• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2003년도 제8차 학술대회 초록집
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• pp.67-68
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• 2003

We will present work done at our institution on the use of MRI in breast cancer. The presentation will start by describing a compartmental model that has been used by us since 1993 in studying tumor vascular function in animal models and humans. The employment of this method for diagnosis, therapy monitoring, and disease prognosis in breast cancer will be presented with examples.

• 대한한의정보학회지
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• 제14권2호
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• pp.21-46
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• 2008

Though modern medicine has taken rapid strides, varieties of intractable maladies and diseases go on increasing more and more. And so medical technologies and academic achievements related to diagnoses and prognoses are being carried on. As the progress of genetics, all sorts of diseases have proved to be hereditary. This makes efficient use of the prevention of diseases. According to Sasang-Constitution medicine, each person inherently possesses a unique constitution different from that of any other person. The shapes and sizes, temperaments and characters of people have enormous variations that must affect our health and happiness. Without understanding our particular constitution, we must fall into poor health and disease. The food and exercise that are good for one person's constitution may not be good for another. No standardized medicine can adequately deal with our individual variations. Only a system that can discern our different constitutional types has this capacity. This paper is to study Life-Regulating Science that has taken firm root in our culture from time immemorial, so that I suggest the methods of diagnoses and prognoses by using Life-Regulating Science. In the medical texts, psychological imbalances of Eum-Yang and Five Phases generate all kinds of diseases. Accordingly visceral manifestation and diseases as a future possibility may be known by the Four Pillars.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제34권1호
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• pp.65-70
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• 2012

Polymorphous low-grade adenocarcinoma (PLGA) is a neoplasm that is regarded as the second most common malignant salivary gland tumor after mucoepidermoid carcinoma. After the diagnosis of PLGA it is important to make a treatment decision and consider the prognosis. A histopathologic examination is necessary for diagnosis. Treatment is primarily surgical excision and long-term follow up is essential to evaluate local recurrences. This report describes 2 cases of PLGA located in the soft palate without any evidence of metastasis. The first case was PLGA with bony infiltration and an irregular margin lesion. The second case was PLGA localized in palatal soft tissue. We present diagnoses, histopathologic features, treatments and prognosis of PLGA.

• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1403-1407
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• 2015

Background: New tumour biomarkers are being intensely investigated for malignant mesothelioma (MM). Fibulin-3 is produced in MM but its role remains uncertain. The aim of this study was to evaluate the validity of measuring serum fibulin-3 in the diagnosis and prognosis of MM. Materials and Methods: This prospective study was performed on 43 patients and 40 healthy controls who were admitted to our hospital between January 2012 and January 2014. Data from MM patients, including demographic and clinical features, routine laboratory data, levels of serum fibulin-3, and treatment outcomes were defined as potential prognostic factors. The receiver operating characteristic (ROC) curve for fibulin-3 was used to detect the cut-off value with highest sensitivity and specificity. Univariate survival analysis was performed using the Kaplan-Meier method in patients with MM. Afterwards, the possible factors identified with univariate analyses were entered into the cox regression analysis. Results: Our results revealed that patients with MM had significantly higher serum levels of fibulin-3 than controls. The results showed that the best cut-off point was 36.6 ng/ml with an AUC (area under the curve)=0.976, sensitivity=93.0% and specificity=90.0. In our study, the initial significant poor prognostic factors were advanced stage, high white blood cell count, high platelet count, high C-reactive protein (p<0.05 for each variable). Later, according to multivariate analysis the results showed only advanced stage as significant parameter (p=0.040). Conclusions: We determined that real use for serum fibulin-3 was not for prognosis but for diagnosis in MM. Also advanced stage was associated with poor MM prognosis.

• Clinical and Experimental Pediatrics
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• 제49권11호
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• pp.1152-1157
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• 2006

Inherited metabolic disease is rare disorders that show symptoms mainly in pediatric age and early treatment is important for preventing complications of the disease. Recent development in molecular and biochemical techniques help clinicians with proper diagnosis of patients, however, many of the disease still remain lack of effective therapeutic strategies. Better understanding on biochemical and molecular basis of pathogenesis of the disease combined with advanced medical care would provide new sight on the disease that can also improve the quality of life and long-term prognosis of patients. Traditionally, there are several modalities in the treatment of metabolic diseases depend on the biochemical basis of the disease such as diet restriction, removing or blocking the production of toxic metabolites, and stimulating residual enzyme activity. The inherited metabolic disease is not familiar for many clinicians because the diagnosis is troublesome, treatment is complicated and prognosis may not as good as expected in other diseases. Recently, new therapeutic regimens have been introduced that can significantly improve the medical care of patients with metabolic disease. Enzyme replacement therapy has showed promising efficacy for lysosomal storage disease, bone marrow transplantation is effective in some disease and gene therapy has been trying for different diseases. The new trials for treatment of the disease will give us promising insight on the disease and most clinicians should have more interest in medical progress of the metabolic disease.

• 대한치과보철학회지
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• 제51권4호
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• pp.339-346
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• 2013

외상이나 선천적 결손에 의한 영구치아의 결손은 치료 방법과 적용 시기의 결정이 치료의 예후에 중요한 영향을 미친다. 본 증례는 성장기 환자로서 치아와 두개안면골 상태에 대한 정확한 진단 및 적절한 치료방법을 선택하고 성장 양식을 고려해서 일정기간 임시수복물과 임시 가철성 보철물을 사용하였으며, 성장 완료 후 임플란트 등을 이용한 고정성 보철수복 치료를 시행한 경우로써 교정과와 보철과의 협진 진료, 붕괴된 교합고경의 재확립 과정, 임플란트 보철치료 시 고려해야할 사항들에 대해 발표하고자 한다.

• Journal of Korean Neurosurgical Society
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• 제38권2호
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• pp.116-120
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• 2005

Objective : The aim of this study is to analyze the clinical symptoms, radiological changes, interval from first operation to symptom recurrence and to propose the proper treatment method for re-operated patients following chronic subdural hematoma surgery. Methods : Between January 1992 and April 2003, 18 of 138patients of chronic subdural hematoma repeatedly underwent surgical treatment. The symptoms, mental status by Bender grade, radiological hematoma size and midline shifting, interval from symptom onset to diagnosis, surgical method and prognosis by Glasgow outcome scale[GOS] between the first attack and the recurrence were compared. Results : The symptoms at the time of recurrence were nearly the same as with the first attack, but two patients[2/18, 11.1%] showed a more declined mentality. In addition, the recurred hematoma sizes were the same or large than those previously found. Many patients were recurred within two weeks[13/18, 72.2%]. Most patients were operated on using the previous burr hole, with the exception of one patient who recurred at a different site. All patients had a good prognosis more than GOS 4 [GOS 4:4, GOS 5:12], but two died due to extracranial complication and infection. Conclusion : These results suggest that the early diagnosis and treatment are important, mostly recurred same symptoms within two weeks. Re-operation using the previous burr hole site is a good method.

• 전기학회논문지
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• 제61권6호
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• pp.810-816
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• 2012

As wind power has increased steadily, the importance of a condition monitoring system is being emphasized to maximize the availability and reliability of a wind turbine. To develop the advanced algorithms for fault detection and lifespan estimation, a wind turbine simulator is essential for verification of the proposed algorithms before applying them to a condition diagnosis & integrity prognosis system. The developed new-type simulator in this paper includes blades and various sensors as well as a motor, a gearbox and a generator of which the existing simulators generally consist. It also has similarity with a 3MW class wind turbine and can be used to acquire operational data from various operation conditions. This paper presents a design method of control logic for the wind turbine simulator, which gives a wind generation method and similar dynamic characteristics with the 3MW wind turbine. Finally, the proposed control logic is verified through experiments.

• Annals of Clinical Neurophysiology
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• 제9권2호
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• pp.69-74
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• 2007

Electroencephalogram (EEG) is a representative diagnostic tool in epilepsy. However, there are several points of debate on the role of EEG in diagnosis and management of epilepsy. We suggest that EEG has some limitations for differential diagnosis from nonepileptic episodic diseases, classification of epilepsy, prediction of recurrence, and evaluation of treatment response. Interictal EEG cannot diagnose or exclude epilepsy because interictal epileptic discharge (IED) is frequently absent in epilepsy and can appear in nonepileptic conditions. Although EEG is helpful in classification of epilepsy, focal spikes in generalized epilepsy and secondary bilateral synchrony in localization related epilepsy cause interrater disagreement. It is controversial whether EEG predicts recurrence after the first seizure in adults. The predictive value of EEG in antiepileptic drug (AED) withdrawal is not absolute. The prognosis after AED withdrawal depends on epilepsy syndrome. Many studies could not confirm the value of EEG in assessing the treatment response. After all, epilepsy is clinically diagnosed and assessed. Interictal EEG alone does not provide decisive information and routine follow-up of EEG is not recommended.

• Neonatal Medicine
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• 제28권2호
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• pp.89-93
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• 2021

Nemaline myopathy is a genetically heterogeneous neuromuscular disorder and one of the most common congenital myopathies. The clinical manifestations usually vary depending on the age of onset. Neonatal nemaline myopathy has the worst prognosis, primarily due to respiratory failure. Several genes associated with nemaline myopathy have been identified, including NEB, ACTA1, TPM3, TPM2, TNNT1, CFL2, KBTBD13, KLHL40, KLHL41, LMOD3, and KBTBD13. Here, we report a neonatal Korean female patient with nemaline myopathy carrying compound heterozygous mutations in the gene KLHL40 as revealed using next generation sequencing (NGS). The patient presented with postnatal cyanosis, respiratory failure, dysphagia, and hypotonia just after birth. To identify the genetic cause underlying the neonatal myopathy, NGS-based gene panel sequencing was performed. Compound heterozygous pathogenic variants were detected in KLHL40: c.[1405G>T];[1582G>A] (p. [Gly469cys];[Glu528Lys]). NGS allows quick and accurate diagnosis at a lower cost compared to traditional serial single gene sequencing, which is greatly advantageous in genetically heterogeneous disorders such as myopathies. Rapid diagnosis will facilitate efficient and timely genetic counseling, prediction of disease prognosis, and establishment of treatments.