• Molecules and Cells
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• v.37 no.5
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• pp.389-398
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• 2014

Siah acts as an E3 ubiquitin ligase that binds proteins destined for degradation. Extensive homology between siah and Drosophila Siah homologue (sina) suggests their important physiological roles during embryonic development. However, detailed functional studies of Siah in vertebrate development have not been carried out. Here we report that Siah2 specifically augments nodal related gene expression in marginal blastomeres at late blastula through early gastrula stages of zebrafish embryos. Siah2 dependent Nodal signaling augmentation is confirmed by cell-based reporter gene assays using 293T cells and 3TP-luciferase reporter plasmid. We also established a molecular hierarchy of Siah as a upstream regulator of FoxH1/Fast1 transcriptional factor in Nodal signaling. Elevated expression of nodal related genes by overexpression of Siah2 was enough to override the inhibitory effects of atv and lft2 on the Nodal signaling. In particular, E3 ubiquitin ligase activity of Siah2 is critical to limit the duration and/or magnitude of Nodal signaling. Additionally, since the embryos injected with Siah morpholinos mimicked the atv overexpression phenotype at least in part, our data support a model in which Siah is involved in mesendoderm patterning via modulating Nodal signaling.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.4
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• pp.1025-1029
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• 2007

It is widely assumed that Intelligence Quotient (IQ) is determined by inherent disposition and environmental factor. IQ is estimated by age-conversion score and stabilized around age 4 and IQ of adult age can be predicted after age 10. Though children with Mental Retardation (MR) are delayed in language development since early infant period, they receive only special education including speech and language therapy, but no special medication. In traditional Korean medicine, the etiology and treatment for developmental delay of language have been handed down for a long time. Some studies on herbs and prescriptions for improving language development have been undertaken recently. We have found several cases of significant elevation of IQ in the children treated with long term medications of Korean herbal medicine for improvement of language. Analyzing these cases, especially performance IQ showed significant change. Therefore we suggest that Korean herbal medicine might improve cognition development in children with MR.

• Journal of the Korea Institute of Military Science and Technology
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• v.19 no.1
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• pp.26-34
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• 2016

Military devices and systems powered by batteries need to operate at extreme temperature and estimate the available capacity of the battery at different temperature conditions. However, accurate estimation of battery capacity is challenging due to the temperature-sensitive nature of electrochemical energy storage. In this paper, Peukert's equation with temperature factor is derived, and methods for estimating the absolute capacity of lithium-polymer battery and the state-of-charge(SOC) with respect to varying currents and temperatures are presented. The proposed estimation method is experimentally verified under three different discharge currents(0.5 A, 1 A, 3 A) and six different temperatures ranging from -30 to 45 deg. C. The results show the proposed method reduces the Peukert's estimation error by up to 30 % under or at extreme condition.

• Journal of Information Processing Systems
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• v.14 no.3
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• pp.621-630
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• 2018

Selection of a suitable task from the extensively available large set of tasks is an intricate job for the developers in crowdsourcing software development (CSD). Besides, it is also a tiring and a time-consuming job for the platform to evaluate thousands of tasks submitted by developers. Previous studies stated that managerial and technical aspects have prime importance in bringing success for software development projects, however, these two aspects can be more effective and conducive if combined with human aspects. The main purpose of this paper is to present a conceptual framework for task assignment model for future research on the basis of personality types, that will provide a basic structure for CSD workers to find suitable tasks and also a platform to assign the task directly. This will also match their personality and task. Because personality is an internal force which whittles the behavior of developers. Consequently, this research presented a Task Assignment Model (TAM) from a developers point of view, moreover, it will also provide an opportunity to the platform to assign a task to CSD workers according to their personality types directly.

• Molecules and Cells
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• v.43 no.2
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• pp.126-138
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• 2020

The transcription factor RUNX1 first came to prominence due to its involvement in the t(8;21) translocation in acute myeloid leukemia (AML). Since this discovery, RUNX1 has been shown to play important roles not only in leukemia but also in the ontogeny of the normal hematopoietic system. Although it is currently still challenging to fully assess the different parameters regulating RUNX1 dosage, it has become clear that the dose of RUNX1 can greatly affect both leukemia and normal hematopoietic development. It is also becoming evident that varying levels of RUNX1 expression can be used as markers of tumor progression not only in the hematopoietic system, but also in non-hematopoietic cancers. Here, we provide an overview of the current knowledge of the effects of RUNX1 dosage in normal development of both hematopoietic and epithelial tissues and their associated cancers.

• Advances in Energy Research
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• v.7 no.2
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• pp.135-146
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• 2020

In developing countries especially in African continent, rapid population growth in cities is a major concern. Majority of governments in Africa have made more effort to develop urban areas as compared to the rural ones. Social and economic activities are more concentrated in urban areas. This is a pushing factor for the rapid population growth in cities as many people, especially young generation, tend to migrate from rural to urban. This growth leads to excessive exploitation of natural resources, environmental degradation and increased pressure on social services. Rapid increased population acts as an encouragement to construct smart cities for achieving needs for present and future generations. Tanzania as one of the developing countries in Africa has taken initiatives in establishing smart cities. The aim of this study therefore, is to examine opportunities and challenges in the development of Smart cities in Tanzania with a case study of Mbeya city. In addition, conceptualization about development of smart cities is proposed to prioritize the planning of smart grid among other smart city infrastructure systems. Conclusively, Mbeya city has a full potential of many strengths and opportunities for successful development as a smart city.

• Journal of the Korean Society of School Health
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• v.30 no.3
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• pp.306-316
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• 2017

Purpose: The purpose of this study was to investigate the operational status and operational problems of health promoting model schools, particularly of the large-sized elementary schools in urban areas. Methods: The study analyzed the data of 14 large-sized elementary schools in urban areas selected from 85 health promoting model schools, an initiative led by the Ministry of Education from 2012 to 2014. Results: The study examined the operation process of health promoting schools in five stages; system development, needs survey & current status survey, school health policy development, program development & execution, and evaluation. In addition, the study discovered three key factors in operating health promoting schools and examined the status of each factor; connection with the curriculum, connection with the community, and consensus among members. Four problems were identified as operational problems: lack of research on faculty health issues, school physical environment and community resources, inadequate presentation of performance indicators, no close coordination in core task development and lack of linkage with the curriculum. Conclusion: It turned out the concept of health promoting school suggested by WHO was relatively faithfully realized in this study. Compared to small-sized elementary schools in rural areas, health promoting schools in this study showed better aspects overall. The connection with the community was good, but the connection with the curriculum was poor.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.3
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• pp.821-832
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• 2021

Economic deprivation of households remains a significant economic issue in the world. Researchers have shown great concern in identifying crucial factors to enhance poor households' socio-economic performance. Therefore, this paper aims to develop a new conceptual framework to investigate the influence of different microfinance services on households' socioeconomic performance using moderated mediation analysis of various crucial factors. Focus-group interviews with managements of the microfinance institution, i.e. Amanah Ikhtiar Malaysia (AIM), and a systematic literature review were conducted for this purpose, and a new framework for the future study has been developed. The result from focus-group interviews and systematic literature review propose microfinance financial services, training programs, and business coaching as independent factors, whereas household socioeconomic performance as a dependent factor in the proposed model. Specifically, this study provides the direction to scholars to empirically test the direct relationship between financial services and household socioeconomic performance and the indirect relationship between training programs, business coaching, and household socioeconomic performance. Further, microfinance institutions' service efficiency is also included as a moderator that can strengthen microfinance services' effectiveness. The study also provides useful implications for policymakers, financial institutions, households, micro-enterprises, and researchers to better understand microfinance interventions and household economic mechanisms.

• Journal of the Regional Association of Architectural Institute of Korea
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• v.21 no.6
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• pp.1-6
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• 2019

Construction automation can be an effective alternative for the lack of skilled labor and loss of productivity. With such a background, Korean government has provided a lot of financial supports for the development of construction automation technology. However, despite of those efforts, automation systems at construction sites have rarely been employed. This is because the systems have not been developed with full consideration of the needs and environments on construction sites. Thus, the purpose of this study is to identify the critical success factors for efficient development of construction automation systems. This study compares and analyzes key factors for automated construction system(ACS) and construction information system(CIS). As a result, 'stability and reliability' in the ACS showed the highest importance while 'manageability' in the CIS was. Consequently, for the successful introduction of the ACS, technical capability and stability should be firstly considered to cope with dynamic construction environment, while the CIS should be built to enable efficient management and use of information. The result of this study can serve as an evaluation base for the current construction automation technologies and an index for more efficient technology development in the future as well.

• Journal of Agricultural Extension & Community Development
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• v.29 no.2
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• pp.51-64
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• 2022

This study aims to investigate relationships between lifestyle and benefit sought of rural healing tourists. For data collection, a total of 3,000 copies of questionnaires were collected by nationwide online survey. The data were analyzed by using SPSS 26.0. The factor analysis identified seven dimensions of the lifestyle : conservative, sports activity orientation, health orientation, consumption orientation, achievement orientation, adventure orientation, and personal orientation. Five dimensions of benefit sought were identified as psychological recovery, outdoor activities, rest, rural experience, and exercise. The results of the canonical correlation analysis indicated that adventure orientation of lifestyle and psychological recovery, outdoor activities, rural experience, exercise of benefit sought were highly correlated. This means it is important to place an emphasis on psychological recovery, outdoor activities, rural experience, and exercise for tourists looking for an adventure away from everyday life. Rural healing tourism marketers should consider lifestyle aspects as the most important factors affecting benefit sought of rural healing tourism.