• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.445-453
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• 2016

Epidermal growth factor receptors (EGFRs/HERs) and downstream signaling pathways have been implicated in the pathogenesis of several malignancies including breast cancer and its resistance to treatment with chemotherapeutic drugs. Consequently, several monoclonal antibodies as well as small molecule inhibitors targeting these pathways have emerged as therapeutic tools in the recent past. However, studies have shown that utilizing these molecules in combination with chemotherapy has yielded only limited success. This review describes the current understanding of EGFRs/HERs and associated signaling pathways in relation to development of breast cancer and responses to various cancer treatments in the hope of pointing to improved prevention, diagnosis and treatment. Also, we review the role of breast cancer stem cells (BCSCs) in disease and the potential to target these cells.

• The Korean Journal of Physiology and Pharmacology
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• v.17 no.2
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• pp.111-120
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• 2013

Prolyl 4 hydroxylases (P4H) are iron- and 2-oxoglutamate-dependent dioxygenase enzymes and hypoxia-inducible transcription factor (HIF)-P4Hs play a critical role in the regulating oxygen homeostasis in the local tissues as well in the systemic circulation. Over a period of time, a number of prolyl hydroxylase inhibitors and activators have been developed. By employing the pharmacological tools and transgenic knock out animals, the critical role of these enzymes has been established in the pathophysiology of number of diseases including myocardial infarction, congestive heart failure, stroke, neurodegeneration, inflammatory disease, respiratory diseases, retinopathy and others. The present review discusses the different aspects of these enzymes including their pathophysiological role in disease development.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2010.05a
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• pp.3-14
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• 2010

Through time-series plots, we can see relatively stable trend of energy factor share and the decreasing trend of relative energy prices (to wages) in Korea. We can compromise these empirical facts with the following explanation: if elasticity of substitution between capital and energy is smaller than one(<1) in Korea, a change(decrease) in energy price can prevent income share of resources from rising in the process of economic growth. This is consistent with theoretical and empirical results that substitution between energy and capital is so difficult. From simple empirical analysis and limited information, we can carefully infer that, in the past in Korea, resource-specific innovation was performed widely. Finally, If we are to reduce the magnitude of "growth drag", we should decrease energy factor share. This can be accomplished by energy-augmenting technical progress in the case of elasticity of substitution less than 1 as in Korea.

• Journal of Institute of Convergence Technology
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• v.2 no.2
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• pp.20-24
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• 2012

In this paper, we perform a ANSYS simulation of assembly structure composed of three parts, bolt, nut, and coil spring, under the loading of a screw torque 640~800 ($N{\cdot}m$) derived from the given bolt tensile strength 10.9, which allows us to investigate a lock-nut mechanism for the prevention of bolt-loosening after three parts are fastened. And also we investigate the safety factor of each component with effective stress distribution obtained from the simulation, which enables us to estimate the structural safety of a new lock-nut structure. Both simulation and investigation shown in this paper will contribute to the development of a new lock nut structure.

• Proceedings of the KIEE Conference
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• 2001.07b
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• pp.1079-1081
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• 2001

A propulsion system apparatus is needed for a railroad vehicle to test and estimate propulsion performance. The electrical inertia simulator to facilitate the development and testing of propulsion systems, is presented in this paper. It is based on a vector-controlled induction motor drive supplied from the AC mains through a double PWM converter that provides desirable features such as bi-directional power flow, nearly unity power factor and low harmonic factor at the AC mains. A theoretical analysis is first presented, followed by a detailed simulation study to assess the overall system performance under dynamic conditions.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.328.3-329
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• 2002

A convenient bioassay of nerve growth factor(NGF) is essential for assessing its potency during the course of product development and quality controls afterwards. We have set up a cell-based bioassay for determining the potency of recombinant NGF using rat pheochromocytoma (PC12) cells. Cell survival was measured by monitoring the reduction of the alamarBlue$^{TM}$ dye by living cells. (omitted)d)

• Elastomers and Composites
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• v.32 no.1
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• pp.20-28
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• 1997

This study have Investigated the effect of various factors related to the physical properties of vulcanizated rubber compounds. rubber type, carbon black type and carbon black loading were selected as main factors and evaluation were tested by tables of orthogonal arrays with 3 factors and 3 levels. rubber types have affected cure time, tensile strength, and $T_g$ as main factor and carbon black loading have affected viscosity, scorch time, maximum torque, hardness, 300% modulus, rebound, heat build-up, $0\;&\;60^{\circ}C$ tangent delta, PICO and CUT/CHIP loss as main factor but the effects of carbon black type have affected only bound rubber content.

• Journal of the Korean Solar Energy Society
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• v.31 no.3
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• pp.17-22
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• 2011

Techniques for mismatch loss minimization to increase the PV system efficiency are under development recently. In this paper, a method to make diagnosis of PV module mismatch is presented, which uses a concept of operating point factor. The method is based on the fact that the ratio of the incremental conductance of a PV module to instantaneous conductance is 1 when the module is operating at its maximum power point. The variations of module voltage and current are taking place by the maximum power point tracker in the power conditioning units of PV system. The effectiveness of the method is verified through an application to a real PV system.

• 한국태양에너지학회:학술대회논문집
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• 2008.11a
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• pp.300-305
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• 2008

Using WindPRO that was software for windfarm design developed by EMD from Denmark, wind resources for the western Jeju island were analyzed, and the performance of WindPRO prediction was evaluated in detail. The Hansu site and the Yongdang site that were located in coastal region were selected, and wind data for one year at the two sites were analyzed using WindPRO. As a result, the relative error of the Prediction for annual energy Production and capacity factor was about ${\pm}20%$. For evaluating wind energy more accurately, it is necessary to obtain lots of wind data and real electric power production data from real windfarm.

• Journal of Korean Academy of Nursing
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• v.28 no.3
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• pp.563-572
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• 1998

The purpose of study was to develop and validate Korean Sleep Scale A which can be easily administrated by nurses for a wide range of adult subjects. Dimensions of sleep concept were derived by literature review. Previously developed sleep sclaes were also analyzed in order to develop scale items. The Korean sleep scale A was structured as a 15 item, 4 point likert type scale. The Scale was tested an 298 female and male adult subjects after pilottest and content validation. The results showed reliability by internal consistency of Cronbach's α=.75 Construct validity was tested by factor analysis and known group technique. Factor analysis showed 4 factors-sleep pattern, sleep evaluation, sleep result, and cause of sleep disturbance. These four factors explained 55.9% of total variance. Correlations between factors ranged from .15-.32. There was correlation among Korean Sleep ScaleA score, Verran and Snyder-Halpern(VSH) Sleep Scale score, and sleep satisfaction scale score, r=.71(p=.00), r=.51(p=.03), respectively, These study results partially support reliability, construct validity, and criterion related validity of Korean Sleep Scale A. Further validation study is required with other subjects and other settings.