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Hai, Chi-Ming
- Archives of Pharmacal Research
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- v.23 no.6
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- pp.535-547
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- 2000
Recent findings indicate that mechanical strain (deformation) exerted by the extracellular matrix modulates activation of airway smooth muscle cells. Furthermore, cytoskeletal organization in airway smooth muscle appears to be dynamic, and subject to modulation by receptor activation and mechanical strain. Mechanosensitive modulation of crossbridge activation and cytoskeletal organization may represent intracellular feedback mechanisms that limit the shortening of airway smooth muscle during bronchoconstriction. Recent findings suggest that receptor-mediated signal transduction is the primary target of mechanosensitive modulation. Mechanical strain appears to regulate the number of functional G-proteins and/or phospholipase C enzymes in the cell membrane possibly by membrane trafficking and/or protein translocation. Dense plaques, membrane structures analogous to focal adhesions, appear to be the primary target of cytoskeletal regulation. Mechanical strain and receptor-binding appear to regulate the assembly and phosphorylation of dense plaque proteins in airway smooth muscle cells. Understanding these mechanisms may reveal new pharmacological targets for control1ing airway resistance in airway diseases.
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Devi, V. Renuka;Sivaraj, D.;Chelvam, T. Tamizh
- Kyungpook Mathematical Journal
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- v.45 no.2
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- pp.199-209
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- 2005
An ideal space is ${\cal{I}}-resolvable$ if it has two disjoint ${\cal{I}}-dense$ subsets. We answer the question: If X is ${\cal{I}}-resolvable$, then is X (${\cal{I}}\;{\cup}\;{\cal{N}$)-resolvable?, posed by Dontchev, Ganster and Rose. We give three generalizations of the well known Banach Category Theorem and deduce the Banach category Theorem as a corollary. Characterizations of completely codense ideals and ${\cal{I}-locally$ closed sets are given and their properties are discussed.
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Han Won-Jeong;Cha Sang-Yun;Kim Eun-Kyung
- Imaging Science in Dentistry
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- v.30 no.2
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- pp.144-148
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- 2000
Sjogren's syndrome is a chronic inflammatory disease that predominantly affects salivary, lacrimal and other exocrine glands. We report a case of Sjogren's syndrome combined with MALT (mucose associated lymphoid tissue) lymphoma which occured in the parotid gland. A 57-year-old female with the complaint of painful swelling and lymph node enlargement was referred to our department. Sialograms of both parotid glands showed globular collections of contrast material uniformly distributed throughout the parotid gland. Salivary scintigraphy showed decreased uptake of the parotid gland. CT scan showed larger, slightly more dense parotid gland than normal and honeycomb glandular appearance. Also, It showed discrete, slightly more enhanced round mass in the left parotid gland. Histopathological finding showed replacement of salivary gland parenchyma with dense small lymphocytic infiltration having the feature of epimyoepithelial islands. Kappa light chain restriction of interglandular plasma cell could be seen.
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