• Journal of Oriental Neuropsychiatry
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• v.15 no.1
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• pp.211-217
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• 2004

Chronic acquired hepatocerebral degeneration(CAHD) is a heterogenous that can occur with a primary neurologic, hepatic, or combined presentation. Symptoms and signs of that included progressive dementia, dysarthria, involuntary movements(including tremor, asterixis, and choreoathetosis), ataxia of limb and gait, typically in a patient with chronic liver cirrhosis. Characteristic radiologic findings is high signal on globus pallidus on T1W1 MRI. Recently, we experienced a patients, a 73-year-old female with CAHD presenting mental change, cognitive deficits, and various involuntary movement. In our patient, T1 weighted MRI of the brain showed symmetric high signal intensity in both basal ganglia. Increased ammonia $level(226{\mu}g/dl)$ in whole blood and a multiple anomalous vessels with spleno-renal shunt on abdominal CT were found. But, liver cirrhosis is absent. In admission care, these mental change and involuntary movements had a good response to herbal medication. We report on patient with CAHD which had a spontaneous spleno-renal shunt without liver disease.

• Korea Journal of Hospital Management
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• v.8 no.4
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• pp.149-181
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• 2003

It has been asserted that per diem payment system should be introduced, in place of the current fee-for-service system, for payment of the inpatient services of the geriatric hospitals, Based on the assentation, this study aims at calculating costs and profits per inpatient-day of the geriatric hospitals, and thereby at contributing to the managerial improvement from the both sides of the Government and the hospitals. Relevant data of the three months, May to August, 2002 were collected from the five geriatric hospitals, and per inpatient-day costs and profits were calculated for the three disease groups. Major results and conclusions are as follow : Firstly, total costs per insured inpatient-day of the geriatric hospitals are 65, 389 won for dementia (including optimal profit of 3,858 won), 69,730 won for stroke (including optimal profit of 4,117 won), and 70,085 won for other diseases (including optimal profit of 4,134 won). Secondly, the amount of the non-insured costs per inpatient-day occupies 34.5% of the total costs for dementia, 30.3% for stroke, and 30.1% for other diseases. Thirdly, the total amount of the per inpatient-day costs calculated including the optimal profits is, on the average, higher by 12% than the present price level calculated for the current fee-far-service system. This implies that the present price level should rise by 12% when the current fee-far-service payment system be maintained, and Finally, introduction of a sliding-scale payment system should be considered for the inpatient medical management fees for the length of stay over six months or more that are being cut in the claim examination process by the insurance corporation.

• Korean Institute of Interior Design Journal
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• v.19 no.3
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• pp.242-250
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• 2010

Recently, the long-term care insurance for the elderly was carried out according to the elderly is increased rapidly and the formation of sympathy that a nation and society try commonly to share health and welfare promotion of the elderly. The purpose of this study is to analyze the present status of nursing home after that the long-term care insurance is enforced in chungcheongbuk-do and to utilize as basic data. The study limited its survey to those facilities that refer to the Ministry of Health and Welfare data, that had the capacity of more than 50 people. The result are as followings. Firstly, most of the nursing home were located on the outskirts of the city. But it must be constructed in the city center if the recent deinstitutionalization trend is reflected. Secondly, notwithstanding the provisions of the Elderly Welfare Law, if the Livability and amenity are considered, the plan of a single or a twin room is needed. The ondol(溫突) system bedroom for the safety of the elderly had to be planned and for the color planning of a bedroom, a heating, the furniture, the form of a door, corridors, etc. should be partly improved. The fastener in which it is appropriate for the main exit, a stair, an elevator, the lighting device, and etc. is needed and the installation of a wandering path for the dementia patient and etc. is required. Thirdly, most of the dining room arranged on the first floor but it is not nearly used and it used for employee or the other use. Therefore, we have to consider the system in which it can deliver the meal to a bedroom. If the smell of the elderly and etc. is considered, the sufficient height of the floor should be reflected for the ventilation equipment. Lastly, The improvement of the existing law are required.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2011.04a
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• pp.215-219
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• 2011

Along with the rapid increase of the elderly population, our country is facing the elderly problem as a social issue due to nuclear family, the increase of female social activities and recognition changes about the elderly support. In this connection, the welfare services to protect the overall elderly is requested urgently and the countries which have been experiencing aging earlier than our country are studying a lot a community daycare method which delays moving of the elderly into facilities as long as possible, reduces costs and efficiently provides services in order to curtail the big burden to the national economy. As one of these solutions, there is the elderly daycare center and this can be considered to be a compromising service type to correspond to our social changes, make individual and social supports without damage to the sense of value about support. Therefore, the space for the elderly can keep up with the falloff of mental and physical functions, dementia and geriatric diseases according to aging and careful consideration about the space considering stability and convenience is required. At this point, this study has the purpose to plan a daycare center which reflects the characteristics of the elderly to protect them within the community safely and comfortably. As for the research method, case study was conducted to understand the overall situation on the space plan of the daycare center for 5 daycare centers located in Seoul and found out problems. In addition, interview research was conducted for the heads of daycare centers or social workers, care workers and photographing and drawing collection were performed simultaneously. From the generalization of the above study, a space plan for a daycare center considering the characteristics of the elderly was provided.

• Therapeutic Science for Rehabilitation
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• v.9 no.3
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• pp.23-34
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• 2020

Objective : Recently, the demand for wearable mobile devices for the monitoring and improvement of one's health and quality of life is increasing. Therefore, the purpose of this study is to analyze the need of potential users in order to develop mobile health based and lifestyle care application for the elderly. Methods : Participants who lived in their community and used a mobile phone were recruited. Finally, a total of 84 participants completed the survey. Data were analyzed using descriptive statistics and a t-test, which was carried out with SPSS version 25.0. Results : The application functions that users deemed important for a lifestyle care app were the number of daily steps, physical activity, blood pressure, sleep, nutrition and participation in activity. Interestingly, there was a significant difference in the importance given to the app function of participation in activities between age groups. Conclusion : This study investigated the need and preferences of potential users of health and lifestyle care application for the promotion of health among the elderly. The, findings obtained from this study could be a valuable resource for the development of lifestyle care application.

• Journal of Society of Preventive Korean Medicine
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• v.22 no.1
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• pp.61-67
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• 2018

Objectives : The purpose of this study was to examine the effectiveness and satisfaction of visiting Korean Medicine doctor program. Method : The senior center visiting Korean Medicine doctor program was conducted in ten senior centers in Seongnam city from April 2016 to December 2016. Korean Medicine doctors were assigned senior center one by one. The program consisted of health lectures and health counseling. The health lectures embraces stroke, musculoskeletal disease, dementia, depression and self care for the elderly Results : A total of 194 elderly persons participated the program. The self-health awareness level were changed from $50.86{\pm}25.31$ to $57.17{\pm}24.62$ (p-value=0.003). The physical pain level was decreased from $5.33{\pm}2.99$ to $5.04{\pm}2.86$. The quality of life were changed from $0.791{\pm}0.155$ to $0.792{\pm}0.144$ (p-value=0.923). Overall satisfaction of visiting Korean Medicine doctor program was $9.36{\pm}2.11$. The need for sustainability for visiting Korean Medicine doctor program was $9.76{\pm}0.60$. Conclusions : The study demonstrated that visiting Korean Medicine doctor program had a positive effect on the health awareness level. The overall satisfaction and further need were high. Further program for senior center will be needed.

• BMB Reports
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• v.55 no.11
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• pp.547-552
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• 2022

Sorafenib, originally identified as an inhibitor of multiple oncogenic kinases, induces ferroptosis in hepatocellular carcinoma (HCC) cells. Several pathways that mitigate sorafenib-induced ferroptosis confer drug resistance; thus strategies that enhance ferroptosis increase sorafenib efficacy. Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is upregulated in human HCC tissues and plays a role in cancer cell proliferation. The aim of this study was to determine whether inhibition of ERRγ with DN200434, an orally available inverse agonist, can overcome resistance to sorafenib through induction of ferroptosis. Sorafenib-resistant HCC cells were less sensitive to sorafenibinduced ferroptosis and showed significantly higher ERRγ levels than sorafenib-sensitive HCC cells. DN200434 induced lipid peroxidation and ferroptosis in sorafenib-resistant HCC cells. Mechanistically, DN200434 increased mitochondrial ROS generation by reducing glutathione/glutathione disulfide levels, which subsequently reduced mTOR activity and GPX4 levels. DN200434 induced amplification of the antitumor effects of sorafenib was confirmed in a tumor xenograft model. The present results indicate that DN200434 may be a novel therapeutic strategy to re-sensitize HCC cells to sorafenib.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.8
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• pp.5096-5110
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• 2015

The purpose of this study was to identify the effects of brain wave change through therapeutic recreation programs on depression, sleep disturbance and quality of life among elderly with dementia. The subjects of this quasi-experimental study consisted of two groups, one experimental group (N=14) and one control group (N=18), after excluding 8 participants from a total of 40 participants. The subjects of experimental group were randomly selected from the elderly (order than 65 years old) of senior care center in Daejoen and participated in 3-month therapeutic recreation program. On the other hand, the subjects of control group did not participated in any therapeutic recreation program. Each group's pre-post brain wave change, depression, sleep disturbance and quality of life were estimated. Through ANCOVA and Analysis of Structural Equation Modeling with SPSS window 17.0 and AMOS 7.0, this study found followings. Frist, the therapeutic recreation program group indicated significant improvement of brain waves, sleep disturbance and quality of Life. In addition, depression was significantly reduced in the therapeutic recreation program group. Second, significant causal relationships was found among brain waves, depression, sleep disturbance, and Quality of Life.

• Industry Promotion Research
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• v.5 no.2
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• pp.41-50
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• 2020

WIn Korea, the rapid rise of elderly population and dementia prevalence resulting from the unprecedently rapid aging in the world is being emerged as a serious social issue. Caring the elderly with dementia is a different way from a general life and is a world which new cultural existential relationships are interlaced from the relationship viewpoint. From this aspect, the psychological matter of family caring a demented elderly needs to be studied for existential understanding in depth and fundamentally. This study focused on in-depth understanding and description of the stress phenomena experienced by family caregivers with a demented elderly based on Giorgi's method among phenomenological research methods and using existential group counseling techniques. Total 8 sessions of existential group counseling were conducted. This study drew out the outcomes(emotional stress, psychosocial stress, time-dependent stress) of participants' self-awareness experiences by applying 4 steps of Giorgi's phenomenological research methodology based on the Existential Philosophy to participant's intensive statements about stress of family caring a demented elderly drawn out of the existential group counselling sessions. It is hoped that understanding the pain of the supporters who cannot express their own pains through the research results and their self-help group counseling activities will become active, contributing to the health of our society which is about to enter post-aged society.

• 제어로봇시스템학회:학술대회논문집
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• 1988.10b
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• pp.885-890
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• 1988

This is a successive study of the development and application of an electronic safeguard system for elderly men (senile dementia patients) who wander without purpose because of declined mental capability, while retaining their physical ability. The new safeguard system is designed with some additional functions on the basis of the previously developed system. Firstly, alarms are designed not to disturb other patients at night, so that informations about doors from which the patients go out may be transmitted to helpers individually by radio paging system. Secondly, the system hardware can be set up anywhere without laying particular signal transmission cables, provided that there exist AC power distribution lines for the utilization as a transmission line of signals to alarm indicators. Thirdly, it is possible to have a grasp of the whole states of the safeguard systems at the center of operation by monitoring the operational state of each system with a necessary data acquisition according to its instruction through telecommunication network. Thus, each safeguard system can be economically supplied to the special nursing homes and the helpers are ensured more released from physical and psychological burdens so that they can devote themselves to the care of senile elderly men, thereby improving their patients' comfort and human dignity.