• Archives of Pharmacal Research
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• v.27 no.7
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• pp.734-737
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• 2004

5,8-Epidioxycholest-6-en-3-ol (1), cholesterol (2), glycerol 1-palmitate (3) and glycerol 1,3-dioleate-2-stearate (4) were isolated from the methanol extract of the sea urchin Diadema setosum, which was collected from the Halong sea, Vietnam. Chemical structures were established based on extensive 1D, 2D-NMR, FAB-MS, EI-MS spectroscopic data and GC-MS analysis. The NMR spectral data of compound 1 were reassigned by using HMQC and HMBC. Compound 1 was found to have strong cytotoxic effect against various cancer cell lines, such as KB ($IC_{50}$, 2.0 $\mu\textrm{g}$/mL), FL($IC_{50}$, 3.93 $\mu\textrm{g}$/mL), and Hep-2 ($IC_{50}$, 2.4 $\mu\textrm{g}$/mL) by in vitro assay.

• Animal Systematics, Evolution and Diversity
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• v.16 no.2
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• pp.219-226
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• 2000

Some echinoids were collected at about 20m depth of the sea in Moseulpo of Jejudo Island. Among them two species, Diadema setosum (Leske, 1778) and Toxopneu-stes pileolus(Lamarck, 18716), turned out to be new to the Korean fauna. They were redescribed on the morphological characteristics with illustrations. The order Diadematoida is new to Korea. Fourteen echinoids species so far have been report-ed from the sea around Jejudo Island in Korea.