• 대한의용생체공학회:의공학회지
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• 제20권4호
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• pp.451-459
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• 1999

신경질환의 진단에 있어서 근육군에서의 세동전위나 양성예각파와 같은 탈신경전위를 관찰함으로써 신경의 이상유무와 손상부위를 예측할수 있는데 이는 임상의의 주관적인 경험에만 의존하여 구별되고 있으며 검사과정 중 정상인에게서도 나타날 수 있는 종판전위가 탈신경전위로 오인되어 진단에 혼선을초래할 수 있다. 따라서 본 연구는 탈신경전위와 종판전위를 정량적으로 구별할 수 있는 알고리듬을 수립하는데 필요한 매개변수들을 추출함으로써 신경손상의 진단과 병변의 국소화에 정확성을 향상시키고자 하였다. 본 연구에서는 여러 종류의 신경손상을 보이는 10명의 환자들에 대한 근전도 검사를 실시하여 탈신경전위인 양성예각파나 세동전위, 그리고 종판전위를 검출하였다. 이들 신호로부터 지속시간, 면적, 기울기, 첨두시간 진폭, 양첨두지 진폭, 음첨두치 진폭 및 첨두치 비율 그리고 상(phase)의 여덟가지 매개변수를 구하고 각 파형에서의 값들을 비교하였다. 그 결과, 두 종류의 탈신경전위와 종판전위의 구분에 공통적으로 좋은 결과를 제공하는 매개변수는 기울기, 첨두치간 진폭, 양첨두치 진폭 그리고 첨두치간의 비율로 나타났다. 본 연구를 통해 구해진 매개변수들의 특성은 근전도 분석의 자동화를 위한 알고리듬의 수립에 응용되어질 수 있을 것이며 보다 정량화된 근전도 분석을 통해 진단의 정확성을 향상시켜 줄 것이다.

• Journal of Korean Neurosurgical Society
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• 제29권1호
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• pp.101-107
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• 2000

Objectives : The evaluation of peripheral nerve injuries has traditionally relied on a clinical history, physical examination, and electrodiagnostic studies. The purpose of the present study was to examine serial magnetic resonance image(MRI) changes following acute muscle denervation under experimental conditions and to identify potential advantages and disadvantages of this use of MRI. Methods : An experimental transection of right sciatic nerve on Spargue-Dawley rats was performed. MRI was performed with T1-weighted spin-echo and STIR sequences. The imaging findings were compared with EMG in order to determine its sensitivity relative to this standard procedure. A simultaneous histopathological study provided information about the morphological basis of the imaging findings. Signal intensities were expressed as a ratio of abnormal to normal. Results : The signal intensity ratio of muscles with the STIR sequence was increased significantly at 2 weeks after sciatic nerve transection(p<0.05), although definite signal change was seen as early as 4 days postdenervation in one. EMG revealed significant denervation potential from 3 days after nerve transection. Diffuse cell atrophy was revealed hostologically at 2 weeks after transection, which was at the same time of significant signal change in MRI. Conclusion : MRI signal changes in denervated muscles secondary to nerve injury correlate with the degree of muscle atrophy on histologic examination. In addition to EMG, MRI can document the course of muscle atrophy and mesenchymal abnormalities in denervation. These results indicate that MRI can play a complementary role in the evaluation of patients with denervation.

• Journal of Ginseng Research
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• 제48권1호
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• pp.52-58
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• 2024

Background: Skeletal muscle denervation leads to motor neuron degeneration, which in turn reduces muscle fiber volumes. Recent studies have revealed that apoptosis plays a role in regulating denervation-associated pathologic muscle wasting. Korean red ginseng (KRG) has various biological activities and is currently widely consumed as a medicinal product worldwide. Among them, ginseng has protective effects against muscle atrophy in in vivo and in vitro. However, the effects of KRG on denervation-induced muscle damage have not been fully elucidated. Methods: We induced skeletal muscle atrophy in mice by dissecting the sciatic nerves, administered KRG, and then analyzed the muscles. KRG was administered to the mice once daily for 3 weeks at 100 and 400 mg/kg/day doses after operation. Results: KRG treatment significantly increased skeletal muscle weight and tibialis anterior (TA) muscle fiber volume in injured areas and reduced histological alterations in TA muscle. In addition, KRG treatment reduced denervation-induced apoptotic changes in TA muscle. KRG attenuated p53/Bax/cytochrome c/Caspase 3 signaling induced by nerve injury in a dose-dependent manner. Also, KRG decreases protein kinase B/mammalian target of rapamycin pathway, reducing restorative myogenesis. Conclusion: Thus, KRG has potential protective role against denervation-induced muscle atrophy. The effect of KRG treatment was accompanied by reduced levels of mitochondria-associated apoptosis.

• Clinical and Experimental Pediatrics
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• 제50권6호
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• pp.585-587
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• 2007

출생시에 나타나는 신생아 종아리신경병증은 아직 국내에는 보고된 적이 없는 매우 드문 질환으로, 대부분이 자연 치유되는 양성 경과를 취한다. 신생아의 홑신경병증은 대개 산과적 합병증이지만, 출생 전 원인도 고려하여야 한다. 저자들은 볼기태위로 인해 제왕절개술로 만기 태어난 신생아에서 발견된 발처짐을 보고한다. 생후 4일째 시행한 전기생리학적 검사에서 종아리신경의 복합근육활동전위 소실과 앞정간근과 긴엄지폄근의 탈신경전위가 관찰된 것으로 미루어 자궁 내에서 발병한 종아리신경병증으로 추정한다. 조기에 전기생리학적검사를 시행하고 추적검사를 하면 발병시기와 병리적 기전 및 예후를 판단하는데 도움이 된다.

• 대한한방내과학회지
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• 제27권3호
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• pp.737-744
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• 2006

Guillain-Barre Syndrome is a disorder caused by nerve inflammation. The inflammation damages portions of the nerve cells, resulting in pain, numbness, muscle weakness or paralysis and sensory loss. The damage can also leads to denervation (killing the axon part of the nerve cell), which stops nerve function entirely. Without the axon, messages cannot be transferred from one nerve cell to another, but the causes and mechanism of this syndrome are unknown. This is a clinical report about two patients diagnosed with Guillain-Barre Syndrome. The patients, a 54-year-old woman and a 37-years-old man, had pain, and weakness in both legs and arms. After about 4 weeks of Korean medicine and acupuncture treatment, most of their symptoms improved. Therefore, Korean traditional therapy has potential for treatment of Guillain-Barre Syndrome.

• The Korean Journal of Pain
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• 제37권1호
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• pp.13-25
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• 2024

Knee osteoarthritis (OA) is a prevalent and debilitating musculoskeletal condition that significantly affects the quality of life of millions of individuals worldwide. In recent years, cooled radiofrequency ablation (CRFA) has become a viable treatment option for knee OA. This review thoroughly evaluated the existing literature on CRFA therapy for knee OA. It delved into the mechanisms behind CRFA, evaluated its clinical efficacy, and investigated potential avenues for future research and application. The insights gained from this review are crucial for healthcare professionals, researchers, and policymakers, offering an updated perspective on CRFA's role as a viable therapeutic option for knee OA.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2018년도 춘계학술발표회
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• pp.8-8
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• 2018

Muscle atrophy, known as a sarcopenia, is defined as a loss of muscle mass resulting from a reduction in muscle fiber area or density due to a decrease in muscle protein synthesis and an increase in protein breakdown. Many conditions are associated with muscle atrophy, such as aging, denervation, disuse, starvation, severe injury and inflammation, prolonged bed rest, glucocorticoid treatment, sepsis, cancer, and other cachectic diseases. On the other hand, osteoarthritis (OA) is the most common form of joint disease and is wide spread in the elderly population and is characterized by erosion of articular cartilage, osteophyte formation, and subchondral bone sclerosis. The cytokine network plays an important role in the development and progression of OA with the inflammatory cytokine. Schisandrae Fructus (SF) derived from the ripe fruit of Schisandra chinensis (Turcz.) Baill. (Magnoliaceae) has been extensively used in traditional herbal medicines in Asia. It was originally used as a tonic and has been traditionally used for the treatment of many uncomfortable symptoms, such as cough, dyspnea, dysentery, insomnia, and amnesia for a long time. Previous reports have shown that SF and its related compounds possess various biological activities such as antioxidant, anti-inflammatory, anticancer, anti-microbial, antiseptic, anti-aging, hepatoprotective and immunostimulating effects. However, the therapeutic effects of SF on muscle atrophy and OA has not yet been evaluated. In the present study, we aimed to determine whether extracts of SF, the dried fruit of S. chinensis, mitigates the development of muscle atrophy and OA.