• Journal of Korean Neurosurgical Society
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• v.62 no.6
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• pp.661-670
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• 2019

Objective : Rheumatoid arthritis (RA) is known to involve the cervical spine up to 86%. It often causes cervical instability like atlantoaxial subluxation (AAS), subaxial subluxation, and vertical subluxation (VS). In order to find the relation between RA and cord compression, we will evaluate the characteristics and risk factors of basilar invagination (BI) and cervicomedullary junction (CMJ) compression. Methods : From January 2007 to May 2015, 12667 patients administrated to Hanyang University Medical Center. Four thousand three hundred eighty-six patients took cervical X-ray and 250 patients took cervical computed tomography or magnetic resonance imaging. Radiologic parameters, medication records were obtained from 242 patients. Multivariate logistic regression analysis was performed with correlation of CMJ compression, basin-dental interval (BDI), basin-posterior axial line interval (BAI), pannus formation, BI, and AAS. Results : In the point of CMJ compression, atlantodental interval (ADI), posterior-atlantodental interval, BAI, AAS, and BI are relatively highly correlated. Patients with BI have 82 times strong possibility of radiologic confirmed CMJ compression, while AAS has 6-fold and pannus formation has the 3-fold possibility. Compared to the low incidence of BI, AAS and pannus formation have more proportion in CMJ compression. Furthermore, wrist joint erosion was correlated with VS and AAS. Conclusion : BI has a very strong possibility of CMJ compression, while AAS and pannus formation have a high proportion in CMJ compression. Hence bilateral wrist joint erosion can be used as an indicator for the timing of screening test for cervical involvement. We suggest the early recommendation of cervical spine examination for the diagnosis of cervical involvement in order to prevent morbidity and mortality.

• Journal of the Korean Academy of Esthetic Dentistry
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• v.11 no.2
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• pp.33-36
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• 2002

As patients have concerned the esthetics of dental restorations, the porcelain fused to metal restorations have gain their popularity due to their strength and esthetic appearance for many years. However, metal collar in subgingival level of porcelain fused to metal restoration often causes black shadows. Inadequately positioned metal collar causes plaque depositions, gingival inflammations, black shadows, and discolorations of margin area. Those problems can be avoided by a clear finishing line, well-fabricated provisional restorations with precise margin and fine polishing, collarless porcelain fused to metal restoration, and all ceramic restoration. In this case report, collarless porcelain fused to metal restoration was used to treat cervical discoloration from old restorations.

• Journal of Periodontal and Implant Science
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• v.45 no.5
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• pp.162-168
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• 2015

Purpose: The aim of this study was to analyze the anatomical dimensions of the buccal bone walls of the aesthetic maxillary region for immediate implant placement, based upon cone-beam computed tomography (CBCT) scans in a sample of adult patients. Methods: Two calibrated examiners analyzed a sample of 50 CBCT scans, performing morphometric analyses of both incisors and canines on the left and right sides. Subsequently, in the sagittal view, a line was traced through the major axis of the selected tooth. Then, a second line (E) was traced from the buccal to the palatal wall at the level of the observed bone ridges. The heights of the buccal and palatal bone ridges were determined at the major axis of the tooth. The buccal bone thickness was measured across five lines. The first was at the level of line E. The second was at the most apical point of the tooth, and the other three lines were equidistant between the apical and the cervical lines, and parallel to them. Statistical analysis was performed with a significance level of $P{\leq}0.05$ for the bone thickness means and standard deviations per tooth and patient for the five lines at varying depths. Results: The means of the buccal wall thicknesses in the central incisors, lateral incisors and canines were $1.14{\pm}0.65mm$, $0.95{\pm}0.67mm$ and $1.15{\pm}0.68mm$, respectively. Additionally, only on the left side were significant differences in some measurements of buccal bone thickness observed according to age and gender. However, age and gender did not show significant differences in heights between the palatal and buccal plates. In a few cases, the buccal wall had a greater height than the palatal wall. Conclusions: Less than 10% of sites showed more than a 2-mm thickness of the buccal bone wall, with the exception of the central incisor region, wherein 14.4% of cases were ${\geq}2mm$.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6273-6280
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• 2013

Goniothalamin, a natural compound extracted from Goniothalamus sp. belonging to the Annonacae family, possesses anticancer properties towards several tumor cell lines. This study focused on apoptosis induction by goniothalamin (GTN) in the Hela cervical cancer cell line. Cell growth inhibition was measured by MTT assay and the $IC_{50}$ value of goniothalamin was $3.2{\pm}0.72{\mu}g/ml$. Morphological changes and biochemical processes associated with apoptosis were evident on phase contrast microscopy and fluorescence microscopy. DNA fragmentation, DNA damage, caspase-9 activation and a large increase in the sub-G1 and S cell cycle phases confirmed the occurrence of apoptosis in a time-dependent manner. It could be concluded that goniothalamin show a promising cytotoxicity effect against cervical cancer cells (Hela) and the cell death mode induced by goniothalamin was apoptosis.

• The Journal of the Korean dental association
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• v.17 no.5 s.120
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• pp.345-350
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• 1979

The patient, 16 years female, complained of anterior cross-bite and retrusion of maxilla. Mandibular incisors occluded labially to maxillary incisors. Normally developed mandibular arch in normal elation to facial line, S-N-Pog was within normal range. Cross-bite of anterior teeth was corrected by means of Class III elastics under multibanded system. Space for alignment of crowding of upper anterior teeth was regained by means of cervical headgear and sliding yoke. She gained good alignment of anterior teeth and attractive facial profile after 2 years.

• Journal of Technologic Dentistry
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• v.25 no.1
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• pp.29-40
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• 2003

This study was aimed to verify a comparison by dental alloys upon the marginal fitness of dental prosthesis. Firstly, we waxed up on 45 epoxy resin dies, pressed the margin with hands, and identified the marginal fitness with microscope. And we made a single direct spruing system type of sprue by 3 dental alloys - metal crown alloys, PFM crown alloys, and gold crown alloys - each 15, total 45 waxing up, adjusting W/P ratio and invested the cast ring. Then, we made the dental prosthesis using the electric casting machine. In these processes we followed the manufacturer's instructions, in order to maintain the other conditions from the inner and outer, which included investment and burning out. After we tried on the dental prosthesis on epoxy resin dies, we have got the means of marginal gap at 9 points with same distances, around the cervical line which was checked already, using microscope($\times$300). The results of this study were as follows : 1. Metal crown alloys showed 2.9% better in marginal fitness than PFM crown alloys, and the difference was not statistically significant(P=0.497). 2. Gold crown alloys showed 31.3% better in marginal fitness than Metal crown alloys, and the difference was statistically significant(P=0.004). 3. Gold crown alloys showed 32.4% better in marginal fitness than PFM crown alloys, and the difference was statistically significant(P=0.002). 4. We saw that Gold crown alloys was the best dental alloys in the marginal fitness among the three.(P=0.049).

• Restorative Dentistry and Endodontics
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• v.37 no.3
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• pp.180-184
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• 2012

Traumatic injuries of the face often involve root fractures especially in anterior teeth. The prognosis and the treatment of the root fracture depend on the extent of the fracture line, general health and patient compliance. This case report outlines a new conservative trial treatment modality to stabilize the maxillary central incisors with horizontal root fracture on the cervical to middle third by fabricating canine guidance to remove loading on the traumatized maxillary central incisors during eccentric movements and thus inducing spontaneous healing of the fractured line between the fragments. Radiographs after thirty months showed adequate healing with no signs of pathological changes including root resorption, ankylosis or displacement. Long term follow-up revealed that vitality, stability and aesthetics were maintained and the patient was satisfied with the outcome.

• The Journal of Advanced Prosthodontics
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• v.3 no.3
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• pp.113-118
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• 2011

PURPOSE. The objective of the present study was to evaluate the effect of five different metal framework designs on the fracture resistance of the metal-ceramic restorations. MATERIALS AND METHODS. For the purpose of this study, the central incisor tooth was prepared, and the metal analogue of it and a master die were fabricated. The counter die with the 0.5 mm clearance was used for fabricating the wax patterns for the metal copings. The metal copings with five different metal framework designs were designed from Group 1 to 5. Group 1 with the metal collar, Group 2, 3, 4 and 5 with 0 mm, 0.5 mm, 1 mm and 1.5 mm cervical metal reduction respectively were fabricated. Total of fifty metal ceramic crown samples were fabricated. The fracture resistance was evaluated with the Universal Testing Machine (Instron model No 1011, UK). The basic data was subjected to statistical analysis by ANOVA and Student's t-test. RESULTS. Results revealed that the fracture resistance ranged from 651.2 to 993.6 N/$m^2$. Group 1 showed the maximum and Group 5 showed the least value. CONCLUSION. The maximum load required to fracture the test specimens even in the groups without the metal collar was found to be exceeding the occlusal forces. Therefore, the metal frameworks with 0.5 mm and 1 mm short of the finish line are recommended for anterior metal ceramic restoration having adequate fracture resistance.

• Journal of dental hygiene science
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• v.7 no.1
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• pp.31-35
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• 2007

Caesalpinia sappan L. (Leguminosae) is an oriental medicinal herb distributed in China and Taiwan, and its heartwood has been traditionally used as an analgesic, a therapy for thrombosis or tumor. This study was to investigate the proliferation and inhibition effects of Caesalpinia sappan extracts against human epithelial cell and cancer cell lines. The methanol extract of dried C. sappan heartwood was evaporated (KS-6), and then sequentially extracted by hexane (KS-01), chloroform (KS-02), ethyl acetate (KS-03), n-butanol (KS-04), and water (KS-05). After 48 hr of exposure, these fractions at a concentration of $50{\mu}g/ml$ significantly increased, and reduced cell proliferation in both human normal epithelial and cancer cell lines. The ethyl acetate fraction (KS-03) among organic solvent fractions was 120.2% of the most proliferation activity ($50{\mu}g/ml$) against HaCaT human epithelial cell. However, fractions from chloroform, butanolic and methanolic extract had 7.2, 28.7 and 20.8% of antiproliferative effect on HaCaT cell, respectively. In cell proliferation effects of C. sappan extract on HeLa, SiHa and C33A human cervical cancer cells, chloroform fraction (KS-2) was the most antiproliferative activity, its antiproliferative rate (dosage, $50{\mu}g/ml$) relative to control was 25.8, 12.2 and 17.4% for SiHa, HeLa and C33A, respectively. The results indicated that the six extract fractions could induce cell cycle stimulate or arrest in some way. Finally, further investigation is needed to assess the molecular mechanisms mediated anticancer activities of this plant.

• Imaging Science in Dentistry
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• v.43 no.4
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• pp.219-225
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• 2013

Purpose: The purpose of this study was to determine the prevalence of missing and impacted third molars in people aged 25 years and above. Materials and Methods: The study sample of 3,799 patients was chosen randomly from patients who visited Pusan National University Dental Hospital and had panoramic radiographs taken. The data collected included presence and impaction state, angulation, and depth of impaction of third molars, and radiographically detected lesions of third molars and adjacent second molars. Results: A greater percentage of men than women retained at least one third molar. The incidence of third molars decreased with increasing age. The incidence of partially impacted third molars greatly declined after the age of 30. Vertically impacted maxillary third molars and horizontally impacted mandibular third molars were most frequent in all age groups. Among the maxillary third molars, those impacted below the cervical line of the second molar were most frequent in all age groups, and among the mandibular third molars, deeply impacted third molars were most frequent in those aged over 40. Dental caries was the most common radiographic lesion of the third molars. Mesioangularly impacted third molars showed radiographic lesions in 13 (9.5%) adjacent maxillary second molars and 117 (27.4%) mandibular second molars. Conclusion: The number of remaining third molars decreased and the percentage of Class C depth increased with age. Caries was the most frequent lesion in third molars. Partially impacted mesioangular third molars showed a high incidence of caries or periodontal bone loss of the adjacent second molar. Regular oral examination will be essential to keep asymptomatic third molars in good health.