• 제목/요약/키워드: Definitive

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상악 구개부 치은에 발생한 편평상피세포암의 증례보고 (Squamous Cell Carcinoma In Palatal Gingiva. A Case Report)

  • 김옥수;정현주
    • Journal of Periodontal and Implant Science
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    • 제26권1호
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    • pp.309-316
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    • 1996
  • Squamous cell carcinoma is the most common malignant tumor of the gingiva. Oral cancer accounts for 5 percent of all malignant tumors in the body, and 6 percent of these occur in the gingiva. We present one case of squamous cell carcinoma of the gingiva in 23-year-old female. She complained of gingival swelling and pain during mastication between left maxillary first molar and second molar. Since she had received scaling 2 years ago, food impaction occurred frequently in this site and an ulcerative lesion recurred several times. When she was referred from local clinic, she had a large, irregularly ulcerated lesion of palatal gingiva between left maxillary first molar and second molar, accompanying induration in center and slight elevation around ulcerative margin. The etiology could not be defined but we could diagnose by careful history taking and excisional biopsy of the recurrent ulcerative lesion. In addition, computed tomography and nuclear medicine imaging were undertaken. As a result, we finally diagnosed as moderately differentiated squamous cell carcinoma without metastases. It is concluded that if ulcerations do not respond to therapy in the usual manner, it should be biopsed and histologically evaluated for the definitive diagnosis and treatment.

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In Search for a Common Pathway for Health Issues in Men - the Sign of a Holmesian Deduction

  • Aoun, Fouad;Chemaly, Anthony Kallas;Albisinni, Simone;Zanaty, Marc;Roumeguere, Thierry
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권1호
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    • pp.1-13
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    • 2016
  • The evidence for the existence of a common pathway for health issues in men is presented in this review. Several epidemiological studies have shown that conditions like cardiovascular diseases (CVD), metabolic syndrome, diabetes, lower urinary tract symptom (LUTS), erectile dysfunction (ED), prostate cancer, hypogonadism, depression and suicide can be associated as risk factors for each other. Thus, the risk of CVD is significantly increased in men with metabolic syndrome, ED, hypogonadism, prostate cancer and/or LUTS. In addition, the above mentioned conditions are more prevalent in atherosclerotic patients. In addition, growing evidence indicates that low androgen levels can cause metabolic syndrome. In addition, obesity, dyslipidaemia and diabetes can further reduce androgen levels potentiating their adverse effect. Low testosterone levels are also associated with a higher incidence of aggressive prostate cancer on biopsy and on definitive pathology, and lower probability of abiraterone response in the metastatic setting. Several recent studies point towards diffuse endothelial dysfunction and dysregulated pro-inflammatory state as the biological link between all these disorders. Our current hypothesis is that oxidative stress caused by these dysfunctions explains the pathogenesis of each of these conditions.

Clinicopathologic Characteristics of Breast Cancer in Jamaica

  • Chin, Sheray Nicole;Green, Cheryl;Strachan, Georgiana Gordon;Wharfe, Gilian
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권7호
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    • pp.3319-3322
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    • 2014
  • Breast cancer is the most common cancer in Jamaican women. This study assessed the clinicopathologic features of cases in a hospital-based specialist clinic in Kingston, Jamaica. A retrospective chart review was performed for the 2-year study period and relevant clinical and surgico-pathologic data were recorded and analyzed. Median age of the 121 breast cancer patients was 52 years (range 22-84, IQR 20) and there was 1 case of male breast cancer. Most patients (65%) were referred from the surgical service after definitive breast cancer surgery, 20% were referred for pre-operative systemic therapy, and 15% had a diagnosis of metastatic disease. The surgico-pathologic group comprised 78 women who were referred for adjuvant therapy. The majority had presented with a palpable breast lump (91%), with median tumour size 3.5cm (range 0.4-13, IQR 4). Most tumours were node positive (56%). Approximately one-third of patients had stage III disease (33%). Most women presented with large palpable tumours and had lymph node involvement confirmed on surgicopathological evaluation, indicative of limited early breast cancer detection. A national screening mammography programme is recommended for detection of earlier lesions. Pre-operative systemic therapy should be considered as an option for eligible patients.

Homogeneity in Case/Control Numbers and North Indian Caste Criteria in Cervical Cancer/Female Urology Genetic-Studies at a Premier Medical Research Institute in Lucknow, India

  • Pandey, Saumya;Chandravati, Chandravati
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권10호
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    • pp.6185-6187
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    • 2013
  • Cervical cancer has emerged as a major public health problem in Lucknow and New York in the $21^{st}$ century. Cancer genetic studies are essential to identify/stratify disease-susceptible individuals in a population-based cohort. Sample size homogeneity and North Indian caste in female urology genetic-studies are significant issues in meaningful interpretation of data. A review of scientific literature using Pubmed database was conducted, including an assessment of cervical cancer genetic studies conducted as part of the author's doctoral dissertation at a premier Lucknow-based medical research Institute. Sample size numbers and caste criteria in the North Indian cohort ($N{\leq}400$ subjects) were evaluated with homogeneity in the sample cohort data set(s). Subgroup caste-stratification of North Indian cohort is equally essential, for instance, Brahmin (e.g. Pandey), Vaishya (e.g. Mittal), Rajput (e.g. Singh) and Kshudra (e.g. Yadav) during the conception and design of genetics-based studies. Sample size homogeneity in histopathologically confirmed case and control numbers and caste-based stratification in a North Indian cohort is essential in single nucleotide polymorphism (SNP) studies in cervical cancer susceptible populations to draw more definitive conclusions.

Intra-Operative Frozen Sections: Experience at A Tertiary Care Centre

  • Preeti, Agarwal;Sameer, Gupta;Kulranjan, Singh;Abhinav, Sonkar Arun;Preeti, Rani;Sunita, Yadav;Mati, Goel Madhu
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권12호
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    • pp.5057-5061
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    • 2016
  • The present study was conducted to assess error rates with diagnosis using intra-operative frozen sections, and to indicate ways to increase overall performance. Over a period of two years, 227 cases were biopsied intra-operatively. Errors were observed in 14 cases. Four of these were sampling errors, one by a pathologist and three by surgeons. In seven cases incorrect interpretations were made. Epithelial dysplasia was observed on definitive histology in two cases which was not reported intra-operatively. One case was of ectopic thyroid. In cases of oral cancer where sentinel lymph nodes were sampled, immunohistochemistry for cytokeratin was performed to facilitate identification of micrometastasis. Only single case displayed tumor deposits which was not evident morphologically. Resection margins were reported in seventy eight cases. Some 18% (14/50) benefited from revision of margins; overall sensitivity of intra-operative frozen sections for marginal status was 71.4%, with a specificity of 90.3%. Overall sensitivity was 75% and specificity was 97.5%. Careful observation, pathologist experience and knowledge of limitations help in improving the overall diagnostic outcome.

Multimodality Treatment for Patients with Node-Positive Prostate Cancer: the Role of Radiation Therapy

  • Ochiai, Satoru;Nomoto, Yoshihito;Kobayashi, Shigeki;Yamashita, Yasufumi;Watanabe, Yui;Toyomasu, Yutaka;Kawamura, Tomoko;Takada, Akinori;II, Noriko;Sakuma, Hajime
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권4호
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    • pp.1625-1630
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    • 2016
  • Prostate cancer is the secondary most frequently diagnosed cancer in the world. Although numerous prospective randomized trial have been conducted to guide the management of patients with localized or locally advanced prostate cancer, few clinical trials targeting node-positive prostate cancer have been reported. Therefore, there are still controversies in the optimal management of node-positive prostate cancer. Recently, efficacy of multimodality treatment, including radiation therapy (RT), for such patients has been reported in several articles. The results indicate potential benefit of RT both in adjuvant therapy after prostatectomy and in definitive therapy for node-positive prostate cancer. The aim in this article was to summarize the current evidence for RT and evaluate the role in multimodality treatment for patients with node-positive prostate cancer.

Autoimmune encephalitis and epilepsy: evolving definition and clinical spectrum

  • Seo, Joo Hee;Lee, Yun-Jin;Lee, Ki Hyeong;Gireesh, Elakkat;Skinner, Holly;Westerveld, Michael
    • Clinical and Experimental Pediatrics
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    • 제63권8호
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    • pp.291-300
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    • 2020
  • Advances in autoimmune encephalitis studies in the past 10 years have led to the identification of new syndromes and biomarkers that have transformed the diagnostic approach to the disorder. The disorder or syndrome has been linked to a wide variety of pathologic processes associated with the neuron-specific autoantibodies targeting intracellular and plasma membrane antigens. However, current criteria for autoimmune encephalitis are quite dependent on antibody testing and responses to immunotherapy, which might delay the diagnosis. This form of encephalitis can involve the multifaceted presentation of seizures and unexpected behavioral changes. The spectrum of neuropsychiatric symptoms in children is less definitive than that in adults, and the incorporation of clinical, immunological, electrophysiological, and neuroradiological results is critical to the diagnostic approach. In this review, we document the clinical and immunologic characteristics of autoimmune encephalitis known to date, with the goal of helping clinicians in differential diagnosis and to provide prompt and effective treatment.

한국인에서 중합효소반응을 이용한 Short Tandem Repeat(STR)유전좌위 F13B분석 (Analysis of Short Tandem Repeat(STR) Locus F13B by Polymerase Chain Reaction in Korean)

  • Yong-Sik Kim;Woong Hur;Chang-Lyuk Yoon
    • Journal of Oral Medicine and Pain
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    • 제21권2호
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    • pp.243-253
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    • 1996
  • In order to be utilized as a database in forensic identification and parentage test, allelic frequency and genotype distribution of short tandem repeat(STR) F13B locus was analysed by polymerase chain reaction in 210 Korean adults who are not related. The results were as follows. 1. 3 alleles and 56 genotypes of F13B locus were detected and heterozygosity value was 48.6% and allelic diversity value was 0.639 and the power of discrimination was 0.804. 2. The observed each alleles and allelic frequency was 8(0.069), 9(0.193), 10(0.738). In conclusion, the allelic frequency of STR F13B locus in the Korean is considered as an useful DNA allelic profile for forensic identification, but it should be used with several other STR locus to get definitive conclusion of analysis for individual identification and parentage testing.

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러시아의 도서관 행정.법제에 관한 고찰 (On the Library Administrative Systems and Legislations in Russia)

  • 윤희윤
    • 한국도서관정보학회지
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    • 제35권3호
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    • pp.23-40
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    • 2004
  • 이 연구는 국내에서 전혀 논급되지 않은 러시아의 도서관 행정체계와 법제를 고찰하는데 목적이 있다. 1991년 소비에트연방이 붕괴된 이후, 러시아는 새로운 정치적, 법적, 경제적 시스템을 도입하기 시작하였다. 현재 러시아에는 약 51,000개의 공공도서관이 있으며, 대체로 행정구역을 중심으로 중앙집중적 시스템으로 운영되고 있다. 연방정부의 도서관 주무부처는 문화부이며, 1994년에 핵심법제인 ‘도서관법’과 ‘납본법’을 제정하였다. 그리고 2001년에는 러시아도서관협회가 ‘공공도서관 모델기준’을 공표하였으며, 사서집단과 지방행정청이 이를 준용하고 있다.

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이기종-다중 기상레이더 자료의 실시간 통합 모니터링 기법 연구 (Study about Real-time Total Monitoring Technique for Various Kinds of Multi Weather Radar Data)

  • 장봉주;이건행;임상훈;이동률;권기룡
    • 한국멀티미디어학회논문지
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    • 제19권4호
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    • pp.689-705
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    • 2016
  • This paper proposed an realtime total monitoring platform for various kind of multi weather radars to analyze and predict weather phenomenons and prevent meteorological disasters. Our platform is designed to process each weather radar data on each radar site to minimize overloads from conversion and transmission of large volumed radar data, and to set observers up the definitive radar data via public framework server separately. By proposed method, weather radar data having different spatial or temporal resolutions can be automatically synchronized with there own spatio-temporal domains on public GIS platform having only one spatio-temporal criterion. Simulation result shows that our method facilitates the realtime weather monitoring from weather radars having various spatio-temporal resolutions without other data synchronization or assimilation processes. Moreover, since this platform doesn't require some additional computer equipments or high-technical mechanisms it has economic efficiency for it's systemic constructions.