• International Journal of Computer Science & Network Security
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• v.21 no.12spc
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• pp.427-436
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• 2021

The article reveals and theoretically substantiates the trends of foreign language teachers' professional training in universities of Ukraine in terms of European integration, which are systematized in three areas: macro-level (system of education), meso-level (universities) and micro-level (subjects of educational process). The article aims to substantiate the trends of foreign language teacher training in the context of European integration and the main directions of creative use of constructive ideas of European experience in the innovative development of education. The article lights up the system for improving foreign language teacher training in universities, which is based on updated goals, content and approaches to the implementation of basic concepts, principles and features of teacher training in European experience, enable us to improve the quality of teacher training, its competitiveness in the European labor market. In the article developed the conceptual model of strategic development of the university in the conditions of European integration. It is emphasized that information technologies provide great opportunities for the development of professional skills and intellectual potential of future professionals. At present, the computerization of the educational process in higher education institutions is considered as one of the first and most promising areas for improving the quality of education. The article offered directions of internationalization of educational activity of university in the conditions of European integration. Diagnostic tools for the development of the university in terms of integration into the European educational space, individual rating and ranking of structural units of the university have been developed; main directions of activity of the laboratory of the skill of the teacher of higher school and methodical recommendations on the creation and the organization of work of scientific laboratories.

• Journal of Oral Medicine and Pain
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• v.45 no.4
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• pp.89-96
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• 2020

Purpose: To investigate the expression of malondialdehyde (MDA), lipid peroxidation marker for oxidative stress (OS), in autoimmune Sjögren's syndrome (SjS) by utilizing the SjS-prone C57BL/6.NOD-Aec1Aec2 (B6DC) mouse and the SjS patient plasma samples. Methods: The MDA concentrations in the lysates of the submandibular gland, liver, and serum samples from the SjS-prone B6DC mouse model were compared with those from the C57BL/6J as a control. A thiobarbituric acid reactive substance (TBARS) assay kit was used to measure MDA. Plasma samples from five SjS patients and five control subjects were also evaluated. Results: The MDA concentrations in experimental animals and controls were not significantly different. There were no significant differences between the plasma of SjS patients and of controls. Conclusions: The expression of MDA was investigated in the organs from the SjS-prone B6DC mouse for the first time and in the plasma samples of SjS patients. No significant differences were observed between SjS and control samples when MDA was the target molecule with the TBARS assay. MDA may not be a reliable marker to measure OS contrary to the published studies involving OS of SjS.

• Journal of Sasang Constitutional Medicine
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• v.32 no.4
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• pp.86-95
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• 2020

Objectives Meal and nutrition are important lifestyle factors that affect maintenance and promotion of health status and are also associated with chronic diseases. In Sasang constitutional medicine, dietary behavior according to the characteristics of Sasang constitution (SC) types is a key component in health management. The aim of this study was to evaluate the nutritional status and quality of meals according to the SC. Methods This was a cross-sectional study of 1,947 subjects surveyed in a community-based cohort called the Korean Medicine Daejeon Citizen Cohort study. Data were collected including demographic characteristics, Korea Sasang Constitutional Diagnostic Questionnaire, and nutrition quotient (NQ) for adults. We analyzed the differences in NQ grade and scores among three SC types: Taeeumin (TE), Soeumin (SE), and Soyangin (SY), by conducting chi-square and ANCOVA tests. Results The distribution of SC into TE, SE, and SY types was 43.1%, 25.2%, and 31.8%, respectively. The mean NQ score of all subjects was 53.4±8.6. There was a significant difference in the distribution of NQ grades and mean of NQ scores among SC types, including total and four sub-factors: balance, diversity, moderation, and dietary behavior. The TE type had the lowest score for the moderation factors in the crude model. The SE type showed lower NQ scores than the TE and SY types in all domains except moderation after adjusting for variables. Conclusions We found that dietary behaviors had to be distinct according to the SC types. These results elucidate why it is important to develop a customized dietary habit management program considering the SC types.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.32 no.1
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• pp.28-34
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• 2021

Objectives: This study aimed to examine the effect of maternal adverse childhood experiences (ACEs) on the attention-deficit/hyperactivity disorder (ADHD) symptoms in the offspring and to examine the mediating role of antepartum health risk on the intergenerational transmission of maternal ACEs. Methods: The participants consisted of 461 mother-child dyads. Mothers completed the ACEs questionnaire and Diagnostic Predictive Scales. Multivariate logistic regression analysis was used to estimate the risk of ADHD symptoms in the offspring of mothers with ACEs and the mediating effect of antepartum health risks by path analysis. Results: In all, 35.4% (n=163) had at least one maternal ACE, and 11.1% (n=51) had three or more. Compared to the non-ADHD symptom group, the group of offspring with ADHD symptoms showed a significant association with maternal ACE score (p<0.001) and antepartum health risks (p<0.001). Multivariate analysis further showed a significant association between the sum of maternal ACEs [odds ratio (OR)=1.264, 95% confidence interval (CI)= 1.060-1.516, p=0.009], antepartum health risks (OR=1.236, 95% CI=1.036-1.475, p=0.019), and ADHD symptoms in the offspring. In the mediation model in which the mother's ACE score affected the offspring's ADHD symptoms, partial mediation through antepartum health risks was found to be significant (B=0.041, 95% CI=0.011-0.124). Conclusion: Maternal ACEs are significantly related to the incidence of ADHD symptoms in the offspring and antepartum health risks exert an indirect effect. These findings suggest that maternal ACEs have a negative impact on the offspring's brain development through intergenerational transmission, resulting in neurodevelopmental disorders such as ADHD.

• The Korean Journal of Pain
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• v.34 no.3
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• pp.262-270
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• 2021

Background: Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel implicated in pain sensation in response to heat, protons, and capsaicin (CAPS). It is well established that TRPV1 is involved in mechanical allodynia. This study investigates the effect of Ononis spinosa (Fabaceae) in CAPS-induced mechanical allodynia and its mechanism of action. Methods: Mechanical allodynia was induced by the intraplantar (ipl) injection of 40 ㎍ CAPS into the left hind paw of male Wistar rats. Animals received an ipl injection of 100 ㎍ O. spinosa methanolic leaf extract or 2.5% diclofenac sodium 20 minutes before CAPS injection. Paw withdrawal threshold (PWT) was measured using von Frey filament 30, 90, and 150 minutes after CAPS injection. A molecular docking tool, AutoDock 4.2, was used to study the binding energies and intermolecular interactions between O. spinosa constituents and TRPV1 receptor. Results: The ipsilateral ipl injection of O. spinosa before CAPS injection increased PWT in rats at all time points. O. spinosa decreased mechanical allodynia by 5.35-fold compared to a 3.59-fold decrease produced by diclofenac sodium. The ipsilateral pretreatment with TRPV1 antagonist (300 ㎍ 4-[3-Chloro-2-pyridinyl]-N-[4-[1,1-dimethylethyl] phenyl]-1-piperazinecarboxamide [BCTC]) as well as the β2-adrenoreceptor antagonist (150 ㎍ butoxamine) attenuated the action of O. spinosa. Depending on molecular docking results, the activity of the extract could be attributed to the bindings of campesterol, stigmasterol, and ononin compounds to TRPV1. Conclusions: O. spinosa alleviated CAPS-induced mechanical allodynia through 2 mechanisms: the direct modulation of TRPV1 and the involvement of β2 adrenoreceptor signaling.

• Imaging Science in Dentistry
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• v.51 no.2
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• pp.137-148
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• 2021

Purpose: This study aimed to assess the computer monitors used for analysis and interpretation of digital radiographs within the clinics of the Oral Health Centre of Western Australia. Materials and Methods: In total, 135 computer monitors(3 brands, 6 models) were assessed by analysing the same radiographic image of a combined 13-step aluminium step wedge and the Artinis CDDent 1.0^® (Artinis Medical Systems B.V.^®, Elst, the Netherlands) test object. The number of steps and cylindrical objects observed on each monitor was recorded along with the monitor's make, model, position relative to the researcher's eye level, and proximity to the nearest window. The number of window panels blocked by blinds, the outside weather conditions, and the number of ceiling lights over the surgical suite/cubicle were also recorded. MedCalc^® version 19.2.1 (MedCalc Software Ltd^®, Ostend, Belgium, https://www.medcalc.org; 2020) was used for statistical analyses(Kruskal-Wallis test and stepwise regression analysis). The level of significance was set at P<0.05. Results: Stepwise regression analysis showed that only the monitor brand and proximity of the monitor to a window had a significant impact on the monitor's performance (P<0.05). The Kruskal-Wallis test showed significant differences (P<0.05) in monitor performance for all variables investigated, except for the weather and the clinic in which the monitors were placed. Conclusion: The vast performance variation present between computer monitors implies the need for a review of monitor selection, calibration, and viewing conditions.

• Journal of the Institute of Convergence Signal Processing
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• v.21 no.4
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• pp.183-194
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• 2020

Recently, the number of hip dysplasia (DDH) that occurs during infant and child growth has been increasing. DDH should be detected and treated as early as possible because it hinders infant growth and causes many other side effects In this study, two modelling techniques were used for multiple training techniques. Based on the results after the first transformation, the training was designed to be possible even with a small amount of data. The vertical flip, rotation, width and height shift functions were used to improve the efficiency of the model. Adam optimization was applied for parameter learning with the learning parameter initially set at 2.0 x 10e-4. Training was stopped when the validation loss was at the minimum. respectively A novel image overlay system using 3D laser scanner and a non-rigid registration method is implemented and its accuracy is evaluated. By using the proposed system, we successfully related the preoperative images with an open organ in the operating room

• Imaging Science in Dentistry
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• v.51 no.1
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• pp.1-7
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• 2021

Purpose: The aim of this study was to assess artifacts generated in cone-beam computed tomography (CBCT) of 3 types of dental implants using 3 metal artifact reduction (MAR) algorithm conditions (pre-acquisition MAR, post-acquisition MAR, and no MAR), and 2 peak kilovoltage (kVp) settings. Materials and Methods: Titanium-zirconium, titanium, and zirconium alloy implants were placed in a dry mandible. CBCT images were acquired using 84 and 90 kVp and at normal resolution for all 3 MAR conditions. The images were analyzed using ImageJ software (National Institutes of Health, Bethesda, MD) to calculate the intensity of artifacts for each combination of material and settings. A 3-factor analysis of variance model with up to 3-way interactions was used to determine whether there was a statistically significant difference in the mean intensity of artifacts associated with each factor. Results: The analysis of all 3 MAR conditions showed that using no MAR resulted in substantially more severe artifacts than either of the 2 MAR algorithms for the 3 implant materials; however, there were no significant differences between pre- and post-acquisition MAR. The 90 kVp setting generated less intense artifacts on average than the 84 kVp setting. The titanium-zirconium alloy generated significantly less intense artifacts than zirconium. Titanium generated artifacts at an intermediate level relative to the other 2 implant materials, but was not statistically significantly different from either. Conclusion: This in vitro study suggests that artifacts can be minimized by using a titanium-zirconium alloy at the 90 kVp setting, with either MAR setting.

• Imaging Science in Dentistry
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• v.52 no.2
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• pp.133-140
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• 2022

Purpose: The aim of this review was to systematically analyze the available literature on the correlation between the gray values (GVs) of cone-beam computed tomography (CBCT) and the Hounsfield units (HUs) of computed tomography (CT) for assessing bone mineral density. Materials and Methods: A literature search was carried out in PubMed, Cochrane Library, Google Scholar, Scopus, and LILACS for studies published through September 2021. In vitro, in vivo, and animal studies that analyzed the correlations GVs of CBCT and HUs of CT were included in this review. The review was prepared according to the PRISMA checklist for systematic reviews, and the risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. A quantitative analysis was performed using a fixed-effects model. Results: The literature search identified a total of 5,955 studies, of which 14 studies were included for the qualitative analysis and 2 studies for the quantitative analysis. A positive correlation was observed between the GVs of CBCT and HUs of CT. Out of the 14 studies, 100% had low risks of bias for the domains of patient selection, index test, and reference standards, while 95% of studies had a low risk of bias for the domain of flow and timing. The fixed-effects meta-analysis performed for Pearson correlation coefficients between CBCT and CT showed a moderate positive correlation (r=0.669; 95% CI, 0.388 to 0.836; P<0.05). Conclusion: The available evidence showed a positive correlation between the GVs of CBCT and HUs of CT.

• Nuclear Engineering and Technology
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• v.54 no.9
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• pp.3317-3323
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• 2022

Half Value Layer calculations theoretically need prior specification of linear attenuation calculations, since the HVL value is derived by dividing ln(2) by the linear attenuation coefficient. The purpose of this study was to establish a direct computational model for determining HVL, a vital parameter in nuclear radiation safety studies and shielding material design. Accordingly, a typical gamma-ray transmission setup has been modeled using MCNPX (version 2.4.0) general-purpose Monte Carlo code. The MCNPX code's INPUT file was designed with two detection locations for primary and secondary gamma-rays, as well as attenuator material between those detectors. Next, Half Value Layer values of some well-known gamma-ray shielding materials such as lead and ordinary concrete have been calculated throughout a broad gamma-ray energy range. The outcomes were then compared to data from the National Institute of Standards and Technology. The Half Value Layer values obtained from MCNPX were reported to be highly compatible with the HVL values obtained from the NIST standard database. Our results indicate that the developed INPUT file may be utilized for direct computations of Half Value Layer values for nuclear safety assessments as well as medical radiation applications. In conclusion, advanced simulation methods such as the Monte Carlo code are very powerful and useful instruments that should be considered for daily radiation safety measures. The modeled MCNPX input file will be provided to the scientific community upon reasonable request.