• 제목/요약/키워드: Department of Internal Medicine

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양측 미만성 폐침윤과 전신 홍반을 동반한 말초 T세포 림프종 (A Case of Peripheral T-cell Lymphoma with Diffuse Bilateral Pulmonary Infiltration and Whole Body Rash)

  • 이승현;하은실;김정하;정진용;이경주;김세중;이은주;허규영;정기환;정혜철;이승룡;이상엽;김제형;신철;심재정;인광호;강경호;유세화
    • Tuberculosis and Respiratory Diseases
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    • 제59권5호
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    • pp.566-570
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    • 2005
  • 폐에 발생하는 원발성 비호지킨 림프종은 아주 드문 질환으로 대개 폐문이나 중격동의 림프절 비대로 나타난다. 조직학적으로 대개 low grade B-cell 형태로 주로 발생하고 말초 T세포 형태로 폐에 원발성으로 발생하는 림프종은 드문 것으로 알려져 있다. 저자들은 발열과 전신 홍반이 있으면서, 흉부 X-선 사진상 급속히 진행하는 미만성 폐침윤 및 흉수 소견을 보여 초기에는 감염성 질환을 의심하였으나 피부병변과 림프절 및 골수 검사상 말초 T세포 림프종으로 진단된 예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

도관적입법(導管滴入法)으로 호전된 장폐쇄증(腸閉鎖症) 환자 치험 2례 보고 (A Clinical Report on Retention Enema Therapy for Patients with Ileus)

  • 이남헌;윤담희;이지영;채은영;유화승;조정효;이연월;손창규;조종관
    • 대한한방내과학회지
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    • 제25권4호
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    • pp.364-372
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    • 2004
  • This study was designed to evaluate the effects of retention enema therapy on patients with ileus. We retrospectively analyzed the medical records of two patients with ileus whose main symptoms were nausea, vomiting, constipation and abdominal pain. They were treated with retention enema therapy. After treatment, improvement was seen in nausea, vomiting, constipation and abdominal pain. The results of this study suggests that retention enema therapy is effective for the treatment of ileus.

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고칼륨혈증으로 이뇨제 중단된 소변빈삭 환자의 한방치험 1례 (A Case Report of Urinary Incontinence with Discontinuance of Diuretics for Hyperkalemia)

  • 최은영;현진오;신원용;강아미;김용형;한이수;김학재;최흥민;임성우
    • 대한한방내과학회지
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    • 제27권3호
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    • pp.745-750
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    • 2006
  • Spironolactone reduces potassium excretion in renal collecting ducts and causes hyperkalemia. A 66-year-old female with urinary incontinence had to discontinue diuretics for hyperkalemia. After treatment with Jesaengsinkihwan-gagambang. she reduced urinary incontinence and her total urine volume was increased. BUN decreased from 32.2 to 16 and creatinine decreased from 1.5 th 0.9. So. we report one case of urinary incontinence with discontinuance of diuretics for hyperkalemia treated with Jesaengsinkihwan-gagambang.

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간이식 환자에서 발생한 Nocardia farcinia 폐렴 및 패혈성 쇼크 1예 (A Case of Pneumonia with Septic Shock Due to Nocardia farcinia in Liver Transplant Patient)

  • 이수환;박병훈;손지영;정지예;김은영;임주은;이지훈;현신영;이상훈;이상국;김송이;이경종;강영애;김영삼;김세규;장준;서유경;이경원;박무석
    • Tuberculosis and Respiratory Diseases
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    • 제69권6호
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    • pp.469-473
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    • 2010
  • Nocardia farcinia, an aerobic, gram-positive bacilli actinomycetes of the genus Nocardia, is an uncommon pathogen found in humans. The most common Nocardia infection sites are the lung, central nervous system, and skin. Even though hematogenous dissemination can occur, isolation of the organism from blood cultures is very rare. We report a case of Nocardia infection that was isolated on blood cultures. A 59-year-old male with a medical history that includes a liver transplantation 6-years prior due to hepatocellular carcinoma secondary to chronic hepatitis B, developed pneumonia and was transferred to Severance Hospital. At the time of admission, the patient's initial exam showed hypothermia, tachypnea, and hypotension. His chest radiograph showed severe pneumonia and a large abscess on left upper lobe. Under the presumptive diagnosis of bacterial pneumonia or other opportunistic infection, we started broad spectrum antibiotics. However, he developed Nocardia sepsis, rapidly deteriorated, and subsequently died.

Geriatric risk model for older patients with diffuse large B-cell lymphoma (GERIAD): a prospective multicenter cohort study

  • Ho-Young Yhim;Yong Park;Jeong-A Kim;Ho-Jin Shin;Young Rok Do;Joon Ho Moon;Min Kyoung Kim;Won Sik Lee;Dae Sik Kim;Myung-Won Lee;Yoon Seok Choi;Seong Hyun Jeong;Kyoung Ha Kim;Jinhang Kim;Chang-Hoon Lee;Ga-Young Song;Deok-Hwan Yang;Jae-Yong Kwak
    • The Korean journal of internal medicine
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    • 제39권3호
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    • pp.501-512
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    • 2024
  • Background/Aims: Optimal risk stratification based on simplified geriatric assessment to predict treatment-related toxicity and survival needs to be clarified in older patients with diffuse large B-cell lymphoma (DLBCL). Methods: This multicenter prospective cohort study enrolled newly diagnosed patients with DLBCL (≥ 65 yr) between September 2015 and April 2018. A simplified geriatric assessment was performed at baseline using Activities of Daily Living (ADL), Instrumental ADL (IADL), and Charlson's Comorbidity Index (CCI). The primary endpoint was event-free survival (EFS). Results: The study included 249 patients, the median age was 74 years (range, 65-88), and 125 (50.2%) were female. In multivariable Cox analysis, ADL, IADL, CCI, and age were independent factors for EFS; an integrated geriatric score was derived and the patients stratified into three geriatric categories: fit (n = 162, 65.1%), intermediate-fit (n = 25, 10.0%), and frail (n = 62, 24.9%). The established geriatric model was significantly associated with EFS (fit vs. intermediate-fit, HR 2.61, p < 0.001; fit vs. frail, HR 4.61, p < 0.001) and outperformed each covariate alone or in combination. In 87 intermediate-fit or frail patients, the relative doxorubicin dose intensity (RDDI) ≥ 62.4% was significantly associated with worse EFS (HR, 2.15, 95% CI 1.30-3.53, p = 0.002). It was related with a higher incidence of grade ≥ 3 symptomatic non-hematologic toxicities (63.2% vs. 27.8%, p < 0.001) and earlier treatment discontinuation (34.5% vs. 8.0%, p < 0.001) in patients with RDDI ≥ 62.4% than in those with RDDI < 62.4%. Conclusions: This model integrating simplified geriatric assessment can risk-stratify older patients with DLBCL and identify those who are highly vulnerable to standard dose-intensity chemoimmunotherapy.