• Journal of Periodontal and Implant Science
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• 제51권5호
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• pp.364-372
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• 2021

Purpose: This study aimed to clinically evaluate the efficacy of vestibuloplasty around lower molar implants using 3 different modalities: apically positioned flap alone (APF), APF with a free gingival graft (FGG), and APF with modified periosteal fenestration (mPF). Methods: Three different vestibuloplasty procedures during second-stage implant surgery were performed at the mandibular molar area in 61 patients with a shallow vestibule and insufficient keratinized tissue (KT). The clinical measurements of KT width were recorded at baseline, immediately after surgery (T0), 6 months after surgery (T6), and 12 months after surgery (T12). Soft tissue esthetic scores were measured. Results: An additional KT width gain from baseline to T12 of approximately 2 mm was obtained with FGG and mPF compared to that with APF. Shrinkage of the re-established tissue was lower with mPF and FGG than with APF, whereas the esthetic profile was better with APF and mPF than with FGG. Conclusions: Within the limitations of this study, mPF showed potential as a promising approach for vestibuloplasty around the lower molar implants compared to the traditional APF and FGG.

• Archives of Plastic Surgery
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• 제50권3호
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• pp.274-278
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• 2023

Ingrown toenails are most common among school-age children and adolescents though they can be observed at any age. Causes of ingrown toenails are increased curvature, trauma, and external pressure. Treatment of ingrown toenails can be broadly characterized as conservative and surgical. Conservative treatment can be performed using various methods, such as a gutter splint, dental floss, and cotton. Surgical treatments may be divided into two main approaches; narrowing of the nail plate and debulking of periungual tissues. However, these various conservative and surgical treatments have high recurrence rates, and thus, the author used a permanent surgical method based on the use of a paronychium flap to treat a 15-year-old male adolescent with excessive periungual tissues and curved ingrown toenails who did not improve despite conservative and several surgical treatments over 4 years. Subsequently, toenail shape was maintained without recurrence 22 months after surgery, and there were no complaints of inflammation or pain while walking. This simple surgical method can be performed on patients with advanced ingrown toenails due to excessive periungual tissues and nail curvature and can be expected to have permanent effects.

• Imaging Science in Dentistry
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• 제53권1호
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• pp.83-89
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• 2023

Nodular fasciitis (NF) is a benign myofibroblastic proliferation that grows very rapidly, mimicking a sarcoma on imaging. It is treated by local excision, and recurrence has been reported in only a few cases, even when excised incompletely. The most prevalent diagnoses of temporomandibular joint(TMJ) masses include synovial chondromatosis, pigmented villonodular synovitis, and sarcomas. Cases of NF in the TMJ are extremely rare, and only 3 cases have been reported to date. Due to its destructive features and rarity, NF has often been misdiagnosed as a more aggressive lesion, which could expose patients to unnecessary and invasive treatment approaches beyond repair. This report presents a case of NF in the TMJ, focusing on various imaging features, along with a literature review aiming to determine the hallmark features of NF in the TMJ and highlight the diagnostic challenges.

• International Journal of Stem Cells
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• 제16권3호
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• pp.304-314
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• 2023

Background and Objectives: Ear cartilage malformations are commonly encountered problems in reconstructive surgery, since cartilage has low self-regenerating capacity. Malformations that impose psychological and social burden on one's life are currently treated using ear prosthesis, synthetic implants or autologous flaps from rib cartilage. These approaches are challenging because not only they request high surgical expertise, but also they lack flexibility and induce severe donor-site morbidity. Through the last decade, tissue engineering gained attention where it aims at regenerating human tissues or organs in order to restore normal functions. This technique consists of three main elements, cells, growth factors, and above all, a scaffold that supports cells and guides their behavior. Several studies have investigated different scaffolds prepared from both synthetic or natural materials and their effects on cellular differentiation and behavior. Methods and Results: In this study, we investigated a natural scaffold (alginate) as tridimensional hydrogel seeded with progenitors from different origins such as bone marrow, perichondrium and dental pulp. In contact with the scaffold, these cells remained viable and were able to differentiate into chondrocytes when cultured in vitro. Quantitative and qualitative results show the presence of different chondrogenic markers as well as elastic ones for the purpose of ear cartilage, upon different culture conditions. Conclusions: We confirmed that auricular perichondrial cells outperform other cells to produce chondrogenic tissue in normal oxygen levels and we report for the first time the effect of hypoxia on these cells. Our results provide updates for cartilage engineering for future clinical applications.

• Journal of Microbiology and Biotechnology
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• 제28권4호
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• pp.645-651
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• 2018

The carcinogenicity of chemicals in the environment is a major concern. Recently, numerous studies have attempted to develop methods for predicting carcinogenicity, including rodent and cell-based approaches. However, rodent carcinogenicity tests for evaluating the carcinogenic potential of a chemical to humans are time-consuming and costly. This study focused on the development of an alternative method for predicting carcinogenicity using quantitative PCR (qPCR) and colon cancer stem cells. A toxicogenomic method, mRNA profiling, is useful for predicting carcinogenicity. Using microarray analysis, we optimized 16 predictive gene sets from five carcinogens (azoxymethane, 3,2'-dimethyl-4-aminobiphenyl, N-ethyl-n-nitrosourea, metronidazole, 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone) used to treat colon cancer stem cell samples. The 16 genes were evaluated by qPCR using 23 positive and negative carcinogens in colon cancer stem cells. Among them, six genes could differentiate between positive and negative carcinogens with a p-value of ${\leq}0.05$. Our qPCR-based prediction system for colon carcinogenesis using colon cancer stem cells is cost- and time-efficient. Thus, this qPCR-based prediction system is an alternative to in vivo carcinogenicity screening assays.

• 대한소아치과학회지
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• 제45권2호
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• pp.154-161
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• 2018

진정작용은 행동조절이 어렵고 광범위한 치료가 필요하거나 의학적 문제가 있는 어린이의 치과 치료에 유용한 행동조절 방식이다. 본 연구의 주된 목적은 연세대학교 치과대학병원 소아치과에서 사용하는 진정제와 진정치료의 경향을 분석하여 진정법의 사용의 변화를 살펴보는데 있다. 본 연구는 2011년 - 2016년까지 연세대학교 치과대학병원 소아치과의 전자의무기록(EMR)을 바탕으로 환자 및 진정법을 검토하였다. 연구 결과에 따르면, 진정법으로 치료받은 환자들의 수가 일반적으로 증가했다. 남자가 여자보다 진정법을 이용한 치과 치료를 더 많이 받았으나 2015년부터는 유사한 비율로 적용되고 있다. 전신질환(ASA II) 환자의 치료 비율은 2013년에 감소했지만, 이후에는 일정하게 유지되었다. 4 - 5세 및 6 - 10세의 진정 치료 비율은 일반적으로 증가하는 반면, 0 - 2세 및 11세 이상은 감소했다. 3세는 비교적 일정한 비율로 유지되고 있다. 가장 자주 사용되는 진정법은 아산화질소 흡입진정법이었으며, chloral hydrate의 사용이 감소하는 동안 benzodiazepine계열의 사용이 증가했다. 최근에는 행동관리 기법으로 진정법이 확대되고 있다. 그러나 안전한 사용을 위하여 다차원적 접근이 요구되고 있으며, 진정제 사용의 안전성과 효능에 대한 추가 연구 역시 동반 수행되어야 한다.

• 대한심미치과학회지
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• 제22권1호
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• pp.22-29
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• 2013

일반적으로 심미 보철을 진행하기 위해서는 초진 시부터 카메라를 사용해서 최종 보철물을 고려하며 여러 가지 분석을 한다. 이 부분에서 많은 치의들이 디지털카메라를 사용하고 있는 현실을 볼 때, 우리는 이미 digital impression을 시작하고 있는 것이 아닐까 생각한다. 최근 세계적인 photographer들도 필름카메라에서 디지털카메라로 넘어오는 추세가 많아지고 있는 것처럼 심미 치과학에서도 CAD/CAM은 향후 우리가 추구하고자 하는 심미 영역에서의 또 한가지 방향성을 제시해 줄 수 있지 않을까 하는 생각이 든다. 흔히 디지털이라고 하면 편의성, 경제성 등을 먼저 떠올리는 경향이 있다. 그러나 치과 임상적 관점에서 기존의 analog방식을 존중하며 CAD/CAM system이 가지는 그 특수성과 우수성을 고민하고 이를 개선, 발전시키는 것 또한 중요하다고 생각된다. 다만 아쉬운 것은 CAD/CAM 장치와 소재가 급격히 발전하는 이유로 인하여 reference, follow-up이 어려운 경우가 많다. 이에 digital은 변화하는 속도가 굉장히 빠르기 때문에, 여러 가지 소재와 장치들을 접해보고 경험해보면서 그에 맞게끔 발맞춰 적용해 볼 수밖에는 없지만 임상에 적용하여 보다 좋은 결과 얻기 위해서는 전통적인 방식이 기본바탕이 된 상태에서 이루어져야 한다는 점을 강조하고 싶다. 본 연구에서는 심미적 관점에서 전통적인 방식과 CAD/CAM과의 조화 통해서 어떤 접근을 할 수 있는지에 대해서 살펴보고자 한다. 그리고 CAD/CAM 보철이 'Digital art' 영역에 한 축의 역할을 할 수 있기를 기다리고 열망한다.

• Journal of Dental Anesthesia and Pain Medicine
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• 제23권6호
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• pp.317-325
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• 2023

Background: Local anesthetic injections may induce pain in children, leading to fear and anxiety during subsequent visits. Among the various approaches recommended to reduce pain, one is the use of a Buzzy Bee^TM device that operates on the concept of gate control theory and distraction. The literature regarding its effectiveness during the deposition of local anesthesia remains limited; hence, the aim of the present study was to determine the efficacy of extraoral cold and vibrating devices in reducing pain perception during the deposition of local anesthesia. Methods: A split-mouth crossover study in which 40 children aged 3-12 years requiring maxillary infiltration or inferior alveolar nerve block for extractions or pulp therapy in the maxillary or mandibular posterior teeth were included. The control intervention involved the application of topical anesthetic gel for one minute (5% lignocaine gel), followed by the administration of local anesthetic (2% lignocaine with 1:80,000 adrenaline) at a rate of 1 ml/ minute. Along with the control protocol, the test intervention involved using the Buzzy Bee^TM device for 2 minutes before and during the deposition of the local anesthetic injection. The heart rate and face, legs, arms, cry, and consolability revised (FLACC-R) scale scores were recorded by the dentist to assess the child's pain perception. Results: The mean age of the participants in Group A and Group B was 7.050 ± 3.12 years and 7.9 ± 2.65 years respectively. A reduction in the mean heart rate and FLACC-R score was observed during the deposition of local anesthetic solution in the tissues when the Buzzy Bee^TM was used in both groups at different visits in the same subjects (P < 0.05) The Buzzy Bee^TM device was effective in reducing the heart rate and FLACC-R scores when used during maxillary infiltration and inferior alveolar nerve block local anesthesia techniques (P < 0.05). Conclusion: The use of extraoral cold and vibrating devices significantly reduces pain perception during local anesthetic deposition in pediatric patients. Considering the results of this study, the device may be incorporated as an adjunct in routine dental practice while administering local anesthesia in children.

• International Journal of Oral Biology
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• 제46권2호
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• pp.67-73
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• 2021

This study summarizes the recent cutting-edge approaches for dentin regeneration that still do not offer adequate solutions. Tertiary dentin is formed when odontoblasts are directly affected by various stimuli. Recent preclinical studies have reported that stimulation of the Wnt/β-catenin signaling pathway could facilitate the formation of reparative dentin and thereby aid in the structural and functional development of the tertiary dentin. A range of signaling pathways, including the Wnt/β-catenin pathway, is activated when dental tissues are damaged and the pulp is exposed. The application of small molecules for dentin regeneration has been suggested as a drug repositioning approach. This study reviews the role of Wnt signaling in tooth formation, particularly dentin formation and dentin regeneration. In addition, the application of the drug repositioning strategy to facilitate the development of new drugs for dentin regeneration has been discussed in this study.

• 대한치과교정학회지
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• 제24권1호
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• pp.149-159
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• 1994

The purposes of present study were to evaluate changes in models and lateral cephalometric head films during orthodontic treatment and to compare the amount of incisal retraction and anterior movement of molars with the two approaches of the retraction method of canine(sectional canine retractions vs sliding canine retractions) and the anchorage management(head gears vs no head gears, transpalatal arches vs no transpalatal arches and lingual arches vs no lingual arches) and to evaluate changes during orthodontic treatment in models with relation to lateral cephalometric head films. 67 Korean women with Angle's Class I bialveolar protrusion were selected, whose initial chronologic age was above 16 yrs. Models and lateral cephalometric head films were taken before and after orthodontic treatment with four bicuspid extraction. the results were obtained as follows. 1. Significant decreases were observed in intermolar width, arch length and arch perimeter of maxilla and mandible but significant difference was not observed in intercanine width of maxilla and mandible during treatment period. 2. The linear change of the upper incisor to upper lip was 2.84:1 and the linear change of the lower incisor to lower lip was 1.45:1 3. There were no significant differences between the two groups(sectional canine retractions vs sliding canine retractions), the !we groups(transpalatal arches vs no transpalatal arches) and the two groups(lingual arches vs no lingual arches) in the amount of incisal retraction and anterior movement of molars. There were a greater amount of maxillary incisal retraction and a lesser amount of anterior movement of maxillary molars with the use of head gears than no use of head gears. 4. Changes during orthodontic treatment in models with relation to lateral cephalometric head films were obtained as follows : 1) Maxilla Central incisors were moved 3.79mm backward, canines were moved 0.22mm laterally and 3.70mm backward, and molars were moved 0.535mm medially and 2.29mm forward. 2) Mandible Central incisors were moved 3.04mm backward, canines were moved 0.145mm laterally and 3.92mm backward, and molars were moved 0.755mm medially and 1.77mm forward.