• Title/Summary/Keyword: Diagnostic Correlation

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Clinicopathologic and Diagnostic Significance of p53 Protein Expression in Papillary Thyroid Carcinoma

  • Shin, Mi Kyung;Kim, Jeong Won
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.5
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    • pp.2341-2344
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    • 2014
  • Background: p53 protein expression has been detected immunohistochemically in papillary thyroid carcinoma(PTC). We investigated the relations between its expression and clinicopathologic features and its significance as a diagnostic marker. Materials and Methods: We compared and evaluated 93 patients in whom thyroidectomy with lymph node dissection had been performed to treat PTC for clinicopathologic significance and 102 patients with 23 papillary thyroid overt carcinomas (POC), 57 papillary thyroid microcarcinomas(PMC), 5 follicular adenomas (FA), 5 Hashimoto's thyroiditis (HT) and 12 nodular hyperplasias (NH) for significance as a diagnostic marker. Expression of p53 protein was evaluated immunohistochemically in sections of paraffinembedded tissue. Results: Statistical analysis showed significantly different expression of p53 in PTC versus other benign thyroid lesions (BTL).The diagnostic sensitivity and specificity were 85.0% and 72.7%, respectively. Overexpression of p53 protein was observed in 44 of the 93 PTC cases (47.3%), but no significant correlation between p53 protein overexpression and clinicopathologic features (age, size, multiplicity, lymph node metastasis, extrathyroidal extension and vascular invasion) was noted. Conclusions: p53 is valuable to distinguish PTC from other BTL, but there is no correlation between p53 protein overexpression and clinicopathologic features.

A Study on Diagnostic Pattern Questionnaire Associated with Body Mass Index in 20-40's Women (20-40대 여성의 체질량지수에 따른 한방변증지표의 특성 연구)

  • Park, Kyoung-Sun;Yoo, Seung-Yeon;Park, Young-Jae;Lee, Chang-Hoon;Cho, Jung-Hoon;Jang, Jun-Bock;Lee, Kyung-Sub;Lee, Jin-Moo
    • Journal of Korean Medicine for Obesity Research
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    • v.11 no.1
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    • pp.25-34
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    • 2011
  • Objectives The purpose of this study was to examine the characteristics of diagnostic pattern questionnaire associated with Body Mass Index in premenopausal women. Methods We studied 41 patients visiting Gangdong Kyung Hee University Hospital from 1st April 2011 to 25th May 2011. The subjects were categorized in two groups, overweight & obesity group (n=12) and low weight & normal group (n=29). We studied the difference of diagnostic pattern questionnaire scores between two groups by Independent samples T-test and correlation between diagnostic pattern questionnaire scores of overweight & obesity group by Pearson's correlation coefficient test using SPSS for windows (version 13.0). Results Blood stasis, retention of undigested food, cold pattern scores of overweight & obesity group were non-significantly higher than low weight & normal group. Heat pattern score of overweight & obesity group was significantly higher than low weight & normal group. Cold-heat, phlegm-cold, blood stasis-cold, phlegm-blood stasis, phlegm-retention of undigested food significantly showed positive correlation coefficient in overweight & obesity group. Conclusions The results suggest that obese women tend to show heat pattern. It seems to be that multiple factors such as phlegm, blood stasis, retention of undigested food are causative of obesity.

Diagnostic Significance of Discography on Multiple Lumbar Disc Herniation (다발성 요추간반 탈출증에서 추간반조영술의 진단적 의의)

  • Lee, Sang-Won;Kim, Keung-Nyun;Chin, Dong-Kyu;Kim, Young-Soo;Cho, Yong-Eun;Jin, Byung Ho
    • Journal of Korean Neurosurgical Society
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    • v.29 no.5
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    • pp.628-634
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    • 2000
  • Objective : The introduction of MRI makes it easy to detect multiple lumbar disc herniation. However, MRI is not a physiologic test for detecting the symptomatic level. For the surgical plan, it is very important to determine the symtomatic level among the multiple lumbar disc herniation. In this regard, we studied diagnostic significance of discography on multiple lumbar disc herniation in determining the symptomatic level. Method and Material : We retrospectvely analyzed the discographic and clinical findings of 121 patients with multiple lumbar disc herniation for investigating the diagnostic availability of discography. All were surgically treated from January 1995 through May 1998. Result : Discography provocated the same pain as usual symptom in 99 out of 121 patients(81.8%). Compared with surgical findings, the diagnostic accuracy of the discography in multiple lumbar disc herniation was 75.6%, sensitivity was 64.6%, and specificity 87.2%. There was no correlation between the pain provocation of discography and the extent of annular degeneration on CT/discogram. The pain provocation showed good correlation with the extent of annular disruption on CT/discogram. The rate of same result(correlation rate) between the discography and D.I.T.I was 81.4% in multiple lumbar disc herniation patients with unilateral leg pain. Conclusion : These results indicate that in multiple lumbar disc herniation, the discography is considered useful diagnostic tool to determine the symptomatic level and to decide the surgical plan.

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Correlation between Insulation Diagnostic Test and AC Breakdown Test for 3.3 kV Class Induction Motor

  • Byun, Doo-Gyoon;Hong, Jin-Woong
    • Transactions on Electrical and Electronic Materials
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    • v.7 no.5
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    • pp.262-266
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    • 2006
  • The insulation diagnostic test and the AC breakdown test were performed under off-line using the 3.3 kV class induction motor which have been served for 10 years. These tests were conducted in means of nondestructive and destructive test. In this paper, we compared the correlation between the nondestructive and destructive test. Furthermore we setup an experimental condition with moisture and compared the insulation characteristics between moist and dry sample. From the results of the nondestructive and destructive test, it was found that the second AC current, which is the previous step of insulation breakdown, suddenly increased at a point of around 8.5 kV. The insulation breakdown of moist sample occurred at 12-14 kV, which is 4-5 kV lower than dry sample.

Study on Body Constitution and Disease Symptoms and Signs (논체질여병증(论体质与病证))

  • Cui, Zheng-Zhi;Cui, Ming-Hua
    • Journal of Korean Medical classics
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    • v.22 no.4
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    • pp.241-247
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    • 2009
  • Body constitution research in Korean traditional medicine adopt the diagnosis and treatment theory of "image-differentiation[body constitution differentiation, disease differentiation] in combination with syndrome differentiation diagnostic model and symptoms and signs of herbal property belong to image" as its core, which is key national medical science research project of State Administration of Traditional Chinese Medicine, the project brought up 4 key scientific problem ? body constitution differentiation theory, correlation theory of body constitution and disease, body constitution adjustable theory and symptoms and signs of herbal property belong to image theory. In body constitution pathology, it brought up "correlation between body constitution and symptoms", "differentiation between body constitution and symptoms" which increase the diagnostic level and diagnostic accuracy rate. In the condition of pathology, it obviously has low reliability according to body constitution differentiation, sometimes happen the description not comply with body constitution and disease symptoms, which lead to decrease the clinic diagnostic and treatment level, treatment effect not satisfying too. Now taking 4 key scientific achievement as criterion to illustrate the body constitution and disease symptoms.

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Relationship of Somatic Cell Count, Physical, Chemical and Enzymatic Properties to the Bacterial Standard Plate Count in Different Breeds of Dairy Goats

  • Ying, Chingwen;Yang, Cheng-Bin;Hsu, Jih-Tay
    • Asian-Australasian Journal of Animal Sciences
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    • v.17 no.4
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    • pp.554-559
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    • 2004
  • The objective of the present study was to investigate the accuracy of mastitis diagnostic indicators for different dairy goat breeds. Biweekly milk samples were collected from individual half mammary gland of seven Saanen and seven Alpine dairy goats in the period of 40 to 120 days in milk. With threshold value set at 2.8 and 3.1 for Alpine and Saanen dairy goats, respectively, log (SPC) offered good sensitivity (0.89, 0.93), specificity (0.88, 0.95), positive predictive value (0.75, 0.85) and negative predictive value (0.95, 0.98) as a mastitis diagnostic tool. The correlations of log (SPC) with milk yield, log (SCC), ALP, LDH, $Na^{+}$, $K^{+}$ and EC were significant in Saanen dairy goats (p<0.05), with the highest correlation coefficient (0.653) existing between log (SPC) and log (SCC). The correlations of log (SPC) with milk yield, milk fat, milk protein, log (SCC), $Na^{+}$, $K^{+}$, EC were significant in Alpine dairy goats (p<0.05), with the highest correlation coefficient (0.416) existing between log (SPC) and log (SCC). There were different best-fit regression equations with different multiple diagnostic indicators for Saanen and Alpine dairy goats. In conclusion, different breeds of dairy goats may have to adapt different mastitis diagnostic parameters for a better diagnosis.

Correlation between Qi-Stagnation and Pressure Pain Threshold on $CV_{17}$ (Danzhong : 膻中) in Burning Mouth Syndrome Patients - In the Perspective of Quantification of Pressure Pain Threshold on $CV_{17}$ by using Algometer - (구강작열감증후군 환자에서 기울과 전중($CV_{17}$)압통의 상관성 - Algometer를 이용한 전중압통의 정량화 측면에서 -)

  • Kang, Kyung;Kim, Jin-Sung;Seon, Jong-Ki;Son, Ji-Hee;Kim, Ju-Yeon;Jang, Seung-Won;Son, Ji-Young;Lee, Hyun-Ju;Ryu, Bong-Ha
    • The Journal of Internal Korean Medicine
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    • v.33 no.4
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    • pp.498-510
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    • 2012
  • Objectives : This study was designed to find out whether there is a correlation between qi-stagnation score and pressure pain threshold (PPT) on acupuncture point $CV_{17}$ in burning mouth syndrome (BMS) patients. Methods : Thirty BMS patients who newly visited Oral Disease Clinic at the Kyung Hee University Korean Medicine Hospital were surveyed. The subjects were evaluated on age, illness duration, sex, self-assessed severity of BMS, qi-stagnation score, and PPT on 3 acupuncture points ($CV_{17}$, Rt. $SP_9$, Lt. $SP_9$). Results : There was significant correlation between age and PPT on $CV_{17}$ (p=0.005). Therefore, partial correlation analysis with age as control variable was done, and the result showed significant correlation between qi-stagnation score and PPT on $CV_{17}$ (p=0.001). Qi-stagnation diagnostic point by PPT on $CV_{17}$ was suggested as 3.8056 $kg/cm^2$ based on the fact that diagnostic score is 28.50 in the qi-stagnation questionnaire. Furthermore, considering that PPT is effected by age, we could attain qi-stagnation diagnostic equation of PPT on $CV_{17}$, that is suggested as $0.047{\times}(age)+0.848kg/cm^2$. PPT of 3 acupuncture points ($CV_{17}$, Rt. $SP_9$, Lt. $SP_9$) was compared, and the result showed that PPT was significantly lower on $CV_{17}$ (w/Rt $SP_9$: p=0.022, w/Lt. $SP_9$: p=0.012). Also, significance and correlation coefficient with qi-stagnation were higher on $CV_{17}$ (p<0.001, r=-0.620) than Rt. $SP_9$ (p=0.023, r=-0.413) or Lt. $SP_9$ (p=0.014, r=-0.444). Conclusions : The result of this study suggested that PPT on $CV_{17}$, measured quantitatively by algometer, had a strong correlation with qi-stagnation score in BMS patients. Therefore, the study showed that $CV_{17}$ can be a useful acupuncture point in diagnosing qi-stagnation by measuring PPT in BMS patients.

An Experimental Study on Flame Structure and Combustion Characteristics of Turbulent Diffusion Flame(II) (난류확산화염의 화염구조와 연소특성에 관한 실험적 연구(2))

  • Choe, Byeong-Ryun;Jang, In-Gap;Choe, Gyeong-Min
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.20 no.3
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    • pp.1050-1060
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    • 1996
  • Recently, attention has been paid to the flame diagnostic by noncontact methods which dose not deform the flame shape. One of them is a method which is using the radical luminous intensity. Generally, this diagnostic method using radical luminous has been investigated its reliability by applying to laminar flame. This study, however, investigated each radical luminous signals through stocastical analysis like auto-correlation, cross-correlation, phase and coherence which were acquired from measuring radical luminous intensity of OH, CH, $O_{2}$, radicals in turbulent diffusion flame. To compare radical luminous intensity in flame with temperature, ion current and concentration , radious distribution of each properties was investigated and considered. In radical luminous intensity, correlation in the reaction zone of flame was higher than in correlation in combusted gas zone. And radious distribution of radical luminous intensity was corresponded with radious distribution of temperature, ion current and concentration. The result of the study confirms that a radical luminous flame diagnosis is possible in the turbulent diffusion flame.

Comparison of the lateralization using the activation of the Brocas and the Wernickes area with that of total cortical activation amount of cerebral hemisphere in the functional MR for measuring language lateralization based on Wada test

  • Lee, Sang-Hyun;Chang, Kee-Hyun;Chung, Chun-Kee;Song, In-Chan;Han, Moon-Hee
    • Proceedings of the KSMRM Conference
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    • 2001.11a
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    • pp.105-105
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    • 2001
  • Purpose: The activation of the Brocas and the Wernickes area in the language functional MR (fMR) well-known phenomena. We want to evaluate correlation of that activation with langua lateralization. So we evaluate the lateralization using the activation of the Brocas and t Wernickes area comparing with total cortical activation amount of cerebral hemisphere in t functional MR for measuring language lateralization based on Wada test.

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