟁력에 영향을 미치는 요인들에 대한 중요도를 분석하였다. 분석 결과 인공지능 산업의 국가 경쟁력에 가장 큰 영향을 미치는 요인은 연구개발, 자본, ICT 기술 경쟁력 순으로 나타났다. 인공지능 산업은 자본집약적 특성이 강한 하이테크놀로지 산업이므로 국가경쟁력 확보를 위해 무엇보다 인공지능 기술과 그 기반인 정보통신 기술에 대한 국가 R&D 역량의 결집과 인프라 구축을 위한 공격적인 투자가 중요할 것으로 판단된다. 인공지능 기술의 근간을 이루는 ICT 인프라 및 활용역량 등을 고려할 때 국내 소비자의 높은 요구수준은 인공지능 산업의 국가 경쟁력 확보에 긍정적 촉매요인으로 작용할 것으로 예상된다. 또한, 인공지능 기술은 빠른 확산속도와 강한 파급력을 지닐것으로 전망되므로 적시 대응을 위한 기업의 선제적 역량확보가 필수적일 것으로 사료된다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1996년도 하계학술대회 논문집 C
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• pp.1446-1449
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• 1996

Thin films of diamond-like carbon(DLC) have been deposited using a magnetron plasma-enhanced chemical vapor deposition(PECVD) method with an rf(13.56 MHz) plasma of $C_{3}H_{8}$. From the Langmuir probe I-V characteristics, it can be observed that increasing the magnetic field yields an increase of the temperature($T_e$) and density($N_e$) of electron. At a magnetic field of 82 Gauss, the estimated values of $T_e$ and $N_e$ are approximately $1.5\;{\times}\;10^5$ K(13.5 eV) and $1.3\;{\times}\;10^{11}\;cm^{-3}$, respectively. Such a highly dense plasma can be attributed to the enhanced ionization caused by the cyclotron motion of electrons in the presence of a magnetic field. On the other hand, the negative dc self-bias voltage($-V_{sb}$) decreases with an increasing magnetic field, which is irrespective of gas pressure in the range of $1{\sim}7$ mTorr. This result is well explained by a theoretical model considering the variation of $T_e$. Deposition rates of DLC films increases with a magnetic field. This may be due to the increased mean free path of electrons in the magnetron plasma. Structures of DLC films are examined by using various techniques such as FTIR and Raman spectroscopy. Most of hydrocarbon bonds in DLC films prepared consist of $sp^3$ tetrahedral bonds. Increasing the rf power leads to an enhancement of cross-linking of carbon atoms in DLC films. At approximately 140 W, the maximum film density obtained is about 2.4 $g/cm^3$.

• 한국안광학회지
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• 제5권2호
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• pp.127-138
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• 2000

안경테의 temple 및 front frame의 탄성율, 길이, 두께, 폭 등의 변화에 따른 temple 및 front frame의 변형과 이들에 작용하는 힘(압력)을 예측할 수 있는 미분방정식을 수립하였으며 그 해에 따라 이러한 제반 변수들이 temple 및 front frame의 변형과 작용하는 힘(압력)에 미치는 영향을 모사하였다. 단면적 및 두께가 일정한 temple의 변형은 단면의 형상에 따라 차이를 보였으며 단면이 마름모일 때 최대, 직사각형일 때 최소값을 나타내었다. Front frame의 구성 요소들이 frame의 변형에 미치는 영향은 temple의 경우와 유사하며 특히 temple에 의해 front frame이 변형을 일으키는 경우 최대변형은 temple의 길이가 길어질수록 감소하며 또한 중심부에 작용하는 압력도 감소한다. 또한 temple의 변형을 일정하게 유지하는 경우 front frame의 길이가 증가할수록 그 변형도 증가하는 것을 알 수 있었다. 안경테의 재질, 구조변화에 따른 테의 각 부분(부품)들에 작용하는 stress를 정확히 해석함으로서 주문형 안경테나 착용감이 뛰어난 안경테의 디자인에 응용이 가능할 것으로 생각된다.

• Steel and Composite Structures
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• 제37권2호
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• pp.175-191
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• 2020

In this article, for the first time, the seismic behavior of elliptic-braced moment resisting frame (ELBRF) is assessed through a laboratory program and numerical analyses of FEM specifically focused on the development of global- and local-type failure mechanisms. The ELBRF as a new lateral braced system, when installed in the middle bay of the frames in the facade of a building, not only causes no problem to the opening space of the facade, but also improves the structural behavior. Quantitative and qualitative investigations were pursued to find out how elliptic braces would affect the failure mechanism of ELBRF structures exposed to seismic action as a nonlinear process. To this aim, an experimental test of a ½ scale single-story single-bay ELBRF specimen under cyclic quasi-static loading was run and the results were compared with those for X-bracing, knee-bracing, K-bracing, and diamond-bracing systems in a story base model. Nonlinear FEM analyses were carried out to evaluate failure mechanism, yield order of components, distribution of plasticity, degradation of structural nonlinear stiffness, distribution of internal forces, and energy dissipation capacity. The test results indicated that the yield of elliptic braces would delay the failure mode of adjacent elliptic columns and thus, help tolerate a significant nonlinear deformation to the point of ultimate failure. Symmetrical behavior, high energy absorption, appropriate stiffness, and high ductility in comparison with the conventional systems are some of the advantages of the proposed system.

• 디지털융복합연구
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• 제15권7호
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• pp.367-373
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• 2017

본 연구는 지속해서 증가하는 유방암 환자의 수술 후 신체 및 정신적 고통 완화를 도와주는 모바일 애플리케이션 서비스 제안에 목적이 있다. 먼저 연구 목적 달성을 위해 문헌연구를 통한 유방암의 전반적인 이해와 이와 유사한 서비스를 분석하였다. 이후 서비스 디자인 방법론인 더블 다이아몬드 디자인 프로세스 모델을 단계별로 적용하여 사후관리 중심의 1:1 맞춤형 전문가 코칭(coaching) 서비스를 제공하는 모바일 애플리케이션을 고안하였다. 세부적으로는 첫째, 현재 진행되는 프로그램 분석과 이해관계자들(유방암 환자, 보호자, 간호사 및 병원 내 암센터 용품 판매원)과의 인터뷰를 통해 사용자 니즈(needs)를 도출하였다. 둘째, 이를 기반으로 사용자를 대표하는 페르소나와 고객여정맵을 토대로 한 전체적인 시나리오를 시각화, 콘셉트 설정 및 키워드 도출로 본 연구를 구체화하였다. 셋째, 구체적인 기능 설명과 함께 효과적으로 전달하기 위한 프로토타입을 제작하여 최종 목표인 모바일 애플리케이션 서비스를 제안하였다. 본 서비스를 통하여 그들의 삶의 질을 향상시키는 서비스가 되길 기대한다.

• 한국산학기술학회논문지
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• 제14권3호
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• pp.1081-1089
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• 2013

본 연구는 국내 녹색산업의 경쟁력 강화를 위한 클러스터 형성방안을 제시하고자, 녹색산업의 지역경쟁력과 영향요인을 분석했다. 첫째, 신재생에너지산업은 경기, 경남, 충북, 충남, 울산, 전남에서, 탄소저감산업은 울산, 경기, 경북, 충남, 서울, 충북, 인천에서 각각 경쟁력이 있는 것으로 나타났다. 둘째, 신재생에너지산업은 기업, 노동, 연구개발 등의 요소조건 부문이, 탄소저감산업은 성과, 정책 제도, 시장점유, 산업특화 등의 구조 및 경쟁 부문이 가장 중요한 요인으로 분석되었다. 셋째, 녹색산업은 기존의 산업기반이 양호한 지역에서 상대적으로 경쟁력이 있는 것으로 나타났다. 따라서 국내 녹색산업의 경쟁력 강화를 위해서는 기존 산업기반의 녹색화와 더불어 선택과 집중의 전략이 요구된다.

• 보건의료산업학회지
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• 제5권2호
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• pp.209-226
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• 2011

The purpose of this study is to analyze and find out key success factors and marketing strategies of Bumrungrad Hospital in Bangkok, Thailand. The major success factors of Bumrungrad Hospital are as follows; First, Bumrungrad Hospital had professional medical team and board of directors who had the international career. Second, Bumrungrad was supported by Thai government and they were in a cooperative relationship with each other for the development of the medical industry. Third, Bumrungrad appropriately handled the internal and external changes including Asia Financial Crises in 1997 and others. Fourth, Bumrungrad diversified and broaden its business field such as global medical investing and management, medical technology, anti-age medicine and wellness. Marketing strategies of Bumrungrad analyzed are the following four factors. First, Bumrungrad focused on the quality of services by employing professional medical staffs, who have the international certification, and by constructing IT system for hospital management. Second, Bumrungrad has maintained an equalized price policy to attract the customers bothin the domestic and foreign markets. The cost for care has appealed the foreign customers for its comparatively low price, but it focused mainly on the upper middle class in Thailand. Third, it established, managed, and consulted hospitals in the foreign countries including the Philippines and the Arab Emirates. Fourth, it adopted differentiated promotion strategies suitable for the special needs of domestic and foreign customers, and put emphasis on the buzz marketing.