• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제12권sup1호
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• pp.77-84
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• 2009

Pediatric dysphagia comes from disturbances in swallowing process, which has 'preparatory phase', 'oral phase', 'pharyngeal phase', and 'esophageal phase', and mainly the causes are neuro-muscular discoor-dination. It is necessary to recognize clinical manifestation if they have accompanied organic disorder and diagnose accurately. Videofluoroscopic study evaluation is a valuable method to find out abnormal swallowing mechanism at each phases. Treatment should be diagnosis specific, and multidisciplinary team approach is desirable. We can use various behavioral techniques to facilitate normal swallowing mechanism including conditioning of oral and pharyngeal structures, bolus manipulation, postural compensation, and adaptive feeding utensils. Important point is that the diagnosis and treatment for pediatric dysphagia should not be delayed because children are under development.

• 대한치매학회지
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• 제22권1호
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• pp.16-27
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• 2023

Alzheimer's disease (AD), one of the most representative neurodegenerative diseases, has diverse neurobiological and pathophysiological mechanisms. Treatment strategies targeting a single mechanism have repeated faced failures because the mechanism of neuronal cell death is very complex that is not fully understood yet. Since complex mechanisms exist to explain AD, a variety of diagnostic biomarkers for diagnosing AD are required. Moreover, standardized evaluations for comprehensive diagnosis using neuropsychological, imaging, and laboratory tools are needed. In this review, we summarize the latest clinical, neuropsychological, imaging, and laboratory evaluations to diagnose patients with AD based on our own experience in conducting a prospective study.

• Genes and Genomics
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• 제40권12호
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• pp.1339-1349
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• 2018

Cerebral palsy (CP) is a non-progressive neurological disease, of which susceptibility is linked to genetic and environmental risk factors. More and more studies have shown that CP might be caused by multiple genetic factors, similar to other neurodevelopmental disorders. Due to the high genetic heterogeneity of CP, we focused on investigating related molecular pathways. Ten children with CP were collected for whole-exome sequencing by next-generation sequencing (NGS) technology. Customized processes were used to identify potential pathogenic pathways and variants. Three pathways (axon guidance, transmission across chemical synapses, protein-protein interactions at synapses) with twenty-three genes were identified to be highly correlated with CP. This study showed that the three pathways associated with CP might be the molecular mechanism of pathogenesis. These findings could provide useful clues for developing pathway-based pharmacotherapies. Further studies are required to confirm potential roles for these pathways in the pathogenesis of CP.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1991년도 추계학술대회
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• pp.66-69
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• 1991

This paper describes a design of transducer for non-invasively detecting pressure radial pulse wave in aterial system and a recording system that for the studing the aterial pulse diagnosis of korean traditional medicine. The mechanism of transducer is composed of sensing mechanism, pressure sensor, conditioning amplifier. The variation of radial pulse pressure in the sensing mechanism is converted to the electric signal by piezo-resistive pressure sensor and it converted to the digital signal after preprocessing via A/D converter. The converted signals inputed to the computer as data files and then it display to the monitor for waveform watching and this datas can be used as the aterial pulse diagnosis data. This system effectively detect non-differential radial pulse wave and we conside that if analizing the recorded radial pulse wave, compared each other, it can be helpful in quantify radial pulse wave diagonosis of the Korean traditional medicine.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2003년도 ISIS 2003
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• pp.447-450
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• 2003

In this research, we propose an automatic knowledge acquisition and composite knowledge expression mechanism based on machine learning and relational database. Most of traditional approaches to develop a knowledge base and inference engine of expert systems were based on IF-THEN rules, AND-OR graph, Semantic networks, and Frame separately. However, there are some limitations such as automatic knowledge acquisition, complicate knowledge expression, expansibility of knowledge base, speed of inference, and hierarchies among rules. To overcome these limitations, many of researchers tried to develop an automatic knowledge acquisition, composite knowledge expression, and fast inference method. As a result, the adaptability of the expert systems was improved rapidly. Nonetheless, they didn't suggest a hybrid and generalized solution to support the entire process of development of expert systems. Our proposed mechanism has five advantages empirically. First, it could extract the specific domain knowledge from incomplete database based on machine learning algorithm. Second, this mechanism could reduce the number of rules efficiently according to the rule extraction mechanism used in machine learning. Third, our proposed mechanism could expand the knowledge base unlimitedly by using relational database. Fourth, the backward inference engine developed in this study, could manipulate the knowledge base stored in relational database rapidly. Therefore, the speed of inference is faster than traditional text -oriented inference mechanism. Fifth, our composite knowledge expression mechanism could reflect the traditional knowledge expression method such as IF-THEN rules, AND-OR graph, and Relationship matrix simultaneously. To validate the inference ability of our system, a real data set was adopted from a clinical diagnosis classifying the dermatology disease.

• Nuclear Engineering and Technology
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• 제50권4호
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• pp.613-618
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• 2018

We are developing a shared remote control mobile robot for aerial work in nuclear power plants (NPPs); a robot consists of a mobile platform, a telescopic mast, and a dual-arm slave with a working tool. It is used at a high location operating the manual operation mechanism of a fuel changer of a heavy water NPP. The robot system can cut/weld a pipe remotely in the case of an emergency or during the dismantling of the NPP. Owing to the challenging control mission considering limited human operator cognitive capability, some remote tasks require a shared control scheme, which demands systematic software design and integration. Therefore, we designed the architecture of the software systematically.

• Journal of Mechanical Science and Technology
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• 제18권12호
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• pp.2174-2181
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• 2004

The metal processing system usually consists of various components such as motors, work rolls, backup rolls, idle rolls, sensors, etc. Even a simple fault in a single component in the system may cause a serious damage on the final product. It is, therefore, necessary to diagnose the faults of the components to detect and prevent a system failure. Especially, the defects in a work roll are critical to the quality of strip. In this study, a new 3-D diagnosis method was developed for roll shape defects in rolling processes. The new method was induced from analyzing the rolling mechanism by using a rolling force model, a tension model, the Hitchcock's equation, and measurement of the strip thickness, etc. Computer simulation shows that the proposed method is very useful in the diagnosis of the 3-D roll shape.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1987년도 한국자동제어학술회의논문집; 한국과학기술대학, 충남; 16-17 Oct. 1987
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• pp.674-679
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• 1987

Process failures can occur at any time during operation, so a continuous effort of fault detection, diagsis, and correction is required. Expert system paridigm has been regarded as a promising approach to real time process supervisory control especially to fault diagnosis. The most important aspects of fault diagnostic expert systems(FDES) are the problem-solving inference strategy and knowledge organizations. The necessity of FDES, the nature of diagnostic knowledge, the representation of knowledge, and the inference mechanism of FDES, et al. are described, which are announced by previous researchers. And the existing FDES are categorized and critically reviewed in this work.

• 융합보안논문지
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• 제14권2호
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• pp.17-24
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• 2014

백도어의 침투공격 형태는 "trapdoor" 침투점을 이용하여 보안기능을 우회하고 데이터에 직접 접근을 허용하게 한다. 백도어는 소스코드 수정 없이도 코드 생성이 가능하고 심지어 컴파일 후에 수정도 가능하다. 이같은 방식은 컴파일러를 다시 작성하여 소스코드를 컴파일 할 때 특정 부분에 백도어를 삽입시키는 방법을 사용하기 때문에 가능하다. 백도어 방역작업에는 백도어 기본적 구조나 특성에 따라 피해영역이나 차단방법이 조금씩 다를 수 있다. 본 연구는 백도어 동작 메커니즘 진단을 기반으로 하여 백도어 행동분석 방법 모델을 도출하였다. 연구의 목적은 백도어에 대한 구조 및 감염형태를 파악하고 행동방식을 분석함으로서 앞으로 악성코드 대응과 해킹공격에 유용하게 활용할 수 있는 정보를 확보하는 데 있다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제39권6호
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• pp.292-296
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• 2013

Verruciform xanthoma (VX) is a rare, benign lesion that presents in the oral cavity, skin, or genital organs as a verrucous, papillomatous, or flat papule with varying colors. VX has indistinct clinical features, making histopathological examination necessary for a definitive diagnosis. Histologically, VX is characterized by parakeratosis, rete ridges with uniform depth, and an accumulation of the foam cells, which are also known as the "xanthoma cells". These foam cells test positive for antibodies, such as CD-68 and vimentin; it is thought that VX foam cells are derived from the monocyte-macrophage lineage, and that VX's pathogenic mechanism is partly related to an immune mechanism. Nevertheless, the pathogenesis of VX remains unclear. VX can be treated by surgical excision; other medical, chemical, and radiological treatments are not required postoperatively. Recurrence and malignant transformation of VX are rare. Two patients, each with a mass of unknown origin on the palatal gingiva, were presented at our clinic. Excisional biopsies of the masses were performed for a histological diagnosis after clinical and radiological examinations. Histological examination confirmed a diagnosis of VX in both cases.