• BMB Reports
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• 제51권10호
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• pp.538-543
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• 2018

Pancreatic beta cell destruction and dysfunction induced by cytokines is a major cause of type 1 diabetes. Paraoxonase 1 (PON1), an arylesterase with antioxidant activity, has been shown to play an important role in preventing the development of diabetes in transgenic mice. However, no studies have examined the anti-diabetic effect of PON1 delivered to beta cells using protein transduction. In this study, we expressed the cell-permeable PON1 fused with PEP-1 protein transduction domain (PEP-1-PON1) to investigate whether transduced PEP-1-PON1 protects beta cells against cytokine-induced cytotoxicity. PEP-1-PON1 was effectively delivered to INS-1 cells and prevented cytokine-induced cell destruction in a dose-dependent manner. Transduced PEP-1-PON1 significantly reduced the levels of reactive oxygen species (ROS) and nitric oxide (NO), DNA fragmentation, and expression of inflammatory mediators, endoplasmic reticulum (ER) stress proteins, and apoptosis-related proteins in cytokine-treated cells. Moreover, transduced PEP-1-PON1 restored the decrease in basal and glucose-stimulated insulin secretion induced by cytokines. These data indicate that PEP-1-PON1 protects beta cells from cytokine-induced cytotoxicity by alleviating oxidative/nitrosative stress, ER stress, and inflammation. Thus, PEP-1-mediated PON1 transduction might be an effective method to reduce the extent of destruction and dysfunction of pancreatic beta cells in autoimmune diabetes.

• 전기전자학회논문지
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• 제19권3호
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• pp.440-446
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• 2015

본 연구는 안테나에 커플링되는 협대역 고출력 전자기파에 대한 저 잡음 증폭기(LNA)의 민감성 특성을 알아보았다. LNA 소자의 오동작/파괴는 MFR/DFR((Malfunction Failure Rate/Destruction Failure Rate)을 이용하여 소자의 민감성을 확인하였다. 그리고 LNA 소자의 내부 칩 상태는 Decapsulation 분석을 이용하여 손상부위를 관찰하였다. 협대역 고출력 전자기파 장치는 2.45 GHz 마그네트론을 사용하였고, LNA의 민간성 레벨은 협대역 고출력 전자기파의 전계강도에 따라 오동작/파괴율을 평가하였다. 그 결과, LNA 소자의 오동작은 셀프리셋(Self Reset)과 파워리셋(Power Reset)의 형태로 나타내었고, 이때 오동작 임계 전계강도는 각각 524 V/m, 1150 V/m로 측정되었다. 그리고 LNA의 소자의 파괴 임계 전계강도는 1530 V/m이다. 협대역 고출력 전자기파에 의한 LNA 소자의 내부 칩 파괴는 본드와이어, 온칩와이어 그리고 컴포넌트 세가지 형태로 관찰되었다. 이 결과로, 협대역 고출력 전자기파에 의한 반도체 전자회로의 내성평가 자료로 활용할 수 있을 것으로 판단된다.

• 노동경제논집
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• 제27권2호
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• pp.29-66
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• 2004

이 글은 1981년부터 2000년까지 한국의 "광공업통계조사" 원자료를 이용하여 한국 광공업의 사업체 수준에서의 일자리창출률과 소멸률을 측정하고 분석하는 것을 목적으로 한다. Davis and Haltiwanger(19992)의 방법론에 따라 측정한 결과 동 기간 광공업 5인 이상 지속사업체의 일자리창출률과 소멸률은 각각 9.75, 10.33로서 다른 나라의 일자리변동과 비교할 때 상대적으로 높은 수준이었다. 또한 창출된 일자리의 지속성이 낮고 일자리변동의 집중성은 높은 수준임을 확인할 수 있다. 노동자 재배치 중에서 일자리 재배치가 설명하는 비중을 측정한 결과 미국과 비슷하거나 더 높은 비중을 보여서 일자리변동이 노동이동의 중요한 요인으로 작용했음을 확인할 수 있었다. 외환위기 직전까지 노동이동이 감소하는 추세였던 데 비해 일자리 재배치 수준에는 변함이 없어 외환위기 직전에는 일자리 재배치가 설명하는 비중이 최대 60%까지 높아졌다. 마지막으로 일자리창출과 소멸의 변화가 호황과 불황기에 어떤 차이가 있는지를 연구하였다. 창출률과 소멸률은 각각 경기순행적, 경기역행적으로서 일반적인 양상을 띠고 있었으며, 미국과 달리 일자리 재배치율의 경기역행성은 관측할 수 없었다.

• 한국안전학회지
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• 제22권4호
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• pp.102-109
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• 2007

A bioterrorism attack is the deliberate release of viruses, bacteria, or other germs(agents) used to cause illness or death in people, animals, or plant. These agents are found in nature, but it is possible that they could be changed to increase their ability to cause disease, make them resistant to current medicines, or to increase their ability to be spread into the environment. Terrorists may use biological agents because these agents can be extremely difficult to detect and do not cause illness for several days. Some bioterrorism agents, like smallpox virus, can spread from person to person, like anthrax, can not. From these agents, we discussed the characteristics of biological agents and national safety regulation on the weapons of mass destruction including bioterrorism.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집D
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• pp.751-758
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• 2001

Exergy concept is applied to the analysis of part-load performance of gas turbine engine. Exergy is a useful tool to find the source of irreversibility in thermal system. In this study, details of the performance characteristics of a heavy-duty gas turbine, l50MW-class GE 7FA model, are described by theoretical investigations with exergy analysis. Result shows that exergy destruction rate of gas turbine increases with decreased load, which means increase of irreversibility. Also, it is found that variations of IGV angle and amount of cooling air for turbine blades are closely related to the inefficiencies of compressor and turbine, respectively.

• 무역상무연구
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• 제42권
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• pp.309-335
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• 2009

Over the last several years, regarding to the strategic items, the international community has seen governments make more formal commitments to adopt and implement effective export controls to counter the proliferation of weapons of mass destruction(WMD). United Nations Security Council Resolution 1540(that is "S/RES/1540") stands as the most important of these commitments. Many UN members already have export control laws and regulations in place to prevent the proliferation of weapons of mass destruction. Many members also participate in a variety of formal and informal international arrangements to coordinate their export control efforts. Nonetheless, each of these countries has its own unique legal framework for export controls. This generates considerable diversity in the construction of the specific national legal authorities. Over the last few years, however, a consensus over what constitutes the key elements of effective legal authorities for export controls has begun to emerge. Evidence for this development comes in the identification of best legal authorities or principles at several multilateral conferences on export controls.

• 한국전기전자재료학회논문지
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• 제14권1호
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• pp.26-33
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• 2001

The proposed system was composed of pre-processor which was executing binary/high-pass filtering and post-processor which ranged from statistic data to prediction. In post-processor work, step one was filter process of image, step two was image recognition, and step three was destruction degree/time prediction. After these processing, we could predict image of the last destruction timestamp. This research was produced variation value according to growth of tree pattern. This result showed improved correction, when this research was applied image Processing. Pre-processing step of original image had good result binary work after high pas- filter execution. In the case of using partial discharge of the image, our research could predict the last destruction timestamp. By means of experimental data, this prediction system was acquired $\pm$3.2% error range.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2001년도 하계학술대회 논문집
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• pp.319-322
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• 2001

The proposed system was composed of pre-processor which was executing binary/high-pass filtering and post-processor which ranged from statistic data to prediction. In post-processor work, step one was filter process of image, step two was image recognition, and step three was destruction degree/time prediction. After these processing, we could predict image of the last destruction timestamp. This research was produced variation value according to growth of tree pattern. This result showed improved correction, when this research was applied image Processing. Pre-processing step of original image had good result binary work after high pass- filter execution. In the case of using partial discharge of the image, our research could predict the last destruction timestamp. By means of experimental data, this Prediction system was acquired ${\pm}$3.2% error range.

• 생약학회지
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• 제21권1호
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• pp.74-82
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• 1990

The effects of naturally occurring furanocoumarins on cytochrome P-450 have been investigated in rat liver microsomes. Incubation of microsomes with an NADPH-generating system and four furanocoumarins such as imperatorin, isoimperatorin, phellopterin and byakangelicin at $37^{\circ}$ in vitro resulted in a significant destruction of cytochrome P-450. A single treatment(50 mg/kg, i.p.) of rats with each furanocoumarin caused a rapid loss of cytochrome P-450 accompanied by the loss of heme from the microsomes but not by the loss of cytochrome $b_5$. It is suggested that cytochrome P-450 is specifically destroyed by furanocoumarins in a metabolic process involving destruction of its heme group and as a consequence, hepatic enzyme activities are depressed markedly.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2000년도 추계학술대회 논문집
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• pp.154-158
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• 2000

Hydraultic experiments were performed in 2-D were flume to investigate the stability o the breakwaters, the destruction of armor blocks and overtopping under irregular wave attack on the structures armored by \`Core-Loc\`. Overtopping rate and stability were examined and compared when armored by Core-Loc and by T.T.P. Results shows both type of blocks are stable and overtopping rates are similar in the adopted experimental condition. Therefore Core-Loc can replace some portion of T.T.P. which is uniquely used in Korea. Further integrated experimental data with Core-loc are need for destruction mechanism or overtopping rate.