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'Simultaneous Modulated Accelerated Radiation Therapy' (SMART) Intensity-Modulated Radiotherapy in the Treatment of Nasopharyngeal Carcinoma : the Asan Medical Center (비인강암의 세기조절방사선치료기술을 이용한 동시차등조사가속치료의 예비성적)

  • Lee Sang-Wook;Back Geum-Mun;Yi Byong-Yong;Choi Eun-Kyung;Kim Jong-Hoon;Ahn Seung-Do;Shin Seong-Soo;Kim Sang-Yoon;Nam Soon-Yuhl;Choi Seung-Ho;Kim Sung-Bae;Song Si-Yeol
    • Korean Journal of Head & Neck Oncology
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    • v.19 no.1
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    • pp.9-15
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    • 2003
  • Purpose: To introduce our early experience with intensity-modulated radiotherapy (IMRT) in the treatment of nasopharyngeal carcinoma. Methods and Materials: Eight patients who underwent IMRT for no disseminated nasopharyngeal carcinoma at the Asan Medical Center between September 2001 and November 2002 were evaluate by prospective analysis. According to the 1997 American Joint Committee on Cancer staging classification, 5 had Stage III, and 3 had Stage IVB disease. The IMRT plans were designed to be delivered as a 'Simultaneous Modulated Accelerated Radiation Therapy' (SMART) using the 'step and shoot' technique with a MLC (multileaf collimator). Daily fractions of 2.2-2.5Gy and 1.9-2Gy were prescribed and delivered to the GTV and CTV and clinically negative neck node, respectively. The prescribed dose was 70A-79.0Gy to the gross tumor volume (GTV), 60Gy to the clinical target volume (CTV) and metastatic nodal station, and 46Gy to the clinically negative neck. All patients also received weekly cisplatin during radiotherapy. Acute and late normal tissue effects were graded according to the Radiation Therapy Oncology Group (RTOG) radiation morbidity scoring criteria. Results: Follow-up period was ranging from 5 to 18 months. All patients showed complete response and loco-regional control rate was 100% but one patient died of malnutrition due to treatment related toxicity. There were no Grade 3 or 4 xerostomia and all patients had experienced improvement of salivary gland function. Conclusion: 'Simultaneous Modulated Accelerated Radiation Therapy' (SMART) boost intensity-modulated radiotherapy technique allows parotid sparing as evidenced both clinically and by dosimetry. Initial tumor response and loco-regional control was promising. It is clinically feasible. A larger population of patients and a long-term follow-up are needed to evaluate ultimate tumor control and late toxicity.

Ultrasound-guided Needle Aspiration of Cranial Epidural Hematoma in a Neonate

  • Lee, Dong-Hoon;Lee, Sang-Weon;Lee, Tae-Hong;Ban, Ji-Eun
    • Journal of Korean Neurosurgical Society
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    • v.39 no.1
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    • pp.61-63
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    • 2006
  • We report a unique case of a neonate with an epidural hematoma induced by vacuum extraction. The epidural hematoma, communicating with a cephalhematoma through a linear skull fracture, disappeared after ultrasound-guided needle aspiration. The patient quickly recovered and one month later computed tomography revealed a complete resolution of the epidural hematoma.

Cerebellar Glioblastoma Presenting as a Cerebellar Hemorrhage in a Child

  • Joung, Young-Il;Cheong, Jin-Hwan;Bak, Koang-Hum;Kim, Choong-Hyun
    • Journal of Korean Neurosurgical Society
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    • v.39 no.5
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    • pp.374-377
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    • 2006
  • Cerebellar hemorrhage in adults is a well-described condition, but rarely occurs in children. Such hemorrhages in children are commonly results from arteriovenous malformations, trauma, infection or hematological abnormalities; a neoplastic origin is rare. We report a case of cerebellar hemorrhage as the initial manifestation of cerebellar glioblastoma in a child with review of literature.

Purely Extradural Spinal Meningioma of the Cervical Spine

  • Choi, Jun-Woong;Park, In-Seo;Yoon, Seung-Hwan;Park, Jong-Oon
    • Journal of Korean Neurosurgical Society
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    • v.37 no.1
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    • pp.73-75
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    • 2005
  • Spinal meningiomas located purely in the extradural space are rare, and they may easily be confused with malignant neoplasm. We report an unusual case of a purely extradural spinal meningioma mimcking metestatic neoplasm. A 38-year-old woman had neck pain and left side weakness. MRI scan revealed extradural spinal mass. Preoperative and intraoperative diagnosis was metastatic carcinoma, but permanent diagnosis was extradural meningioma.

Diffuse Large B-cell Lymphoma of the Sacral Nerve Root; Presenting as a Polyradiculoneuropathy

  • Oh, Sung-Han;Noh, Jae-Sub;Chung, Bong-Sub;Paik, So-Ya
    • Journal of Korean Neurosurgical Society
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    • v.37 no.1
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    • pp.70-72
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    • 2005
  • Primary spinal cord lymphomas are rare, and are either extra-/intradural masses with leptomeningeal infiltration or intramedullary in nature. The authors present a patient with a diffuse large B-cell lymphoma involving the sacral nerve root, extension to extradural space, and the cranial nerve.

The Critical Phenomena of a Model for the Metabolic Control System with Positive Feedback

  • Kim, Cheol-Ju;Lee, Dong- J.;Shin, Kook-Joe;Lee, Jong-Myung;Ko, Seuk-Beum;Jeon, Il-Cheol
    • Bulletin of the Korean Chemical Society
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    • v.10 no.5
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    • pp.452-458
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    • 1989
  • The static and dynamic phenomena of a model for the metabolic control system with positive feedback are discussed with the static and dynamic renormalization group theory. Then, the explicit results for the static and dynamic exponents are obtained up to the second order of ${\varepsilon}$-expansion, ${\varepsilon}$ being 4-d, where d is the space dimensionality of the system.