• Parasites, Hosts and Diseases
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• v.61 no.3
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• pp.282-291
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• 2023

Despite the recent progress in public health measures, malaria remains a troublesome disease that needs to be eradicated. It is essential to develop new antimalarial medications that are reliable and secure. This report evaluated the pharmacokinetics and antimalarial activity of 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89) using the rodent malaria parasite Plasmodium berghei in vivo. After a single oral dose (75 mg /kg) of N-89, its pharmacokinetic parameters were measured, and t_1/2 was 0.97 h, T_max was 0.75 h, and bioavailability was 7.01%. A plasma concentration of 8.1 ng/ml of N-89 was maintained for 8 h but could not be detected at 10 h. The dose inhibiting 50% of parasite growth (ED₅₀) and ED₉₀ values of oral N-89 obtained following a 4-day suppressive test were 20 and 40 mg/kg, respectively. Based on the plasma concentration of N-89, we evaluated the antimalarial activity and cure effects of oral N-89 at a dose of 75 mg/kg 3 times daily for 3 consecutive days in mice harboring more than 0.5% parasitemia. In all the N-89-treated groups, the parasites were eliminated on day 5 post-treatment, and all mice recovered without a parasite recurrence for 30 days. Additionally, administering oral N-89 at a low dose of 50 mg/kg was sufficient to cure mice from day 6 without parasite recurrence. This work was the first to investigate the pharmacokinetic characteristics and antimalarial activity of N-89 as an oral drug. In the future, the following steps should be focused on developing N-89 for malaria treatments; its administration schedule and metabolic pathways should be investigated.

• Journal of Service Research and Studies
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• v.12 no.3
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• pp.115-133
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• 2022

This study was conducted to design a new human model and education system for the sustainable life of mankind. Human society is facing a crisis. This study presents a comprehensive plan as the final version of the servicism study. Since the problems of human society are all human problems, research was conducted focusing on the new human and education system. Modern society is markedly different from the existing society in terms of time, space, and humanity, and the leading role of individuals is increased due to the increase in literacy, which can lead to breakdown and ground breaking in an instant. As the value of growth and freedom is increasing, technological innovation is accelerating, and industries and enterprises are growing significantly, so new technologies and industries may put human society at great risk. This study comprehensively diagnosed these problems in the current human society. The problems related to human and education were presented in depth while analyzing and synthesizing the problems presented in the existing servicism studies. The necessary and sufficient conditions for a new system to solve the problems raised were derived. And a system that satisfies these conditions was derived and presented. The new system was named servicism human and education system as a system based on the service philosophy. The structure, operation model, and implementation plan of the new system were presented. The basic structure is a human view that recognizes both reason and irrationality, an education system in which intelligence education and virtue education are balanced, and an education system in which human effort and the values of unwieldy nature are respected. A new education system needs to be put into operation along with the improvement of modern ideology and the compensation system for efforts. Since this study presented a macroscopic direction, further studies are needed to further refine this study.

• Nuclear Engineering and Technology
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• v.54 no.12
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• pp.4571-4584
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• 2022

The analysis of rapid flow transients in Reactor Coolant Pumps (RCP) is essential for a reactor safety study. An accurate and precise analysis of the RCP coastdown is necessary for the reactor design. The coastdown of RCP affects the coolant temperature and the colloidal crud in the primary coolant. A realistic and kinetic model has been used to investigate the behavior of activated colloidal crud in the primary coolant and steam generator that solves the pump speed analytically. The analytic solution of the non-dimensional flow rate has been determined by the energy ratio β. The kinetic energy of the coolant fluid and the kinetic energy stored in the rotating parts of a pump are two essential parameters in the form of β. Under normal operation, the pump's speed and moment of inertia are constant. However, in a coastdown situation, kinetic damping in the interval has been implemented. A dynamic model ACCP-SMART has been developed for System Integrated Modular and Advanced Reactor (SMART) to investigate the corrosion due to activated colloidal crud. The Fickian diffusion model has been implemented as the reference corrosion model for the constituent component of the primary loop of the SMART reactor. The activated colloidal crud activity in the primary coolant and steam generator of the SMART reactor has been studied for different equilibrium corrosion rates, linear increase in corrosion rate, and dynamic RCP coastdown situation energy ratio b. The coolant specific activity of SMART reactor equilibrium corrosion (4.0 mg s^-1) has been found 9.63×10^-3 µCi cm^-3, 3.53×10^-3 µC cm^-3, 2.39×10^-2 µC cm^-3, 8.10×10^-3 µC cm^-3, 6.77× 10^-3 µC cm^-3, 4.95×10^-4 µC cm^-3, 1.19×10^-3 µC cm^-3, and 7.87×10^-4 µC cm^-3 for ²⁴Na, ⁵⁴Mn, ⁵⁶Mn, ⁵⁹Fe, ⁵⁸Co, ⁶⁰Co, ⁹⁹Mo, and ⁵¹Cr which are 14.95%, 5.48%, 37.08%, 12.57%, 10.51%, 0.77%, 18.50%, and 0.12% respectively. For linear and exponential coastdown with a constant corrosion rate, the total coolant and steam generator activity approaches a higher saturation value than the normal values. The coolant and steam generator activity changes considerably with kinetic corrosion rate, equilibrium corrosion, growth of corrosion rate (ΔC/Δt), and RCP coastdown situations. The effect of the RCP coastdown on the specific activity of the steam generators is smeared by linearly rising corrosion rates, equilibrium corrosion, and rapid coasting down of the RCP. However, the time taken to reach the saturation activity is also influenced by the slope of corrosion rate, coastdown situation, equilibrium corrosion rate, and energy ratio β.

• Journal of the Korean Geotechnical Society
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• v.24 no.2
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• pp.77-86
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• 2008

The disturbance zone and measured values are affected by the size of the penetrometer. The local value may be measured by the smaller penetrometer. An ultra small Micro-Cone penetrometer (5mm in outer diameter) is designed and manufactured to characterize soil properties with minimum disturbance during penetration tests. The tip resistance is measured by using stain gauges attached near the Micro-Cone. In addition, the friction sleeve is adopted to effectively remove the skin friction from the tip resistance. Design concern includes the installation of stain gauges, circuits, penetration systems, penetration rate, sampling rate, operating temperature, and calibration. Application tests show that the clay interface, and the soil layers consisting of clay and sand are clearly detected by the Micro-Cone. Furthermore, the cone tip resistances measured by the Micro-Cone and the miniature cone (16mm in outer diameter) are similar. Note the resolution is much higher in the Micro-Cone. This study shows that the Micro-Cone may effectively detect the soil interface with high resolution, and with minimum disturbance.

• Journal of the Korean Geotechnical Society
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• v.25 no.9
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• pp.57-66
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• 2009

In the preliminary investigation (Park et al., 2009), the use of compressional wave velocity and its measurement techniques were proposed as a new quality control measure for trackbed fills. The methodology follows exactly the same procedure as the density control, except the density being replaced by the compressional wave velocity involving consistently with resilient modulus of design stage. The specifications for the control also include field compaction water content of optimum moisture content ${\pm}2%$ as well as the compressional wave velocity. In this sequel paper, crosshole and resonant column tests were performed as well direct-arrival method and laboratory compressional wave measurements to verify the practical applicability of a methodology far the new quality control procedure based upon compressional wave velocity. The stress-modified crosshole results reasonably well agree with the direct-arrival values, and the resonant column test results also agree well with the field crosshole results. The compressional wave velocity turned out to be an excellent control measure for trackbed fills both in the theoretical and practical point of view.

• Steel and Composite Structures
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• v.47 no.1
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• pp.91-102
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• 2023

To study the evaluation standard and control limit of mortar filling layer void length, in this paper, the train sub-model was developed by MATLAB and the track-bridge sub-model considering the mortar filling layer void was established by ANSYS. The two sub-models were assembled into a train-track-bridge coupling dynamic model through the wheel-rail contact relationship, and the validity was corroborated by the coupling dynamic model with the literature model. Considering the randomness of fastening stiffness, mortar elastic modulus, length of mortar filling layer void, and pier settlement, the test points were designed by the Box-Behnken method based on Design-Expert software. The coupled dynamic model was calculated, and the support vector regression (SVR) nonlinear mapping model of the wheel-rail system was established. The learning, prediction, and verification were carried out. Finally, the reliable probability of the amplification coefficient distribution of the response index of the train and structure in different ranges was obtained based on the SVR nonlinear mapping model and Latin hypercube sampling method. The limit of the length of the mortar filling layer void was, thus, obtained. The results show that the SVR nonlinear mapping model developed in this paper has a high fitting accuracy of 0.993, and the computational efficiency is significantly improved by 99.86%. It can be used to calculate the dynamic response of the wheel-rail system. The length of the mortar filling layer void significantly affects the wheel-rail vertical force, wheel weight load reduction ratio, rail vertical displacement, and track plate vertical displacement. The dynamic response of the track structure has a more significant effect on the limit value of the length of the mortar filling layer void than the dynamic response of the vehicle, and the rail vertical displacement is the most obvious. At 250 km/h - 350 km/h train running speed, the limit values of grade I, II, and III of the lengths of the mortar filling layer void are 3.932 m, 4.337 m, and 4.766 m, respectively. The results can provide some reference for the long-term service performance reliability of the ballastless track-bridge system of HRS.

• Korea Science and Art Forum
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• v.23
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• pp.95-109
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• 2016

The background and objective of this study are as follows. Gwangheemun, one of the 4 small gates of Seoul Castle is a space to represent ordinary people and it is a valuable cultural heritage that shows the process of technical transition of fortification technology during Chosun Dynasty. It is a place that we can expect to play a role as a field where history and culture mix and communicate together. But currently, the environment and facilities around Gwangheemun have fallen behind and become old, so they need to be reorganized as their local feature is not shown distinctly. We need to vitalize the new traditional space that shows local feature. This study has drawn out the method, contents and the result of study like as follows. This study aims to establish an identity based on the historical and cultural backgrounds and suggest the contents to vitalize the space of Gwangheemun as a traditional cultural heritage. By this, this study aims to create a historical and cultural space where people can enjoy, eat and look around. Therefore, based on the historical and cultural feature, it gives an identity as moonlight street, and it has developed and suggested 5 contents to vitalize space: Gwangheemun maintenance, plan, castle restoration plan, village inside the castle, village outside the castle and fashion art street. Contents to vitalize space has a meaning as a specific developmen method of urban restoration, and we can expect to be used as a direction to develop the area to enhance the cultural quality of life of both inhabitants and visitors by forming the brand identity of surrounding area with traditional cultural heritage.

• Journal of Cadastre & Land InformatiX
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• v.53 no.1
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• pp.37-46
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• 2023

As real estate values rise, interest in cadastral resurvey is increasing. Accordingly, a cadastral resurvey project is actively underway for drone operation through securing work efficiency and improving accuracy. The need for utilization and management of cadastral resurvey results (drone images) is being raised, and through this study, a 3D spatial information platform was developed to solve the existing drone image management and utilization limitations and to provide drone image-based 3D cadastral information. It is proposed to build and use. The study area was selected as a district that completed the latest cadastral resurvey project in which the study was organized in February 2023. Afterwards, a web-based 3D platform was applied to the study to solve the user's spatial limitations, and the platform was designed and implemented based on drone images, spatial information, and attribute information. Major functions such as visualization of cadastral resurvey results based on 3D information and comparison of performance between previous cadastral maps and final cadastral maps were implemented. Through the open platform established in this study, anyone can easily utilize the cadastral resurvey results, and it is expected to utilize and share systematic cadastral resurvey results based on 3-dimensional information that reflects the actual business district. In addition, a continuous management plan was proposed by integrating the distributed results into one platform. It is expected that the usability of the 3D platform will be further improved if a platform is established for the whole country in the future and a service linked to the cadastral resurvey administrative system is established.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.4D
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• pp.377-386
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• 2010

This study was conducted to find out the characteristics of the expanded road embankment constructed by the lightweight air-mixed soil (slurry density $10kN/m^3$) for a short-term without any ground improvement. Compression strength, capillary rise height of the lightweight air-mixed soil and settlement behavior of soft ground were studied. Compression strengths of the specimens sampled at the site after 1 and 5 months of construction were all satisfied the required strength 500 kPa. However, it was not convinced the homogeneity construction, because the values of strength were depending on the sampled location. Also, strength difference between laboratory and site specimens were found about 19%, and thus it should be considered for mixing design. Capillary rise reached about 20 cm for 70 hours because of a numerous tiny pores existed inside the lightweight air-mixed soil. Relationship between settlement and time of the soft ground placed underneath the expanded embankment was estimated by using the measured data and back analysis technique. The current average consolidation ratio and the final settlement after 120 months later were estimated about 32% and 4.5cm, respectively. This settlement is much less value than the allowable settlement 10cm for this structure.

• The Journal of Korean Academy of Sensory Integration
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• v.21 no.1
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• pp.23-33
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• 2023

Objective : The purpose of this study is was to find ouetermine whether training to applying vibration stimulation to the biceps brachii of children in the late stages of spasticity hemiplegic cerebral palsy can helps to improve the function of the upper extremity. Methods : This The study was conducted on with three children with cerebral palsy, all between the ages of 13 and 15 years. Among the experimental research methods of used with individual subjects, an AB research design using multiple basic baseline individual experimental studies was used, and vibration stimulation was provided to the paralyzed hand during the intervention period. The An evaluation was conducted before and after each session used to measure the function of the upper extremity using was conducted after each session of the Rapael Smart Board and The Jebsen-Tayler hand function test and the Motor Activity Log (MAL) were conducted before and after the experiment. Results : As a result of measuring the smooth The average score and total scores of for using the Rapael Smart Board to measure the upper extremity function in following each therapeutic session using the Rafale smart pegboard showed that, Subject 3 did not showevidenced a no significant change in the average value, and but Subjects 1 and 2 did showed a significant changes in their average values. All three subjects showed significant changes in the Jepson-Taylor hand function test and in the Motor Activity Log test, as evaluated before and after the intervention. Conclusion : Training The using use of vibration stimulation showed a positive effect on in improving upper limb function and exercise in hemiplegia hemiplegic children with who had little experience on using their hemiplegic side.