• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.38-40
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• 1995

There have reports suggested that cerebral blood flow (CBF) has decreased in patients with both senile dementia of the Alzheimer's type and multi-infarct dementia, which are characterized by marked cognitive impairments. In addition, recent studies have demonstrated that decrease of CBF precedes the onset of multi-infarct dementia. These findings further suggest that chronic reduction of CBF may play an important role in the formation and progression of cerebral vascular dementia. Although transient cerebral ischemia, based upon vascular “reperfusion”, is apparently not paralleling the clinical condition, the transient cerebral ischemia model is one of the major methods investigated and the other is the cerebral embolism operation. Cognitive impairment and neuronal damages have been fully studied using these transient and/or embolic ischemia models. There are, however, few investigations focused the attention on the influence of chronic decrease of CBF on cognitive processes. In the present study, we have chosen a chronic ischemic model which is produced by permanent occlusion of bilateral common carotid arteries (2VO) in rats to investigate the neuronal damage and cognitive deficits through radial maze performance. We investigated furtherly the effects of tetramethylpyrazine (TMP), a constituent isolated from Ligusticum Chuanxiong on such a model.

• Dementia and Neurocognitive Disorders
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• v.23 no.4
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• pp.212-223
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• 2024

Background and Purpose: Dementia, particularly Alzheimer's disease, is a significant global health concern, with early diagnosis and treatment development being critical goals. While numerous cohorts have advanced dementia research, there is a lack of comprehensive data on ethnic differences, particularly for the Korean population. The Korea-Registries to Overcome Dementia and Accelerate Dementia Research (K-ROAD) aims to establish a large-scale, hospital-based dementia cohort to address this gap, with a focus on understanding disease progression, developing early diagnostics, and supporting treatment advancements specific to the Korean population. Methods: K-ROAD comprises multiple prospective cohorts. Participants underwent clinical evaluations, neuroimaging, and biomarker analysis, with data collected on a range of clinical and genomic markers. Results: As of December 2023, K-ROAD has recruited over 5,800 participants, including individuals across the Alzheimer's clinical syndrome, subcortical vascular cognitive impairment, and frontotemporal dementia spectra. Preliminary findings highlight significant ethnic differences in amyloid positivity, cognitive decline, and biomarker profiles, compared to Western cohorts. Conclusions: The K-ROAD cohort offers a unique and critical resource for dementia research, providing insights into ethnic-specific disease characteristics and biomarker profiles. These findings will contribute to the development of personalized diagnostic and therapeutic approaches to dementia, enhancing global understanding of the disease.

• Journal of Haehwa Medicine
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• v.12 no.2
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• pp.11-40
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• 2004

This study analyzed the contents of the research papers concerning the vascular dementia(VD) recorded in Chinese medical journal published over the period between 1998 and 2000. As a result, the following conclusion was drawn. The Chinese medical category of VD includes Sun-Mang(善忘), Chi-Mae, Jung-Pung-Chi-Mae and so on, and the Major mechanism of the VD is Bon-Heo- Pyo-Sil(state of deficient vital essence and excessive pestilential vapor;本虛標實), Bon(本) includes Sin-Jeong-Heo-Son(腎精虧損), Ki-Hyeol-Hyu-Heo(氣血虧虛) and Pyo(標) includes Dam-Chae-Eo-Jo(痰滯瘀阻), Ki-Chae-Hyeol-Eo(氣滯血瘀), Gan-Yang-Sang-Hang(肝陽上亢). It is mainly used DSM and evidence of brain-vascular disease in brain CT or MRI as the criterion for diagnosis in Western medicine and MMSE, HDS, ADL is used as assistant diagnostic indicator. "Principle of clinical study guidance for treatment of dementia by Chinese medicine, Western medicine"("中藥新藥治療痴呆 病的臨床硏究指導原則") is mainly used as the criterion for diagnosis in Chinese medicine. It is mainly used "Principle of clinical study guidance for treatment of senile disease by Chinese medicine, Western medicine"("中藥新藥治療老年病臨床硏究指導原則"), "Principle of clinical study guidance for treatment of dementia by Chinese medicine, Western medicine" as the criterion for treatment effect evaluation, and score change of MMSE and HDS is used as assistant evaluation indicator. The research papers reported that the use of prescriptions such as Hwan-Chong-Dan(還聰丹), Noi-Hyeol-So-Tong-Gu-Bok-Yaek(腦血疏通口服液), Yik-Gi-Gyo-Nang(益智膠囊), Cheon-Ma-Chok-Gi-Chung-Je(天麻促智沖劑), Sam-Gap-San-Ga-Mi-Bang(三甲散加味方), Seon-Ryong-Gyo-Nang(仙龍膠囊), Seong-Noi-Tang II(醒腦湯II號), Bo-Sin-Geon-Noi-Tang(補腎健腦湯), Ga-Mi-Tong-Gyu-Hyal-Hyeol-Tang(加味通竅活血湯), So-Jo-Yik-Ji-Bang(疏調益智方), Tong-Gyu-Hwal-Hyeol-Tang-Ga-Gam(通竅活血湯加減), Yik-Sin-Seong-Noi-Tang(益腎醒腦湯) led to the high efficacy.

• The Journal of Internal Korean Medicine
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• v.24 no.4_2
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• pp.1037-1045
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• 2003

Objectives: Dementia is a kind of chronic, progressive, degenerative disease. The symptoms results in troubles in intellectual functions. memory, orientation, intelligence, judgement, common sense and calculating ability. The Korean version of Mini-Mental State Examination(MMSE-K) has been used widely to screen cognitive impairment of the elderly in Korea. This instrument has been specifically developed and evaluated for the assessment of cognitive function in older Korean populations. Methods: Cognitive function was evaluated by the Korean version of Mini-Mental State Examination(MMSE-K). This patient was diagnosed as Vascular dementia and We treated her cognitive impairment with Gagambosim-tang(Jiajianbuxin-tang). Results: After treated with Gagambosim-tang(Jiajianbuxin-tang), Cognitive function was improved. Conclusion: This report may have a meaning to treat Vascular dementia.

• Journal of Oriental Neuropsychiatry
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• v.28 no.4
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• pp.401-408
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• 2017

Objectives: The purpose of this study is to obtain the differential variable and learning effect of the serial position effect, targeting individuals aged 60 years and over. A total of 89 individuals were categorized into the following groups: Alzheimer's group, vascular dementia group, elderly depression group, and normal group. Methods: Considering the size of the groups used for comparison, of the total 89 participants, 28 were in the Alzheimer's group, 24 in the vascular dementia group, 16 in the elderly depression group, and 21 were randomly chosen for the normal group. In the CERAD-K word list memory test, 10 words were shown to the subjects. We then asked them to freely recall the words. After changing the order of the words three times, the same process was followed. Results: First, a significant difference was observed among the groups in terms of word recalling rate. The analysis conducted afterward showed that, as predicted, the depressed group showed significantly better performance in recalling the words. Second, the vascular dementia patients and the Alzheimer's patients showed, as predicted, better recall of the largest recency region of words shown. Third, the normal group and the elderly depressed group showed a high-performance rate, proving that the reiterative method can contribute to the recalling process. Thus, we demonstrated that the Alzheimer's group showed the deterioration of short memory recalling skills and the elderly depressed showed deteriorated output performance skill.

• The Journal of Internal Korean Medicine
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• v.44 no.5
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• pp.1033-1040
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• 2023

Objectives: The aim of this study is to describe the effects of traditional Korean medicine treatment on a patient with vascular dementia caused by an intracerebral hemorrhage. Methods: The patient was treated with herbal medicine (modified Guibi-tang) and acupuncture. The effects of these treatments were evaluated using the Korean Mini Mental Status Examination (K-MMSE-2), Cognitive Dementia Rating (CDR), Manual Muscle Test (MMT), Korean version of Modified Barthel Index (K-MBI), and Videofluoroscopic Swallow Study (VFSS). Results: After treatment, the K-MMSE-2 score, CDR score, MMT, K-MBI, and VFSS improved. Conclusion: The results suggest that traditional Korean medicine may be effective for the symptoms of vascular dementia caused by intracerebral hemorrhage.

• The Journal of Korean Physical Therapy
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• v.22 no.1
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• pp.53-60
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• 2010

Purpose: The purpose of our study was to evaluate the effects of an exercise program on activities of daily living (ADL), balance and cognition in elderly individuals with Alzheimer’s disease and vascular dementia. Methods: Thirty-two patients with mild to moderate cognitive impairment were assigned to one of two groups: an exercise group (n=16) and a control group (n=16). The exercise group carried on regular exercise for 60 minutes a day, 4-5 times per week for 8 weeks. The exercise group participated in an exercise program (treadmill training and physical training). ADL, balance and cognitive function were evaluated before and at the end of the program using the Korean modified Bathel Index (K-MBI), the Functional independence measure (FIM), the Berg balance scale (BBS), the Balance performance monitor (BPM), and the Mini mental state examination (MMSE) in both groups. Results: There were significant exercise-induced improvements in ADL and Balance from pre to post tests; but not in MMSE. Conclusion: Exercise programs can improve ADL and balance in elderly with Alzheimer’s disease and vascular dementia.

• Journal of Oriental Neuropsychiatry
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• v.21 no.4
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• pp.137-149
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• 2010

Objectives : The aim of this study was to describe the clinical aspects in dementia outpatients who visited oriental neuropsychiatry clinic and to analyze the efficacy of herbal medicine. Methods: We analysed medical records of dementia outpatients who visited oriental neuropsychiatry clinic of K medical center from August. 2000 to July, 2010 and matched our criteria. Results: Ninety-two subjects were selected for analysis and consisted of 77.3% dementia of Alzheimer type. 13.0% vascular dementia. and 9.8% mixed type of dementia. Herbal medicine prescribed mainly were Jowjseungchung-tang(Tiaowejshengqing-tang). Kunneo-tang(Jjannao-tang) and Chenwangbosim-dan(Tianwangbuxin-dan) for dementia of Alzheimer type, and Sunghyangjungki-san(Xjngxjangzhengqi-san) and Upung-dan (Yufeng-dan) for vascular dementia. Scores of K-DRS were not changed for some subs cales and decreased but less than natural decline of Alzheimer disease. Score on the Memory subscale in group of Kunneo-tang(Jjannao-tang) increased significantly. Conclusions : These results suggest that the herbal medicine may be effective for dementia. More prospective studies are needed to assess the efficacy and prognosis of herbal medicine for dementia. Clinical guideline is needed for systematic data accumulation.

• Journal of Periodontal and Implant Science
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• v.50 no.5
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• pp.303-312
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• 2020

Purpose: The purpose of this study was to evaluate severe periodontitis with tooth loss as a modifiable risk factor for Alzheimer dementia (AD), vascular dementia (VaD), and mixed dementia (MD) using the National Health Insurance Service-National Health Screening Retrospective Cohort database with long-term follow-up over 14 years. Methods: Multivariate Cox hazards regression analysis was applied to a longitudinal retrospective database, which was updated in 2018, to evaluate the association between severe periodontitis with few remaining teeth and dementia after adjusting for potential risk factors, including sociodemographic factors and comorbid diseases. Results: Among 514,866 individuals in South Korea, 237,940 (46.2%) participants satisfying the inclusion criteria were selected. A total of 10,115 age- and sex-matched participants with severe periodontitis and 10,115 periodontally healthy participants were randomly selected and evenly assigned. The results showed that the risks of AD (hazard ratio [HR], 1.08), VaD (HR, 1.24), and MD (HR, 1.16) were significantly higher in patients with severe periodontitis with 1-9 remaining teeth after adjustment for sociodemographic factors, anthropomorphic measurements, lifestyle factors, and comorbidities. Conclusions: Severe periodontitis with few remaining teeth (1-9) may be considered a modifiable risk factor for the development of AD, VaD, and MD in Korean adults.

• The Journal of Internal Korean Medicine
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• v.16 no.1
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• pp.1-16
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• 1995

This study was done in order to investigate the etiology and pathology of dementia in the variety literature. Dementia in elderly persons(above the age of 60) mainly classfied Alzheimer disease and Cerebral vascular dementia. The results were as follows: 1. Dementia patients have abnormal mental function, who have no mental weakness but defects of memory, verbal disturbance, behavior disturbance and loss of intellectual function. 2. Dementia regard as 'me-beng(?病)', 'jeon-gwang(癲狂)', and 'heo-ro(虛勞)' in oriental medicine and the symptom is a silence with no response, mixing, a crying or a laugh, a stranger behavior and a amnesia; disturbances of speech, emotion, behavior. 3. Dementia caused by Alzheimer disease, Multi infarct dementia, Parkinson's disease, sequelae of acute CO poisoning, head injury and alcoholism(occidental medically) and the 'Dam(痰) and Damhwa(痰火), weakness of heart and spleen(心脾虛) caused by pent up anger of seven emotions(七情鬱結), the weakness of liver and kidney(肝腎不足)(oriental medically). 4. The causes of Alzheimer disease are various; a heredity factor, a morphological factor of brain tissues, a psychological factor and a biochemical factor (occidental medically) ; the 'Dam(痰) and Damhwa(痰火) caused by weakness of the internal organs and disturbance of the emotions(oriental medically). 5. Cerebral vascular dementia caused by loss of the certain cerebral neurons and oriental medically caused by obstruction of 'dam(痰)' or 'eo heul(瘀血)'. It is recommended that further study of many sided investigations, specially against a weakness of spiritual functions and a certain neurotoxin in the future.