• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.1737-1744
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• 2012

Macrophage migration inhibitory factor (MIF) is a pluripotent cytokine which plays roles in inflammation, immune responses and cancer development. It assists macrophages in carrying out functions like phagocytosis, adherence and motility. Of late, MIF is implicated in almost all stages of neoplasia and expression is a feature of most types of cancer. The presence of MIF in almost all tumors and all stages of cancer makes it an interesting candidate for cancer therapy. This review explores the roles of MIF in neoplasia.

• CELLMED
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• v.3 no.1
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• pp.3.1-3.3
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• 2013

The receptor activator of NF-${\kappa}B$ ligand (RANKL), a member of the tumor necrosis factor ligand family, has extensive functions beyond osteoclast development. RANKL is expressed in many immune cells such as osteoblasts, osteocytes, marrow stromal cells, activated T cells, synovial cells, keratinocytes, and mammary gland epithelial cells as well as in various tissues. The ligation of RANK by RANKL promotes dendritic cells (DCs) survival through prosurvival signals and the up-regulation of the anti-apoptotic proteins Bcl-2 and Bcl-$x_L$ and plays a crucial role in DCs-mediated Th1 differentiation. Therefore, RANKL plays an important role in the regulation of DCs/T cells-mediated specific immunity. This review will briefly inform our current understanding of the role of RANKL signaling in T cells-DCs communication in the immune system.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.4965-4972
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• 2013

This study aimed to discuss the consumption of alcohol as a risk factor for major cancers. We performed a search in the PubMed database, using the following inclusion criteria: meta-analysis published in English in the last 10 years that addressed the relationship between alcohol and the risk of developing cancer. The results indicate that moderate to heavy consumption of alcohol increases the risk of developing cancer of the oral cavity and pharynx, esophagus, stomach, larynx, colorectum, central nervous system, pancreas, breast and prostate. This review did not find any association between alcohol consumption and an increased risk of cancers of the lung, bladder, endometrium and ovary. It was also observed that alcohol consumption may be inversely related to thyroid cancer. Our systematic review has confirmed consumption of alcohol as a risk factor for the development of several types of cancer.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.14 no.2
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• pp.16-24
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• 2008

Anatomy: Advanced knowledges of cellular and molecular biology led to the development of therapies of rheumatoid arthritis(RA). Rheumatoid arthritis (RA) is a chronic, recurrent, systemic inflammatory disease and results in major deformity or dysfunction of joints. Etiology: Rheumatoid arthritis is now concevied as autoimmune disease. There have been many trials to define the immunological changes in rheumatoid arthritis. But now pathogenesis and significance of immunoglobulin complement and rheumatoid factor are not full accepted. Syndrome: Joints are characteristically involved with early inflammatory changes in the synovial membrane, peripheral portions of the articular cartilage, and lation tissue(pannus) forms, covers, and erodes the articular cartilage, bone and ligaments within the jiont capsule. Inflammatory changes also occur in tendon sheaths(tenosynovitis), and if subjected to a lot of friction, the tendons may fray or rupture. Extra-articular pathological changes sometimes occur, these include rheumatoid nodules, atrophy and fibrosis of muscles, and mild cardiac changes. Treatment: Tumor necrosis factor(TNF) inhibitor for the treatment of rheumatoid arthritis(RA) induces not only significant improvement of symptoms and signs of RA but also substantial inhibition of progressive joint damage.

• Journal of the Korea Institute of Military Science and Technology
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• v.14 no.2
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• pp.246-263
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• 2011

Mankind has just begun to recognize that the most crucial factor to achieve the sustainable society in the future is green technology. Most countries support the development of green technology to prevent catastrophes from global warming, mainly in the areas of reducing carbon dioxide from the atmosphere. However, most products we consume in everyday life are produced through chemical processes, and we often oversee the fact that the huge amount of waste and energy during these chemical processes will seriously influence our goal to achieve our future society sustainable. Thus the technologies to minimize the amount of disposed waste and energy consumption during chemical processes may be more important than to reduce the greenhouse gases. In this regard this review introduces the recent status of green chemistry and future prospects in order to help our chemists and engineers establish research projects based on the green chemistry principles.

• Transactions of the Korean Society of Mechanical Engineers
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• v.18 no.2
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• pp.278-291
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• 1994

A computer-aided robust design (CARD) technique is developed to search for the design variables, optimal as well as robust in the sense of Taguchi method. The CARD technique can effectively handle inequality problems by employing the variable penalty method, and dynamic problems with many design variables and/or with mixed discrete and continuous variables. It is also capable of providing contributions of each design variables to the object funtion and information for future designs. As the illustrative examples, two dynamic systems, engine mounting system and in-line feeder, are treated.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.8
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• pp.1273-1280
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• 2003

In this paper, transparent dynamic photoelastic experimental hybrid method for propagating cracks in orthotropic material was developed. Using transparent dynamic photoelastic experimental hybrid method, we can obtain stress intensity factor and separate the stress components from only isochromatic fringe patterns without using isoclinics. When crack is propagated with constant velocity, the contours of stress components in the vicinity of crack tip in orthotropic material are similar to those of isotropic material or orthotropic material with stationary crack under the static load. Dynamic stress intensity factors are decreased as crack growths. It was certified that the dynamic photoelastic experimental hybrid method was very useful for the analysis of the dynamic fracture mechanics.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.8
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• pp.1426-1435
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• 2003

Design goal is to find the one that has the highest probability of success and the smallest variation. A robustness index has been proposed to satisfy these conditions. The two-step optimization process of the target problem requires a scaling factor. The search process of a scaling factor is replaced with the making of the decoupled design between the mean and the standard deviation. The decoupled design matrix is formed from the sensitivity or the sum of squares. After establishing the design matrix, the robust design process has a new three-step one. The first is ″reduce variability,″ the second is ″make the candidate designs that satisfy constraints and move the mean on the target,″ and the final is ″select the best robust design using the proposed robustness index.″ The robust design process is verified by three examples and the results using the robustness index are compared with those of other indices.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2013.05a
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• pp.534-535
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• 2013

최근 LED 기술을 활용한 LED 조명은 밝기와 수명 및 저전력이라는 장점으로 인하여 현재 시중에 급속도로 퍼저 나가고 있다. 이러한 LED를 조명으로 사용하기 위한 기반 기술은 SMPS(Switching Mode Power Supply) 설계 기술이라 할 수 있다. 또한 LED 성능은 입력 전원 상태 및 LED 조명의 부하 조건에 따라 오차가 발생하여 LED등의 균일한 밝기를 유지하는데 기술적으로 많은 어려움이 있다. 본 논문에서는 12[W] 급 LED 다운 라이트에 대하여 LED SMPS의 전류 출력에 대하여 정전류제어를 함으로서 입/출력 조건의 변동에 대응하여 보다 안정적인 LED 등의 균일한 밝기를 유지하기 위한 12[W] 급 LED 다운 라이트용 SMPS에 PFC(Power Factor Correction) 회로를 추가하여 역율을 개선을 하며, 전압 위상에 따른 전류 위상 분포를 규일 비율로 제어 하여 보다 안정적인 밝기를 제공하는 12[W] 급 LED 조명용 SMPS를 개발하여 상품화를 제안하고자 한다.

• Journal of Construction Engineering and Project Management
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• v.3 no.2
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• pp.49-57
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• 2013

A sea dike construction has been increased in Korea because of the actively deployed reclamation project in basis of efficient application in land. The degree of completion in sea dike construction is affected by final closing construction, which has a lot of uncertainty that often results in higher accidents rate. Therefore, this research identified risk factors of final closing construction and classified them. This research examines the likelihood and its impact for each risk factor and calculates the risk degree as to the risk matrix. Based on this, the impact and the environmental conditions that affect to risk factors are investigated and further responsive methods are established for each risk factor. Ultimately, this research attempts to provide the risk retrenchment method for inspectors by proposing risk estimation model, responsive action list, and risk management process.